Janelia Research Campus

📢Apply by Dec. 3 for our joint graduate programs with the Johns Hopkins University School of Medicine in neuroscience & cross-disciplinary biology.

🧠Develop interdisciplinary research projects
🌍Join a collaborative environment
🔬Leverage shared resources & support teams

➡️ janelia.org/graduate

Microscopist Hari Shroff takes us deeper into the world of nature's tiniest beings in the latest episode of Ashoka University's #TheScienceofIt podcast. What made a computer scientist and physicist turn to building microscopes to explore the beauty of ... The Science of Microscopy | Innovator Hari Shroff | The Science of It Ep. 4

🔊 Listen to Senior Group Leader Hari Shroff discuss microscopy, biology and his path through science in the latest episode of Ashoka University's The Science of It podcast: https://www.youtube.com/watch?v=dyoP5HwAFAc&list=PLaTCrA79FLSx-NV34W0Ee2Ei8FgmBDEKn&index=16

Foraging as an ethological framework for neuroscience The study of foraging is central to a renewed interest in naturalistic behavior in neuroscience. Applying a foraging framework grounded in behavioral …

Pleased to have this review out in @cp-trendsneuro.bsky.social. In it we discuss various aspects of the intersection between foraging behaviors and neuroscience, and offer some future directions: www.sciencedirect.com/science/arti...

🪰 A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system—a seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the millions of connections between them.
🔗 https://hhmi.news/4o3EJnk

Become a Theory Fellow @hhmijanelia.bsky.social

🧪 Work alongside experimentalists to test and refine theories
🎯 Receive mentorship from leading computational scientists
🔁 Contribute to Janelia’s cross-disciplinary research environment

Apply by Nov. 3 @ https://janelia.link/theoryfellowprogram

🥼 New research from the Wang Lab reveals a novel connection between lysosomes & the epigenome and provides new insights into how lysosomes regulate longevity over generations & drive the histone-based transfer of epigenetic information between cells.
🔗 https://hhmi.news/4mCD3QO

Text reads Plenary Speaker Meng Wang Professor, Baylor College of Medicine, HHMI. Racing the clock: molecular mechanisms of aging. There is a photo of Meng Wang and the background is a scientific image behind a blue, pink and orange gradient.

Plenary speaker spotlight ✨ Meng Wang (@bcmhouston.bsky.social / @hhmi.org) at #ASBMB26: “Racing the clock: Molecular mechanisms of aging.”

➡️Dive into the biochemical basis of aging, from metabolism to the genome: ow.ly/68i150X37Pm.
#MakeItPossibble #AgingResearch #FutureOfScience

Researchers detail how neurotransmitter receptors in the fly brain change during development New proteomics research is enabling scientists to decipher how neurotransmitter receptors behave and change as an organism develops. The new work could help scientists better understand the formation and function of synapses--the junctions where communi...

✨ ICYMI: Researchers detail how neurotransmitter receptors in the fly brain change during development ➡️ https://hhmi.news/4mFMhMY

Leaving a mark: New research shows how longevity is inherited across generations New research from the Wang Lab reveals a novel connection between lysosomes & the epigenome and provides new insights into how lysosomes regulate longevity over generations & drive the histone-based t...

🪱New research from the Wang Lab shows how changes in a worm’s lysosomes promoting longevity are transferred to its offspring through the epigenome, revealing how epigenetic modifications that help organisms cope with environmental stress can be inherited.

🔗 www.janelia.org/news/leaving...

🥼 Working with tool developers & support teams, Janelia’s GENIE Project Team recently created next generation sensors for detecting the neurotransmitters glutamate & GABA and adapted a new tool aimed at controlling & studying specific neural circuits in flies.
🔗 https://hhmi.news/4gFqwKX

📢 Applications are open for the 4th installment of our ChemTools conference.

We'll explore:
🧪 Platforms & tools for analyzing cell/tissue networks
⚡ Methods to perturb biological networks
🔍 Applications that yield new insights

🛏️ Lodging + meals covered
➡️ Apply by Dec 5: https://janelia.news/CHM26

AI Engineer - Evolutionary Protein Language Models Primary Work Address: 19700 Helix Drive, Ashburn, VA, 20147 Current HHMI Employees, click here to apply via your Workday account. Intro: AI@HHMI: HHMI is investing $500 million over the next 10 years ...

We are looking for an #AIEngineer to help build protein language models that capture evolutionary constraints with @matsen.bsky.social and @jbloomlab.bsky.social at #AI@HHMI @hhmijanelia.bsky.social
hhmi.wd1.myworkdayjobs.com/en-US/Extern...

🌟 Launch your own lab at Janelia 🌟

Advance our understanding of biology through theory, computational modeling & machine learning.

🔹 No teaching requirements
🔹 100% internally funded
🔹 Collaborate with expert support teams

📅 Apply by Nov. 4 👉 https://janelia.link/groupleader

Unleashing the GENIE: Janelia’s Project Team develops state-of-the-art sensors for biological research For more than a decade, the GENIE Project Team at HHMI’s Janelia Research Campus has collaborated with the research campus’s tool developers and tool users to take innovative biological sensors from n...

