Diego García González's Avatar

Diego García González

@diegoconcalma.bsky.social

Developmental neurobiologist Neurogenesis, neurodevelopmental disorders & evolution Group leader in a hotel named IBIS (room #207)

156 Followers  |  275 Following  |  19 Posts  |  Joined: 30.08.2023  |  1.9846

Latest posts by diegoconcalma.bsky.social on Bluesky

Estamos bien jodidos

25.07.2025 11:19 — 👍 1    🔁 0    💬 0    📌 0
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Lamentamos profundamente el fallecimiento del académico José Manuel García Verdugo, catedrático de la Universitat de Valencia. Referente internacional en Neurocencia y Microscopía Electrónica.
Su última charla en la #raciencias puedes recuperarla aquí: www.youtube.com/live/g7nPBVo...

07.07.2025 10:20 — 👍 5    🔁 2    💬 0    📌 2
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Incredible diversity of #pollen grains!

Pollen autofluorescence acquired with @zeiss-microscopy.bsky.social #superresolution Airyscan & color-coded for depth

#microscopy #bioimaging #bioart #sciart #botany #plantscience #fluorescencefriday

27.06.2025 16:40 — 👍 148    🔁 39    💬 4    📌 4
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Inactivation of the PHD3-FOXO3 axis blunts the type I interferon response in microglia and ameliorates Alzheimer’s disease progression PHD3 inhibition slows down the pathology and behavioral decline of an Alzheimer’s disease mouse model.

Really happy to see our work on Alzheimer’s disease (AD) microglia published in @science.org www.science.org/doi/10.1126/.... A great work at IBiS from Manuel Sanchez-Garcia, Nieves Lara-Ureña, Rosana March-Diaz, @alicielena.bsky.social , and all our collaborators.

29.05.2025 12:40 — 👍 3    🔁 2    💬 3    📌 1
A graphic for the Marie Skłodowska-Curie Actions (MSCA), showing a historical portrait of Marie Skłodowska-Curie overlaid with an image of four young researchers walking down a hallway. The European Commission logo is in the top left. Text reads: "Marie Skłodowska-Curie Actions – €404.3 million to support postdoctoral researchers”

A graphic for the Marie Skłodowska-Curie Actions (MSCA), showing a historical portrait of Marie Skłodowska-Curie overlaid with an image of four young researchers walking down a hallway. The European Commission logo is in the top left. Text reads: "Marie Skłodowska-Curie Actions – €404.3 million to support postdoctoral researchers”

Choose Science. Choose Europe.

A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open.

With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond.

Apply by 10 September → europa.eu/!fBTMgF

08.05.2025 10:12 — 👍 962    🔁 564    💬 15    📌 99
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Amazing differences within the EU.

Via prof. Marco te Brömmelstroet on LinkedIn.
NB: 2019 data.

22.05.2025 19:12 — 👍 237    🔁 68    💬 14    📌 7
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Sequential and independent probabilistic events regulate differential axon targeting during development in Drosophila melanogaster Nature Neuroscience - The developmental origin of behavioral individuality is unclear. The authors show that a temporal sequence of genetically encoded stochastic mechanisms explains variation in...

Hot off the press:
The excellent Maheva Andriatsilavo and colleagues show how a temporal sequence of stochastic molecular mechanisms allow the emergence of stereotyped individualised neuronal circuits. Just published in Nature Neuroscience:
rdcu.be/ek010

07.05.2025 11:26 — 👍 79    🔁 38    💬 4    📌 4
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A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain Although topographical maps organize many peripheral sensory systems, it remains unclear whether olfactory sensory neurons (OSNs) choose which of the ~1100 odor receptors (ORs) to express based upon t...

Maps are everywhere in the brain...and finally we've discovered one in the nose! Led by @davidhbrann.bsky.social, we uncovered the logic that specifies the positions of each of the 1,000 sensory neuron subtypes in the nose and aligns their projections to the brain.👇👃see more details below👃👇

09.05.2025 20:44 — 👍 148    🔁 52    💬 5    📌 2
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Why does the forebrain expand dramatically while other neural regions grow less? Our new publication reveals progenitor metabolism critically shapes region-specific brain growth. Thread below. authors.elsevier.com/a/1k-udL7PXu...

