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Nikita Harvey

@nickynak3.bsky.social

NMR Facility Manager at UCL School of Pharmacy, violist, asexual, nerd and all round bibliophile. She/her πŸ‘©πŸΎβ€πŸ”¬πŸ’œ

842 Followers  |  438 Following  |  709 Posts  |  Joined: 08.02.2024  |  1.9895

Latest posts by nickynak3.bsky.social on Bluesky

Screenshot of LinkedIn’s menu: β€œHow LinkedIn uses your data”. Near the bottom, is the option to turn off β€œData for Generative AI improvement”, shown with a red arrow.

Screenshot of LinkedIn’s menu: β€œHow LinkedIn uses your data”. Near the bottom, is the option to turn off β€œData for Generative AI improvement”, shown with a red arrow.

πŸ€– If you use LinkedIn, please be aware that they automatically use your profile to train their GenAI. To turn off, go to Settings > Data Privacy > Data for Gen AI improvements.

11.10.2025 23:04 β€” πŸ‘ 121    πŸ” 90    πŸ’¬ 7    πŸ“Œ 4
Kinetic NMR screening: rapidly quantifying fast ligand dissociation in fragment mixtures using ¹⁹F relaxation dispersion Ligand-observed NMR is a key tool for detecting weak protein-ligand interactions, but translating binding signals into meaningful affinity measurements remains difficult, limiting the ability to rank ...

So excited that our lab's first home-grown paper is now available on ChemRxiv!

Kinetic NMR screening: rapidly quantifying fast ligand dissociation in fragment mixtures using ¹⁹F relaxation dispersion | doi.org/10.26434/che... 🧲πŸ§ͺ

24.09.2025 12:54 β€” πŸ‘ 11    πŸ” 4    πŸ’¬ 0    πŸ“Œ 0
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Is it OK for me to collect NMR data while the magnet is being refilled with liquid helium? u-of-o-nmr-facility.blogspot.com/2011/09/reso... #nmr #nmrchat #chemsky

23.09.2025 08:47 β€” πŸ‘ 9    πŸ” 3    πŸ’¬ 1    πŸ“Œ 0
Webinar: Fragment Screening using 19F NMR at the UCL School of Pharmacy Join Dr Nikita Harvey and Dr Christopher Waudby to delve into the subject and interact with research fellows.

Looking forward to giving a webinar tomorrow with @nickynak3.bsky.social about our efforts to establish a 19F NMR fragment screening platform at UCL. Register below and join us to find out more!

Friday 19th September, 2pm (UK)
www.eventbrite.co.uk/e/webinar-fr... #NMRchat #NMR @ucltro.bsky.social

18.09.2025 15:48 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0

Just assembled my own NMR 'LABO' set thanks to @fredaperras.bsky.social! Now I only need to buy a head which actually fits on the body πŸ˜‚ #nmrchat

28.08.2025 12:19 β€” πŸ‘ 9    πŸ” 3    πŸ’¬ 3    πŸ“Œ 0

There's nothing quite like struggling through a day's worth of experiments (including the spec deciding to lock onto the wrong solvent just for funsies) and then just before leaving finally - finally! - getting proof of protein-ligand binding πŸ˜… #nmrchat

27.08.2025 16:22 β€” πŸ‘ 7    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Imagine if people showed pride for their country by making it a genuinely nice place to be and welcoming others so your actual actions reinforced the very thing you are proud of

26.08.2025 14:27 β€” πŸ‘ 151    πŸ” 52    πŸ’¬ 1    πŸ“Œ 0
Preview
Basics of Nuclear Magnetic Resonance NMR : A powerful technique to probe the structure and dynamics of molecules

MOOC NMR 2025 training course (in three parts) 🧲
The first part, Basics of Nuclear Magnetic Resonance, from Sep 23 to Nov 10, 2025. Free registration is now open. Make sure your students are enrolled, excellent introduction to NMR! www.fun-mooc.fr/en/courses/b... #NMRchat @olivierlafon.bsky.social

25.08.2025 19:37 β€” πŸ‘ 3    πŸ” 1    πŸ’¬ 0    πŸ“Œ 1

Ring: take over Gondor and then the world
Boromir: tempting. need

Ring: all shall love you and despair
Galadriel: tempting what a test

Ring: do so much good that you become a god
Gandalf: don't! tempt me frodo!

