Ivano Amelio

The Scientific Drunk and the Lamppost: Massive Sequencing Efforts in Cancer Discovery and Treatment Signaling networks may provide greater return for the investment in cancer research.

www.science.org/doi/10.1126/...

A fantastic viewpoint by @frezzalab.bsky.social network.febs.org/posts/thinki...

It reminds me of the lampost-and-key analogy described in this article by Michael Yaffe www.science.org/doi/10.1126/....
The goal is to understand network-based signalling.

👉 Check it out and join the movement

Universities are — and must continue to be — a force for good From funding squeezes to political attacks, higher education is in trouble in many parts of the world. Fresh ideas will allow the sector to thrive and deliver value for society.

Universities generate ideas and knowledge, for long-term societal progress, not short-term metrics.

"Universities are — and must continue to be — a force for good. Fresh ideas will allow the sector to thrive and deliver value for society."
@nature.com

www.nature.com/articles/d41...

It was a fantastic Swiss Apoptosis Meeting.
Great science and nice colleagues as usual.

This time this view of the Swiss Alps from Bern to Konstanz was a plus.

Moonlight. Bodensee. Silence. ✨

⏳ Just 3 days left! Don’t miss the chance to present your science at #ECDO2025 in Berlin.

Submit your abstract today 👉 www.ecdo.eu/ecdo2025/con...

#CellDeath #Berlin2025

Congrats to ‪@linkermannlab.bsky.social‬ on this important work highlighting the role of sex hormones in regulating susceptibility to ferroptosis.

... and welcome on Bleusky, btw.

Register to the ECDO-2025 in Berlin!!!

Registration is on a first come, first served basis, so we highly recommend securing your spot as soon as possible.
Join us in Berlin for an unforgettable event.

We can’t wait to welcome you to ECDO-2025! 🌍🎓

Very proud on our stellar Alina Ritter for her frist first-author paper:

Targeting CXADR-mediated AKT signaling suppresses tumorigenesis and enhances #chemotherapy efficacy in #Ewing #sarcoma

tinyurl.com/3kcs3bc9

@dkfz.bsky.social
@uniheidelberg.bsky.social
@nct-heidelberg.bsky.social

Targeting CXADR-mediated AKT signaling suppresses tumorigenesis and enhances chemotherapy efficacy in Ewing sarcoma Distant metastasis is the leading cause of mortality in Ewing sarcoma (EwS) -a malignant bone or soft-tissue cancer mainly affecting children, adolescents, and young adults. Despite continuous efforts...

Congratulations @grunewaldlab.bsky.social team for another impressive work...

www.biorxiv.org/content/10.1...

Aberrant basal cell clonal dynamics shape early lung carcinogenesis Preinvasive squamous lung lesions are precursors of lung squamous cell carcinoma (LUSC). The cellular events underlying lesion formation are unknown. Using a carcinogen-induced model of LUSC with no a...

www.science.org/doi/10.1126/...

Delving into LLM-assisted writing in biomedical publications through excess vocabulary Excess words track LLM usage in biomedical publications.

"This excess word analysis suggests that at least 13.5% of 2024 abstracts were processed with LLMs. This lower bound differed across disciplines, countries, and journals, reaching 40% for some subcorpora"

www.science.org/doi/10.1126/...

Neuronal transfer of mitochondria to tumour cells promotes cancer spread Neurons often receive organelles called mitochondria from other cells. It emerges that neurons donate mitochondria that support cancer-cell spread.

Neurons often receive mitochondria from other cells, supporting cancer cell spread

https://go.nature.com/3ZLBhnV

Register now for the 7th German-French DNA Repair Meeting, which will take place at the Campus Pierre et Marie Curie of Sorbonne University in Paris, France, from 5–7 November 2025. premc.org/dnarepair202...

A great cell death meeting is happening in Bern, Switzerland on Sept. 4-5, 2025!

and registration is free!!!

meetings.ls2.ch/sa2m-2025

Cancer associated to low-penetrance TP53 variants: insights from p.R337H The TP53 p.R337H variant, prevalent in Southern Brazil, is linked to variable cancer risk for pediatric and adult cancers. Unlike high-penetrance TP53 pathogenic variants, many carriers remain cancer ...

www.cell.com/trends/cance...

Good Sunday!

www.nature.com/articles/s41...

Register now: application deadline for the 7th 🇩🇪German-🇫🇷French 🧬DNA Repair Meeting, taking place in Paris from November 5 to 7, 2025, is fast approaching.
To submit applications and for full event details, please go to the website:
👉 lnkd.in/dfJVjYFQ

p53 status determines the epigenetic response to demethylating agents Azacitidine and Decitabine 5’-Azacitidine (Aza) and 5-Aza-2’-deoxycytidine (Dac) are widely used demethylating drugs that directly integrate into nucleic acids. They are frequently used interchangeably, surprisingly as their se...

"p53 status determines the epigenetic response to demethylating agents Azacitidine and Decitabine"

Nice to see this work finalised on @biorxivpreprint.bsky.social

Congrats to Matthew van de Pette @mrc-tu.bsky.social and colleagues.

www.biorxiv.org/content/10.1...

Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...

Multigenerational cell tracking of DNA replication and heritable DNA damage

Congrats @altmeyerlab and collaborators

www.nature.com/articles/s41...

A PhD position is open in my group here in Heidelberg. We'll use cool primary cell models of osteosarcoma and genetic screens to understand and overcome mechanisms of clinically acquired drug resistance. It'll be a blast!

karriere.klinikum.uni-heidelberg.de/index.php?ac...

aligning identity is a challenge 👇

"The search for worth is endless because the benchmarks by which we are measured are constantly changing; it is a moving target."

I completely agree, it is a losing battle. And often, the criteria are also subjective.

Thank you, Christian, for sharing such a beautiful piece.

Integrating exposomics into biomedicine Assessing a full range of environmental exposures will improve human health

www.science.org/doi/10.1126/...

Pervasive phenotypic effects of FBXO42 controlled by regulation of PP4 phosphatase F-box proteins are the substrate recognition modules of the SCF (SKP1–Cullin– F-box) E3 ubiquitin ligase complex. FBXO42, an understudied member of this family, has recently emerged as a modulator of ...

🧬 New Research Alert! 🧬

"Pervasive phenotypic effects of FBXO42 controlled by regulation of PP4 phosphatase"
www.biorxiv.org/content/10.1...
Our findings reveal that Fbxo42 main function is to control PP4 phosphatase.
Discussions are highly welcome!
#bioRxiv #Research #Science #ubiquitin

Make science more collegial: why the time for ‘adversarial collaboration’ has come Bringing together proponents of rival theories to test their ideas against each other can advance science — but only if all sides can accept that they might be wrong.

... yes, but of course I am right!

www.nature.com/articles/d41...

🔥🔥🔥The stochasticity of biological aging: Read now our Correspondence in @naturemedicine.bsky.social
to clarify the roles of stochasticity in aging and in age prediction. We argue that aging clocks are reflecting the very mechanisms of aging.
@meyerdh.bsky.social
@cecad.bsky.social
rdcu.be/ejQv7

Please repost: Deadline extended until May 1st - join us for discussing cutting-edge cardiometabolic basic and translational research!

Outstanding speaker lineup, highly interactive program, ca. 35 short talks selected from abstracts, and the most beautiful venue at Lake Starnberg: eas-elc.org