David A. Sinclair, Ph.D.

Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission The 2024 update of the Lancet Commission on dementia provides new hopeful evidence about dementia prevention, intervention, and care. As people live longer, the number of people who live with…

~45% of dementia cases could be prevented or delayed by addressing 14 lifestyle factors

What factors?

Education, hearing loss, BP, smoking, obesity, depression, inactivity, diabetes, alcohol consumption, brain injury, pollution, isolation, LDL and vision loss

Reaching 50 without high blood pressure, high cholesterol, diabetes, smoking or abnormal BMI can add over 10 extra years free of cardiovascular disease

Each cigarette costs ~20 min of life, and lifelong smokers lose about 10 years. Quitting gives much of that back

Miss you mom ❤️

People with strong social ties have 50% higher odds of survival. Being isolated can be as harmful as smoking up to 15 cigarettes/day. And no, your “smoke break friend” does not cut it

Women who followed a Mediterranean diet for 25 years had 23% lower mortality, lower inflammation and better insulin sensitivity.
(Ahmad et al., JAMA Netw Open 2024)

Five daily servings of fruit and veg was linked to a 13% lower risk of death vs 2 servings. Plants are still an underrated medicine

Irregular bedtimes raised the risk of major cardiovascular events by ~26%, even with similar total sleep. Go to bed at roughly the same time if you can. Your arteries notice

CRISPR-Cas9-induced double-strand breaks disrupt maintenance of epigenetic information - Genome Biology Background CRISPR-Cas9 genome editing enables precise genetic modifications by introducing targeted DNA double-strand breaks (DSBs). While Cas9-induced DSBs are known to cause unintended on-target mut...

New paper relevant to why we age:

1. CRISPR/Cas9-mediated DNA breaks cause methylation loss

2. This effect occurs genome-wide, not just the cut site

3. Natural DSBs show the same methylation disruption

These data strongly support The Information Theory of Aging link.springer.com/article/10.1...

Less than 7 hours of sleep is associated with ~14% higher mortality

Too much (8–9 hours) can raise it up to 34%

The sweet spot for most people is ~7–8 hours

Sitting >3 h/day may account for ~3.8% of all deaths worldwide—over 400,000 deaths/year. Micro-movements matter
(Rezende et al., Am J Prev Med 2016)

Good news: you don’t need 12,000 steps. In 15 cohorts, the most active people had 40–53% lower mortality, with benefits plateauing at 6–10k steps
(Paluch et al., Lancet Public Health 2022)

Frontiers | Inhibition of mesenchymal drift as a strategy for rejuvenation Mesenchymal drift (MD), the progressive acquisition of mesenchymal traits by epithelial and endothelial cells, has emerged as a unifying mechanism of aging. ...

New article: The Information Theory of Aging (ITOA) states that epigenetic drift is a cause of aging, with cells taking up new identities. New review says slowing a process called "mesenchymal drift" has emerged as a new strategy for rejuvenation www.frontiersin.org/journals/pha...

The ITOA paper from 2023, in which Michael played a seminal role, not just in generating data, but keeping the team and especially the young students motivated, despite the difficulty of the decade-long project and the harsh scientific critics of the day. R.I.P. Michael 🍻🙏🧎

Five years ago today, our dear friend and colleague Michael Bonkowski passed away unexpectedly. For a decade, he was the life of the Sinclair lab, a major force testing The Information Theory of Aging & cared so deeply about his students they still speak of him like a father🙏

Patent granted!

“Cellular reprogramming to reverse aging and promote organ and tissue regeneration.“

Super proud of the team’s invention of the first truly safe age-reversal technology - for healing injuries, treating diseases, and hopefully extending human lifespan @y_ryan_lu

Jim Watson and me at his office at Cold spring Harbor

RIP James D. Watson, co-discoverer of DNAs double helix🥇Jim was a kind, generous mentor to me, who never hesitated to meet, give feedback, or share stories from the early days of molecular biology. His signed double helix hangs in my office as a reminder how one discovery can change the world 🙏

Life Biosciences Appoints Industry Veteran David Guyer, M.D. to Board of Directors Life Bio adds accomplished biotech leader to its Board as the company prepares for an early 2026 initiation of human trials BOSTON, November 3, 2025 – Life Biosciences (“Life Bio”), a biotechnology co...

Thrilled to have David Guyer join the @lifebiosciences.bsky.social board, maker of the first anti-VEGF eye drug, two successful biotech IPOs, the largest ever ex-US pharma deal, and sale of his latest company, EyeBio, for ~$3B to Merck in 2024. Midas touch 🙏✨🥇
www.lifebiosciences.com/life-bioscie...

Asia University Partners with NucleicAI to Build a Sovereign AI Life Science Data Platform /PRNewswire/ -- Asia University will partner with NucleicAI LLC, a next-generation platform and data company specializing in AI-driven genomics, precision...

Grateful for the leadership of President. Jeffrey Tsai at Asia University and so excited for what’s ahead 🚀
Press release:
tinyurl.com/fdn8ckd9

Dr. Haghighi is Chief Executive and Director, Harvard Medical School International Center for Genetic Disease, Principal Investigator and Director, Bahrain National Genome Program at Harvard and Assistant Professor of Medicine, Harvard Medical School, and Brigham and Women's Hospital

This is more than a regional milestone. It reflects our broader commitment to working with governments, academia, and industry worldwide to responsibly unlock the full potential of genomics and AI

nucleicAI website

Dr. Alireza Haghighi, my cofounder and I, are proud to announce an exciting partnership with Asia University to develop a "Sovereign AI Life Science Data Platform for Taiwan", a national system for secure health data sharing, AI-powered analytics, and collaborative research

Asia University Partners with NucleicAI to Build a Sovereign AI Life Science Data Platform /PRNewswire/ -- Asia University will partner with NucleicAI LLC, a next-generation platform and data company specializing in AI-driven genomics, precision...

The AI-powered bioanalytics company NucleicAI.com, founded by Harvard geneticists Alireza Haghighi & David Sinclair, takes another big step forward towards their goal of building a global AI infrastructure to advance longevity science & affordable healthcare for all
tinyurl.com/fdn8ckd9

Centenarians don’t just live longer, they get sick later, and their diseases progress more slowly. Longevity isn’t just about living longer, it’s avoiding illnesses that kill you

We’re the first generation to understand aging at the molecular level. That knowledge changes everything

1 in 10,000 humans lives past 100. In some villages, it’s 1 in 10. Lifestyle matters

Every healthy habit you choose is a vote for your future self

Computers in the future may weigh no more than 1.5 tons @popmech, 1949

Loneliness is as dangerous as smoking. Put your phone down and get out there

Aging is not inevitable, it’s biology. And biology can be changed

With ER-100 on track for human trials in Q1 2026, this program is moving quickly 💉👁️ Jerry McLaughlin, our CEO, and I are so grateful for the creativity, dedication, and persistence the board & entire R&D team led by Dr. Sharon Rosenzweig-Lipson