Mass General Brigham Research

Scientists sharpen genetic maps to help pinpoint DNA changes that influence human health traits and disease risk By rapidly testing hundreds of thousands of DNA sequences, scientists have identified specific genetic variations that contribute to blood pressure, cholesterol, blood sugar, and more.

Pinpointing the exact noncoding variants driving locus-disease associations is an enduring challenge. Using MPRA, a @jacksonlab.bsky.social, Broad & @yaleschoolofmed.bsky.social team tested >220,000 variants in 5 cell types, resolving >13,000 and revealing mechanisms behind several disease traits.

Study reveals genetic balancing act between autoimmunity and cancer risk Researchers pinpoint genetic factors linked to both higher risk of a common autoimmune disorder and lower cancer risk

The same genetic variants that heighten the risk of autoimmune hypothyroidism — the most common autoimmune disorder — may also lower cancer risk, according to a new study led by scientists at Broad, @helsinki.fi, and @mgbresearch.bsky.social. broad.io/AIHT-news

New research shines a light on why long-term relapse happens in alcohol use disorder, even after a year or more of sustained remission.

Read the full press release to learn how this work can change the way we think about relapse prevention: www.massgeneralbrigham.org/en/about/new...

New publication on how researchers created AI-designed DNA ⤵️

A long engaging and amazing journey for me in Kidney Genetics !!

In a new Cell Reports study, we examine a specific antibody family elicited by early COVID-19 vaccination and show how antibody maturation and binding diversity can allow some antibodies to remain effective against later variants, including Omicron. mgriblog.org/science-insi...

Genetic variant increases risk of heart muscle disease common in individuals of African ancestry A single mutation in the CD36 gene, present in 17 percent of people with African ancestry, increases a person's dilated cardiomyopathy risk by 33 percent.

A new @natgenet.nature.com study by Broad, @mgbresearch.bsky.social, and VA Boston collaborators reveals a genetic variant that helps explain the high dilated cardiomyopathy risk in people of African ancestry.

Great summary from the @mgbresearch.bsky.social team on our new Science paper about ENS–immune system interactions! Check it out: www.massgeneralbrigham.org/en/about/new...

In a new study, @shuimd.bsky.social and her colleagues in neonatology used electrical impedance technology (EIT) for a precision approach to optimize ventilator settings in infants with bronchopulmonary dysplasia.

Read more: www.nature.com/articles/s41...

Join us in congratulating three of our 2025 #DistinguishedInvestigators 🏅!

These Investigators will be honored at a ceremony and celebration at #RSNA25 in Chicago. For more details, visit www.acadrad.org/wp-content/u.... @washumedicine.bsky.social @upenn.edu @mgbresearch.bsky.social

Join us in congratulating three of our 2025 #DistinguishedInvestigators 🏅!

These Investigators will be honored at a ceremony and celebration at #RSNA25 in Chicago. For more details, visit www.acadrad.org/wp-content/u.... @ucirvine.bsky.social @mgbresearch.bsky.social

Congrats to @connorjtou.bsky.social on being named a 2025 #STATWunderkind. His enthusiasm in the lab is contagious and he thrives on doing really hard things.
Really well deserved recognition for an innovator and emerging leader in our field! 👏 🙌
@mgbresearch.bsky.social @harvardmed.bsky.social

In a new study, researchers from Brigham and Women's Hospital and colleagues investigated the neuronal-activity dependent mechanisms of small cell lung cancer pathogenesis. The study was published on @nature.com

Read more: www.nature.com/articles/s41... @venkatesh-lab.bsky.social

In a new study, researchers from Mass General Brigham and colleagues found that the use of #AI ambient documentation tech significantly reduced physician burnout. The study was published in @jamanetworkopen.com.

Read more: www.massgeneralbrigham.org/en/about/new... jamanetwork.com/journals/jam...

The 2025 World Medical Innovation Forum is returning to Encore Boston Harbor from September 15-17! Join us as industry leaders and innovators come together to explore the most exciting breakthroughs shaping the future of healthcare.
Register now!: 2025.worldmedicalinnovation.org/register/
#WMIF2025

Three scientific projects from Brigham and Women's Hospital are competing for YOUR #vote in this year’s $100,000 Bright Futures Prize competition.

Cast your vote for the project you think should win, and register for the live event on 9/15:

www.discoverbrigham.org/funding/bri-...