Peter Seavill

Ampere-level electrosynthesis of a nylon-6 precursor by local NO coverage tuning - Nature Synthesis Cyclohexanone oxime electrosynthesis has low Faradaic efficiency at high current densities. Now, high NO coverage is found to favour oxime production. A doping strategy is proposed to break the electr...

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Article by Bin Zhang & co-workers

Ampere-level electrosynthesis of a nylon-6 precursor by local NO coverage tuning

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Associate or Senior Editor, Nature Synthesis Title: Associate or Senior Editor, Nature Synthesis Organization: Nature Portfolio Locations: New York, Jersey City, Shanghai or Beijing - Hybrid Working Model Application Deadline: August 20th, 2025 ...

Join us! We're hiring an Associate or Senior Editor at
@natsynth.nature.com. This is a great opportunity if you're interested in the preparation of molecules and materials.

New York, Jersey City, Beijing, Shanghai

Deadline 20th August

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Associate or Senior Editor, Nature Synthesis Title: Associate or Senior Editor, Nature Synthesis Organization: Nature Portfolio Locations: New York, Jersey City, Shanghai or Beijing - Hybrid Working Model Application Deadline: August 20th, 2025 ...

We’re hiring!

Hey #Chemsky, we have an opening for an Associate or Senior Editor with experience in synthetic chemistry or materials science.

📍New York, Jersey City, Shanghai or Beijing

📆Closing date: 20th August 2025

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Gram-per-litre-scale production of lutein by engineered Corynebacterium - Nature Synthesis Commercial lutein is mainly extracted from marigold flowers, which is an inefficient process. Now a gram-per-litre-scale process for microbial production of lutein is reported using metabolically engi...

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Article by Hyunmin Eun, Cindy Pricilia Surya Prabowo & Sang Yup Lee

Gram-per-litre-scale production of lutein by engineered Corynebacterium

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Topochemical exfoliation of metal oxyhydroxides for the electrolytic oxygen evolution reaction - Nature Synthesis A topochemical oxidation process is developed to exfoliate metal oxyhydroxides, in which active oxygen species and alkali cations modulate interlayer repulsion. The resulting Cs⁺-CoFeOOH nanosheets de...

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Article by Hao Ming Chen, Fang Song & co-workers

Topochemical exfoliation of metal oxyhydroxides for the electrolytic oxygen evolution reaction

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Strain-dependent enantioselectivity in mechanochemically coupled catalytic hydrogenation - Nature Synthesis The selectivity of a catalytic reaction is manipulated by straining a polymer support to which the catalyst is covalently bound. Enantioselective rhodium-catalysed hydrogenation of a series of 2-aceta...

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Article by Roman Boulatov, Stephen L. Craig, Ross A. Widenhoefer & co-workers

Strain-dependent enantioselectivity in mechanochemically coupled catalytic hydrogenation

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Base-promoted azaarene and polyazaarene synthesis through C–C bond cleavage and alkyl transfer - Nature Synthesis Potassium tert-butoxide is used in a precious-metal-free alkyl transfer strategy for synthesizing azaarenes and polyazaarenes from alkenes and nitriles via carbon–carbon bond cleavage. This method pro...

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Article by Yan-Biao Kang & co-workers

Base-promoted azaarene and polyazaarene synthesis through C–C bond cleavage and alkyl transfer

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Light-fuelled growth dynamics and structural transition of synthetic protocells - Nature Synthesis An adaptive supramolecular system is designed which exhibits complex droplet growth and phase behaviours, driven by the interplay between environmental factors (light input) and intrinsic chemical act...

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Article by Ke Shi, Peiyong Song, Jianwei Li, Yan Qiao & Yiyang Lin

Light-fuelled growth dynamics and structural transition of synthetic protocells

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Ethylene electrosynthesis at low voltages enabled by dopant-induced modulation of the rate-determining step - Nature Synthesis Cobalt-based subsurface dopants induce a shift in the rate-determining step of electrochemical CO2 reduction on copper to the chemical step: OCCO* + H* → OCCHO* + *. Electrochemical production of ethy...

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Article by Ziyun Wang, Yanwei Lum & co-workers

Ethylene electrosynthesis at low voltages enabled by dopant-induced modulation of the rate-determining step

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From light to life-like protocells - Nature Synthesis Light-driven chemical reactivity enables a synthetic system to give rise to protocells with dynamic, life-like behaviour.

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News & Views on the Article by Ke Shi, Peiyong Song, Jianwei Li, Yan Qiao & Yiyang Lin

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From light to life-like protocells by @continiclau.bsky.social

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Generating reliable and reproducible data for reusable quantum chemical reaction free-energy profiles - Nature Synthesis The guidance of experimental studies with computational exploration of reaction mechanisms has become a key tool in chemistry. This Perspective highlights challenges and best practices for generating ...

