Sebastian Streichan

Which features of tissue flows are most robust and how do they emerge from #EpithelialMechanics?

I’m @alex-plum.bsky.social (@mattiaserra.bsky.social group) and I’ll be sharing some papers on characterizing and controlling avian gastrulation flows.

What are these?

You are looking at embryos of a sea squirt. Each of the 'soap bubbles' is a living cell, about a fourtieth of a millimetre in size. The outlines of the cells are visible thanks to fluorescent markers identified by Hitoyoshi Yasuo @hitoyas.bsky.social

see doi.org/10.1101/2024... 🧵

🚨Excited to kick off our online seminar series on Metabolism in Development and Physiology!

Please help us grow a collaborative and supportive community by joining (<1min): forms.gle/Y8QzucogKKrZ...
#Metabolism #Development #StemCells

Please RT! 🙏

During these uncertain times, I’m very happy to see that my institution, @scripps.edu has an open tenure-track Assistant Professor position. Any field in Chemistry or Biology is welcome. I’d especially love to see fellow neuroscientists apply. Please repost!

apply.interfolio.com/174756

📣Announcing the 4th edition of the EMBL‑IBEC Conference on “Engineering Multicellular Systems”, taking place 11–13 March 2026 in Barcelona. Exploring organoids, mechanobiology, embryo models, organ-on-chip systems, multiomics and more. Abstracts open now!
events.ibecbarcelona.eu/embl-ibec-co...

We have TWO papers out in @jcb.org this month! 🎉

First, @kirstin-rollins.bsky.social showed that macrophages nibble adherent target cells, like the ones found in solid tumors, instead of phagocytosing. Amazing movies from @sareenfiaz.bsky.social

doi.org/10.1083/jcb....

HerBrain, the first digital twin of the maternal brain, has been named one of TIME Magazine's Best Inventions of 2025! 👏

Led by @ninamiolane.bsky.social the HerBrain app illustrates how brain structures change across the pregnancy and postpartum periods, so a woman can predict her weekly shifts.

✴️Sea urchins have illuminated fertilization 🧫, early cleavage divisions 🔬, and gene regulation in embryonic patterning 🧬. A classic marine model that shaped our understanding of cell fate and axis formation. 📸 Image by Laurent Formery #ModelMonday #DevBio

Tenure-track faculty position at all levels in Data Science and Artificial Intelligence for Mechanical Engineering at Hopkins. APPLY :) apply.interfolio.com/175773

Poster with QR code linking to the position

I'm very excited to announce that UNC Biology has 6 faculty positions open this year! The first is for an Asst Professor who studies organismal resilience using an integrative approach 1/n
unc.peopleadmin.com/postings/307...

The connectome of the entire male Drosophila central nervous system is out!! Acquired using FIB-SEM @ 8x8x8nm, we aligned 7.5 mio 2D images aligned into one seamless 3D volume, which was used to segment & proofread neurons and synapses. @hhmijanelia.bsky.social

www.biorxiv.org/content/10.1...

Very excited about this project: we believe that 3D anatomical atlases have a huge potential for developmental biology. As a starting point, we made the first ever Drosophila wing disc atlas!

Four large circular bulbs are spread out like a square. Between the colourful bulbs, and in the background, are long, differently-coloured tendrils, which take up most of the rest of the image.

This image shows neurons being grown on a surface with tiny patterns that resemble human tissue to ‘steer’ their growth.

Models like this allow us to learn more about our nervous system and conditions like motor neurone disease.
Image credit: Cathleen Hagemann and @andreaserio.bsky.social

Jonathan's "Opus Magnum" is finally out. Fundamental discovery. Congratulations!

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Faculty positions in animal morphogenesis that may be filled at the Assistant or Associate Professor level in one of my favorite Departments" Cell and Systems Biology at the University of Toronto. 1/n
jobs.utoronto.ca/job/Toronto-...
jobs.utoronto.ca/job/Toronto-...

