John Lukens

been there too😆

Human brain vascular multi-omics elucidates disease-risk associations Reid et al. develop MultiVINE-seq to map thousands of non-coding disease variants to genes in human brain vascular cells. Cerebrovascular disease variants compromise vessel integrity, whereas Alzheime...

Human brain vascular multi-omics elucidates disease-risk associations @cp-neuron.bsky.social www.cell.com/neuron/fullt...

Neural anticipation of virtual infection triggers an immune response - Nature Neuroscience Serino et al. show that seeing an infectious avatar approach the body in virtual reality triggers an immune response, indicating that the brain prepares the body to fight infections even for perceived...

Neural anticipation of virtual infection triggers an immune response
www.nature.com/articles/s41...

Spatial proteomics of Alzheimer’s disease-specific human microglial states - Nature Immunology In this Resource paper, the authors use MIBI spatial proteomics to map microglial cell states in brains from cognitively normal humans and those with Alzheimer’s disease.

Spatial proteomics of Alzheimer’s disease-specific human microglial states
www.nature.com/articles/s41...

G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation Microglial ADGRG1 drives a protective state in Alzheimer’s disease by activating the transcription factor MYC, which upregulates genes associated with homeostasis, phagocytosis, and lysosomal function...

G-protein-coupled receptor ADGRG1 drives a protective microglial state in Alzheimer's disease through MYC activation: @cp-neuron.bsky.social www.cell.com/neuron/fullt...

Mast cells regulate the brain-dura interface and CSF dynamics Dural mast cells control cerebrospinal fluid dynamics at critical brain-dura interfaces, specifically arachnoid cuff exit points. Their activation limits pathogen brain entry via histamine-induced vas...

Mast cells regulate the brain-dura interface and CSF dynamics @cellpress.bsky.social www.cell.com/cell/fulltex...

Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration Murray et al. introduce “transformative neuropathology” through dynamic, technology-integrated approaches to accelerate tissue-based discoveries and offer actionable strategies to strengthen brain ban...

Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration @cp-neuron.bsky.social www.cell.com/neuron/fullt...

Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense Enteric nervous system (ENS)–derived neuropeptides modulate immune cell function, yet our understanding of how inflammatory cues directly influence enteric neuron responses during infection is conside...

Type 2 cytokines act on enteric sensory neurons to regulate neuropeptide-driven host defense @science.org www.science.org/doi/10.1126/...

APOE ε4 carriers share immune-related proteomic changes across neurodegenerative diseases
www.nature.com/articles/s41...

Cognate interaction-dependent pathogenicity of meningeal B cells drives neuroinflammation relapse The brain meninges maintain self-tolerized B cells, but the pathological consequences of breaking this tolerance are unknown. Wang et al. reveal that autoreactive leptomeningeal B cells drive neuroinf...

Cognate interaction-dependent pathogenicity of meningeal B cells drives neuroinflammation relapse: @cp-immunity.bsky.social www.cell.com/immunity/ful...

Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer’s disease
www.nature.com/articles/s41...

Taking the STING out of neurodegenerative disease url: rupress.org/jem/article/...

Microglia replacement halts the progression of microgliopathy in mice and humans Colony-stimulating factor 1 receptor (CSF1R) is primarily expressed in microglia. Its monoallelic mutation causes CSF1R-associated microgliopathy (CAMP), a major form of adult-onset leukoencephalopath...

Microglia replacement halts the progression of microgliopathy in mice and humans @science.org www.science.org/doi/10.1126/...

Glymphatic dysfunction in Alzheimer’s disease: A critical appraisal @science.org www.science.org/doi/10.1126/...

Synthetic efferocytic receptor microglia enhances anti-inflammatory clearance of amyloid-β for AD treatment in mice Microglia with a synthetic receptor show enhanced Aβ clearance without inflammation, opening pathways for AD treatment.

Synthetic efferocytic receptor microglia enhances anti-inflammatory clearance of amyloid-β for AD treatment in mice | Science Advances www.science.org/doi/10.1126/...

Turbocharged ‘killer’ cells show promise for autoimmune disease Experimental treatment could offer a safer, cheaper alternative to CAR T cell therapies for disorders such as lupus.

