Sebastian Streichan

Sebastian Streichan

@streichan.bsky.social

Excited about animal and synthetic morphogenesis, light-sheet microscopy, and quantitative biology

1,188 Followers 1,036 Following 30 Posts Joined Sep 2023
23 hours ago
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Lab Manager - Stuart Group The European Molecular Biology Laboratory (EMBL) is one of the world’s leading life science research organisations. With sites across Europe, EMBL fosters an international, collaborative, and inclusiv...

Are you fascinated by self-organised patterning processes?

The brand-new Stuart lab at EMBL Barcelona is looking for a lab manager!

Hannah @htstuart.bsky.social is a fantastic scientist and mentor. Building the lab with her will be a lot of fun!

embl.wd103.myworkdayjobs.com/EMBL/job/Bar...

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4 days ago
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Gene regulatory networks: from correlative models to causal explanations Nature Reviews Genetics - In this Perspective, Maizels and Briscoe discuss the limitations of current models of gene regulatory networks and outline solutions to harness data abundance without...

New Perspective form Rory Maizels & me: "Gene regulatory networks: from correlative models to causal explanations"

Gene regulatory networks are supposed to give us mechanistic explanations of development, so why are we drowning in 'hairballs' of statistical correlations?

rdcu.be/e7zx7

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1 week ago

Final version @nature.com of our paper describing unconventional multicellular development in a choanoflagellate inhabiting an extreme environment. A ton of new data since the first @biorxivpreprint.bsky.social preprint (which we've kept updating).

A brief 🧵 (carried over from the old place)

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6 days ago

Please check out our new preprint! Using single cell analysis paired with HCR to visualize transcript localization we have identified cell and tissue-specific expression of various genes encoding tubulins, kifs, and dyneins during neural crest development!

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Finally I can join #FluorescenceFriday as a theorist 😊.

This is a DNA-PAINT recording of E-Cadherin and F-actin in Drosophila embryonic epidermis. You can see E-cadherin clusters and their counterparts across junctions. Cover in @biophysj.bsky.social . doi.org/10.1016/j.bp... #devbio #cellbio

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1 week ago

New preprint from Meri Saez & co

How much information does a developmental landscape encode?

Integrating information theory, dynamical systems & dev bio to quantify the number of signalling regimes that generate distinguishable cell fates

biorxiv.org/content/10.64898/2026.03.03.709461v1

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3 weeks ago
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🚨 New Preprint from the Paluch & Chalut Labs 🚨
Ana Raffaelli et al show that the stiffness of substrate (in vitro) / basal membrane (in vivo) determine how cells interpret biochemical signals (BMP4) and which fates they acquire
#mechanobiology #hESCs #substratemechanics
doi.org/10.64898/202...

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1 week ago
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🚨3-year Postdoc Position @halloulab.bsky.social (Kennedy Institute, Oxford) - on Spatial Biology & Bioinformatics of Fibrosis🚨

An exciting project combining #SpatialTranscriptomics & #Mechanobiology👇:

shorturl.at/LLS5r

Deadline: 16 March - Please RT 📢!

@kiroxford.bsky.social @ox.ac.uk

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2 weeks ago
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Circumferential actomyosin bundles anchored by CCM1 drive endothelial cell contraction and vessel constriction - Nature Communications Dysregulation of blood vessel size can cause vascular malformations. Here, the authors demonstrate that endothelial cells generate circumferential actomyosin cables to control the size of cells and ve...

Here's the link to the original article if you haven't checked it out already! www.nature.com/articles/s41...

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2 weeks ago
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Spiral phyllotaxis in the moss Physcomitrium patens emerges from simple division rules of the apical cell Cammarata et al. explore how cell division orientation generates phyllotaxis in moss with a unicellular meristem. They show that successive rotational divisions in the apical cell are precisely placed...

How moss makes a spiral of leaves through a rotating asymmetric division of the apical cell meristem--our paper is out @currentbiology.bsky.social today! @soestrauss.bsky.social Richard Smith, Joe Cammarata
www.cell.com/current-biol...

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2 weeks ago
Poster for Stand Up for Science RTP--UNC campus, March 7 noon

1 year ago at the @standupforscience.bsky.social rally, scientists, students, advocates, & community members joined in cities nationwide. Now we're returning to the streets in nearly 30 cities & towns o demand scientific integrity, strong public health protections, & democratic accountability 1/n

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2 weeks ago
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In our latest preprint we show that Lifeact::mKate2 can reverse the chirality of active torques in the actomyosin cortex. This results in cortical flows with opposite handedness during left-right symmetry breaking, leading to the formation of situs inversus worms.

www.biorxiv.org/content/10.6...

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3 weeks ago

Send us your stem cell manuscripts! Very easy to transfer from biorxiv and we can also quickly consider a manuscript based on reviews received elsewhere. JCS does a tremendous job of supporting the scientific community (see the link below). Reach out if you have questions!

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1 month ago
Santa Cruz Developmental Biology Meeting

Registration is OPEN for the 2026 Santa Cruz Meeting on Developmental Biology!!! Please spread the word!

