Colm Ryan

I too am 'programming' with Claude! it's fun isn't it?

Autocrine interferon poisoning mediates ADAR1-dependent synthetic lethality in BRCA1/2-mutant cancers Nature Communications - The RNA editing enzyme ADAR1 blocks interferon responses triggered by cytosolic RNA sensors, and has been proposed as a potential target in immuno-oncology. Here, the...

With super Roman Chabanon and Sophie Postal Vinay, we show that inhibition of RNA editor ADAR1 causes a new form of BRCA synthetic lethality>autocrine inferferon poisoning. Relevant for ADAR1 drug discovery. Could provide a mechanistically different approach than PARPi. rdcu.be/eyo6t

This is one of those awesome "I always wanted to do that experiment" papers. And a great 🧵.

congrats Tríona!

when an Irish funding agency launches a new grant call in July with a deadline in August it's hard to feel that researcher well-being is one of their priorities...

I'm not the person to ask!

The final day of #ICSB2025 on Thurs, Oct 9, will finish with 3 more outstanding breakout sessions.
✨Clinical Decision Support Tools
✨Evolution & Development
✨AI/ML Approaches in Systems Biology

For more info: bit.ly/4mPNfGQ
@ucddublin.bsky.social @ucd-chas.bsky.social @precisiononcire.bsky.social

I'm in School of Medicine, you would need to approach a relevant School/Department in one of the Irish universities

Research Ireland's remit is broad, so I can't see why not. You would need to find a host institute www.ucd.ie/music/

Unexpectedly, @jurgjn.bsky.social found that running Alphafold3 predictions for protein interactions can yield ipTM scores that are more predictive of true interactions when run in pools of proteins instead of pairwise predictions. Presumably, this reflects some sort of "competition effect".

School of Medicine @ucddublin.bsky.social are interested in expressions of interest. Note that the deadline is relatively tight – 28th August

Interested in moving your research to Ireland? Research Ireland have just launched a new call to recruit mid-career (5-15 year post PhD) and established researchers (>15 years post PhD).

Great to have an additional social option for #ICSB2025 – a walking tour of Dublin. It's a small city centre, so walking is the easiest way to see it! icsb2025.com/social-progr... #systemsbiology

Group Leader at the Wellcome Sanger Institute, David Adams stands outdoors, discussing the significant genetic discovery related to uveal melanoma and cancer therapy. His quote reads: “Our study reveals a previously unrecognised genetic relationship in uveal melanoma, driven by a particular relationship between the CDS1 and CDS2 genes. This discovery not only deepens our understanding of tumour biology but also opens new routes for precise therapy development. What makes this finding especially exciting is its relevance beyond uveal melanoma as our research suggests a therapeutic potential for a broad range of cancers.”

A new drug target that has the potential to treat aggressive eye cancer has been discovered 👁️

This research may provide a hopeful outlook for eye cancer patients with very limited treatment options and has implications for a range of other cancers ⤵️

www.sanger.ac.uk/news_item/ne...

The synthetic lethal interaction between CDS1 and CDS2 is a vulnerability in uveal melanoma and across multiple tumor types - Nature Genetics This study employs a functional genomic approach to identify a synthetic lethal interaction between CDS1 and CDS2 in uveal melanoma and other cancers, which may represent a potential therapeutic targe...

New work out in @natgenet.nature.com from @davidjadams.bsky.social Lab @sangerinstitute.bsky.social (with a contribution from us led by A.Vinceti): CDS2 is a cancer dependency in uveal melanomas with low CDS1 expression: a synthetic lethal axis with broad potential
🔗 www.nature.com/articles/s41...

Fantastic opportunity to launch your research group following the @embl.org model in a great environment with a solid startup package and access to state-of-the-art resources.

Join us at the @ncmbm.bsky.social, part of the @nordicembl.bsky.social, at @uio.no

Feel free to reach out if you have Qs.

