Brian DeFelice

Brian DeFelice

@briancdefelice.bsky.social

Father, scientist (#TeamMassSpec), metabolomics/lipidomics, snowboarder, dog lover, CZ Biohub, Fiehn Lab alum

232 Followers 121 Following 6 Posts Joined Nov 2024
4 months ago
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FSP1-mediated lipid droplet quality control prevents neutral lipid peroxidation and ferroptosis - Nature Cell Biology Lange et al. identify a lipid droplet quality control pathway in which FSP1 safeguards stored neutral lipids from lipid peroxidation, thereby preventing the induction of ferroptosis.

Excited to share my postdoc work @olzmannlab.bsky.social! We found lipid droplets, the cell’s lipid storage depots, are subject to oxidative damage and are protected by FSP1. Loss of FSP1 triggers droplet peroxidation and cell death, revealing a new layer of lipid quality control!

shorturl.at/B5XYD

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6 months ago
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Interested in a co-authorship?
We’re building a tool for repository-scale untargeted #metabolomics and #exposomics of #environmental data. To make it the best it can be, we’re looking for people willing to share high-resolution LC-MS/MS (DDA) data from #water, #soil, #sediment, and related samples.

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8 months ago

Working on a way to centrally search all 3. We will be discussing at a workshop this Sunday at MetSoc

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9 months ago
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Join us at Metabolomics 2025 for our workshop -> W10: EMN – MetaboMentors!

Grow as a mentor or mentee through insights, tools & global perspectives.

📅 Monday, June 23rd, 8:15 - 10:15 in South Hall 2
🔗 www.metabolomics2025.org/workshops
🎤 #EMN #MetaboMentors #Mentorship #Metabolomics2025

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1 year ago

Awesome technology and application! Viral infection mediates astounding protein relocalization. I wonder, what else might be moving around when cells are infected?

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1 year ago

Great way for early career folks to contribute to the field and make connections with editors

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1 year ago

If you are not using a Thermo instrument we are happy to support forks for other manufacturers. Please feel free to reach out @czbiohub.bsky.social #TeamMassSpec

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1 year ago
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Rapid QC-MS: Interactive Dashboard for Synchronous Mass Spectrometry Data Acquisition Quality Control Consistently collecting high-quality liquid chromatography-coupled tandem mass spectrometry (LC-MS/MS) data is a time-consuming hurdle for untargeted workflows. Analytical controls such as internal an...

If your lab is using a Thermo LCMS consider trying our tool Rapid QC-MS for automated QC of internal and external standards. Check out our recent publication in Analytical Chemistry: doi.org/10.1021/acs....
Git: github.com/czbiohub-sf/...
User guide: czbiohub-sf.github.io/Rapid-QC-MS/ #OpenScience

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1 year ago

What a great idea! Would love to added

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