Dr Lizzie Coker

Talk by Chris Lord at the 2nd European Cancer Dependency Map Symposium

We continue with the talk from @icrlordlab.bsky.social focusing on the complexity of synthetic lethality in cancer and how we can move forward in exploiting it @eurocancerdepmap.bsky.social

We are back, starting the afternoon session with a joint talk by Debora Sesia/ @ciriellolab.bsky.social and @aurorasavino.bsky.social / @ioriolab.bsky.social showing their work on the functional assessment of Variants of Unknown Significance through cancer dependency map data analysis

Next we have @emanuelvgo.bsky.social , presenting the work on Minimal Libraries and use of AI-Synthetic Augmentation of CRISPR-Cas9 Screens for Drug Target Discovery

Colm Ryan presenting at the 2nd European Cancer Dependency Map Symposium

@colmr.bsky.social takes the stage to share the work of his group that aims to understand and predict synthetic lethality between paralogs in cancer

Evangelia Petsalaki presenting at the 2nd European Cancer Dependency Map Symposium

And we finish this session with @epetsalaki.bsky.social showing the potential of using CRISPR data to study context specific signalling and drug responses

Last but not least, we are thrilled to have representatives from academia, industry, foundations and publishers to share with us their take during the roundtable discussion on Bridging Sectors for Translational Impact!

We start with Carmen Herranz-Ors from @sangerinstitute.bsky.social giving us an overview of the impressive work done to generate Tumour Organoid Biobank and develop a 3D Dependency Map @eurocancerdepmap.bsky.social

Now @alejandrapcelab.bsky.social is taking us through the multidimensional map of early adaptation to treatment and how targeting cell plasticity can prevent childhood cancer relapse @eurocancerdepmap.bsky.social

The last session starts with Lodewyk Wessels from @nkinl.bsky.social sharing the work on perturbation response models!

Emanuel’s slide depicts a bridge between lab data and patients - but the bridge is carefully labelled as the Ponte 25 de Abril in Lisbon

@emanuelvgo.bsky.social insisting the metaphors used in @eurocancerdepmap.bsky.social presentations have strong Portuguese representation 😄

The 2nd @eurocancerdepmap.bsky.social meeting is starting with introduction from @francescoiorio.bsky.social ! Full day of exciting talks ahead. Stay with us for live updates @humantechnopole.bsky.social

Roland Rad gives the final talk of the second session of the 2nd European Cancer Dependency Map Symposium

To wrap up the second session, Roland Rad from the Institute of Molecular Oncology and Functional Genomics is sharing their work on mapping genetic interactions in cancer evolution and therapy @eurocancerdepmap.bsky.social

Great to see detailed characterisation is being applied to murine models too 🙌

Interesting to note his observations on the small-world nature of buffering networks, and that he relates it to my post doc work on target distances in combination therapies! (I didn’t tell him to say that 😄) #networks #DepMap

Chris Lord of the ICR presents on variable penetrance of synthetic lethality, and introduces his team’s app SYLVER for identifying synthetic lethalities #genetics #cancer

Session 2 kicks off with Manuel Kaulich showing exciting new work on nuclear mRNA processing masking CRISPR KO phenotypes - so new it’s not yet published, so no photo this time #CancerResearch #CRISPR #DepMap

Forgot to include alt text - my apologies. Will add for next posts

First session of the @eurocancerdepmap.bsky.social symposium and so much fantastic work presented already! #CancerResearch #TranslationalScience #plasticity

pre-writing a devastating obituary for your enemy is god-tier hating of a kind you don’t often see anymore. renaissance haterism. beautiful stuff.

@nathanbroon.bsky.social have you seen this?

Screenshot of part of the LEGO Ideas website, showing a side view of a diorama featuring both creatures

🚨 THIS IS NOT A DRILL 🚨

We’ve just seen this, by creator “Menapian” - a 4,998-piece set of the Great Exhibition (1851) Crystal Palace - complete with a bonus Megalosaurus and Ichthyosaur…

beta.ideas.lego.com/product-idea...

CUH Cancer Support Service are teaming up with local organisations to run a #MentalHealthAwarenessWeek Wellbeing Event on the 16 May at the Cambridge Cancer Help Centre, CB22 5JT. 💚

Come along and find out how local services and teams can assist with mental health. @cuh.nhs.uk

@dereklowe.bsky.social puts it perfectly yet again! #facepalm #AI #machinelearning #dontbelievethehype

Metamorphine, An Unwelcome Product

No one realized it until recently, but a new drug was forming inside some of the patient-controlled-anaesthesia pumps used in hospitals. Beware the Mannich condensation:

Today I lost an NIH grant training clinicians to do research about intimate partner violence with perinatal women.

More women are murdered in the perinatal period than die of obstetric complications.

I didn't just lose a grant. We lost an entire cohort of people building careers to prevent that.

If this story checks out according to the below, it is insane and shameful. As I asked on the blog the other day: "What are we turning into?"

If teams forming around the 'Rewiring Cancer Cells' or 'TME Dynamics' Grand Challenges would like to include our high-throughput organoid co-culture signalling technologies please get in touch!

Termination notices going out this afternoon to more than 300 employees of the National Cancer Institute. Access likely ends today. Four weeks paid leave and that’s it.

Strong power move for Team Cancer.

Dr Carol Cooper sits in front of an audience in an independent bookshop, discussing her latest book

Fantastic to see fellow @newnhamcollege.bsky.social alumna @carolcooper.bsky.social this evening at Hart’s bookshop - can highly recommend ‘The History of Medicine in Twelve Objects’ #Medicine #MedicalHistory #HartsBookshop

Ancestral Differences in Anticancer Treatment Efficacy and Their Underlying Genomic and Molecular Alterations Abstract. Systematic multiomic analysis has revealed ancestry-dependent molecular alterations, but their impact on the efficacy of anticancer treatment is yet largely unknown. In this study, we analyz...

Fascinating paper on how different races/ethnicities respond differently to anticancer therapies - such an important thing to understand for personalised medicine #CancerResearch

aacrjournals.org/cancerdiscov...