@mads100tist.bsky.social @socdevbio.bsky.social @bsdb.bsky.social @xenbase.bsky.social @isdb.bsky.social @devbiol.bsky.social @the-node.bsky.social

scdb2026.sites.ucsc.edu

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3 weeks ago
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Are you working on stem cell biology? Our Academic Editor Aryeh Warmflash (@warmflashlab.bsky.social) is committed to handling articles on this topic so send your article our way.

There are lots of reasons to choose JCS – find out more: journals.biologists.com/jcs/pages/re...

#stemcells

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3 weeks ago
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New from us in @pnas.org :
We considered the limits of condensate diversity, and engineered DNA droplets to form 9 distinct, homotypic, coexisting phases. Very hard to do this except with nucleic acids. Probably you can make more than 9. (1/3)

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3 weeks ago

We summarised the many roles of material phase transitions in development (and they are not just mechanical 🤔)

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Tissue phase transitions in development: more than just mechanics Summary: Tissue material phase transitions are classically thought to regulate tissue deformability. This Review emphasises their unexpected roles in directly influencing growth and patterning signall...

Excited to share our new review in @dev-journal.bsky.social on tissue phase transitions during development!

@karengrace12.bsky.social @nicolettapetridou.bsky.social

🔗 doi.org/10.1242/dev....

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New preprint @biorxiv-devbio.bsky.social by Harshath Amal and colleagues from our lab @uni-muenster.de shows how a BMP #morphogen gradient is translated into graded junctional permeability by tuning adhesion and actomyosin contractility in #Drosophila
See tinyurl.com/yhbwd9xh
@sfb1348.bsky.social

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3 weeks ago

We‘re looking for a motivated Master student to join our team!

Do you want to optogenetically control metabolic activity to see how metabolism affects patterning and morphogenesis? 💡🧫🧬🔬

Then please apply!
#optogenetics #metabolism #devbio #hESCs

Please RT. Thank you!🙏

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3 weeks ago

For those interested! Speakers include @dianapinheiro.bsky.social, @ritamateus.bsky.social & @streichan.bsky.social 🐟

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3 weeks ago
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A Postdoctoral Associate position is available in the Roeder Laboratory at Cornell University in Ithaca, NY with a focus on researching Polyploidy. Apply by March 1. Please spread the word. apps.hr.cornell.edu/recruiting/f...

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1 month ago
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Break to build: fracture as a unifying morphogenetic strategy Summary: This Review presents mechanical fracture as a unifying morphogenetic strategy and describes how developmental systems actively exploit mechanical fracture to drive morphogenesis, reproduction...

Our latest with @torres-sanchez.bsky.social journals.biologists.com/dev/article-...
Breaking isn’t always a bad thing! Think of birth, seed release...
We highlight how living tissue not only tolerates fractures but actively fracture to grow, shape, reproduce, or adapt – across species and scales.

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1 month ago
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Pulsatile dynamics propagate crystalline order in the developing Drosophila eye Couturier et al. show that the development of regular rows of light-receiving units in the Drosophila eye is accompanied by pulses of proneural gene expression and Notch signaling activity. Pattern pr...

Very interesting study from the Schweisguth lab - Pulsatile dynamics propagate crystalline order in the developing Drosophila eye: Developmental Cell www.cell.com/developmenta...

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1 month ago
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Endogenous FGFs drive ERK-dependent cell fate patterning in 2D human gastruloids Summary: In a 2D gastruloid model for human gastrulation, FGF4 and FGF17 signal through basolateral receptors to induce primitive streak-like cells and derivatives, potentially restricted by FGF8.

After being reviewed as a preprint in Elife our paper about endogenous FGF signaling in 2D human gastruloids is now published in Development:
journals.biologists.com/dev/article-...

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1 month ago

Postdoc position available!!! We are looking for a creative postdoc to develop independent research directions in tissue morphogenesis using embryos, stem cell/organoid systems, and quantitative imaging and/or biophysics. Here are the details: livejohnshopkins-my.sharepoint.com/:b:/g/person...

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1 month ago

El Paso is my hometown, and my birthday happens to be this week. Please join me in donating to Annunciation House (annunciationhouse.org). They help migrants, immigrants, and refugees in El Paso. More recently, they've sheltered people released from ICE detention: www.elpasotimes.com/story/news/i...

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1 month ago

Instructors include @akankshi.bsky.social, @nicolettapetridou.bsky.social, @dianapinheiro.bsky.social, @chloeroffay.bsky.social, & @streichan.bsky.social among others! 🐟

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1 month ago

Seconded. If anything, it has never been a better time to be a biophysicist, a complex system physicists, etc…. And it is a bit sad that much of it now happens *outside* of physics departments (for good and bad reasons…)

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1 month ago
YouTube
Bruce Springsteen - Streets Of Minneapolis (Official Audio) YouTube video by Bruce Springsteen

I wrote this song on Saturday, recorded it yesterday and released it to you today in response to the state terror being visited on the city of Minneapolis. It’s dedicated to the people of Minneapolis, our innocent immigrant neighbors and in memory of Alex Pretti and Renee Good.

Stay free

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