Javier Oliver

Virtual cells for predictive immunotherapy - @fertiglab.bsky.social @genomescience.bsky.social go.nature.com/4jfqM3Y

Adiponectin to the rescue: extracorporeal photopheresis for managing immune checkpoint inhibitor-induced toxicities - Signal Transduction and Targeted Therapy Signal Transduction and Targeted Therapy - Adiponectin to the rescue: extracorporeal photopheresis for managing immune checkpoint inhibitor-induced toxicities

www.nature.com/articles/s41...

The complexity of tobacco smoke-induced mutagenesis in head and neck cancer - Nature Genetics Whole-genome sequencing and mutational signature analysis of 265 head and neck cancer samples collected from eight different countries provide insight into the vital contribution of tobacco smoke in disease etiology.

www.nature.com/articles/s41...

insight.jci.org/articles/vie...

The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells Proteolysis targeting chimeras (PROTACs) enable degradation of proteins involved in cancer growth. The efficacy of PROTACs depends on cellular factors that may enable or prevent target degradation. Wo...

The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells

A genomics learning framework for undergraduates Genomics is an increasingly important part of biology research. However, educating undergraduates in genomics is not yet a standard part of life sciences curricula. We believe this is, in part, due to...

journals.plos.org/plosone/arti...

The genomic architecture of circulating cytokine levels points to drug targets for immune-related diseases - Communications Biology The study uses GWAS for 40 circulating cytokines in meta-analyses of 74,783 individuals. With Mendelian randomization, key cytokines like G-CSF/CSF-3 and CXCL9/MIG are identified as potential causal m...

www.nature.com/articles/s42...

Deep profiling of gene expression across 18 human cancers - Nature Biomedical Engineering Using unsupervised deep learning to generate low-dimensional latent spaces for gene-expression data can unveil biological insight across cancers.

www.nature.com/articles/s41...

Conventional chemotherapy: millions of cures, unresolved therapeutic index - Nature Reviews Cancer Conventional chemotherapy has successfully cured millions of patients with cancer, yet the mechanisms of action for this remain unclear. In this Perspective, Letai and de The assess the existing mecha...

It's craaazy that chemo has been in the clinic for so long, yet its therapeutic index remains incompletely understood. In this #Perspective, Letai & de The explore existing models + knowledge gaps, & suggest principles for optimizing dosing + scheduling.

@natrevcancer.bsky.social

bit.ly/3C53w8g

This year, the term “scientist” turns 190 years old!
It was coined by William Whewell, who also considered the alternatives:
“savant”,
“philosopher”,
“nature-poker”, and
“nature-peeper”
Did he choose the right one?

A concise, insightful review of liquid biopsies for cancer
www.cell.com/cancer-cell/...

WHO releases new principles for ethical human genomic data collection and sharing The World Health Organization (WHO) has issued a set of principles for the ethical collection, access, use and sharing of human genomic data. Created with guidance from the WHO Technical Advisory Grou...

New principles for international genomic collaborations
No more helicopter research, no more using and extracting resources without recognition to the local researchers and communities
www.who.int/news/item/20...

Five latent factors underlie response to immunotherapy - Nature Genetics Analysis of human tumor datasets shows that all features that appear significantly associated with immunotherapy response and survival may be collapsed into five latent factors: tumor mutation burden,...

www.nature.com/articles/s41...

Cancer cells impair monocyte-mediated T cell stimulation to evade immunity - Nature Inflammatory monocytes are identified as important players in T cell restimulation in the tumour microenvironment.

www.nature.com/articles/s41...

Our Paper out in @natureportfolio.bsky.social with correct link www.nature.com/articles/s41...

Next-generation combination approaches for immune checkpoint therapy - Nature Immunology In this Review, Sharma and colleagues describe the current landscape of combination therapies and discuss requirements for the development of effective combination strategies.

www.nature.com/articles/s41...

Sharing our latest review article to highlight the importance of appropriately developing combination strategies for immune checkpoint therapy. Grateful for working with 3 brilliant scientists: Sangeeta Goswami, Kristen Pauken & Linghua Wang

The hallmarks of cancer immune evasion Cancer cells often evade the host immune system, challenging the effectiveness of immunotherapy. In this comprehensive review, Galassi et al. summarize key mechanisms of immune evasion within the “thr...

www.cell.com/cancer-cell/...

The interplay of mutagenesis and ecDNA shapes urothelial cancer evolution - Nature Whole-genome sequencing of matched serial tumours from patients identifies two key mutagenic factors (APOBEC3 and chemotherapy) and extrachromosomal DNA-forming structural variants that driv...

www.nature.com/articles/s41...

Out today in Nature: "The Human Cell Atlas"! In my News and Views, I compare the cell atlas to early naturalists creating an atlas of South America. Researchers mining this cell atlas can now make big discoveries, just as the next naturalists then discovered evolution.
www.nature.com/articles/d41...

Somatic mutation and selection at epidemiological scale As we age, many tissues become colonised by microscopic clones carrying somatic driver mutations ([1][1]–[10][2]. Some of these clones represent a first step towards cancer whereas others may contribu...

Resharing here a recent X post. In this preprint, we introduce an improved version of NanoSeq, a duplex sequencing protocol with <5 errors per billion bp in single DNA molecules, and use it to study the somatic mutation landscape of oral epithelium in >1000 people. 1/ www.medrxiv.org/content/10.1...

Origins and impact of extrachromosomal DNA - Nature A study examines the diversity of extrachromosomal DNA elements in cancer, and provides details on the frequency and origin of extrachromosomal DNA and its role in the development of different types o...

www.nature.com/articles/s41...

www.biorxiv.org/content/10.1...

Inspired by the other amazing starter packs - here's one for cancer researchers!

I tried to make this broad - from immunology to genomics to cell biology and so much more..

This list also includes organizations & institutes supporting cancer researchers 🧪🔬⚕️🩺

Hope its useful!

go.bsky.app/FEoaJMc

A thread with some new starter packs in genomics and bioinformatics 🧵 1/13...

Understanding the Biology and Testing Techniques for Pharmacogenomics in Oncology: A Practical Guide for the Clinician | JCO Oncology Practice Pharmacogenomic (PGx) testing is a growing area of personalized medicine with demonstrated clinical utility in improving patient outcomes in oncology. PGx testing of pharmacogenes affecting drug pharm...

ascopubs.org/doi/10.1200/...