Brian Glancy

Impaired stem cell migration and divisions in Duchenne muscular dystrophy revealed by live imaging - Nature Communications Using live-imaging in vivo and ex vivo, Sarde et al. show that dystrophic muscle stem cells have precocious differentiation through symmetric divisions and impaired migration, with differential impact...

Bravo Liza, Brendan and colleagues for the elegant work on multiple live imaging strategies to untangle mechanisms of muscular dystrophy! www.nature.com/articles/s41...

Two funded PhD positions investigating the evolution of sarcomeres @ibdm.bsky.social in @biancah0406.bsky.social and our lab, together with @cnidevo.bsky.social - Interested to explore how similar or different Jellyfish sarcomeres are to Drosophila or human ones?
www.ibdm.univ-amu.fr/ibdm_job/2-a...

Experienced Post-Doc in Skeletal Muscle Molecular Physiology and Epigenetics (296037) | The Norwegian School of Sport Sciences Job title: Experienced Post-Doc in Skeletal Muscle Molecular Physiology and Epigenetics (296037), Employer: The Norwegian School of Sport Sciences , Deadline: Wednesday, March 11, 2026

Now recruiting an experienced Post‑Doc in Skeletal Muscle Molecular Physiology @nih-sport-sciences.bsky.social Oslo, Norway

Join our multi‑omics EMMA project on mitochondrial epigenetic memory in human muscle aging

4‑year position

Start May

Apply at Jobbnorge: www.jobbnorge.no/en/available...

Macroscopic to Ultrastructural Analyses Identify the Loss of Myofibrils as the Primary Mediator of Muscle Fiber Atrophy in Aging and Disuse https://www.biorxiv.org/content/10.64898/2026.02.16.706166v1

Can we make brains “smarter”? By boosting mitochondrial metabolism in neurons of memory circuits, we improved memory in flies and mice. Thrilled to see this work out - congrats to @amrapalianjali.bsky.social for spectacular work, and to all lab members for invaluable contributions!

We are ready to scale up glycogen analysis using electron microscopy.
By applying a new AI-based image analysis pipeline, workload for 50 samples was reduced from ~600 hours to ~20 hours. This moves us beyond small-scale TEM studies.
Details below 👇

An overhead view of a dissected rat muscle resting on grid paper.

The same view of the muscle as Image 1, but the muscle is translucent and grid lines are visible through it.

A fluorescence micrograph of the rat tibialis anterior muscle, stained to differentiate the long nerve fibers from the dot-like neuromuscular junctions.

A higher magnification of Image 3.

The innervation of the tibialis anterior muscle in a rat has never been so clear! Processed with SmartBatch+ by the UIC/Structural Circuits Core, for @greisinglab.bsky.social in the UMN School of Kinesiology. Red = nerves, yellow = neuromuscular junctions. #3DThursday @lifecanvastech.bsky.social

We are hiring!
Fully funded PhD position on an exciting project to understand a fundamental mechanism of mitochondrial biogenesis. We will primarily rely on cryo-EM and protein-biochemical approaches.
Please share!

More about us: martinottlab.com

Apply here:
web103.reachmee.com/ext/I005/103...

Breaking Fundamental Biological Law: Research by Takashi Akera Investigates Selfish DNA - Vilcek Foundation Winner of the Vilcek Prize for Creative Promise, Akera’s novel research findings have huge implications for infertility and chromosomal disorders.

vilcek.org/news/breakin...

New #NatureComms paper: CHAMP1 is an essential regulator for human myoblast fusion and muscle development. #Myoblue tinyurl.com/2wyu39fr

High carotid blood flow velocity and pulsatility are negatively associated with hippocampal mitochondrial respiratory states.

High carotid blood flow velocity and pulsatility correlate with lower hippocampal mito oxygen consumption, while both low and high flow increase mito fusion protein expression compared to control. Thanks to Drs. J. Carson Smith and Gabriel Pena for the collaboration! ahajrnls.org/3YmmdMj

Mitochondrial Reticulum in Skeletal Muscles: Proven and Hypothetical Functions - Biochemistry (Moscow) Abstract The mitochondrial reticulum of skeletal muscles has been characterized in the 1970-80s. It has been suggested and then proven its role is delivering energy in a form of transmembrane potentia...

Mitochondrial Reticulum in Skeletal Muscles: Proven and Hypothetical Functions
link.springer.com/article/10.1...

My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...

📄 New preprint

Using deep physiological and molecular phenotyping in individuals carrying a diabetogenic mtDNA mutation, we probe whether, which, and how mitochondrial defects drive insulin resistance in humans.

👇 Link in first comment

#Physiology #Diabetes #Mitochondria #Metabolism

Self-renewal of neuronal mitochondria through asymmetric division Mitochondrial ATP production is essential for life. Mitochondrial function depends on the spatio-temporal coordination of nuclear and mitochondrial genome expression, yet how this coordination occurs ...

⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...

Rapid mitochondrial repolarization upon reperfusion after cardiac ischemia - Nature Cardiovascular Research Giles et al. developed a method for noninvasive absorbance measurement of mitochondrial hemes to monitor the mitochondrial membrane potential in the perfused heart. They then applied this approach to ...

Huge congratulations to Abigail Giles whose paper has just come out in Nature Cardiovascular Research - from a great collaboration with Bob Balaban, along with Thomas Krieg and Tish Murphy.

doi.org/10.1038/s441...

