Ferroptosis1

Iron on trial: recasting the role of iron in neurodegeneration Iron is essential for brain health but can become harmful when dysregulated. Ayton et al. summarise recent clinical trial results showing negative effects

academic.oup.com/brain/advanc...

Terrible figure. FerrOztosis is a great ferroptosis conference in Melbourne though.

HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis Modulating the intracellular labile iron pool (LIP) has emerged as a promising strategy to induce ferroptosis in cancer cells, offering a way to overcome resistance to apoptosis-based therapies. One o...

(1) New preprint from our lab!
HMOX1 controls a heme/ferritin switch that protects cells from ferroptosis.
Loss of HMOX1 stabilizes heme, boosts ferritin, and suppresses ferroptotic death.
👉 doi.org/10.1101/2025...
#ferroptosis #heme #ironmetabolism #preprint

Heme and iron toxicity in the aged spleen impairs T cell immunity through iron deprivation - Nature Aging In their study, Ezuz et al. show that the aged spleen contributes to T cell aging through hemolytic stress and an increasingly heme- and iron-rich microenvironment. T cells adapt by limiting their iro...

www.nature.com/articles/s43...

New research presents a data common named the "Neurolipid Atlas" - a useful resource prepopulated with isogenic iPS cell-derived lipidomics data for different brain conditions ( #Alzheimers, #Parkinsons, #ALS, #FTD)
www.nature.com/articles/s42...

We are excited to announce FerrOZtosis 2.0! | Scott Ayton We are excited to announce FerrOZtosis 2.0! Come join us on the 19th of September at the Florey for a day full of ferroptosis. Our international guest speaker is the co-discoverer of ferroptosis, Pro...

🔬 Exciting news for the ferroptosis community!
FerrOZtosis 2.0 symposium is happening this 19th September 2025 at The Florey, Melbourne.
📅 Abstract deadline: August 15
📍 Details & registration: lnkd.in/dn7imCzd

Lithium Chloride Inhibits Iron Dysregulation and Ferroptosis in Induced Pluripotent Stem Cells with ApoE4/E4 from a sporadic Alzheimer's disease patient #NeuroDegeneration 🧪🧠
https://www.biorxiv.org/content/10.1101/2025.08.28.672956v1

Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy - Nature Decreased brain coenzyme Q10 levels cause encephalopathy and are associated with neurodegeneration; supplementation with 4-HMA or 4-HB restores coenzyme Q10 synthesis in mice and humans with HPDL vari...

www.nature.com/articles/s41...

Coenzyme Q headgroup intermediates can ameliorate a mitochondrial encephalopathy

Wow

Fascinating idea!

FYI - We've extended abstract submission deadline to June 8. Submit soon to be considered for a short talk. Come join us at the first FASEB #Ferroptosis meeting! It's going to be awwwwesome! 🤩
events.faseb.org/event/11797f...

Cocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1 | PNAS FSP1 is an FAD-dependent oxidoreductase that uses NAD(P)H to regenerate the reduced forms of lipophilic quinone antioxidants, such as coenzyme Q10 ...

Thrilled this paper is out! We solved the first cocrystal structure of FSP1 with an inhibitor (FSEN1), providing mechanistic insight & a foundation for medchem. Led by Amalia Megarioti & Sitao Zhang. A terrific collaboration with Da Jia.
Brief Skytorial!
1/9

Congratulations James! From basic discovery to drugging it in such a short time! Amazing work out of #MolecularTherapeutics @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social!!!

Neuroferroptosis in health and diseases Nature Reviews Neuroscience - The brain’s high lipid content, iron levels and oxygen metabolism uniquely predispose it to ferroptosis, an iron-dependent form of regulated cell death. In this...

rdcu.be/emFqP Excellent review of our current understanding of ferroptosis in the brain and some of the challenges of studying it

Human mitochondrial ferritin exhibits highly unusual iron-O2 chemistry distinct from that of cytosolic ferritins - Nature Communications Human mitochondrial ferritin protects against oxidative stress by detoxifying iron. Here, highly unusual iron-oxygen chemistry, involving formation of a mixed valent diiron site and a tyrosine radical...

"Despite 80% sequence identity with cytosolic human H-chain ferritin, ferrous ion oxidation at the catalytic diiron ferroxidase center of mitochondrial ferritin proceeds via a distinct mechanism"
www.nature.com/articles/s41...

Lipid-degrading small molecule kills cancer cells by ferroptosis A molecule designed to activate iron locked up in organelles called lysosomes and thereby induce cell death might offer a way to tackle treatment-resistant cancer.

Excited to see our N&V w/ @mikelangelipid.bsky.social published in Nature, highlighting new work from Raphael Rodriguez and team. A heterofunctional molecule that activates lysosomal iron triggers lipid peroxidation and ferroptosis in therapy-resistant cancer cells. www.nature.com/articles/d41...