05.05.2025 16:52 — 👍 107    🔁 40    💬 3    📌 3
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El próximo Viernes 9 de Mayo, a las 12:30 hrs. en la Sala Washington Buño del #InstitutoCajal, seminario presencial del Dr. Diego García González, @ibis_sevilla @CSIC, con el título: "How to make a newron".
Organizado por: Dra. Aixa V. Morales

05.05.2025 09:28 — 👍 2    🔁 1    💬 0    📌 0
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Óscar Marín, neurocientífico: “Están en marcha los primeros trasplantes de neuronas 'viajeras' para tratar el cerebro” El investigador español es pionero en el estudio de trastornos del neurodesarrollo como el autismo, la epilepsia y la esquizofrenia, que considera posibles efectos colaterales de la increíble capacida...

🔴 ENTREVISTA | Óscar Marín, neurocientífico: “Están en marcha los primeros trasplantes de neuronas 'viajeras' para tratar el cerebro” www.eldiario.es/128_bace79?u...

04.05.2025 05:54 — 👍 34    🔁 14    💬 1    📌 1
Four images to illustrate some prominent single-gene myths. Top left shows a photograph of a person deftly rolling their tongue into a U-shape. Top right shows a photograph of a person’s ear, highlighting the shape and features of the earlobe and cartilage. Bottom left shows a close-up photograph of a person’s eye, with a vivid blue colouration. Bottom right shows a photograph of a person poised to write with their left hand on the blank white page of a spiral-bound notebook.

Four images to illustrate some prominent single-gene myths. Top left shows a photograph of a person deftly rolling their tongue into a U-shape. Top right shows a photograph of a person’s ear, highlighting the shape and features of the earlobe and cartilage. Bottom left shows a close-up photograph of a person’s eye, with a vivid blue colouration. Bottom right shows a photograph of a person poised to write with their left hand on the blank white page of a spiral-bound notebook.

Remember when you first learned about genetics at school? All those fascinating examples of human traits that are each apparently determined by just a single gene? Time to check in on some of your favourites to see how they’re doing. 🧬🧵🧪 1/n

02.05.2025 14:50 — 👍 1266    🔁 595    💬 57    📌 83

I could go on with more examples but instead here’s a message to take home. If you’re curious how your genome helps make you unique, don’t expect neat & tidy answers. Indeed, the richness of this tapestry is one of the reasons why human genetics is such a dynamic & exciting field of science. 11/n 🧬🧪

02.05.2025 17:31 — 👍 287    🔁 37    💬 13    📌 0
Post image 14.04.2025 21:49 — 👍 399    🔁 87    💬 11    📌 1

La ciencia como provocación

12.04.2025 09:52 — 👍 0    🔁 0    💬 0    📌 0

La UE debe hacer "un poquito más" que doblar su presupuesto para investigación para abandonar la categoría de "simpática anécdota" a nivel global. De lo contrario, nos vamos por el desagüe.
@eloisadelpino.bsky.social @dianamorantr.bsky.social

www.nature.com/articles/d41...

27.03.2025 11:51 — 👍 1    🔁 0    💬 0    📌 0
Two scutoids... a gran one and a yellow one.

Two scutoids... a gran one and a yellow one.

Graphical abstract of the paper. We infer Forces from geometry to find that scutoids are necessary to form epithelial tubes.

Graphical abstract of the paper. We infer Forces from geometry to find that scutoids are necessary to form epithelial tubes.

So... Can be animals without #scutoids?
This a difficult question to answer, you cannot get mutants without scutoids.
So we designed a computational model to demonstrated that it is not possible to form epithelial tubes without apico-basal intercalations.
www.csbj.org/article/S200...

24.03.2025 09:17 — 👍 24    🔁 13    💬 2    📌 1
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Cancer research needs neuroscience and neuroscientists - Nature Neuroscience The nervous system can drive the initiation, growth, spread, and therapy resistance of cancer, and cancer can manipulate the nervous system in ways that further support disease progression. Tumors gro...

