Inserm UMR 1069 N2COx

A specific bone marrow cytokine pattern in de novo acute myeloid leukemia Acute myeloid leukemia (AML) is a heterogeneous group of hematopoietic cancers. Cytokines play an important role in the regulation of normal and patho…

Delighted to share our new article www.sciencedirect.com/science/arti... in Clinical immunology @elsevierhms.bsky.social
@inserm.fr @insermgrandouest.bsky.social @chrudetours.bsky.social
in collaboration with Pr Delhommeau's team @sorbonne-universite.fr
#cytokines
#leukemia
#institut_Carnot_Opale

🔬 @cnrs.fr
@inserm-u1069-n2cox.bsky.social
@inserm.fr
@igdrennes.bsky.social
@chunantes.bsky.social
@insermgrandouest.bsky.social
@cnrs-bretagneloire.bsky.social
#cancer #cancerologie #oncologie #recherche #grandouest #cancersein #cancerdusein #cancerprostate #cancerdelaprostate

Pulmonary arterial hypertension and cancer: exploring their resemblance as channelopathies Pulmonary arterial hypertension (PAH) and cancer may appear to be unrelated at first, but there is increasing evidence that they share many characteri…

Thrilled to share our collaborative review exploring the resemblance of pulmonary arterial hypertension and cancers as channelopathies @cellpress.bsky.social Trends in Molecular Medicine
@inserm.fr Inserm UMR 999
@univparissaclay.bsky.social Université de Tours
www.sciencedirect.com/science/arti...

L'université de Tours s'associe au mouvement international Stand-up for Science

www.univ-tours.fr/recherche/ac...

Image décorative.

L’Inserm rejoint Bluesky !

Découvrez ici toutes les actualités de la recherche médicale menée par l’Inserm, pour la santé de toutes et tous.

An oldie but a goodie!

DNA, mitochondria, actin and tubulin for #fluorescencefriday

Triacylglycerol mobilization underpins mitochondrial stress recovery - Nature Cell Biology Baker et al. show that mitochondrial stress recovery requires mobilization of lipid droplet triacylglycerol stores to facilitate cardiolipin biosynthesis and mitochondrial biogenesis.

💫NEW: @zakbaker.bsky.social, Pagliarini & co show that #mitochondria stress recovery requires mobilization of #LipidDroplet triacylglycerol stores to facilitate #cardiolipin biosynthesis and mitochondrial biogenesis.
www.nature.com/articles/s41...

Transcriptional regulation of KCNA2 coding Kv1.2 by EWS::FLI1: involvement in controlling the YAP/Hippo signalling pathway and cell proliferation - Cell Communication and Signaling Background Ewing sarcoma (ES), the second main pediatric bone sarcoma, is characterised by a chromosomal translocation leading to the formation of fusion proteins like EWS::FLI1. While several studies...

Very pleased to share our last collaborative publication with Child team #CRCI2NA @inserm.fr @insermgrandouest.bsky.social #cancéropole_Grand_Ouest #Ewing_sarcoma #KCNA2 #Kv1.2 #EWS::FLI1 #YAP/Hippo

biosignaling.biomedcentral.com/articles/10....

with the presence of David Julius, Nobel Prize in Medicine 2021, and many other internationally recognized speakers

Redirecting glucose flux during in vitro expansion generates epigenetically and metabolically superior T cells for cancer immunotherapy T cell therapies for cancer currently rely on extensive in vitro expansion in hypermetabolic conditions. Frisch et al. demonstrate that T cells grown in vitro perform extensive aerobic glycolysis. Rer...

www.cell.com/cell-metabol...

Our latest paper is out:
Unveiling the Functional Connectivity of Astrocytic Networks with AstroNet

Dive into how our graph reconstruction algorithm, paired with calcium image processing, deciphers astrocytic networks.

👉 doi.org/10.1038/s420...

#Astrocytes #Neuroscience #DataScience #Inserm

Université : vivre ou survivre ? Avec près de 80% des universités en déficit, la France a-t-elle laissé tomber l’université ? Reste-t-il des raisons d’espérer pour l’enseignement supérieur public ?

#Budget2025. Les universités font face à une crise financière sans précédent !

Université : vivre ou survivre ? Podcast de @franceculture.fr avec Edouard kaminski :
👉 www.radiofrance.fr/francecultur...

Cancers les plus fréquents : le rôle du « gras » dans leur prévention et leur évolution Le gras influence certains cancers fréquents. Le rôle préventif des acides gras oméga-3 est bien documenté. Mais l'impact de la graisse en excès dans les situations d'obésité reste mal compris.

Cancers les plus fréquents : le rôle du « gras » dans leur prévention et leur évolution @insermgrandouest.bsky.social
@france.theconversation.com #nutrition #cancer #lipides
#acides-gras #oméga-3
theconversation.com/cancers-les-...

Selective deficiency of mitochondrial respiratory complex I subunits Ndufs4/6 causes tumor immunogenicity - Nature Cancer Puigserver and colleagues show that genetic targeting of specific mitochondrial respiratory complex I subunits in melanoma and breast cancer cells boosts tumor immune surveillance via upregulation of ...

Online now!

