James Saenz

Hilariously bad idea. In my subfield author lists are almost always alphabetical!

VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach,...

Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...

Beautiful piece of work! Congratulations!

Prof. Hamilton Smith at J. Craig Venter Institute, a Nobel laureate for discovering type II restriction enzymes, passed away last night.
@jcvi.org @nobelprize.bsky.social
A huge loss in Science, but his legacy will be remembered.
www.jcvi.org/about/hamilt...

An event honoring late Prof. Clyde Hutchison at J. Craig Venter Institute
@jcvi.org

Happy birthday to Antonie van Leeuwenhoek, the "Father of Microbiology" and first person to observe bacteria with a microscope! 🔬

Learn how microscopes made microbiology possible, leading to innumerable insights for biology, medicine & technology. asm.org/articles/202...

The views were pretty spectacular! #Chur #Calanda

I mean, that’s 1/10th the price of an iPad…what a deal!

There’s a great Döner place on top of that tower

T cell cholesterol transport links intestinal immune responses to dietary lipid absorption The intrinsic pathways that control membrane organization in immune cells and their impact on cellular functions are poorly defined. We found that the nonvesicular cholesterol transporter Aster-A link...

amazing #lipidtime story from Tontonoz lab! Lipid scrambling and cholesterol accessibility IN T-CELLS regulates nutrient uptake in small intestine 🤯🤯

Physiology is so weird!
www.science.org/doi/10.1126/...

@paveltomancak.bsky.social we need to step up our game in Dresden 🎃

BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 (thread 👇)

“Treat questions as threats” 😅😅

How do RNA molecules shape genome regulation in the nervous system? (AKAY_U26CASE) | Doctoral Training Partnership This PhD project will investigate how RNA modifications influence the activity of topoisomerase I (TOP1), a crucial enzyme that regulates DNA supercoiling during replication and transcription. Using C...

New BBSRC funded PhD opportunity in my group with Inspiralis Ltd and @conradn.bsky.social. If you are interested in RNA - protein interactions and RNA modifications check the details below for how to apply. @nrpdtp.bsky.social @biouea.bsky.social @earlhaminst.bsky.social tinyurl.com/bdzvn4dr

Extracellular ATP is an environmental cue in bacteria Extracellular ATP acts as a signal regulating physiology and immunity in eukaryotes and is elevated during intestinal infection or damage. Tronnet et al. show that extracellular ATP reprograms the tra...

Extracellular ATP is an environmental cue in bacteria

@cp-cellreports.bsky.social

www.cell.com/cell-reports...

Lab hike in the #DresdnerHeide… lots of mushrooms today! And apparently we’ve recruited a new feline lab member 🐈

FEBS Press The bacterial dynamin-like protein DynA from Bacillus subtilis plays a key role in phage defense. It binds the plasma membrane through a unique paddle domain in its D1 subunit. This membrane associat...

🫴🏻 Binding of Bacillus subtilis dynamin‐like protein DynA to the bacterial membrane is essential for effective phage defense:

Shafqat - The FEBS Journal - Wiley Online Library febs.onlinelibrary.wiley.com/doi/10.1111/...

#subtiwiki

How awesome to catch up with old Simonslab mates in #Saarbrücken at #CellPhysics2025 🎉 It was a wonderful well-organized and inspiring conference, congratulations to the organizers!

Credit to @biancaschrul.bsky.social for the lovely photo 🤩

@sciezgin.bsky.social

Lipids are so hot right now 🔥

Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...

Always skip breakfast before a talk 😅

Ah ok, then all ist in Ordnung!

a red gummy bear standing in front of a pile of candy ALT: a red gummy bear standing in front of a pile of candy

The bag still isn’t full, Simon 😅

DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...

We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...

Effects of extreme acceleration, microgravity, and deceleration on Bacillus subtilis onboard a suborbital space flight - npj Microgravity npj Microgravity - Effects of extreme acceleration, microgravity, and deceleration on Bacillus subtilis onboard a suborbital space flight

Humans began travelling into space in 1961 with single orbits of the Earth. Now Bacillus subtilis!

👉

www.nature.com/articles/s41...

#subtiwiki

Thank you @joergstuelke.bsky.social for the reading recommendation!

🎉 Congratulations to the winners of the Best Poster Awards at #BiomembraneDays2025 sponsored by @lipotype.bsky.social

🏆Manpreet Kaur (with @fabiololicato.com &W. Nickel)
🏆Jana Kroll (@janakroll.bsky.social @mdc-berlin.bsky.social)
🏆Ha Ngoc Anh Nguyen (with @jamessaenz.bsky.social)

🚀Science rocks!

Loved listening to all the fantastic talks at #BiomembraneDays2025 — such a cool atmosphere to learn and get inspired! Also nervous but excited to present my poster and share my work. Huge thanks to the Saenz group and my amazing supervisor James for making it possible ✨ 💅🏻

I’m truly honored to have received the Poster Award at #BiomembraneDays! Huge thanks to the organizers for an excellent conference and to the Saenz Lab for their continuous support!

Celebrating the last night of Biomembrane Days with a proper German meal 🍺

Congratulations to @anh-nhn.bsky.social for winning the @lipotype.bsky.social poster award at #BiomembraneDays Berlin! 🎉🔥 @bcube-tud.bsky.social