#Cancer research needs #neuroscience and neuroscientists. Sharing some thoughts on #CancerNeuroscience, together with Frank Winkler.
www.nature.com/articles/s41...

21.03.2025 07:11 — 👍 85    🔁 26    💬 1    📌 0

Science under attack: a growing list of statements from journals
@jama.com
jamanetwork.com/journals/jam...

@plos.org
theplosblog.plos.org/2025/02/plos...

@science.org
www.science.org/doi/10.1126/...

@nature.com
www.nature.com/articles/d41...

@embopress.org
www.embopress.org/doi/full/10....

19.03.2025 12:01 — 👍 53    🔁 36    💬 8    📌 0
Drosophila follicle showing retrotransposons (pink & yellow) expressed in somatic cells infecting the oocyte

Drosophila follicle showing retrotransposons (pink & yellow) expressed in somatic cells infecting the oocyte

1/ Transposable elements are often called "jumping genes" because they mobilize within genomes. 🧬
But did you know they can also jump 𝘣𝘦𝘵𝘸𝘦𝘦𝘯 cells? 🤯
Our new study reveals how retrotransposons invade the germline directly from somatic cells.
www.biorxiv.org/content/10.1...
A short thread 🧵👇

17.03.2025 11:56 — 👍 544    🔁 259    💬 11    📌 33
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Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter
www.nytimes.com/2025/03/01/u...

01.03.2025 18:07 — 👍 3176    🔁 1405    💬 62    📌 95

This piece of work is truly amazing, hats off to you!
Massive congrats to all authors! 🥳

14.02.2025 10:40 — 👍 2    🔁 0    💬 1    📌 0
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Mamíferos, aves y reptiles llegaron a tener cerebros complejos por caminos evolutivos diferentes Tres estudios de las regiones cerebrales encargadas de procesar la información sensorial muestran que sus neuronas son y se comunican de forma diferente

elpais.com/ciencia/2025...
Mirad esto!!!

13.02.2025 23:03 — 👍 3    🔁 1    💬 1    📌 0
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Constrained roads to complex brains Neural development and brain circuit evolution converged in birds and mammals

And please check out the wonderful Perspective by Maria Tosches and Giacomo Gattoni on our paper and the two related ones by the groups of @steinaerts.bsky.social and Fernando Garcia-Moreno!!
www.science.org/doi/10.1126/...

13.02.2025 22:32 — 👍 21    🔁 8    💬 0    📌 0

Beautiful story!! Congratulations, Henrik!!

13.02.2025 22:46 — 👍 3    🔁 0    💬 1    📌 0
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Interesting: following hemispherotomy – this is typically performed for severe intractable epilepsies, where one hemisphere is fully disconnected but left in place – there remains "islands of awareness" although most activity is sleep-like.

www.biorxiv.org/content/10.1...

13.02.2025 07:41 — 👍 3    🔁 1    💬 0    📌 0

Empieza la semana del #11F, con mil eventos para dar visibilidad a la mujer en la ciencia

Pues estaría bien que también sirva para reivindicar salarios y horarios razonables, estabilidad y corresponsabilidad en los cuidados

Basta de fomentar vocaciones que abocan al abismo de las triples jornadas

10.02.2025 06:56 — 👍 115    🔁 51    💬 1    📌 2
NOT-OD-25-068: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Supplemental Guidance to the 2024 NIH Grants Policy Statement: Indirect Cost Rates NOT-OD-25-068. OD

1. Today the NIH director issued a new directive slashing overhead rates to 15%.

I want to provide some context on what that means and why it matters.

grants.nih.gov/grants/guide...

08.02.2025 00:18 — 👍 7124    🔁 4163    💬 266    📌 917

Get somebody in this room who knows that the word “transgenic” does not mean “transgendered”

07.02.2025 03:19 — 👍 348    🔁 91    💬 28    📌 8

@diegoconcalma is following 20 prominent accounts