Peter Seavill

Alternating polarity photo-electrocatalysis for asymmetric C−C cross-couplings - Nature Synthesis Photo-electrocatalysis under alternating polarity allows enantioselective redox-neutral cross-coupling through β-scission of alcohols to afford optically pure chiral α-arylated amines.

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News & Views on the Article by Chen Zhu & co-workers

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Alternating polarity photo-electrocatalysis for asymmetric C−C cross-couplings by Samrat Mallick & Suman De Sarkar

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Applications of thianthrene chemistry in organic synthesis - Nature Synthesis Thianthrene, long used in materials science, has recently emerged as a powerful reagent in organic synthesis. Its unique electronic structure enables access to diverse aryl, alkenyl and alkyl thianthrenium salts, which exhibit reactivity beyond conventional (pseudo)halides. This Review highlights the fundamental properties, distinctive reactivity and synthetic applications of these thianthrenium salts.

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Review by Zibo Bai & Tobias Ritter

Applications of thianthrene chemistry in organic synthesis

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Symmetry-driven engineering of long-range-ordered π–π stacking molecules for high-efficiency perovskite photovoltaics - Nature Synthesis Molecular engineering has increased the power conversion efficiency of inverted perovskite solar cells (PSCs), surpassing that of regular PSCs. Here, the symmetric molecule (2-(pyren-2-yl)ethyl)phosphonic acid (pPy) enables long-range-ordered π–π stacking, enhancing charge transport. pPy films show face-on orientation and uniform distribution, yielding PSCs with power conversion efficiencies of 26.6%.

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Article by Xingzhu Wang, Jingbai Li, Yong Zhang, Baomin Xu & co-workers

Symmetry-driven engineering of long-range-ordered π–π stacking molecules for high-efficiency perovskite photovoltaics

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Applying alternating current in paired photo-electrocatalysis for asymmetric cross-coupling of alcohols - Nature Synthesis An alternating current paired photo-electrocatalysis approach, integrating electrochemistry, ligand-to-metal charge transfer photocatalysis and asymmetric nickel catalysis, enables enantioselective C(sp3)–C(sp2) cross-coupling of alcohols. This approach has high catalytic efficiency and stability, achieving up to 99% enantiomeric excess with broad substrate compatibility, and is suitable for late-stage functionalization of complex molecules.

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Article by Chen Zhu & co-workers

Applying alternating current in paired photo-electrocatalysis for asymmetric cross-coupling of alcohols

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Engineering a covalent organic framework-based type-II heterojunction for enhanced photocatalytic H2O2 synthesis - Nature Synthesis A covalent organic framework-based type-II heterojunction (TpPa/TpDz) enables efficient photocatalytic H2O2 production in pure water. The highest and lowest occupied molecular orbitals are spatially separated, driving directional photogenerated carrier transport and minimizing recombination, therefore enhancing photocatalytic activity.

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Article by Zhengping Dong, Yong Yan & co-workers

Engineering a covalent organic framework-based type-II heterojunction for enhanced photocatalytic H2O2 synthesis

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Synthesis of covalent organic frameworks via coupling polymerization - Nature Synthesis A microinterfacial solvothermal polymerization strategy is developed for irreversible coupling reactions to form porous crystalline sp-carbon-conjugated covalent organic frameworks with diverse topologies. These two-dimensional frameworks exhibit enhanced conductivity and tunable magnetic properties.

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Article by Donglin Jiang & co-workers

Synthesis of covalent organic frameworks via coupling polymerization

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Selective dynamic kinetic asymmetric aldehyde–alkyne reductive coupling - Nature Synthesis A N-heterocyclic carbene–nickel-catalysed dynamic kinetic asymmetric aldehyde–alkyne reductive coupling reaction is reported, achieving control over chemo-, regio-, E/Z-, diastereo-, and enantioselectivity. This approach offers a streamlined route to construct multifunctional allylic alcohols with adjacent stereocentres from readily accessible substrates.

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Article by Shi-Liang Shi & co-workers

Selective dynamic kinetic asymmetric aldehyde–alkyne reductive coupling

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Energy landscape modulation enables helicity overriding in supramolecular copolymers - Nature Synthesis Helicity-overriding behaviour in supramolecular copolymers is reported by manipulating the energy landscape of chiral co-monomers, where one chiral monomer can override the intrinsic helical preference of another, even when present in the minority. This finding offers insights into asymmetry amplification in multicomponent supramolecular systems.