Puigserver and team show that genetic targeting of specific mitochondrial respiratory complex I subunits in melanoma and breast cancer cells boosts tumor immune surveillance via upregulation of antigen-processing and presentation components.

👇
www.nature.com/articles/s43...

Immune evasion through mitochondrial transfer in the tumour microenvironment Nature - Mitochondria with mutations in their DNA from cancer cells can be transferred to T cells in the tumour microenvironment, which leads to T cell dysfunction and impaired...

rdcu.be/d7aW7

☣️ 𝗖𝗮𝗻𝗰𝗲𝗿𝘀 𝗱𝘂 𝗽𝗮𝗻𝗰𝗿𝗲́𝗮𝘀 𝗲𝘁 𝗽𝗲𝘀𝘁𝗶𝗰𝗶𝗱𝗲𝘀, 𝘂𝗻𝗲 𝗮𝗹𝗲𝗿𝘁𝗲 𝗲́𝗺𝗲𝗿𝗴𝗲𝗻𝘁𝗲 ? ☣️

Deux études françaises récentes, menées selon deux approches complémentaires par Mathias Brugel et ses collaborateurs, interrogent le rôle des pesticides dans la hausse des cas de cancers du pancréas.

Voici un starter pack pour suivre la recherche en France : instituts, laboratoires, universités et agences.

N'hésitez pas à proposer des comptes à ajouter !
go.bsky.app/JSXcYqn

Our research topics:
#Oncology/Hematological malignancies #lipids #prevention #redox/energy metabolism #Sensitization of tumors to anticancer treatments #biology of cancer cells #ion channels #calcium homeostasis #clinical nutrition #cachexia #mitochondria

www.lestudium-ias.com/regional-eco...

A cancer cell with three nuclei (cyan) videoed through a microscope. Mitochondria (yellow) and the actin cytoskeleton (red) are also shown. #Science #Biology #CellBiology #microscopy

Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma via aberrant expression of KCNN1/SK1 and dysregulation of calcium signaling - Oncogene Oncogene - Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma via aberrant expression of KCNN1/SK1 and dysregulation of calcium signaling

New publication "Chimeric protein EWS::FLI1 drives cell proliferation in Ewing Sarcoma via aberrant expression of KCNN1/SK1 and dysregulation of calcium signaling" @natureportfolio.bsky.social fruitful collaborative project with CRCI2NA @insermgrandouest.bsky.social
www.nature.com/articles/s41...

Glycolytic activity following anti‐CD19 CAR‐T cell infusion in non‐Hodgkin lymphoma Energy metabolism of chimeric antigen receptor-T cells (CAR-T) activation in humans remains unexplored. As a glycolytic activity surrogate, we investigated the dynamics of peripheral blood (PB) lacta...

Pleased to share our article @insermgrandouest.bsky.social @CHRU Tours @Etablissement Français du Sang
Peripheral blood lactate kinetics may reflect immune cells activation and be useful for bedside monitoring in non-Hodgkin lymphoma

#immunometabolism

onlinelibrary.wiley.com/doi/10.1111/...

Thanks to Ligue Contre le Cancer - @inserm.fr - @fondationarc.bsky.social - Labex MabImprove - INCa - Université de Tours - Région Centre-Val de Loire

Sardines, maquereaux et autres poissons gras : contre le cancer, l’intérêt des oméga-3 et lipides du milieu marin Les lipides issus du milieu marin se révèlent prometteurs contre les cancers. Soit en prévention à l’image des oméga-3 présents dans certains aliments (sardines, maquereaux…). Soit pour développer des...

Recherche à Tours en Région Centre Val-de-Loire @inserm.fr @insermgrandouest.bsky.social Université de Tours

Sardines, maquereaux et autres poissons gras : contre le cancer, l’intérêt des oméga-3 et lipides du milieu marin theconversation.com/sardines-maq...
#FDS2024

Thrilled to share our research "MICU2 up-regulation enhances tumor aggressiveness and metabolic reprogramming during colorectal cancer development" in @plosbiology.org ! Hard work of Inserm N2COx team in Tours and our collaborators at Inserm MITOVASC team in Angers journals.plos.org/plosbiology/...

Ion channel signaling in health and disease | LE STUDIUM Mohamed Trebak, Marie Potier-Cartereau & Chistophe Vandier

Save the date !
From June 23 to 26, Ion channel Signaling in Health and Disease conference @insermgrandouest.bsky.social to be held at Château Belmont, Tours. Under the patronage of LE STUDIUM Loire Valley Institute for Advanced Studies
www.lestudium-ias.com/events/ion-c...

Synthesis and biological evaluation of new tri-heterocyclic derivatives as anti-colorectal cancer agents Colorectal cancer is a major health problem, with a poor prognosis if not detected at early stage. It is the third most common cancer worldwide and th…

Pleased to share this article on medicinal chemistry @insermgrandouest.bsky.social @inserm.fr Université de Tours www.sciencedirect.com/science/arti...
#inhibitors #tri-heterocyclic #colorectal #cancer !
Thanks to Ligue contre le cancer, Labex SynOrg and @frm-officiel.bsky.social ImPACcell KissF