Félix Freire

A molecular system with potential to target DNA structures associated with cancer During DNA replication, the classic double helix can temporarily rearrange into an alternative structure known as a DNA three-way junction (3WJ). These configurations form a well-defined central

🔥 New research from CiQUS makes the cover of Journal of the American Chemical Society (JACS): chiral helical polymers meet helicates and chart their path to DNA three-way junctions (3WJ).

🧪 Full story: www.usc.es/ciqus/en/new...

#FondosEuropeos #RedeCIGUS

Unlocking a Biological Interface of Chiral Supramolecular Helical Polymers Here we report a C3-symmetric metal-binding tripeptide, BTMA-1, that self-assembles in water into either a chiral supramolecular helical polymer or a discrete CoII peptide helicate, depending on metal coordination. The CoII peptide helicate exhibits high affinity and selectivity toward DNA three-way junctions (3WJ), a class of noncanonical DNA structures with emerging biological relevance. Importantly, we demonstrate that the recognition process can be triggered dynamically by adding CoII ions to a dispersion of the supramolecular polymer, which acts as an inert precursor reservoir in physiological media. In this way, our strategy shows that chiral supramolecular helical polymers can form temporarily inactive aggregates that release discrete helicates for biomolecular recognition, such as 3WJ binding, upon metal ion coordination. Overall, this mechanism reveals a previously unexplored capability of this class of materials and offers a new approach for the design of responsive supramolecular systems for nucleic acid recognition and anticancer therapy.

Big news! 🚀
Our new paper is out in JACS!
👉 pubs.acs.org/doi/10.1021/...
“Unlocking a Biological Interface of Chiral Supramolecular Helical Polymers”
#DNAjunction #SupramolecularChem #ChemSky
@acs.org @pubs.acs.org @jacs.acspublications.org

Consecutive Complex Aggregation Pathway in Covalent Helical Polymer‐Metal Complexes: Nanospheres with Controlled P/M Macroscopic Chirality Helical polymer-metal complex nanospheres following a consecutive aggregation pathway allow the creation of chiral polymeric particles capable of memorizing their macroscopic chirality and the proper...

Good news from SMALL at the end of 2024. Congratulations to the team 👏👏🍾https://onlinelibrary.wiley.com/doi/10.1002/smll.202409379

Great news from Nanoscale, our work has been accepted 👏🍾. Congratulations to “los Manus” team
pubs.rsc.org/en/content/a...

Thermal Activation of Asymmetry Amplification Effects in Helical Polymer‐Metal Complexes Dynamic helical polymers such as poly(phenylacetylene)s (PPAs) exhibit different asymmetry amplification effects, e.g. helix inversion or screw-sense induction, in the presence of different external ...

Great news from @angew_chem and fantastic work done by Manuel Fernandez Miguez 🎉🎉 Thermal Activation of Asymmetry Amplification Effects in Helical Polymer-Metal Complexes onlinelibrary.wiley.com/doi/abs/10.1...

Thermal Activation of Asymmetry Amplification Effects in Helical Polymer‐Metal Complexes Dynamic helical polymers such as poly(phenylacetylene)s (PPAs) exhibit different asymmetry amplification effects, e.g. helix inversion or screw-sense induction, in the presence of different external ...

Great news from @angew_chem and fantastic work done by Manuel Fernandez Miguez 🎉🎉 Thermal Activation of Asymmetry Amplification Effects in Helical Polymer-Metal Complexes onlinelibrary.wiley.com/doi/abs/10.1...

A Route toward the On-Surface Synthesis of Organic Ferromagnetic Quantum Spin Chains . New collaboration with our friends at IBM-Zurich and CICECO-Aveiro pubs.acs.org/doi/10.1021/...

🧨New preprint on ChemRxiv!

📄Together with @felixfreirelab.bsky.social & @glowsticks.bsky.social, we show how a molecule assembly into a helical polymer or a 3WJ-binding helicate via external stimuli.

🔥New paths for supramolecular polymers in ChemBio!

🔗 Read: chemrxiv.org/engage/chemr...

#ChemSky

Great news from Nanoscale, our work has been accepted 👏🍾. Congratulations to “los Manus” team
pubs.rsc.org/en/content/a...

Consecutive Complex Aggregation Pathway in Covalent Helical Polymer‐Metal Complexes: Nanospheres with Controlled P/M Macroscopic Chirality Helical polymer-metal complex nanospheres following a consecutive aggregation pathway allow the creation of chiral polymeric particles capable of memorizing their macroscopic chirality and the proper...

Good news from SMALL at the end of 2024. Congratulations to the team 👏👏🍾https://onlinelibrary.wiley.com/doi/10.1002/smll.202409379

The Governing Board of the Nanoscience and Molecular Materials Group of the Spanish Royal Societies of Chemistry and Physics wishes you a Merry Christmas and all the best for 2025! @rseq.bsky.social @rsef.bsky.social

Coaxial Helices in Chiral Supramolecular Aggregates from Highly Hindered Chiral Allenes Supramolecular helical aggregates describing two coaxial helices rotating in the same or opposite direction are obtained from the self-assembly of chiral allenes. The internal helix is described by t...

Hot off the press!! 🔝👏 Great job done by our team in the supramolecular self-assembly of chiral allenes. 🍾🍾 onlinelibrary.wiley.com/doi/10.1002/...

Coaxial Helices in Chiral Supramolecular Aggregates from Highly Hindered Chiral Allenes Supramolecular helical aggregates describing two coaxial helices rotating in the same or opposite direction are obtained from the self-assembly of chiral allenes. The internal helix is described by t...

Hot off the press!! 🔝👏 Great job done by our team in the supramolecular self-assembly of chiral allenes. 🍾🍾 onlinelibrary.wiley.com/doi/10.1002/...