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Article by Shiyan Xiao, Feng Wang & co-workers

Energy landscape modulation enables helicity overriding in supramolecular copolymers

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Imidazolium radical-mediated electron transfer enhances electrochemical C–N coupling for glycine synthesis - Nature Synthesis The electrosynthesis of amino acids is hindered by inefficient oxime intermediate conversion. Here, a relayed electron transfer mechanism is proposed using an ionic-liquid@Bi catalyst. Electrons are accepted by the ionic liquid to generate related radicals, which then transfer electrons to oxime, enabling efficient amino acid production.

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Article by Xinchen Kang, Buxing Han & co-workers

Imidazolium radical-mediated electron transfer enhances electrochemical C–N coupling for glycine synthesis

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Dual C–H functionalization of polyolefins for covalent adaptable network formation via cooperative electrolysis - Nature Synthesis A cooperative electrolytic strategy is designed, enabling dual C–H functionalization of deconstructed polyolefin oligomers, converting carbon fibre-reinforced polymer waste into adaptive materials. This approach forms covalently adaptable networks and establishes electrochemical backbone editing as a versatile platform for advanced polymer design and functionalization.

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Article by Yuting Zhou, Zhenchuang Xu & Jeffrey S. Moore

Dual C–H functionalization of polyolefins for covalent adaptable network formation via cooperative electrolysis

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Regiocontrollable [2 + 2] benzannulation of γ,δ-C(sp3)–H bonds with dihaloarenes using palladium catalysis - Nature Synthesis The synthesis of benzocyclobutenes is reported through Pd(II)-catalysed γ,δ-methylene C(sp3)–H bond activation and [2 + 2] annulation between aliphatic carboxylic acids and dihaloarenes, using bidentate carboxyl-pyridone ligands. Regiocontrol is achieved in benzocyclobutene formation through the differentiation of reactivity between the aryl iodide and bromide sites.

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Article by Jin-Quan Yu & co-workers

Regiocontrollable [2 + 2] benzannulation of γ,δ-C(sp3)–H bonds with dihaloarenes using palladium catalysis

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Sustainable oxime production via the electrosynthesis of hydroxylamine in a free state - Nature Synthesis A sustainable two-step strategy for oxime synthesis in a neutral KHCO3 medium is reported. Free-state NH2OH is initially synthesized via nitrite electroreduction over a Ketjen-black-supported iron phthalocyanine catalyst, followed by a chemical aldehyde or ketone oximation using the electrochemically synthesized NH2OH.

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Article by Si-Min Xu, Haohong Duan & co-workers

Sustainable oxime production via the electrosynthesis of hydroxylamine in a free state

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Direct access to a neutral alumene via CO reduction by a dialane and further CO homologation - Nature Synthesis Multiple bonds involving heavier elements were considered impossible but have recently been shown to be stable and offer divergent reactivity. Here the isolation of an alumene (a compound containing an Al=C bond) via direct CO reduction is described. Analysis of the alumene and its ability to homologate CO is reported.

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Article by John A. Kelly, Arseni Kostenko & Shigeyoshi Inoue

Direct access to a neutral alumene via CO reduction by a dialane and further CO homologation

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Dynamic Al–Cd frameworks - Nature Synthesis Nature Synthesis - Dynamic Al–Cd frameworks

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Dynamic Al–Cd frameworks by Joel Cejas-Sánchez

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Global aromaticity at the macrocyclic size limit - Nature Synthesis Nature Synthesis - Global aromaticity at the macrocyclic size limit

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Global aromaticity at the macrocyclic size limit by @jetsinglee.bsky.social

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Hydrogenation using ammonia-borane - Nature Synthesis Nature Synthesis - Hydrogenation using ammonia-borane

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Hydrogenation using ammonia-borane by @peterseavill.bsky.social

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Highlighting the @cp-chem.bsky.social article by Michael J. Tilby, Daniele Leonori and co-workers
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Synthesis of perovskites Perovskites are an important class of materials with applications in optoelectronics and catalysis.

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Synthesis of perovskites
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Editorial: The synthesis of perovskites
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The cover image of the September issue of Nature Synthesis, showing a single-unit-cell-thick perovskite chain contained within a single-walled carbon nanotube.

September issue now online!

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Molecular-dynamics-simulation-guided directed evolution of flavoenzymes for atroposelective desaturation - Nature Synthesis Molecular-dynamics-simulation-guided evolution of flavoenzymes produces efficient catalysts for non-C2-symmetric biaryl synthesis with excellent atroposelectivity, offering promise for natural product...

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Article by Niu Huang, Zhen Liu & co-workers

Molecular-dynamics-simulation-guided directed evolution of flavoenzymes for atroposelective desaturation

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Enantioselective organocatalytic construction of axially chiral sulfoxides - Nature Synthesis Axially chiral sulfoxides have attracted considerable attention due to their broad application potential. Now, a catalytic asymmetric approach to the one-step construction of these compounds is report...