See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

A very inspiring day with great 45 min talks at the Ulm Biophysics Summer Symposium 2025, by Joachim Spatz, Jovica Ninkovic, Max Bi, @streichan.bsky.social, Sabrina Leslie and Joachim Rädler. Many thanks @serwanelab.bsky.social for the invitation and congratulations for the new position👍😀🚀

Cartoon of a speculative heterogenous cell population performing mesenchymal collective cell migration.

1/12 A very special moment for me! 🎉

My first paper as corresponding author—a @jcb.org Perspective on how contact-based decision-making in collective cell migration can itself encode blueprints for complex patterns and shapes.

rupress.org/jcb/article/...

#cellbio #devbio #science

🧵for details

📣 New preprint: Mechanochemical feedback, tissue geometry & rigid-body dynamics initiate rotational migration in Drosophila via spontaneous chiral symmetry breaking. A mechanism generalizable to closed epithelia.
@sreejithsanthosh.bsky.social
biorxiv.org/content/10.1...

1🧵
Excited to share my first PhD paper, published in @dev-journal.bsky.social
What if fish gills —often overlook —hold secrets about development, patterning, and function?
We uncovered how early patterning shapes adult gill architecture.
journals.biologists.com/dev/article/...

#DevBio #Zebrafish

Who knew that the perfect pasta sauce could lead to a Nobel Prize? Congrats to ISTA postdoc Fabrizio Olmeda and collaborators for winning the Ig Nobel Prize with their research on mastering Cacio e Pepe. Bravo! 🍝 🎉

Getting hungry? Here´s the recipe for delicious research: https://bit.ly/42vlpHm

hoxd13a reporter in a zebrafish larva

Are digits modified fins, or evolutionary innovations? Read how we tackled this old question from a new angle🧪
A story with @chasebolt.bsky.social, @homeobox.bsky.social and myself, coordinated by @denisduboule.bsky.social from @college-de-france.fr and published in @nature.com today!
#InHoxWeTrust

Side hustle level-up! My book, IN THE BEGINNING, will be published by @harperonebooks.bsky.social in 2027! It's about the human embryo, how it gets built, and what it means for where we come from and where we're going.
@harpercollins.bsky.social (1/2)
@socdevbio.bsky.social
#devbiol
#scicomm

E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding Epithelial stretching promotes the release of EGF receptor ligands that stimulate ERK activation.

A bit delayed, but excited to still share our latest paper, showing that intercellular forces transduced by E-cadherin activate EGFR-ERK signaling in epithelia by inducing EGFR ligand shedding! Mechanical and biochemical signals can act together within a single, linear cascade! tinyurl.com/mr9mj9j2

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences: Vol 383, No 2304

Our special issue of Phil Trans Roy Soc A on "Biological Fluid Dynamics" Emerging Directions" is officially out now! Originating from discussions at one of our SIG meetings, this special issue has 16 research articles and reviews on all things bioactive! royalsocietypublishing.org/toc/rsta/202...

Epithelial tension controls intestinal cell extrusion Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...

Out in @science.org! We found that the intestine doesn’t just push out cells when crowded. Instead, cells are in a mechanical tug-of-war, and weaker ones are extruded. A new view of how our gut keeps its balance and stays healthy.
www.science.org/doi/10.1126/...

📢🌱 Job alert: Assistant Professor in Plant Molecular Genetics (Tenure-track)
Join our interdisciplinary research environment, in Montréal Botanical Garden!
📅 Deadline: October 13, 2025
📍 Université de Montréal, Canada

Please share! 🌿
drive.google.com/file/d/1Sxkt...

Flagellar gliding in choanoflagellates Freire-Delgado and Brunet discover a new mode of cell motility in choanoflagellates, the closest relatives of animals. Under mild confinement, choanoflagellate move over surfaces without cell deformat...

New short paper from our lab @currentbiology.bsky.social, in which we discover of a new mode of cell motility for choanoflagellates: flagellar gliding. www.cell.com/current-biol... - A 🧵

Preprint alert!
We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.

doi.org/10.1101/2025...