Activation of lysosomal iron triggers ferroptosis in cancer - Nature Some cancer cells exhibit high loads of reactive iron in lysosomes, and this feature is exploited by using fentomycin-1, a newly developed small molecule, to induce ferroptosis.

Our new exciting work on ferroptosis initiation in lysosomes. New molecule killing persister cancer cells. www.nature.com/articles/s41... #ferroptosis #cancer #metastasis

Here is our latest paper in @ACSBiol on compounds that restore activity to the R152H GPX4 variant, found in patients with SSMD. Congrats to Hengrui, Farhad and Russ on a great collaboration! @columbia #ferroptosis pubs.acs.org/doi/full/10....

Our team (hsph.harvard.edu/research/ube...) is excited to have contributed to the intranodal in vivo testing of the remarkable new compound, Fentomycin-1. Congrats to team Rodriguez et al. for the implications of this work in targeting ferroptosis in cancer. Check it out here!

Lipid-degrading small molecule kills cancer cells by ferroptosis A molecule designed to activate iron locked up in organelles called lysosomes and thereby induce cell death might offer a way to tackle treatment-resistant cancer.

Fantastic new study from Raphael Rodriguez' lab shows that induced proximity concepts can be used to induce Ferroptosis! Inducing proximity of lysosomal iron and lipids induces lipid peroxidation! What a cool concept! Have a look at our News/Views with @olzmannlab.bsky.social shorturl.at/cbc8D

Reminder: The 1st FASEB #Ferroptosis Meeting is this summer! Spectacular speaker lineup + short talks selected from submitted abstracts. It is going to be awesome! Trainees, newcomers & all interested are welcome!
📅 Abstract deadline: June 1, 2025.
shorturl.at/QA6T1

Join for the first FASEB Ferroptosis conference in the US this July! This stellar speaker line up brings together almost all leaders in the field!

Thank you to @brentstockwell.bsky.social of @columbiauniversity.bsky.social for visiting #MolecularTherapeutics at @mti-ucb.bsky.social @ucberkeleyofficial.bsky.social and presenting a tour-de-force through the ferroptosis field!

Palmitoylation regulates ferroptosis and anti-tumor immunity Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In...

Palmitoylation regulates ferroptosis and anti-tumor immunity
->Nature | More info from EcoSearch

N-acetyl-l-cysteine averts ferroptosis by fostering glutathione peroxidase 4 Zheng and Zhang et al. identify N-acetyl-l-cysteine (NAC) and its enantiomer N-acetyl-d-cysteine (d-NAC) as direct reducing substrates of glutathione peroxidase 4 (GPX4). They further reveal a broad r...

Interesting study that attempts to explain how NAC rescues from direct GPX4 covalent binding inhibitors. Was always a bit of a mystery and it looks to me like there might be more to it. www.cell.com/cell-chemica...

An atlas of ferroptosis-induced secretomes Cell Death & Differentiation - An atlas of ferroptosis-induced secretomes

What do cells undergoing #ferroptosis #celldeath release? Read all about it in our atlas on ferroptosis #secretomes out now in Cell Death and Differentiation #CDDpress
Great collaboration with @cecad.bsky.social @frezzalab.bsky.social @kreuzaler.bsky.social @almutschulze.bsky.social

rdcu.be/ejp9C

Have you heard of ferroptosis? 💥 This is the iron-driven, propagating form of cell death! Our Membrane Dynamics Department (@office-garcia.bsky.social) has developed an optical tool to trigger and control it.

🔗Find out more: www.biophys.mpg.de/2857694/shining-a-new-light-on-ferroptosis?c=2011019

PRMT5-mediated arginine methylation stabilizes GPX4 to suppress ferroptosis in cancer - Nature Cell Biology Fan et al. report a role for PRMT5 in regulating GPX4 stability and ferroptosis sensitivity through arginine methylation, which may be targeted to inhibit tumour development.

☕Fan et al. report a role for PRMT5 in regulating GPX4 stability and #ferroptosis sensitivity through arginine methylation, which may be targeted to inhibit #tumor development.
rdcu.be/ejc3M
bit.ly/4iyxJMj

PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation a–c, Immunoprecipitation and immunoblotting analyses were performed with the indicated antibodies. Representative results from at least three independent experiments were shown. a,b, The indicated MDA-MB-231 were treated with the indicated peptides with or without IFNγ (25 ng ml−1) for 2...

PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation
->Nature | More info from EcoSearch

ALDH7A1 helps guard cells against ferroptosis by producing membrane NADH, boosting FSP1's antioxidant role. Explore how cells combat iron-induced death! PMID:40233740, CELL 2025, @Cell https://doi.org/10.1016/j.cell.2025.03.019 #Medsky #Pharmsky #RNA #ASHG #ESHG 🧪