David A. Sinclair, Ph.D.

Centenarians don’t just live longer, they get sick later, and their diseases progress more slowly. Longevity isn’t just about living longer, it’s avoiding illnesses that kill you

We’re the first generation to understand aging at the molecular level. That knowledge changes everything

1 in 10,000 humans lives past 100. In some villages, it’s 1 in 10. Lifestyle matters

Every healthy habit you choose is a vote for your future self

Computers in the future may weigh no more than 1.5 tons @popmech, 1949

Loneliness is as dangerous as smoking. Put your phone down and get out there

Aging is not inevitable, it’s biology. And biology can be changed

With ER-100 on track for human trials in Q1 2026, this program is moving quickly 💉👁️ Jerry McLaughlin, our CEO, and I are so grateful for the creativity, dedication, and persistence the board & entire R&D team led by Dr. Sharon Rosenzweig-Lipson

Reprogramming to recover youthful epigenetic information and restore vision - Nature Expression of three Yamanaka transcription factors in mouse retinal ganglion cells restores youthful DNA methylation patterns, promotes axon regeneration after injury, and reverses vision loss in a mo...

This adds to earlier data showing clear functional benefits in the eye. They also beautifully match the mouse data we published in Nature (2020), in fact they are even more dramatic in their reversal of DNA methylation 😲 www.nature.com/articles/s41...

These results add to the weight of evidence that reprogramming is not just for age-reversal, it can be used to treat diseases that affect millions worldwide and with few effective treatments

In liver disease (MASH), ER-300, an AAV-delivered package of reprogramming genes, improved multiple key liver health biomarkers in an animal model, from ALT/AST to cholesterol and steatosis (fat content) scores

Said presenter and CSO, Sharon Rosenzweig-Lipson, "These results bring us closer to pioneering a new class of epigenetic therapies that can modify the biology of aging itself and, in doing so, transform how age-related diseases, such as optic neuropathies and MASH, are addressed”

Life Biosciences presented this new data
the ARDD conference in Copenhagen this week

This news is strong evidence that the original vision to develop therapies that reversal of aging to prevent and cure diseases of aging and injuries isn’t just a fanciful idea

Life Biosciences Presents New Data at ARDD 2025 on the Company’s Partial Epigenetic Reprogramming Platform in Liver and Ocular Diseases ER-300 improves key biomarkers of liver health in an animal model of MASH These data, along with additional ER-100 preclinical data from a nonhuman primate model of NAION demonstrating clear restorati...

NEWS: @lifebiosciences.bsky.social reports new drug candidate ER-300 improves liver health while ER-100 reverses age & restores healthy DNA methylation patterns in the monkey eye, with clear functional improvements in vision. Human trials set for January, 26. It’s happening...
🧵 tinyurl.com/4dysm7bv

Young researcher’s ALS attack plan is now a no-go — Harvard Gazette Career award among the casualties of "terrifying" cuts affecting lab of David Sinclair, which studies aging and disease.

Career award among casualties of ‘terrifying’ cuts affecting lab of David Sinclair news.harvard.edu/gazette/stor...

All NIH grants supporting my lab's trainees and medical research have been terminated. I am not alone. We scientists work hard to make the world a better place & we will not go down without a fight 🥊

Just posted our manuscript on "mPhenoAge," the first composite biological age measure for mice 🐭🧵 Proud of Alice and the entire team! 👏
@biorxivpreprint.bsky.social @volofoundation.bsky.social
tinyurl.com/544kzccz

Link to the review: link.springer.com/article/10.1...

Xenohormesis: Sensing the Chemical Cues of Other Species Many plant molecules interact with and modulate key regulators of mammalian physiology in ways that are beneficial to health, but why? We propose that heterotrophs (animals and fungi) are able to sens...

We called it the Xenohormesis Hypothesis and it explains why many plant molecules are medicinal. When plants are stressed, they make more polyphenols, which our bodies sense to survive a food shortage
cell.com/cell/fulltext/S0092-8674(08)00511-4

Xenohormesis - Wikipedia

This possibility is consistent with current theories about plant-animal interactions. Konrad Howitz & I proposed that many antioxidants are signaling molecules, which interact with enzymes that turn on the body's defenses against cellular damage and aging...
en.wikipedia.org/wiki/Xenohormesis

Where to get polyphenols? From berries, apples with skin, cherries, plums, pomegranates, spinach, red onions, artichokes, broccoli, asparagus, matcha green tea, black tea, coffee, dark chocolate, turmeric, beans, EVOO and any deeply-colored vegetable

The authors of this new review discuss how polyphenols like curcumin, quercetin, resveratrol, and genistein seems to also target cancer-related miRNAs, thereby slowing cancer progression...

In the 1990s, Victor Ambros and Gary Ruvkun (in my Department @harvardmed.bsky.social) were interested in how different cell types develop in worms. They discovered microRNA, a new class of tiny RNA molecules that regulate genes called miRNAs...

In the 1990's, antioxidants were all the rage. Today, we know so much more, while the food and beverage industry still promotes antioxidants as though they were the most important thing...

Polyphenols aren't just antioxidants. They signal to the body ➡️ defend and heal. New evidence indicates that polyphenols might prevent cancer by modulating small RNAs...a thread 🧵

If you turned 100 today and felt like you do now, would you want to die? Of course not.

So asking “How long do you want to live” is pointless

The right question is “When do you want to get frail and sick.”

Science funding agency threatened with mass layoffs National Science Foundation staff heard the plans at a meeting Tuesday.

Sabotage. Criminal sabotage.

"[The NSF] is planning to lay off between a quarter and a half of its staff in the next two months, a top National Science Foundation official said Tuesday."

www.eenews.net/articles/sci...

Fish oil and vitamin D capsules

Omega-3 plus vitamin D “slows biological aging by 3-4 months over 3 years, particularly when combined with exercise.” 👏
t.co/XGexiZFQg3

NIH eases freeze on grant reviews imposed after Trump communications pause Meetings of study sections and closed portion of councils back on track as agency also deals with diversity-related executive orders

The gears of the grantmaking machinery at NIH have begun moving again, after a 2-week standstill following a controversial ban on communications imposed by President Donald Trump. scim.ag/4aLQ0U6