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Stephen Doyle

@stephenrdoyle.bsky.social

Group Leader @ Wellcome Sanger Institute. UKRI Future Leaders Fellow. Molecular & computational biology of parasitic worms of humans and animals. https://helminthgenomics.sanger.ac.uk/ ๐Ÿ‡ฆ๐Ÿ‡บAussie dad of ๐Ÿง’+๐Ÿ‘ถ^2.

462 Followers  |  372 Following  |  37 Posts  |  Joined: 09.11.2024  |  1.9144

Latest posts by stephenrdoyle.bsky.social on Bluesky

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Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets - Nature Communications This study analysed genetic data of soil-transmitted helminths from 27 countries, revealing diversity impacting molecular test accuracy and highlighting the need to adapt diagnostics for effective STH surveillance.

Global diversity of soil-transmitted #helminths reveals genetic variation that impacts diagnostic targets

@stephenrdoyle.bsky.social @marinapapaiakovou.bsky.social @phylofacts.bsky.social โ€ช@camvetschool.bsky.socialโ€ฌ @sangerinstitute.bsky.social

29.09.2025 09:38 โ€” ๐Ÿ‘ 8    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets - Nature Communications This study analysed genetic data of soil-transmitted helminths from 27 countries, revealing diversity impacting molecular test accuracy and highlighting the need to adapt diagnostics for effective STH surveillance.

Global diversity of soil-transmitted #helminths reveals genetic variation that impacts diagnostic targets

@stephenrdoyle.bsky.social @marinapapaiakovou.bsky.social @phylofacts.bsky.social โ€ช@camvetschool.bsky.socialโ€ฌ @sangerinstitute.bsky.social

26.09.2025 09:38 โ€” ๐Ÿ‘ 3    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Final chapter in @marinapapaiakovou.bsky.social 's PhD too - she'll be on the lookout for Postdoc positions soon, so please get in touch with upcoming opportunities!

14.07.2025 08:32 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Many thanks to a very large and diverse group of international collaborators for providing samples. We could not have done it without you.

14.07.2025 08:32 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Here, we look at how genetic diversity in mixed STH populations has the potential to impact qPCR-based diagnostics. Turns out, there is a lot of variation, and a lot of potential to cause misdiagnoses.

14.07.2025 08:32 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets - Nature Communications This study analysed genetic data of soil-transmitted helminths from 27 countries, revealing diversity impacting molecular test accuracy and highlighting the need to adapt diagnostics for effective STH...

New paper, now in Nature Communications!

Thanks to a massive effort by PhD student @marinapapaiakovou.bsky.social, I am excited to share our work "Global diversity of soil-transmitted helminths reveals population-biased genetic variation that impacts diagnostic targets".

doi.org/10.1038/s414...

14.07.2025 08:32 โ€” ๐Ÿ‘ 3    ๐Ÿ” 1    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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Enrichment of Helminth Mitochondrial Genomes From Faecal Samples Using Hybridisation Capture New approaches are urgently needed to enrich rare or low-abundant DNA in complex samples. Soil-transmitted helminths (STHs) inhabit heterogeneous environments, including the gastrointestinal tract of...

I am proud to see our latest work on hybridisation capture in soil-transmitted helminths, led by PhD student @marinapapaiakovou.bsky.social , now published in Molecular Ecology Resources. I am looking forward to scaling this up into larger populations. In the meantime, ๐Ÿฅณ

doi.org/10.1111/1755...

12.07.2025 20:55 โ€” ๐Ÿ‘ 6    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Really nice experiment and paper, congrats!

06.06.2025 11:08 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Congratulations! ๐Ÿฅณ

03.05.2025 20:03 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
LinkedIn This link will take you to a page thatโ€™s not on LinkedIn

Job advert - Please share!

Mark Viney (lnkd.in/dwkZf7mG) and I are seeking a motivated postdoctoral fellow to work on drug treatment responses of soil-transmitted helminth and hookworm genomics in Southeast Asia.

Do reach out if you are keen!

www.jobs.ac.uk/job/DMR456/p...

22.04.2025 21:56 โ€” ๐Ÿ‘ 0    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Uncovering bacterial metabolites that can attenuate vitamin B12 deficiency (AKAY_U25MMB) at University of East Anglia on FindAPhD.com PhD Project - Uncovering bacterial metabolites that can attenuate vitamin B12 deficiency (AKAY_U25MMB) at University of East Anglia, listed on FindAPhD.com

We are advertising for a PhD position to study bacterial metabolites in C. elegans, funded by the MRC Microbes, Microbiomes and Bioinformatics training programme @uniofeastanglia.bsky.social @biouea.bsky.social. Open to UK and international students. www.findaphd.com/phds/project...

16.03.2025 10:57 โ€” ๐Ÿ‘ 14    ๐Ÿ” 22    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 2
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Enrichment of helminth mitochondrial genomes from faecal samples using hybridisation capture New approaches are urgently needed to enrich rare or low-abundant DNA in complex samples. Soil-transmitted helminths (STHs) inhabit heterogeneous environments, including the gastrointestinal tract of ...

