I hope you are feeling better now Sanjay 😜

Well diff SCC - doubt it would have been p16 block positive!

Fascinating case Richard - perhaps best regarded as PD SCC with divergent (adnexal / neuroendocrine) diff. Don't think its basosquamous carcinoma. Collision tumour could be on the cards but I can't see enough for this on what is available.

Wondering about a solid porocarcinoma

Perhaps its a BCC or SCC with adnexal differentiation? I'm interested in the IHC...

DD Sebaceous carcinoma, high grade eccrine duct carcinoma. Especially Interested in AR / Adipophlin / CEA expression.

Looks like part of an scc

I saw the nucleoli and did wonder but it looked too cohesive.....😶

I can't make a diagnosis here without either further history, additional sections / levels or IHC (cutaneous clear cell neoplasm)! Back to the books I guess...

Well circumscribed clear cell epithelial neoplasm - cytological atypia and mitoses present. Do you have a BEREp4 and CD34 perhaps?

I haven't seen Joe for a year or two but can vouch for the identical avatar Richard. Nice case BTW Joe - where IF out-impresses the histology.

Follicular pseudoepitheliomatous hyperplasia?

No past history of malignancy Richard.

I should add, on reflection the periphery appears more FDC sarc than angiomatoid FH-like!

Trying out a post on Blue Sky! Fascinating large cutaneous tumour on an extremity. Pleomorphic / anaplastic sarcomatoid malignant neoplasm with abundant giant cells. I'm interested in areas reminiscent of angiomatoid fibrous histiocytoma at the periphery. IHC to follow. Comments welcome! #pathology