Daniel Krentzel

Daniel Krentzel

@danielkrentzel.bsky.social

Hunting for new antibiotics with deep learning at @pasteur.fr ๐Ÿงซ | Previously @crick.ac.uk and ๐ŸŽ“ @imperialcollegeldn.bsky.social

177 Followers 277 Following 30 Posts Joined Nov 2024
18 hours ago

Thank you!! ๐Ÿ™

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21 hours ago
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Are Vision Foundation Models Foundational for Electron Microscopy Image Segmentation? Although vision foundation models (VFMs) are increasingly reused for biomedical image analysis, it remains unclear whether the latent representations they provide are general enough to support effecti...

Are FMs actually FMing? โ›“๏ธ๐Ÿ”ฌ

Thrilled to share that our paper on Foundational Models for mitochondria segmentation in EM is heading to the
@iclr-conf.bsky.social
2026 LMRL Workshop! ๐Ÿš€

Check out the full work here:
๐Ÿ“„ ArXiv: arxiv.org/abs/2602.08505
๐Ÿ“„ OpenReview: openreview.net/forum?id=Bba...

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2 days ago
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The Human Organ Atlas The Human Organ Atlas provides open access to 3D images of human anatomy spanning whole organs to cellular scale resolution.

The paper that sums up what I've been working on and running for the last three years was published this week ๐ŸŽ‰

www.science.org/doi/10.1126/...

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6 days ago

Weโ€™re excited to share our latest preprint on Fractal: our approach towards FAIR bioimage analysis at scale with OME-Zarr-native workflows.

Fractal defines interoperable tasks on OME-Zarr and provides a platform for TB-scale image analysis.

(1 / 10๐Ÿงต)

www.biorxiv.org/content/10.6...

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2 weeks ago

Final version @nature.com of our paper describing unconventional multicellular development in a choanoflagellate inhabiting an extreme environment. A ton of new data since the first @biorxivpreprint.bsky.social preprint (which we've kept updating).

A brief ๐Ÿงต (carried over from the old place)

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2 weeks ago
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๐Ÿšจ ๐€๐ˆ ๐ฆ๐ž๐ž๐ญ๐ฌ ๐“๐ ๐๐ซ๐ฎ๐  ๐๐ข๐ฌ๐œ๐จ๐ฏ๐ž๐ซ๐ฒ!

Imaging ๐ถ. ๐‘”๐‘™๐‘ข๐‘ก๐‘Ž๐‘š๐‘–๐‘๐‘ข๐‘š (a model for ๐‘€. ๐‘ก๐‘ข๐‘๐‘’๐‘Ÿ๐‘๐‘ข๐‘™๐‘œ๐‘ ๐‘–๐‘ ) + deep learning reveals known, unseen, and novel antibiotic modes of action from images alone, a leap for TB drug discovery.

โœ๏ธ @awehenkel.bsky.social & coll.
๐Ÿ“– shorturl.at/9QPDy

#Tuberculosis #MicroSky

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2 weeks ago

One week left to register to the Bioimage Analysis with AI course in Pasteur!

This June, 1 - 5.

I give a bit more details in the thread below
๐Ÿ‘‡

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2 weeks ago
An advertisement for a PhD position studying "Revealing the mechanistic basis of defence peptide antibacterial specificity." It shows fruit flies infected by green-fluorescent protein expressing bacteria, and describes the project and way to apply.

Very excited to be advertising this project with the excellent cosupervision of Peter Mergaert through @i2bcparissaclay.bsky.social and @uniexecec.bsky.social.

This position is open to international applicants and will involve stints in both Penryn UK and Paris France. Please share!

Apply: adum.fr

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2 weeks ago
Screenshot of the title and author list of the preprint entitled "Deep learning extracts MoA-specific signatures from high-throughput images of chemically and genetically perturbed Corynebacteria"

Our preprint outlining a deep learning-based phenotypic screening approach for the discovery of new TB drugs is out on bioRxiv now ๐Ÿ’Š๐Ÿฆ 

๐Ÿ”— doi.org/10.64898/202...

Thank you @awehenkel.bsky.social @chzimmer.bsky.social @spetrella.bsky.social @curieuseny.bsky.social and everyone else not on bsky (yet)๐Ÿ™

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1 month ago
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The Real Cause of Grade Inflation Grade inflation is the predictable result of how American universities now organize teaching, labor, and money.

"In repeating that colleges have 'gone soft,' pundits are, in some sense, telling universities what they want to hear. Schools would much rather wring their hands over vague cultural 'softness' than admit the obvious: that their revenue-maximizing logic is actively undermining educational quality."

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1 month ago
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Postdoctoral position - Synthetic Biology / Bacterial Immunity - Research The Bikard lab at Institut Pasteur in Paris is seeking to hire postdoctoral researchers. We are investigating bacteria / bacteriophages interactions, and the genetic innovation that happens at this in...

๐Ÿšจ Hiring Alert! ๐ŸšจMy lab at Institut Pasteur is recruiting several Postdocs! We have exciting open projects in: ๐Ÿฆ  Synthetic Biology and๐Ÿ›ก๏ธ Bacterial Immunity. Come do great science with us in the middle of Paris! ๐Ÿ‡ซ๐Ÿ‡ท๐Ÿฅ research.pasteur.fr/en/job/postd...

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1 month ago
Portail Emploi CNRS - Offre d'emploi - Two Postdoctoral (M/F) Positions in the Development of Machine Learning Methods for Single-Cell Multi-Omics Spatiotemporal Data Assurez-vous que votre profil candidat soit correctement renseignรฉ avant de postuler

Two postdoc positions opened in my team @pasteur.fr in Paris on the development of machine learning methods for single-cell multi-omics spatiotemporal data.