Perspective article now online:

Generating reliable and reproducible data for reusable quantum chemical reaction free-energy profiles by Maren Podewitz @podewitzlab.bsky.social

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Advancing Perovskite-Based Photovoltaics Join the Nature Conference on Advancing Perovskite-Based Photovoltaics, where leading scientists, engineers, and industry researchers converge to explore the latest advancements and pressing challenge...

🎉Registration deadline approaching for this fantastic Nature Conference on 'Advancing Perovskite-based Photovoltaics', scheduled to take place in Stuttgart, 29 September - 1st October.

natureconferences.streamgo.live/photovoltaic...

Please do sign up by 15th September if you're interested!

Building complex biochemicals from one-carbon compounds - Nature Synthesis One-carbon compounds, including carbon dioxide and methane, represent a sustainable resource for chemical conversions. This Review highlights recent advances in the biochemical upgrading of one-carbon...

Review article now online:

Building complex biochemicals from one-carbon compounds by Blake Rasor, Simone Giaveri, Andreas Küffner & Tobias Erb

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Supramolecular templating for two-dimensional crystalline polymers with mechanical bonds - Nature Synthesis Crystalline 2D mechanically interlocked polymers synthesized through supramolecular templating demonstrate 47-fold stiffness enhancement upon exfoliation with preserved structural order.

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News & Views on the Article by @zhichangliu.bsky.social & co-workers

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Supramolecular templating for two-dimensional crystalline polymers with mechanical bonds by Dejing Xu & Yuping Wang

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Synthesis of covalently linked knotted cage frameworks - Nature Synthesis Synthesizing topologically complex interwoven molecules with high yield remains challenging due to structural preorganization demands. Here face-bridging ligands on metal–organic cage frameworks are s...

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Article by Yuchong Yang, Jonathan R. Nitschke & co-workers

Synthesis of covalently linked knotted cage frameworks

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Enantioconvergent carbenoid insertion into carbon–boron bonds - Nature Synthesis An enantioconvergent approach for direct asymmetric insertion of racemic carbon-, oxygen-, nitrogen-, sulfur- and silicon-substituted carbenoids into carbon–boron bonds is reported, enabled by a class...

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Article by Qiqiang Xie, Peng Liu, Guangbin Dong & co-workers

Enantioconvergent carbenoid insertion into carbon–boron bonds

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Computationally guided defect-suppressing synthesis of luminescent tin halide perovskite nanocrystals - Nature Synthesis A computationally guided strategy enables the suppression of structural defects in tin halide perovskite nanocrystals. By combining tin-rich conditions to minimize bulk defects, introducing monovalent...

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Article by Jia-Kai Chen, Yifan Zhou, Bin-Bin Zhang, Jun Kikkawa, Jun Yin, Naoto Shirahata, Bin Chen, Edward H. Sargent & Hong-Tao Sun

Computationally guided defect-suppressing synthesis of luminescent tin halide perovskite nanocrystals

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Nickel-catalysed enantioselective migratory reductive cross-coupling enabled by radical 1,2-amino migration - Nature Synthesis Asymmetric migratory cross-coupling reactions, which proceed with heteroatom-based group migration, are challenging. Now a nickel-catalysed coupling reaction of amino alcohol-derived sulfonates with a...

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Article by Xiaolin Ren, Yiwei Qiao, Bingqi Zhou, Song Liu & Yuan Huang

Nickel-catalysed enantioselective migratory reductive cross-coupling enabled by radical 1,2-amino migration

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Programmable synthesis of atomically precise semiconductor artificial atoms - Nature Synthesis Atomic-level control of semiconductor nanomaterials remains difficult due to their complex structures. Now, a programmable approach to synthesize a series of precisely defined Zn14Se13, Cd14Se13 and H...

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Article by Fuyan Ma, Sergei A. Ivanov, Lukasz M. Dobrzycki & Chenjie Zeng

Programmable synthesis of atomically precise semiconductor artificial atoms

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Isolated carbon(I) species featuring a carbone cation radical - Nature Synthesis The isolation of a crystalline radical cation carbon(I) species, generated via single-electron transfer between a carbodicarbene and a nitroaromatic compound, is reported. The resulting radical ion pa...

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Article by Wen-Ching Chen, Yun-Wei Chiang, Gernot Frenking, Lili Zhao, Tiow-Gan Ong & co-workers

Isolated carbon(I) species featuring a carbone cation radical

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Chemoenzymatic platform with coordinated cofactor self-circulation for lignin valorization - Nature Synthesis Lignin valorization is hampered by the requirement for expensive cofactors and low conversions. Now a chemoenzymatic platform with coordinated cofactor self-circulation for realizing efficient lignin-...