Ring:
Sam:
Ring:
Sam:
Ring: like a, like a really big garden
Sam: I'm good
Ring: fuck

22.08.2025 18:01 β€” πŸ‘ 658    πŸ” 149    πŸ’¬ 15    πŸ“Œ 8
Preview
Building safer laboratories by evolving culture and practice Fostering a safe and productive environment in the laboratory is a challenge that faces both institutions and individual researchers at every stage of their careers. This Voices article shares perspec...

Have a read of this article from SoP's own @rachael-dickman.bsky.social, Duncan Browne and others discussing how we can foster a safe and productive environment in chemistry labs. It's so crucial that we develop a culture of responsibility, for everyone's sakes. #ChemSky
www.cell.com/cell-reports...

19.08.2025 12:25 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0
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Olivier Lafon @olivierlafon.bsky.social has been appointed to the rank of Knight of the National Order of Merit (France) infranalytics.eu/en/science/2... #NMRnews #NMRchat #NMR 🧲

12.08.2025 13:09 β€” πŸ‘ 6    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Let them dance!

04.08.2025 22:25 β€” πŸ‘ 3    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Webinar: Fragment Screening using 19F NMR at the UCL School of Pharmacy Join Dr Nikita Harvey and Dr Christopher Waudby to delve into the subject and interact with research fellows.

Friday, September 19, 9 am UK, Webinar: Fragment Screening using 19F NMR at the UCL School of Pharmacy, Nikita Harvey @nickynak3.bsky.social and Christopher Waudby @chriswaudby.bsky.social www.eventbrite.co.uk/e/webinar-fr... #NMRchat #NMR 🧲

25.07.2025 12:56 β€” πŸ‘ 2    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Yep! I usually end up saying this most to Operations/Estates/contractors.

20.07.2025 19:30 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

Simple transfer of 190ul into a 3mm tube took my robot almost exactly one minute for one sample, including the clean step.

16.07.2025 11:45 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

If it would help, I can find out the time per sample for a specific method e.g. straight transfer of 600ul per sample to a tube?

15.07.2025 22:02 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

If you're regularly prepping 96 well plates with the same or similar methods then I think a prep robot is well worth it. It may not be quicker overall than hand prep (though it can be pretty efficient with non-viscous liquids) but you'll get more reliable ergonomic prep with less hands-on time.

15.07.2025 22:01 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

I've also found that they have a very limited selection of plate configurations. A student came to me with the well plates she was using for UV, but the needle didn't go down deep enough into the well and the safeguards won't let me create a minus Z-axis offset.

15.07.2025 21:47 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

In theory we can use an Excel sheet to submit jobs to the queue, which is incredibly helpful when we have varieties of volumes to transfer or a complicated sequence of transfers. Unfortunately their macro has broken on my computer and they haven't figured out how to fix it. I think they've given up.

15.07.2025 21:43 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0

We've got one! We've been using it to prep fragment cocktails for our screening service. It's good in that it works well, but there are caveats. Switching between solvents is a huge faff, for example.

15.07.2025 21:40 β€” πŸ‘ 1    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Kinetic Experiments on Bruker Spectrometers Students often have to monitor the progress of a chemical reaction as a function of time using NMR spectroscopy. I have written three simple...

Three simple ways to follow chemical reactions with your NMR spectrometer u-of-o-nmr-facility.blogspot.com/2008/10/kine... #nmr #nmrchat #chemsky

12.07.2025 09:15 β€” πŸ‘ 7    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
A closeup image of a small cylindrical glass tube used for NMR spectrocopy filled with a blue dye solution that shines a faint pinkish light.

