Nik Joshi

@cp-cancercell.bsky.social

@doctorhunty.bsky.social

Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas Cheung et al. describe efficient T cell control of nascent neoantigen+ and nearby neoantigen-negative sarcoma cells, underlying a ∼50% reduction in tumor penetrance. This otherwise imperceptible immun...

Happy to announce the publication using advanced models to understand how T cells mediate efficient immunoediting in early sarcomas.

This was a collaboration between Julie Cheung and Brian Hunt
in the lab

Thanks to Cancer Cell for publishing our work.

www.cell.com/cancer-cell/...

YouTube video by Steve Lawson Kara Marshall PHD-History of Science in America - Trilogy at Tehaleh 04/27/25

Gave a talk at my parents’ retirement community to describe how science is done, and what is at stake. There was a ton of interest, and anyone can do this. Get the word out about how science affects everyone. I’m happy to share slides with anyone who asks- just get in touch! youtu.be/BY_SFgi-Cig

A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection Type 1 immunity mediates host defense through pathogen elimination, but whether this pathway also impacts tissue function is unknown. Here, we demonst…

I am very excited to share our article on IFNg, stroma and disease tolerance during intestinal helminth infection published today in Cell. This work was lead by the amazing @susanwestfall.bsky.social and supported by many international collaborators.

www.sciencedirect.com/science/arti...

Skin damage signals mediate allergic sensitization to spatially unlinked antigen Skin injury releases damage-encoded systemic signals that can initiate immunity to novel antigens introduced at distal barrier sites.

Systemic IL33 following skin damage can mediate sensitizwtion to a bystander antigen in the gut

www.science.org/doi/10.1126/...

I do not understand how in 2025 we don’t have a calendar/email program that automatically sets up out of office email. There should be an option in any event where you can click and it turns on OOO message that you’ve set up and including the start and end date (if you want).

They are cutting cancer research. They are cutting cancer research. They can deny it all they want, but they are cutting cancer research. These are the cuts being made the DoD CDMRP cancer funding mechanism www.fightcancer.org/sites/defaul...

The situation at the NIH and for all biomedical and cancer cure research in the United States is MUCH MUCH WORSE than you realize.

Foundations of course have very different goals than NIH for example, but there are some opportunities to do good here and asks are potentially more manageable since it’s bridge style funding.

It’s a bit surprising to me we’re not hearing about foundations stepping up to fill the gap on cancelled grants.

These are vetted and ongoing research programs where money can make an immediate impact. Especially for mission aligned goals.

Maybe it’s occurring behind the scenes.

Does your child want to go to college, want to go to med or grad school? The new cures for diseases, new technologies that we depend on come out of universities. #Trump, #Musk, #Vought are now killing higher education. If you haven't been paying attention, this would be a good time to wake up.

Delaware’s innovation pipeline could be at risk with new NIH funding policy With a proposed cap on indirect costs for NIH grants, Delaware's life science sector could be hit the next generation of start-ups and researchers.

These NIH funding cuts threaten research happening in Delaware on heart disease, cancer, diabetes, stroke recovery, & more.

This is what this administration is focused on. Not lowering your household costs.

Trump Administration Stalls Scientific Research Despite Court Ruling (Gift Article) Using an arcane law, officials have effectively delayed funding from the National Institutes of Health, leaving medical studies in jeopardy.

Summary of the infuriating blockade of US medical research

“This crisis...has already consumed one funding cycle” Carole LaBonne said. “But if this block to publishing in the register continues on much longer, it’s going to swallow two funding cycles, and that will put many labs out of business.”🧪⚕️

Hopefully rare 😬.

I have heard a few happened, but not sure the details. It’s nice to know the school has a plan in place.

This is very specific regarding rare stop work orders. The school said if you get one let them know and they’ll asap in terms of assessing legality, rewriting if possible to comply, and potentially bridge funding.

It’s a policy others should adopt bc stop work orders are immediate.

I've been seeing lots of super compelling videos of park rangers and federal lawyers and other federal workers telling their stories. Talking about what they did at their job, how it helped the American people, and why they want to keep doing those jobs.

This is the way.

And they get cut as part of the award and then often after the award based on if the government is on CR, or budget doesn’t rise. We make do with less constantly.

All NCI grants have been cut 20% from what you request for some time. The size of the grant hasn’t increased since 1998, so we need multiple grants to run a lab now. We get 20% less, but at least we get money. It doesn’t come close to covering the costs, but can’t operate otherwise.

Well @mcuban.bsky.social every NCI grant that has been awarded over the past decade+ has been cut 20% for years, so it’s not that hypothetical of a question for cancer researchers.

Science under siege: Trump cuts threaten to undermine decades of research Sweeping layoffs, funding freezes and executive orders have provoked outcry among federal researchers and their university partners, who fear that science itself is under siege.

Reaching out to all Americans through the media to explain how decreasing funding of the NIH will have irreversible harm for developing therapies for all diseases. Please spread the word to your families and friends and contact your congressional representatives.
www.nbcnews.com/science/scie...

The attacks and uncertainty are not just crushing progress for human health, forfeiting the US leadership role in biomedical science, curtaining economic gain, and threatening many livelihoods...but breaking a pipeline of training that will be very hard to rebuild and which will haunt industry too

My family knows the pain of Alzheimer’s. It’s devastating. And now we learn Trump’s NIH cuts led to the firing of top researchers working on it --Infuriating. This isn’t “cutting waste”—it’s cutting and gutting life-saving research.

Oops: Trump-Musk Cuts Just Wrecked an NIH Org Championed by GOPers Republicans once lavished praise on an NIH center that deals with Alzheimer’s. Donald Trump and Elon Musk are hobbling it. What will they say now?

Scoop --> Trump-Musk cuts just resulted in the firing of numerous top researchers at NIH's center for combating Alzheimer's, sources tell me. They predict big setbacks to fighting dementias.

This cause was once championed by *Republicans.*

Details here:
newrepublic.com/article/1917...

Very important to get this word out!

I expect that most academic biomedical researchers have considered leaving the US—if only in theory for now. What a colossal mess! Our representatives need to hear this. Please amplify so they know this matters. @levin.house.gov @repscottpeters.bsky.social @schiff.senate.gov @padilla.senate.gov

So angry to see this.

We are volunteering our time in this system.

Reviewers have better things to do than spend time reviewing grants for a system that doesn’t respect our time.

1/ I am seeing a lot of comments on the slashing of NIH support along the lines of “universities should just spend their huge endowments.”

I’m the last person to cheer on the institutional stratification rising endowments have contributed to. But let me explain why this is not a solution.

My wife and I were postbac IRTAs 25 years ago. Neither would have pursued a career in research if not for this program

We have PhD students in Yale Immunobiology now who also came from this NIH program including (one amazing student in my lab)

This is a valuable program and has been for decades.

I just found out that my first book 📗, LAB GIRL 🌱🌿🌳, was challenged by a parent and subsequently removed from the shelves of the library at Walworth High School in Elkhorn, Wisconsin.

So I decided to write a 🧵 on book 📚 #censorship 🚫 in American 🇺🇸 schools 🚸

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