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Article by Liangxu Liu, Jun Ni & co-workers

Chemoenzymatic platform with coordinated cofactor self-circulation for lignin valorization

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Combining oxygen reduction with glycerol oxidation in a galvanic device - Nature Synthesis Combining cathodic oxygen reduction with anodic glycerol oxidation results in simultaneous chemical synthesis and renewable electricity production.

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News & Views on the Article by Jaramillo, Seo, Jang & co-workers

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Combining oxygen reduction with glycerol oxidation in a galvanic device by Hui Luo & Jesús Barrio

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Thianthrenium-enabled modular synthesis of bicyclo[1.1.1]pentanes - Nature Synthesis The lack of stable and versatile bicyclo[1.1.1]pentyl reagents hinders their broader adoption as aryl bioisosteres in drug discovery. Now, a stable, bifunctional iodobicyclo[1.1.1]pentylmethyl thianth...

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Article by Zibo Bai, Zikuan Wang, Thomas Hin-Fung Wong & Tobias Ritter

Thianthrenium-enabled modular synthesis of bicyclo[1.1.1]pentanes

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Nickel-catalysed deuteration of benzylic C(sp3)–H bonds using D2O - Nature Synthesis A heterogeneous nickel-catalysed deuteration reaction of benzylic C(sp3)–H bonds in alkylarenes and methylarenes using D2O is developed. Such metal–H2–D2O systems could be extended to other catalytic ...

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Article by Aiwen Lei, Wu Li & co-workers

Nickel-catalysed deuteration of benzylic C(sp3)–H bonds using D2O

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Synthesis of chiral difluoromethyl cyclopropanes through desymmetric difluoromethylation of cyclopropenes enabled by enantioselective copper catalysis - Nature Synthesis General methods for the synthesis of chiral difluoromethyl cyclopropanes are challenging to develop, despite the increasing importance of this motif in pharmaceuticals. Now, a copper-catalysed desymme...

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Article by Wei Liu & co-workers

Synthesis of chiral difluoromethyl cyclopropanes through desymmetric difluoromethylation of cyclopropenes enabled by enantioselective copper catalysis

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Chirality retention in Friedel–Crafts spiroannulation for iterative synthesis of spiro-bridged conjugated carbocycles - Nature Synthesis A strategy that preserves stereochemistry in intramolecular Friedel–Crafts alkylation is reported. An iterative synthetic approach to extend spiro-bridged molecular skeletons via C–H activation–annula...

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Article by X Pu, Y Lu, Z Zhou, Y Yang, C Zhang, P Yu, Y S Zhao, J Lan & J You

Chirality retention in Friedel–Crafts spiroannulation for iterative synthesis of spiro-bridged conjugated carbocycles

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Synthesis of chiral sequence-defined oligomers via sulfur–fluoride and sulfur–phenolate exchange reactions - Nature Synthesis Precise control over both sequence and chirality remains a challenge in polymer chemistry. Here sulfur–fluoride exchange and sulfur–phenolate exchange reactions are used to create chiral oligosulfonim...

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Article by Yu Han, Sidharam P. Pujari, Muthusamy Subramaniam, Bo Chen, Fedor M. Miloserdov & Han Zuilhof

Synthesis of chiral sequence-defined oligomers via sulfur–fluoride and sulfur–phenolate exchange reactions

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In-brain synthesis of receptor-based protease sensors by coupling ligand-directed chemistry and click chemistry - Nature Synthesis The complexity of living systems makes methods for chemically functionalizing proteins in vivo rare. Here, a genetic-engineering-free method to modify receptor proteins with various probes in the live...

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Article by S Sakamoto, K Shiraiwa, M Wang, M Ishikawa, H Nonaka & I Hamachi

In-brain synthesis of receptor-based protease sensors by coupling ligand-directed chemistry and click chemistry

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Synthesis of fully π-conjugated non-alternant carbon nanobelts - Nature Synthesis The synthesis of fully π-conjugated, pentagon-embedded non-alternant carbon nanobelts is realized using an iterative Diels–Alder reaction followed by deoxygenative aromatization. Compared with all-ben...

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Article by Yi Han, Chunyan Chi & co-workers

Synthesis of fully π-conjugated non-alternant carbon nanobelts

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A molecular sieve boosts perovskite stability - Nature Synthesis Highly efficient and stable perovskite solar cells are fabricated by introducing a molecular sieve which finely controls the 2D/3D heterointerface reactions.

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News & Views on the Article by Zhimin Li, Pengfei Guo, Yalan Zhang, Weizhen Wang, Songhua Cai & Yuanyuan Zhou

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A molecular sieve boosts perovskite stability by Giulia Grancini & Carolin M. Sutter-Fella

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