🧪For more than a decade, the GENIE Project Team has collaborated with tool developers & users to take innovative biological sensors from novel prototypes to widely used laboratory staples.

Now, @janeliagenie.bsky.social is unveiling their latest collaborations.
www.janelia.org/news/unleash...

📢 Applications are open!

Join us in May to explore computational simulation of biomechanical body models, bridging #neuroethology, #ML, physics simulation & computer vision. 🧠🤖 👁

🛏️ Lodging, meals & registration covered

➡️ Apply by Nov. 21 @ https://janelia.news/SIB26

Become a Theory Fellow at Janelia.

🔍 Use computation & theory to tackle biological problems.
🖥️ Leverage state-of-the-art computational infrastructure
🤝 Collaborate across scientific disciplines

Apply by Nov. 3 @ https://janelia.link/theoryfellowprogram

Preprint -
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...

📢 Conduct your PhD thesis research at Janelia.

🎓 Apply by Dec 3 for our joint graduate programs with Johns Hopkins School of Medicine in neuroscience & cross-disciplinary biology.

🌐 Collaborate across disciplines
🛠️ Work with tool builders
🤝 Train in a supportive environment

➡️ janelia.org/graduate

Research detailing how nicotinic acetylcholine receptors—the main type of neurotransmitter receptor in the fly brain—change during development lays the groundwork for understanding the molecular composition, regulation & adaptability of these synapses➡️ https://hhmi.news/4mFMhMY

🎉Congratulations to David Baker, winner of the @royalsociety.org's Croonian Medal and Lecture for pioneering the design of completely new proteins and playing key roles in the development of protein structure prediction and protein engineering tools.

🔗 royalsociety.org/medals-and-p...

Researchers detail how neurotransmitter receptors in the fly brain change during development New proteomics research is enabling scientists to decipher how neurotransmitter receptors behave and change as an organism develops. The new work could help scientists better understand the formation and function of synapses--the junctions where communi...

🧪 New proteomics research is enabling scientists to decipher how neurotransmitter receptors behave & change as an organism develops, information that could help scientists better understand the formation & function of synapses.➡️ https://hhmi.news/4mFMhMY

📢We're #hiring Group Leaders!

Apply to lead a lab at Janelia & advance biology using theory, computational modeling & machine learning.

🔹5-year renewable appointment
🔹Pioneer new tools & approaches
🔹Collaborate across disciplines

Apply by Nov. 4👉 https://janelia.link/groupleader

❄️Time-deterministic cryo-optical microscopy, developed by researchers at the University of Osaka, Janelia & collaborating institutions, rapidly freezes live cells under an optical microscope, capturing a snapshot of cellular activity in high resolution➡️ https://hhmi.news/421MTUL

Please join us in congratulating HHMI Investigators Jennifer Doudna (@jenniferdoudna.bsky.social) and David R. Liu, recipients of national awards from the American Chemical Society (@acs.org) for 2026.‬‬

🔗 cen.acs.org/people/award...

This is an airyscan confocal movie of mitochondria (white) moving around in a mouse astrocyte. Actin filaments are in orange and microtubules are in blue.

Decoding the language of cells with the power of proteomics Researchers at HHMI’s Janelia Research Campus, Stanford University, and the Broad Institute are developing user-friendly tools to help scientists translate cellular communication and uncover new detai...

🔗 Read more about how the Li Lab is decoding the language of cells with the power of proteomics ➡️ hhmi.news/4lIpqz3

PEELing: an integrated and user-centric platform for spatially resolved proteomics data analysis AbstractSummary. Molecular compartmentalization is vital for cellular physiology. Spatially resolved proteomics allows biologists to survey protein composi

🖥️ PEELing, a user-friendly platform developed by the Li Lab & Janelia’s Scientific Computing Software support team, allows researchers to analyze spatial proteomics data with the click of a mouse ➡️ https://hhmi.news/47FETwh

📷Happy #WorldPhotographyDay!

🎉To celebrate, we’re sharing a few macrophotography images taken by Janelia Research Specialist Igor Siwanowicz.

🔬Siwanowicz's images have placed 20+ times in the Nikon Small World & Olympus BioScapes competitions & were featured on US Postal Service stamps in 2023.

✨ We’re #hiring Theory Fellows!✨

Janelia is recruiting early-career scientists to join our collaborative research environment and use #computation & #theory to tackle bold questions in #biology.

🔗 Apply by Nov. 3 👉 janelia.link/theoryfellow...
@hhmi.org

New computational model could help shed light on how we see Researchers in the Stringer and Pachitariu labs at Janelia set out to create a simpler model to explain what’s going on in the primary visual cortex – the first stop in the brain for visual data.

🧠 Scientists have struggled to build computational models simple enough to understand what individual neurons in the primary visual cortex are doing.

🖥️ Now, Janelia researchers are helping to solve that problem with a new class of simplified “minimodels.”