Pierre Martinez

Cancer evolution and multi-omic profile of relapsed colorectal liver metastases after treatment - Genome Medicine Genome Medicine - Recurrence following resection of colorectal cancer liver metastases remains a major obstacle to prolonged patient survival, often resulting in treatment-refractory disease with...

🧬 New in Genome Medicine! Deep genomic analysis of relapsed colorectal cancer liver metastases reveals patient-specific evolutionary trajectories and multiple routes to recurrence.

link.springer.com/article/10.1...

🤝 Nice collaboration with @soulafa.bsky.social & colleagues

Postdoctoral Training Fellow - Genomics and Evolutionary Dynimcs in Sutton | The Institute of Cancer Research View details and apply for this Postdoctoral Training Fellow - Genomics and Evolutionary Dynimcs vacancy in Sutton. Salary: Dependent on relevant Postdoctoral experience. Durati...

Open postdoc position in our lab @icr.ac.uk to develop a cfDNA test for #early detection of colorectal #cancer in inflammatory bowel disease #IBD:
jobs.icr.ac.uk/vacancies/14...

It's bench-to-bedside research, translating biology of pre-cancer evolution.

Funded by @bowelcanceruk.bsky.social

It feels like the geographically structured oral mucosa undergoes 100s of contingency-like seed/soil experiments, with almost no mutant able to break out from their local niche, while in "well-mixed" blood we see a winner (1st or most advantageous mutant) takes all situation. Food for thought!

Somatic mutation and selection at population scale - Nature A new version of nanorate DNA sequencing, with an error rate lower than five errors per billion base pairs and compatible with whole-exome and targeted capture, enables epidemiological-scale studies of somatic mutation and selection and the generation of high-resolution selection maps across coding and non-coding sites for many genes.

Our latest work is out in Nature today. In this paper, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people www.nature.com/articles/s41...

Congrats Iñigo for a(nother) great article. Figure 4a is my personal favourite finding, because of what it reveals about the role of tissue organisation in keeping clonal expansions in check.

We're now advertising three faculty positions:
* Lecturer in Applied Maths (as below) www.citystgeorges.ac.uk/about/jobs/a...
* Lecturer in Maths (teaching & research) www.citystgeorges.ac.uk/about/jobs/a...
* Lecturer/Senior Lecturer in Maths (teaching only) www.citystgeorges.ac.uk/about/jobs/a...

Last days to apply! Deadline 6th April. Looking for a motivated Postdoc and Computational Biologist to join our lab! If you're passionate about single-cell and spatial omics, this is an exciting opportunity.

I'd suggest forking out the money for a new keyboard. But since it's a Mac, you may have to talk to your bank first.

Our #Cancer #Evolution summer school runs again 30 June-3 July at the beautiful Genome Campus in Hinxton, UK sponsored by @wellcometrust.bsky.social

Ideal for starters in the field; this year's focus is on using genomic data for cancer evo research.

Brilliant & inspiring faculty! bit.ly/40nLdDD

Happy to post our first preprint in a while! www.biorxiv.org/content/10.1.... This was a slightly new direction for us, spearheaded by amazing post-doc @audreylumeau.bsky.social. Short thread to follow 🧬

Come learn how to apply approaches in evo-eco to cancer biology 🧬 ✨

Are you interested in joining the only mathematical oncology department @mathonco.bsky.social in a cancer center @moffittnews.bsky.social in the world? We have an open rank position (assistant/associate/full) available now! Apply here: moffitt-cancer-center-careers.hctsportals.com/jobs/1859278...

Disease as a mediator of somatic mutation-life history coevolution Multicellular organisms are confronted not only with mutation in germline, but also mutations emerging in somatic cells. Somatic mutations can lead cancers and possibly contribute to aging phenotypes....

How would you expect somatic mutation rate to correlate with species longevity? Study in 2022 by @atjcagan.bsky.social etal in @nature.com discovered key patterns. Our model predicts some of these and highlights possible mechanisms driving co-evolutionary dynamics. www.biorxiv.org/content/10.1...

Big thanks and congratulations to my wonderful colleagues @mariaouzounova.bsky.social, Lauriane Muller, Frédérique Fauvet, Anne-pierre Morel & @cyrildegletagne.bsky.social

Our results however suggest that plasticity fosters prospective phenotypic diversification, which facilitates the emergence of “pre-adapted” cells, that are by chance already able to adapt to a given environmental change that hasn’t occurred yet.

We could not see evidence of selection of genetic clones harbouring specific CNAs, but our short (3w) timeframe and the limitations of our purely scRNA-seq-based data do not allow us to fully and accurately characterise selection and genomic evolution.

We used two in vitro TNBC models, in which EMT-driven plasticity was either induced by ZEB1 expression, or spontaneously occurred upon oncogenic transformation. We used single-cell cloning experiments and scRNA-seq data pre and post doxorubicin treatment to investigate phenotype dynamics.

We were interested in the impact of EMT-driven plasticity on the dynamics of phenotypic diversity. And, in particular, whether plasticity-mediated resistance is a prospective or a reactive process.

For my first Bluesky post (bye bye Elon), I’m happy to share our latest article “EMT-driven plasticity prospectively increases cell-cell variability to promote therapeutic adaptation in breast cancer”, published this week:
cancerci.biomedcentral.com/articles/10....