Excited to share our new paper on high-throughput #optogenetic #exercise assays for tissue engineered skeletal muscle! We leverage a multi-well stimulation apparatus to study how exercise regimen of various durations + frequencies impact muscle gene expression:
doi.org/10.1002/btm2...

#myoblue

Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle - Skeletal Muscle Non-peripheral (displaced) myonuclei are characteristic of skeletal muscle pathology and severe injury but also appear after exercise and with aging. Displaced myonuclei are typically attributed to th...

Nice work and congrats @kevinmurachphd.bsky.social & colleagues for their new #SkeletalMuscle paper: Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle. #Myoblue tinyurl.com/3vhxwku4

Structure and mechanism of the mitochondrial calcium transporter NCLX - Nature Cryogenic electron microscopy structures and functional analyses reveal that NCLX functions as a H+/Ca2+ rather than a Na+/Ca2+ exchanger, and uncover its transport mechanism with implications for the...

NCLX is a mitochondrial proton/calcium exchanger, not a sodium/calcium exchanger as previously thought
www.nature.com/articles/s41...

MICU2 controls mitochondrial calcium signaling and migration in neurons during development Berezhnaya et al. showed that MICU2 is present in the brain during development but is replaced during maturation by MICU3. MICU2 loss during development results in neuronal overmigration in the cortex...

Happy to have contributed to this beautiful work led by @elenaberezhnaya.bsky.social and Dr. Gyorgy Hajnoczky, and thrilled to see it finally out! 👏🏽👏🏽👏🏽

MICU2 controls mitochondrial calcium signaling and migration in neurons during development: Cell Reports www.cell.com/cell-reports...

Pantothenate kinase 4 controls skeletal muscle substrate metabolism - Nature Communications Here, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose into...

Curious about muscle metabolism? 🚴‍♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue

Intrinsic dysfunction in muscle stem cells lacking dystrophin begins during secondary myogenesis - Nature Communications In mdx mouse fetuses, the lack of dystrophin markedly impairs secondary myogenesis due to reduced muscle stem cell polarity. AAK1 deletion restores polarity and rescues secondary myogenesis, revealing...

Intrinsic dysfunction in muscle stem cells lacking dystrophin begins during secondary myogenesis | Nature Communications www.nature.com/articles/s41... @myoblue.bsky.social

New @NatMetabolism paper: Impaired cAMP–PKA–CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia. #Myoblue tinyurl.com/4adh7uy3

Muscle Fiber- and Cell Type-Specificity of Training Adaptation in Male Mice Skeletal muscle possesses extraordinary plasticity of structure, metabolism, and function in response to repeated contractile activity. As a syncytium embedded within a complex microenvironment, muscl...

If so, you might want to read our new preprint on @biorxivpreprint.bsky.social! We repeated this experiment (acute exercise in untrained and trained mice, analyzed at different time points, comparison of untrained and trained at rest) on the single nucleus level.

2/3

doi.org/10.1101/2025...

📰🧵📰 REGISTRATION ANNOUNCEMENT!! 💻🧵💻

1/ #IBEC2026 Conference dates are from June 1-3 in #RoanokeVA. Early registration will open January 1, 2026. Early registration/ eligibility for awards through March 1. Preliminary schedule available here: t.co/D2buRVHKGb

Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle Non-peripheral myonuclei are characteristic of skeletal muscle pathology and severe injury but also appear after exercise and with aging. Displaced myonuclei are typically attributed to the activity o...

Some interesting data from postdoc Nate Serrano: “Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle” www.biorxiv.org/content/10.1...

Paternal exercise confers endurance capacity to offspring through sperm microRNAs Yin et al. show that paternal exercise improves offspring endurance capacity and metabolic health via sperm microRNAs that reprogram gene expression in early embryos, revealing how exercise benefits c...

Exercising fathers, enhanced endurance and metabolic heath in offspring, through sperm microRNAs (as demonstrated in mice)
www.cell.com/cell-metabol...

14 postdoctoral fellowships to the BRIDGE – Translational Excellence Programme

We are looking for an enthusiastic MD or PhD to work on a postdoc project on the molecular mechanisms underlying human hibernating myocardium and ischemic cardiomyopathy. If interested send me an email! #heart #cardiomyopathy #sarcomere

Mitochondrial cristae density is increased following high-intensity interval training in patients with type 2 diabetes Aims/hypothesis: Mitochondrial cristae architecture is a key determinant of oxidative capacity in skeletal muscle. While mitochondrial dysfunction is common in type 2 diabetes, it remains unclear whet...

Our new preprint!
Great effort by Martin de Almeida and Amalie Platz has led to the discovery that training increases mitochondrial cristae density.
www.biorxiv.org/cgi/content/...
Thanks to Niels Ørtenblad at SDU and Kurt Højlund and Maria Petersen at Steno Diabetes Center Odense.

🧵 Thread below…

Professor in Exercise and Sport Science or Exercise Physiology - University of Newcastle FullTimePermanent • Callaghan, NSW 2308 • Salary: $222,734 plus 17% superannuation plus annual leave loading Position: Full-time, Continuing Location: Callaghan Campus, Newcastle, NSW Australia About ...

Title: Professor in Exercise and Sport Science or Exercise Physiology

📍Place: @newcastle 🇦🇺

💰Salary: $222,734 plus 17% superannuation plus annual leave loading

📅Deadline: 12/10/25

ℹ For more details👇 www.livehire.com/careers/univ...