David A. Sinclair, Ph.D.

Regular physical activity reduces all-cause mortality risk by about 30 to 35 percent 🏃‍♀️

Association of wearable device-measured vigorous intermittent lifestyle physical activity with mortality - Nature Medicine Using data from wearable activity monitors, this study shows that short bursts of physical activity that are done as part of daily life activities and that are only 1 or 2 minutes in length are…

Just 4.4 min/day of incidental vigorous activity is linked to ~26–30% lower all-cause & cancer mortality
www.nature.com/articles/s41...

The habit you ignore becomes the disease you later manage

Longevity starts where excuses end 🏋️

Most people don’t need more information. They need more repetition 💪

You don’t start by reprogramming an entire person with OSK. You start small and contained. @elonmusk’s first rocket wasn’t Starship. It was Falcon. In 2017, we decided the eye was the best place to test human age reversal, and now we’re ready for launch. If that works, we go systemic 🚀

You don’t need perfect data to make better life choices

The best longevity strategy avoids damage first

The future of medicine is prevention, not rescue

A great relationship is an aging intervention. The converse is also true

Longevity isn’t “anti-aging”. Ditch that term. It’s pro-maintenance

The body doesn’t forget what you stop doing

Decline is optional longer than most people think. Just ask my perfectly healthy 86 year-old father 💪

Exercise isn’t about fitness. It’s about survival

If you don’t prioritize your health, disease will

Most people age faster from neglect and laziness than genetics

Introducing controlled DNA breaks accelerates biological aging without mutations, suggesting aging is epigenetic information loss

Exclusive: In major test for longevity field, FDA greenlights study on a 'near total reset' of cells Life Biosciences gets FDA approval to test aging reversal gene therapy in vision loss patients, using proteins discovered in David Sinclair's Harvard lab.

Thanks @endpts.com
endpoints.news/exclusive-fd...

Proud of the Life Biosciences team! Michael, Sharon and Jerry. Onward!

Muscle is not optional insurance. It’s required coverage

If it were easy, everyone would live past 100

Small, consistent wins compound faster than big promises

Longevity is not self-optimization. It’s self-preservation

Biology doesn’t reward intention, it rewards repetition 💪

Aim for habits that survive stress, travel, and bad weeks

Build muscle and friendships. Both are protective

The best time to start was years ago. The second best time is today

Don’t let aging win by default

Steps per Day and All-Cause Mortality in Middle-aged Adults This cohort study assesses the association of step volume and intensity with premature all-cause mortality among Black and White participants in the Coronary Artery Risk Development in Young Adults…

7,000 steps/day is linked to ~50–70% lower mortality. You move!
jamanetwork.com/journals/jam...