Z-scores outperform similar methods for analyzing CRISPR paralog synthetic lethality screens - Genome Biology Genetic screens offer a promising strategy for identifying tumor-specific therapeutic targets, but single-gene knockout screens often miss functionally redundant paralogs. Multiplex Cas9 and Cas12a CR...

At long last, Rosalind's paper on comparing methods for paralog synthetic lethality is online:

genomebiology.biomedcentral.com/articles/10....

Do you have experience in mechanistic modelling of biological systems and want to do a postdoc with an interdisciplinary team on developing Digital Twins for rare disease? We have the job for you! Check it out below - deadline July 13th, online interviews 24th July.

Computer-vision research powers surveillance technology - Nature An analysis of research papers and citing patents indicates the extensive ties between computer-vision research and surveillance.

New paper hot off the press www.nature.com/articles/s41...

We analysed over 40,000 computer vision papers from CVPR (the longest standing CV conf) & associated patents tracing pathways from research to application. We found that 90% of papers & 86% of downstream patents power surveillance

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As scientists look for alternative homes for their research careers, will Ireland seize the opportunity?

Perspective in @irishtimes.com today.

www.irishtimes.com/opinion/2025...

One more day until abstract submission closes! We are particularly looking forward to learn about your advancements int the Metabolic Diseases area, so make sure you don't miss the opportunity to meet in person in Dublin for ICSB!

🧬 Excited to announce the 2nd Euro Cancer DepMap Symposium bringing together leading minds in functional genomics, cancer vulnerabilities, AI, CRISPR and anti-cancer target discovery.📍Join us in Milan for cutting-edge science, open discussion & collaboration. #EuroDepMap #CancerResearch #CRISPR

🔬 Join us in Milan for the 2nd European Cancer Dependency Map Symposium #ECDM25! A key event for scientists in functional genomics & target discovery. Talks, panels, AI & poster sessions await.

Register now 👉 humantechnopole.it/en/trainings...

Structured Exercise after Adjuvant Chemotherapy for Colon Cancer | NEJM Preclinical and observational studies suggest that exercise may improve cancer outcomes. However, definitive level 1 evidence is lacking. In this phase 3, randomized trial conducted at 55 centers, ...

At #IACR2025 in Belfast Prof. Kerry Courneya gave an excellent talk on the relationship between exercise and cancer outcomes, highlighting the lack of controlled trials. He gave no details but promised a relevant study coming soon, this looks to be it! www.nejm.org/doi/full/10....

‘Nothing left’: Irish whale-watching company closes amid ‘overfishing’ Sprat fishing has disrupted the food chain and diverted humpback, minke and fin whales as well as dolphins

Just to remind people listening to RTÉ's report on the destruction of Irish sprat stocks (the basic food for many other fish) that most sprat go into fishmeal to feed farmed fish. Salmon farming is a major part of the problem. www.theguardian.com/world/2025/m...

Thanks to @researchireland.ie for funding!

Cartoon illustrating proteomic compensation between paralogs

Pairs with these sorts of regulatory relationships are enriched in synthetic lethality – when one gene gets deleted, cells become dependent on the other for survival – suggesting these relationships can identify new therapeutic targets. The cartoon below illustrates the proposed model.

Consistent with earlier work in yeast we find that often when one gene is lost / deleted a duplicate gene displays increased protein abundance in response. We find that this is more common for genes that have important roles in the cell and that are central in the protein-protein interaction network

Why don't these mutations simply break protein-protein interaction networks? Here, using engineered cell lines and tumour proteomic profiles, we characterise one potential mechanism by which cancer cells tolerate loss of protein-coding genes – compensation by paralogs.

Proteins carry out their function in interconnected networks, with interactions necessary both for stabilising proteins and enabling them to execute their molecular functions. Despite this – cancer cells tolerate enormous numbers of genetic perturbations including deletions of protein coding genes.