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Article by Hailong Yan & co-workers

Enantioselective organocatalytic construction of axially chiral sulfoxides

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Iron-catalysed radical difunctionalization of alkenes - Nature Synthesis Three-component, iron-based catalytic transformations offer a promising and sustainable approach to building complex molecules in a single step. This Review highlights advances and ongoing challenges ...

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Review article by Achyut R. Gogoi, Ángel Rentería-Gómez, Tong-De Tan, Jun Wei Ng, Ming Joo Koh & Osvaldo Gutierrez

Iron-catalysed radical difunctionalization of alkenes

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Three-dimensional divergent hydroheteroarylation of internal alkynes with indolizines - Nature Synthesis The hydroheteroarylation of internal alkynes with indolizines via Pd and Rh catalysis is reported. This catalyst-controlled three-dimensional divergent protocol produces eight types of diaryl allyl sk...

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Article by Xiao-Song Xue, Zhi-Tao He & co-workers

Three-dimensional divergent hydroheteroarylation of internal alkynes with indolizines

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Synthesis and purification of materials for scalable perovskite solar cells - Nature Synthesis The synthesis and purification of perovskite precursors and charge-transport materials are critical for achieving stable, high-efficiency lab-scale devices and for the scalable industrial production o...

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Comment article by Atsushi Wakamiya & Nam-Gyu Park

Synthesis and purification of materials for scalable perovskite solar cells

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A colloidal approach for the synthesis of catalytically active solid–liquid–solid nanoparticles - Nature Synthesis Multimetallic solid–liquid–solid core–shell–shell nanoparticles are synthesized using liquid gallium as a nanoreactor. Characterization reveals core dissolution and recrystallization within the liquid...

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Article by Raffaella Buonsanti & co-workers

A colloidal approach for the synthesis of catalytically active solid–liquid–solid nanoparticles

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Electrosynthesis of ethanol via CO–CHx cross-coupling on copper alloy catalysts with engineered oxygen affinity - Nature Synthesis Ethanol electrosynthesis from CO reduction is achieved using an oxygen-affinity-engineered copper alloy catalyst. Unlike conventional CO dimerization pathways, which yield diverse products, this catal...

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Article by Zhenpeng Yao, Jun Li & co-workers

Electrosynthesis of ethanol via CO–CHx cross-coupling on copper alloy catalysts with engineered oxygen affinity

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Spin-density-controlled radical coupling for meta-selective C–H halogenation of pyridines - Nature Synthesis In this study meta-selective single-step bromination and chlorination reactions of pyridines and their derivatives are developed, with pyridinium radical cations as the key intermediates. A spin-densi...

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Article by Xiaotian Qi, Qiang Cheng & co-workers

Spin-density-controlled radical coupling for meta-selective C–H halogenation of pyridines

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Photocoupling of propagating radicals during polymerization realizes universal network strengthening - Nature Synthesis In free radical polymerization, poorly connected nanoclusters lead to heterogeneous polymer networks with diminished mechanical properties. Now, a photogenerated nitroxide that couples propagating rad...

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Article by Jing Lyu, Qiuning Lin & co-workers

Photocoupling of propagating radicals during polymerization realizes universal network strengthening

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Surface diffusion engineering of a 2D perovskite layer for efficient perovskite photovoltaics - Nature Synthesis Dimensional regulation of 2D perovskites remains challenging due to progressive phase transitions in solution-based processes. Now a non-invasive surface reaction strategy enables the formation of pha...

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Article by Yang Wang, Huanping Zhou, Yanlin Song & co-workers

Surface diffusion engineering of a 2D perovskite layer for efficient perovskite photovoltaics

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Modular construction of α- or β-stereogenic organosilanes and organogermanes via enantioselective alkene hydroalkylation - Nature Synthesis Achieving enantioselective C(sp3)–C(sp3) bond formation using a silyl group as an auxiliary is challenging. Now a cobalt-catalysed enantioselective hydroalkylation of vinyl- and allylsilanes to constr...

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Article by Xi Lu, Yao Fu & co-workers

Modular construction of α- or β-stereogenic organosilanes and organogermanes via enantioselective alkene hydroalkylation

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Crystalline coumarin-linked covalent organic frameworks - Nature Synthesis The development of highly stable and functional carbon–carbon bonded covalent organic framework (COF) linkages is desirable but challenging. Now a postsynthetic modification strategy has been applied ...

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Article by Heyang Zhang, Zihui Zhou, Chenhui Zhu & Omar M. Yaghi

Crystalline coumarin-linked covalent organic frameworks

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