See the announcement for all details emploi.cnrs.fr/Offres/CDD/U...

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4 months ago
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Open-Source Developer for Deep Learning Antibiotic Discovery Platform - Research Introduction Antimicrobial resistance (AMR) is one of the most urgent global health threats projected to cause up to 10 million deaths per year by 2050. The AI4AMR project brings together teams from I...

If you're interested in developing an open-source image analysis platform/plugin to profile bacteria with deep learning while living in the beautiful city of Paris ๐Ÿ‡ซ๐Ÿ‡ท, check out this job ad from the @chzimmer.bsky.social lab @pasteur.fr

research.pasteur.fr/fr/job/open-...

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3 months ago
Hackathon participants group picture

We had an amazing OME-NGFF hackathon last week, Wednesday to Friday, following the inspiring OME-NGFF symposium. What a fantastic week! Itโ€™s hard to describe how motivating it is to be surrounded by so many talented, curious & friendly people who care deeply about open, FAIR bioimaging data.
1/14 ๐Ÿงต

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3 months ago
Daniel showing new napari Fractal task plugin

A great plugin prototype to run Fractal tasks interactively in napari: Making interoperable workflow tasks accessible directly in a viewer

(8/14 ๐Ÿงต)

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4 months ago
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Open-Source Developer for Deep Learning Antibiotic Discovery Platform - Research Introduction Antimicrobial resistance (AMR) is one of the most urgent global health threats projected to cause up to 10 million deaths per year by 2050. The AI4AMR project brings together teams from I...

If you're interested in developing an open-source image analysis platform/plugin to profile bacteria with deep learning while living in the beautiful city of Paris ๐Ÿ‡ซ๐Ÿ‡ท, check out this job ad from the @chzimmer.bsky.social lab @pasteur.fr

research.pasteur.fr/fr/job/open-...

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5 months ago
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In vivo antimicrobial activity of engineered mesoporous silica nanoparticles targeting intracellular mycobacteria - Nature Communications Current treatment options for Mycobacterium marinum infections are extensive and challenging. In this work, authors explore the potential of functionalized mesoporous silica nanoparticles as a carrier for delivery of drugs against M. marinum.

In vivo antimicrobial activity of engineered mesoporous silica nanoparticles targeting intracellular #mycobacteria

(doxycycline-loaded nanoparticles, zebrafish model of Mycobacterium marinum #infection)

@lkremer1.bsky.social

#DrugDevelopment

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5 months ago
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** Now seeking postdocs **

Join our interdisciplinary and transnational team in Wรผrzburg (Germany) or Paris (France) to drive projects in translational biology and antibiotic drug discovery.
Backgrounds in computational biology, AI, physics, or microbiology are all welcome. Please spread the word.

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5 months ago
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๐Ÿšจ 1 week left to apply for the Pasteur-Paris University International PhD Program (PPU)!

Join an international community of scientists at the Institut Pasteur ๐ŸŒ Dedicated support, mentorship & world-class labs included.

๐Ÿ“…Deadline: Oct 20, 2025
๐ŸŽ“Program start: October 2026

๐Ÿ‘‰ Apply: bit.ly/CallPPU

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5 months ago
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Research engineer in Bioimage Analysis for the researchers of the inIdEx FORMULA Hi all We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks? The position is in the Instit...

Job alert!

We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?

See also on the forum:
forum.image.sc/t/research-e...

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5 months ago
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Happy to share that ShapeEmbed has been accepted at @neuripsconf.bsky.social ๐ŸŽ‰ SE is self-supervised framework to encode 2D contours from microscopy & natural images into a latent representation invariant to translation, scaling, rotation, reflection & point indexing
๐Ÿ“„ arxiv.org/pdf/2507.01009 (1/N)

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6 months ago
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My journey from Paris to Liverpool in four trains 8 September 2025 by Lรฉa Manke My journey to the Biologists @ 100 conference began early on Saturday morning. Clutching my thermos filled with coffee, I made my way to the major train station inโ€ฆ

We're excited to announce the first of two prize winners in our #biologists100 #sustainable #travel blog competition. Read Leaโ€™s experience of travelling via four trains from France to Liverpool.

www.biologists.com/stories/my-j...

Stay tuned for next weekโ€™s post from winner two.

#Sustainability

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6 months ago

Beautiful work from @danielkrentzel.bsky.social here!

Correlative EM-LM made easy!
Really grateful to be part of the team.

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6 months ago

Thank you so much for having been part of the journey ๐Ÿ™

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6 months ago
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CLEM-Reg automates the 3D alignment of volume correlative light and electron microscopy data.

www.nature.com/articles/s41...

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6 months ago

Awesome to see this out. Thank you for bringing us in the journey @em-stp.bsky.social and @martinjones.bsky.social. Keep rocking @danielkrentzel.bsky.social!

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6 months ago
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Save the date! The @pasteur.fr Pasteur course on image analysis is announced:

It will happen from the 1st of June to the 5th 2026.

This year there will be only one track: the Early Career Investigator track (beginners). ๐Ÿ‘‡

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6 months ago

#preprint:

We optimised the preparation of tissues for #X-ray phase contrast imaging.

Drying tissue samples (instead of embedding them) brings more signal in #X-ray phase contrast images.

The process largely preserves #ultrastructure.

@safekhan.bsky.social @andreas-t-schaefer.bsky.social

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6 months ago

Thank you!

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6 months ago

Finally, I want to give a massive thanks to the amazing team behind CLEM-Reg ๐Ÿ™

@matous-elphick.bsky.social, @lainebioimaging.bsky.social @henriqueslab.bsky.social, @em-stp.bsky.social, @martinjones.bsky.social, MC, Chris and Cameron

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