A closeup image of a small cylindrical glass tube used for NMR spectrocopy filled with a blue dye solution that shines a faint pinkish light.

I love the shine of Silicon Rhodamine in the morning sun ✨

10.07.2025 07:44 β€” πŸ‘ 32    πŸ” 4    πŸ’¬ 1    πŸ“Œ 0
Two Bruker engineers installing the cooling rack on the SamplePro Tube liquid handler

Two Bruker engineers installing the cooling rack on the SamplePro Tube liquid handler

Bruker SamplePro Tube liquid handler with the new cooling rack installed. The cover is open and the robot is lit by a blue LED strip.

Bruker SamplePro Tube liquid handler with the new cooling rack installed. The cover is open and the robot is lit by a blue LED strip.

Today we're having a cooling/heating rack installed into our NMR liquid handling robot! This should help keep protein and DNA samples stable during prep for our 19F fragment screening service #NMRchat

www.ucl.ac.uk/pharmacy/abo...

10.07.2025 10:34 β€” πŸ‘ 9    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

I have 'acquired' one that's no longer wanted and am keeping it as a souvenir / using it as office decor 😁

07.07.2025 15:32 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 1    πŸ“Œ 0
Nikita standing in front of a projector screen showing the agenda for the UK Magnetic Resonance Managers Meeting 2025

Nikita standing in front of a projector screen showing the agenda for the UK Magnetic Resonance Managers Meeting 2025

Prize winners from the RSC NMRDG postgraduate meeting. Back row: Jack Bertovici (poster prize winner), Darshil Kapadia (oral runner-up), Katherine Bonham (oral runner-up), James Williamson (poster runner-up), Dr Ralph Adams (NMRDG Secretary). Front row: Dr Chris Waudby (host), Ella-May Hards (oral presentation winner), Meshezabeel Narciso (poster runner-up), Anupama Acharya (poster runner-up).

Prize winners from the RSC NMRDG postgraduate meeting. Back row: Jack Bertovici (poster prize winner), Darshil Kapadia (oral runner-up), Katherine Bonham (oral runner-up), James Williamson (poster runner-up), Dr Ralph Adams (NMRDG Secretary). Front row: Dr Chris Waudby (host), Ella-May Hards (oral presentation winner), Meshezabeel Narciso (poster runner-up), Anupama Acharya (poster runner-up).

Attendees of the Royal Society of Chemistry NMR Discussion Group postgraduate meeting 2025 standing at the UCL School of Pharmacy entrance

Attendees of the Royal Society of Chemistry NMR Discussion Group postgraduate meeting 2025 standing at the UCL School of Pharmacy entrance

Very proud to have taken the lead in organising the UK NMR manager's meeting last month and to have helped with the @rsc-nmrdg.bsky.social postgraduate discussion group here at UCL! It was a fantastic pair of meetings: www.ucl.ac.uk/pharmacy/new...

07.07.2025 13:28 β€” πŸ‘ 6    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

Ours is so effective that I need a jumper to sit at the computer for the 600! Unless I duck down low enough that the blast from the air con unit goes over my head. It pays to be short in my lab.

26.06.2025 22:45 β€” πŸ‘ 0    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Discussing the state of NMR in the UK at the 2025 @rsc-nmrdg.bsky.social Postgraduate Meeting

17.06.2025 11:07 β€” πŸ‘ 2    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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Opening the 2025 NMRDG Postgraduate Meeting at the UCL School of Pharmacy

16.06.2025 15:25 β€” πŸ‘ 6    πŸ” 2    πŸ’¬ 1    πŸ“Œ 0
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When NMR agrees that you are an absolute clown 🀑 πŸ§ͺ

09.06.2025 12:25 β€” πŸ‘ 11    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0

We're looking forward to it! Especially the opportunity to talk about CcpNmr Analysis and some of the ways the software can be used by people working with small molecules including Peptides or those doing Metabolomics or Fragment Screening.

05.06.2025 16:10 β€” πŸ‘ 1    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0

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