Turbocharged ‘killer’ cells show promise for autoimmune disease @nature.com www.nature.com/articles/d41...

Thanks, David. Looking forward to chatting with Hilarity For Charity about Alzheimer's disease research next week.

Microglial cGAS-STING-TBK1 activation in paraventricular thalamus mediates sleep and emotional disturbances in lupus mice www.sciencedirect.com/science/arti...

Excitatory-neuron-derived interleukin-34 supports cortical developmental microglia function While neurons and microglia are known to talk to one another, the signals that regulate their complex, important interactions are not comprehensively defined. Devlin et al. find that the cytokine IL-3...

Excitatory-neuron-derived interleukin-34 supports cortical developmental microglia function: @cp-immunity.bsky.social www.cell.com/immunity/ful...

TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice Matatall et al. uncover a mutation-specific association between clonal hematopoiesis (CH) and Alzheimer’s disease (AD) in mice and humans. TET2-mutant CH conferred lower odds of AD in humans and reduc...

TET2-mutant myeloid cells mitigate Alzheimer’s disease progression via CNS infiltration and enhanced phagocytosis in mice @cp-cellstemcell.bsky.social www.cell.com/cell-stem-ce...

How fast is your brain ageing? Ordinary scans reveal the pace Images hold clues to risk of dementia and various age-related diseases.

How fast is your brain ageing? Ordinary scans reveal the pace nature.com/articles/d41... @nature.com

Optogenetic vagal nerve stimulation attenuates heart failure by limiting the generation f monocyte-derived inflammatory CCRL2+ macrophages Parasympathetic neuronal dysfunction is associated with heart failure, yet the underlying mechanism is poorly understood. Here, Li et al. demonstrate that optogenetic activation of the vagus nerve pre...

Optogenetic vagal nerve stimulation attenuates heart failure by limiting the generation of monocyte-derived inflammatory CCRL2+ macrophages: @cp-immunity.bsky.social www.cell.com/immunity/ful...

Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity - Nature Immunology Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia is a neurodegenerative disorder caused by pathogenic CSF1R mutations. Here the authors find that microglial loss is linked to r...

Mutations in the human CSF1R gene impact microglia’s maintenance of brain white matter integrity
www.nature.com/articles/s41...

STING deletion protects against amyloid β–induced Alzheimer's disease pathogenesis INTRODUCTION While immune dysfunction has been increasingly linked to Alzheimer's disease (AD) progression, many major innate immune signaling molecules have yet to be explored in AD pathogenesis us...

By #genetically removing STING in mice, researchers saw significant improvements such as better control of harmful #amyloid #plaques, healthier #microglial activity, and protection against #cognitive decline.

GENEWIZ is honored to be cited in this study, providing #RNAseq: hubs.ly/Q03sPs0B0

Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia - Nature Immunology McGavern and colleagues identified a CD8+ T cell population that expresses GZMK in ʽtau-richʼ brains, where it may play a protective role against neurodegeneration.

Granzyme K+ CD8 T cells slow tauopathy progression by targeting microglia
www.nature.com/articles/s41...

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway @cp-immunity.bsky.social www.cell.com/immunity/ful...

Neuroinflammation across neurological diseases The brain’s response to injury includes the activation of intrinsic microglia and the influx of leukocytes, collectively constituting neuroinflammation, the “flame” of the brain. Although details diff...

Neuroinflammation across neurological diseases @science.org www.science.org/doi/10.1126/...

Neuroprotective liver portal area macrophages attenuate hepatic inflammation - Nature Immunology Zhang and colleagues characterize a subset of nerve-associated CX3CR1+ liver portal area macrophages that maintain immune homeostasis and attenuate nonalcoholic steatohepatitis.

Nerve-associated portal macrophages function to maintain liver immune homeostasis
www.nature.com/articles/s41...

Defective peripheral B cell tolerance leads to dysregulated B cell responses in Fibromyalgia Syndrome
www.researchsquare.com/article/rs-6...

Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation - Nature Dysregulated CD4 T cells that recognize gut commensal antigens are able to infiltrate the central nervous systems and are re-stimulated by host proteins, resulting in neuroinflammation.

Gut inflammation promotes microbiota-specific CD4 T cell-mediated neuroinflammation @nature.com
www.nature.com/articles/s41...