Very excited to see our latest work, led by @marinapapaiakovou.bsky.social , on @biorxiv-genomic.bsky.social !

Enrichment of helminth mitochondrial genomes from faecal samples using hybridisation capture

doi.org/10.1101/2025...

28.02.2025 15:53 โ€” ๐Ÿ‘ 5    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Enrichment of helminth mitochondrial genomes from faecal samples using hybridisation capture https://www.biorxiv.org/content/10.1101/2025.02.24.639427v1

28.02.2025 02:40 โ€” ๐Ÿ‘ 1    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

globally, there are ~3500 described mosquito species in the Culicidae family and many of these are important vectors of disease but only a small percentage have genomic resources. we are launching a pilot project to generate high quality reference genomes for 100 important mosquito species [1/3]

24.02.2025 10:51 โ€” ๐Ÿ‘ 148    ๐Ÿ” 28    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 6

Less than one week to apply - deadline 25th of Feb!

If you are from Latin America, work on helminths, and are interested in genetics/bioinformatics, this could be a great opportunity for you ๐Ÿ‘‡

19.02.2025 10:45 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
University College Cork Vacancies

I am hiring! 2 year Post-Doc microbiologist to identify gut bacteria inhibiting fungal pathogens. Join new, expanding gut microbiome research group at @apcmicrobiomeirel.bsky.social and @uccmicrobiology.bsky.social in Cork. Further details and apply here:
ore.ucc.ie
Job ID: 084031

15.02.2025 16:40 โ€” ๐Ÿ‘ 19    ๐Ÿ” 20    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
Research Assistant/Research Associate (anthelmintic resistance management) Job Purposeย We have an exciting opportunity for a Research Assistant/Associate to contribute/make a leading contribution to the project โ€˜Anthelmogram: the next generation decision making tool for a...

We're looking for a post-doc to work on anthelminthic resistance in a new pan-European project. It will involve generating and analysing targeted and whole-genome data from well-phenotyped livestock GIN populations.

Please get in touch if you have any questions.

www.jobs.gla.ac.uk/job/research...

15.02.2025 13:04 โ€” ๐Ÿ‘ 4    ๐Ÿ” 5    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
https://coursesandconferences.wellcomeconnectingscience.org/event/helminth-bioinformatics-latin-america-the-caribbean-20250518/

Are you based in South America and work on helminths?

Join me & a great group of instructors on the Helminth Bioinformatics course in Montevideo during 18โ€“24 May!

We'll cover expenses, you just need to come, interact, and learn.

Please share & apply!

t.co/Dlj4DyG1ul

13.02.2025 18:44 โ€” ๐Ÿ‘ 2    ๐Ÿ” 5    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 1
Post image Post image

๐Ÿ“ฃ๐Ÿ“ฃGenomic data sharing: you donโ€™t know what youโ€™ve got (till itโ€™s gone) www.nature.com/articles/s41...

A comment @natrevgenet.bsky.social from @katholt.bsky.social and me

13.02.2025 09:10 โ€” ๐Ÿ‘ 44    ๐Ÿ” 30    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 1

Good suggestion! I had remembered @zamanian.bsky.social and @wheelerlab.bio had done this, but forgot to look it up ๐Ÿคฆโ€โ™‚๏ธ

12.02.2025 18:11 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 2    ๐Ÿ“Œ 0

Any suggestions for tracking worms like C.elegans and other things from live imaging fluorescence data? Would like an open source tool.

11.02.2025 22:45 โ€” ๐Ÿ‘ 1    ๐Ÿ” 2    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Congratulations Megan and team! ๐Ÿฅณ

06.02.2025 11:34 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Wow, this looks awesome ๐Ÿคฉ

05.02.2025 19:46 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Hookworm genes encoding intestinal excreted-secreted proteins are transcriptionally upregulated in response to the host's immune system https://www.biorxiv.org/content/10.1101/2025.02.01.636063v1

04.02.2025 02:34 โ€” ๐Ÿ‘ 1    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Worm Perturb-Seq: massively parallel whole-animal RNAi and RNA-seq https://www.biorxiv.org/content/10.1101/2025.02.02.636107v1

04.02.2025 02:33 โ€” ๐Ÿ‘ 2    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Really fun to write this paper on spatial transcriptomics with Sarah. Itโ€™s an exciting technique that has a lot of potential in Parasitology for new insights.

28.01.2025 08:58 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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This is too much fun to be called work. #scalingup @sangerinstitute.bsky.social #ukriflf

27.01.2025 21:51 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Donโ€™t get them wetโ€ฆ ๐Ÿ˜ฌ

26.01.2025 09:53 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Today was a great reminder that I work with some really amazing people. Shout out to Joana and Javi for kicking big goals today ๐Ÿคฉ @sangerinstitute.bsky.social

22.01.2025 20:36 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

We share a lot of our ideas, code, datasets (that we spend years sanitizing) early. Often way before we release preprints. We do this so that others can use, build on, improve & even "beat" our approaches. But I want to say a few things about some simple expectations 1/

17.01.2025 17:16 โ€” ๐Ÿ‘ 90    ๐Ÿ” 25    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 5

@stephenrdoyle is following 20 prominent accounts