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Michael D. Burton

@mdburton.bsky.social

Neuroimmunology and Behavior Lab PI @lab_nib at @UT_Dallas. Lover of Genetics @UTDPainCenter #neuroimmunology, #BlackinNeuro #ritaallenscholar #ASCBFREDfellow https://linktr.ee/mdburton

275 Followers  |  112 Following  |  4 Posts  |  Joined: 07.12.2024
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Posts by Michael D. Burton (@mdburton.bsky.social)

Poster advertising our session

Poster advertising our session

Me, Cheryl, Anne-Marie and Michael giving talks

Me, Cheryl, Anne-Marie and Michael giving talks

Ewan, Anne-Marie, Cheryl and Michael having a much deserved post-symposium dinner!

Ewan, Anne-Marie, Cheryl and Michael having a much deserved post-symposium dinner!

Had a great time at our @sfn.org #PainResearch symposium yesterday, talks covering a whole range of pain states & roles of non-neuronal cells, review article for more reading: www.jneurosci.org/content/45/4... Thanks to @cherylstucky.bsky.social, @mdburton.bsky.social & Anne-Marie Heegaard!

16.11.2025 18:58 — 👍 13    🔁 2    💬 0    📌 0
Figure 1. Non-neuronal–neuron communication in the skin. (1) Non-neuronal cells and extracellular matrix in the skin. (2) When in ammatory events such as IL-6, ATP, and protease production from injury or infection are introduced, it causes an activation of cells, a disruption in extracellular matrix, and damage to sensory neurons. (3) During in ammatory cascades, injured or sensitized neurons potentiate pain and the development of a chronic pain state.

Figure 1. Non-neuronal–neuron communication in the skin. (1) Non-neuronal cells and extracellular matrix in the skin. (2) When in ammatory events such as IL-6, ATP, and protease production from injury or infection are introduced, it causes an activation of cells, a disruption in extracellular matrix, and damage to sensory neurons. (3) During in ammatory cascades, injured or sensitized neurons potentiate pain and the development of a chronic pain state.

Figure 2. Cell–cell interactions in joint pain. Numerous pathogenic changes occur within the OA joint and other musculoskeletal conditions that can contribute to pain, including cartilage degradation, synovitis, and bone remodeling (1). Within the joint evidence has established the role of some key non-neuronal cell types that contribute to pain (2) and some of the signaling nociceptor activation and sensitization mechanisms involved (3). There is also growing evidence for cell–cell interactions within the DRG that contribute to pain (4). See text for more details.

Figure 2. Cell–cell interactions in joint pain. Numerous pathogenic changes occur within the OA joint and other musculoskeletal conditions that can contribute to pain, including cartilage degradation, synovitis, and bone remodeling (1). Within the joint evidence has established the role of some key non-neuronal cell types that contribute to pain (2) and some of the signaling nociceptor activation and sensitization mechanisms involved (3). There is also growing evidence for cell–cell interactions within the DRG that contribute to pain (4). See text for more details.

Figure 3. Keratinocytes contribute to normal touch and chemotherapy-induced mechanical sensitivity through PIEZO1. Keratinocytes in the most super cial layer of the skin respond to mechanical forces via their expression of PIEZO1 channels and activated keratinocytes release ATP which signals to P2X4 channels on cutaneous sensory nerve endings. After a patient is treated with the chemotherapeutic paclitaxel, keratinocyte PIEZO1 is sensitized; the keratinocytes release more ATP and additional mediators, resulting in greater action potential signaling in sensory neurons that is sent to the spinal cord and brain through touch and pain pathways.

Figure 3. Keratinocytes contribute to normal touch and chemotherapy-induced mechanical sensitivity through PIEZO1. Keratinocytes in the most super cial layer of the skin respond to mechanical forces via their expression of PIEZO1 channels and activated keratinocytes release ATP which signals to P2X4 channels on cutaneous sensory nerve endings. After a patient is treated with the chemotherapeutic paclitaxel, keratinocyte PIEZO1 is sensitized; the keratinocytes release more ATP and additional mediators, resulting in greater action potential signaling in sensory neurons that is sent to the spinal cord and brain through touch and pain pathways.

With the annual @sfn.org meeting coming up, I'm looking forward to Saturday's symposium with @cherylstucky.bsky.social , @mdburton.bsky.social & Anne-Marie Heegaard on non-neuronal cells in #PainResearch

Here's our accompanying review!
www.jneurosci.org/content/45/4...

12.11.2025 18:19 — 👍 8    🔁 5    💬 0    📌 2

Looking forward to some exciting #PainResearch / #Neuroskyence in our Symposium: "Not just neurons: pain is orchestrated in partnership with many non-neuronal cells"

@cherylstucky.bsky.social / @mdburton.bsky.social / Anne-Marie Heegaard

15.07.2025 08:39 — 👍 7    🔁 2    💬 0    📌 0

Congratulations!

12.07.2025 06:30 — 👍 2    🔁 0    💬 0    📌 0
Preview
TLR4+ Dermal fibroblasts induce acute and transitional pain states The prominence of non-neuronal cells driving pain states has gained attention in recent years. Fibroblasts, a major stromal cell, perform essential functions during inflammation, tissue remodeling, an...

Excited to share a new preprint that discovered how skin fibroblasts are active participants in acute & long-term pain states & not just bystanders. We know this research, partly funded by the NIH will drive the development of new pain drugs. @elsanchez09.bsky.social
www.biorxiv.org/content/10.1...

13.03.2025 18:03 — 👍 3    🔁 2    💬 0    📌 0

Big facts

19.02.2025 01:37 — 👍 1    🔁 0    💬 1    📌 0
Headshot of Michael D. Burton, Ph.D.

Headshot of Michael D. Burton, Ph.D.

This #BlackHistoryMonth, Banbury recognizes meeting participants for their significant contributions to the biosciences & society.

We begin with @mdburton.bsky.social, Assoc. Prof. at @utdallas.bsky.social. We were happy to have him back at Banbury in 2024. (1/4)

05.02.2025 19:56 — 👍 31    🔁 7    💬 1    📌 0
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Proud to watch Shevon Alexandar defend her dissertation this past week. What an awesome part of the job to watch young scientists grow and apply their potential. She marks the 5th PhD student to graduate from the Burton Lab. She's moving on to a postdoc at @tulaneu.bsky.social @utdallas.bsky.social

12.01.2025 20:25 — 👍 7    🔁 0    💬 0    📌 0