Sergi Roig Puiggros

Relating to our recently published paper in @natneuro.nature.com! 🔥🚨
Find here a research briefing that we wrote w/ @djabaudon.bsky.social trying to reach a broader neuroscience audience! Enjoy the reading!

www.nature.com/articles/s41...

Thanks Nikos!

Delighted to have contributed to this thorough and collaborative piece of work with amazing colleagues and friends! 🧠🚀

Thanks Ioana ♥️🫶🏼

Thanks for your involvement since day 1! It wouldn't have been possible without you and all the others!

Thank you Fernando!

Thank you Cedric! 🥳

Mil gracias! Me alegro que lo hayas disfrutado! ❤️

Finally, we have collaborated with Le Figaro to make the findings of this work more accessible, although in french: connect.lefigaro.fr/login?client...
Enjoy the reading! 6/n

This work also expands our understanding on the pathology behind these malformations, and particularly relating to epilepsy. 5/n

We show that heterotopic neurons acquire proper molecular identities, integrate developing and functional circuits, triggering behavioral responses after receiving sensory stimuli. Overall supporting Karten's "circuit equivalence" hypothesis. 4/n

Also, to everyone making this possible through their different expertise, allowing to build a complete view on how gray matter heterotopias integrate cortical circuits and function. @jbmanent.bsky.social @maelleguyoton.bsky.social @elboustanilab.bsky.social and many many others 3/n

A special thanks to @djabaudon.bsky.social, who has allowed me to explore, dig and question several avenues without putting limits and pushing my creativity and curiosity. 2/n

Position-independent emergence of neocortical neuron molecular identity, connectivity and function - Nature Neuroscience Even when neocortical neurons form in abnormal locations, they retain their identity and function, revealing that brain circuit formation can be guided by intrinsic developmental programs rather than ...

I'm very excited to finally see this one out in @natneuro.nature.com ! It has been an incredible journey alongside extremely talented people! Thanks to everyone involved and enjoy the reading! 1/n
www.nature.com/articles/s41...

Position-independent emergence of neocortical neuron molecular identity, connectivity and function - Nature Neuroscience Even when neocortical neurons form in abnormal locations, they retain their identity and function, revealing that brain circuit formation can be guided by intrinsic developmental programs rather than ...

Great @natneuro.nature.com study by @sroig.bsky.social @djabaudon.bsky.social @jbmanent.bsky.social & colleagues,
showing “equivalent circuits can emerge in different spatial configurations, allowing diverse brain architectures to converge on similar functional outcomes” 🧪🧠🧬

Position-independent emergence of neocortical neuron molecular identity, connectivity and function - Nature Neuroscience Even when neocortical neurons form in abnormal locations, they retain their identity and function, revealing that brain circuit formation can be guided by intrinsic developmental programs rather than ...

Very happy to have contributed to this wonderful/tentacular work alongside so many amazing colleagues and friends!

It opens up new ways of understanding grey matter heterotopia associated with altered cortical function and #epilepsy in humans.

🧠🧪🔥

www.nature.com/articles/s41...

Cell-extrinsic controls over neocortical neuron fate and diversity Cell-extrinsic cues are key for neocortical cell identity and diversity.

Ever wondered how robust cellular identity is to external perturbations? Here we disrupt cellular environmnent in vivo and in vitro, and find cell population specific sensitivities. Environment sculpts development yes, but not all cells are made of the same wood. www.science.org/doi/10.1126/...

Cell-extrinsic controls over neocortical neuron fate and diversity Cell-extrinsic cues are key for neocortical cell identity and diversity.

Very happy to have contributed to this great story 🧠🚀. It focuses on environment-dependent neuronal identity acquisition in the cortex! Big congrats to Natalia Baumann, Ilaria Morassut and Sabine Fièvre for pushing this w/ @djabaudon.bsky.social. Congrats to all!

www.science.org/doi/10.1126/...

Super lab looking for postdoc ... do not miss it! 👇🏼

Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development - Nature Ecology & Evolution Single-cell comparison of developing bat and mouse limbs reveals conservation of cell populations and gene expression patterns, and suggests repurposing of genes involved in proximal limb development ...

How bats developed their wings? 🦇

Turns out they reutilize existing gene programs 🔧

Find out more in our paper @natecoevo.nature.com in collaboration with @fany-real.bsky.social and @stemundi.bsky.social labs

www.nature.com/articles/s41...

A postnatal molecular switch drives activity-dependent maturation of parvalbumin interneurons Neuronal activity triggers PGC-1α-mediated transcriptional programs that drive the late maturation of PV+ interneurons, essential for cortical circuit function. PGC-1α partners with ERRγ and Mef2c to ...

1/10 Our latest research, led by Monika Moissidis, identifies a mechanism regulating the maturation of PV interneurons in the #cortex. This is the story @cellcellpress.bsky.social www.cell.com/cell/fulltex... ⬇︎ thread @devneuro.bsky.social @kingsioppn.bsky.social
@wellcometrust.bsky.social

Thrilled to co-chair Symposium S08: Developmental Origins of Astrocyte Diversity tomorrow at #GLIA2025! Join us for cutting-edge insights into how astrocytes are born , diversify, and shape brain function. Wed, July 9 | 🕙 10:00–12:00 With @loulierk.bsky.social , Maryam Faiz & @sloanlab.bsky.social

✨ Astrocyte diversity starts at the source!
🧬 We uncover how dual radial glia lineages generate distinct astrocyte subtypes in the neocortex — revealed by MERFISH, scRNA-seq & clonal tracing.
📍#GLIA2025 | Poster T10-010A
🧠 w/
@alanzhoujf.bsky.social
in Marseille
Come talk glia with us!

Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice - Nature Neuroscience Unlike cortical progenitors, ventral telencephalic progenitors retain the ability to generate diverse neuron types during neurogenesis. Here, the authors show that ventral telencephalic progenitor mat...

Now out in @natneuro.nature.com: Temporal control of progenitor competence shapes maturation in GABAergic neuron development in mice. Congrats to first authors @annrosebright.bsky.social, Yana Kotlyarenko, @flo-neuhaus.bsky.social, and thanks to all collaborators!
www.nature.com/articles/s41...
1/n

Postdoctoral researcher in evolutionary developmental neurobiology Come join our EU cephalopod consortium to discover how octopuses and other coleoids developed their large nervous system. Postdoc position available in the Seuntjens Lab in Leuven, Belgium.

We're hiring! Our lab is looking for a postdoc to investigate the #evodevo of #cephalopod brains. Did you recently graduate, and do you want to join our EU #WEAVE project with the Simakov and @simon-sprecher.bsky.social labs? Find the application form👇Thanks for RT 🐙🦑
www.kuleuven.be/personeel/jo...

Very grateful to have been able to present our work at the @corticodevelopment.bsky.social meeting in Naxos! Thanks putting together such a great line of speakers in this amazing location! 🧠☀️🍕

Still openings, check it out!

🎉 Excited to share that our paper on FCDII is out today! 🙌🏻 Huge thanks to @sbaulac.bsky.social and @sara baldassari for bringing me on board and introducing me to the complexity of somatic mutations. Hope our work helps advance understanding of the disease mechanisms.

Check out our latest work on the evolution of animal genome regulation out today in @nature.com. Nicely summarized below by @ianakim.bsky.social.
www.nature.com/articles/s41...

This is a major output from our ERC-StG project Evocellmap @erc.europa.eu at @crg.eu