Barbara Pernaute

Last days to apply! Cool project, cool cities! :-)

(Please repost! 🙏)

Very happy to share the work of Huanhuan Li et al. While not a natural embryo, you might not have known that if I hadn’t told you. (1/3)

Transgene-free generation of mouse post-gastrulation whole embryo models solely from naive ESCs and iPSCs Hanna and colleagues show that signaling pathway modulation amplifies the inherent flexibility of genetically unmodified mouse naive PSCs to adopt extra-embryonic cell fate potential. This endows them...

1/n Fun journey continues: Our new @cp-cellstemcell.bsky.social paper out on how the Inherent & Dormant Plasticity of Mouse Naive PSCs can be "Exaggerated" to Directly form ~E8.5 Transgene-Free (TF) Mouse SEMs & WITHOUT inducing 8-16-Morula-like "Embryo Founder Cells".

www.cell.com/cell-stem-ce...

Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease - Nature Reviews Molecular Cell Biology Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppressio...

We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...

⚠️ I am really excited to share the work of Anastasios Balaskas, an excellent PhD candidate in the lab, with the wider world. Tasos made a significant advance: generating a stem cell-based embryo model that contains both posterior and anterior neural tissues of the late-stage gastrulating embryo.

How innate immunity starts? Early embryos eliminate bacterial infections by epithelial phagocytosis, a conserved process from zebrafish to human embryos. Check our story:
www.cell.com/cell-host-mi...

Los cursos de verano en #olavidecarmona son 🔝

Nuestras compañeras @anafminan.bsky.social , Sol Sotillos y @proteolaura.bsky.social organizan el curso ‘Modelos genéticos en investigación, de la bacteria al ratón’ dividido en dos partes!

Info ⤵️
www.upo.es/formacionper...

www.upo.es/formacionper...

🚨🚨#Hiring!

3 year #postdoc position open in my lab @cabd-upo-csic.bsky.social to study the interplay between DNA damage responses and #preimplantation embryo development. Fully funded by EARLYFATE #ERCCoG

📆 Apply by 23rd May 2023

🔗Details below

@sebioldev.bsky.social

Please RT!🙏

🧐🧐🧐 Amazing course in Clinical Embryology

📍Santander
🗓️ July 28th-August 1st
💰4 scholarships available by @sebioldev.bsky.social

Counts with great line up of speakers including @bpernaute.bsky.social from #CABD

Enhanced RNA-targeting CRISPR-Cas technology in zebrafish - Nature Communications CRISPR-Cas13 RNA-targeting systems comprise an invaluable set of tools in the fields of basic and applied sciences. Here, Moreno-Sánchez, Hernández-Huertas, and Nahón-Cano et al. enhanced the use of t...

First seen in Biorxiv and now published and updated with more data in @naturecomms.bsky.social. With this work we have further enhanced CRISPR-Cas RNA targeting in vivo using transient approaches such as RNP or mRNA-gRNA in zebrafish embryos as vertebrate model. www.nature.com/articles/s41...

Paper out !!🥳big thanks to all authors @marliesoomen.bsky.social @diego-rt.bsky.social @kaessmannlab.bsky.social @jonathangoeke.bsky.social @lorenzamottes.bsky.social & 'bluesky-less'

Lots of interesting new TE (& genes) biology

Data fully browsable💻 👉 embryo.helmholtz-munich.de/shiny_embryo/

Thanks a lot Miguel!

Happy to share our Slow cooked work together with @mcgregorlab.bsky.social, @posnienlab.bsky.social , @nuneslab.bsky.social sky.social and Saad Arif and the collaboration of @maikekittelmann.bsky.social, Fernando Casares & @laurensr.bsky.social and many other friends
rdcu.be/d8whP

Hello early researchers! Interesting in doing a PhD in senescence, ageing and cancer? We have an open position in our lab in Spain! Please retweet or reach out if interested!

🚨🚨🚨

If you're a bioinformatician who loves:

🧬 #SingleCell #LongReadSequencing & #AlternativeSplicing
🚀 Collaborating and travelling

Apply to work with us at the spectacular BIMSB (@mdc-berlin.bsky.social) in Berlin + @upf.edu-@crg.eu in Barcelona. Qs: www.transdevolab.com

Please RT! 🙏

Thanks a lot!

Thanks Sofia!!

Muchas gracias!!!

Thanks a lot Cristina!!

Thanks a lot!

Thanks!!

Muchas gracias!!

Thanks a lot!! 😊

Thanks!!

Muchas gracias!!

Gracias Sergio!!

Gracias!!

Origin, fate and function of extraembryonic tissues during mammalian development - Nature Reviews Molecular Cell Biology During mammalian embryogenesis, extraembryonic tissues are required for the patterning and morphogenesis of the embryo. This Review discusses how signalling networks and epigenetic modifications regul...

Happy to share our latest review by @shifaant.bsky.social with @cwhanna.bsky.social. A detailed look at extraembryonic tissues – the 'other half' of the conceptus.

www.nature.com/articles/s41... @natrevmcb.bsky.social

Please RT: In my lab we are looking for computational #postdoc researchers to apply to a #juandelacierva or #embo postdoctoral fellowships to work on projects on post-transcriptional regulation on single-cell data (method development and/or data analysis). Contact me if you are interested!

Honored and excited to receive an #ERCCoG grant. Big thanks to my colleagues, former mentors and, most importantly, my amazing lab members. Together, we will be exploring cell type evolution across timescales, from population variation (with @xgrau.bsky.social) to regulatory sequences across phyla.