Neuroprotection

New in #neuroprotection
Therapeutic potential of stem cells in pediatric neurology: Insights from clinical trials
#cell therapy, #clinical trials, #neurology, #pediatrics, #stem cell
doi.org/10.1002/nep3...

Happy holidays from #Neuroprotection
We achieved major database listing this year! Impact factor coming soon. Stay tuned.
#PMC #Scopus #DOAJ #ESCI

New in #neuroprotection
Proposed mechanism for transcriptional regulation of tyrosine hydroxylase (TH), dopamine β hydroxylase (DBH) and monoamine oxidase-A (MAO-A) genes during rapid eye movement sleep (REMS) or its loss.
doi.org/10.1002/nep3...

Exploiting glial cell functions for neurodegeneration therapy The figure illustrates the potential of targeting glial cell functions and their interactions with neurons as a therapeutic strategy for neurodegeneration.

New in #neuroprotection

Enhancing glial functions in glutamate clearance, remyelination, immune regulation, and metabolic support offers promising neuroprotection.
onlinelibrary.wiley.com/doi/10.1002/...

Our editorial board member @Ass. Prof. Dr. Marietta Zille in action!
Recently, she led her outstanding team to attend the #Aging and #Microbiome Conference #AMC2025.

Pluripotent Cells Expressing APOE4 Exhibit a Pronounced Pro-Apoptotic Phenotype Accompanied by Markers of Hyperinflammation and a Blunted NF-κB Response

www.mdpi.com/1422-0067/26...

New in #neuroprotection
①Identified eight core genes linking isoflurane to postoperative delirium.
②Estrogen signaling and endocrine resistance pathways contribute to neurotoxicity.
doi.org/10.1002/nep3...

Better understanding complex pathomechanisms in central nervous system disorders as a prerequisite for improved diagnostic and therapeutic approaches Click on the article title to read more.

New editorial in #Neuroprotection:
Understanding CNS pathomechanisms is key to better diagnostics & therapies.
Feat.
🧠 Neuroinflammation& astrocytes
🔄 Adaptive plasticity after injury
⚡ Mitochondrial transfer & stroke
🧬 Stem cells/exosomes
🧑‍⚕️ BBB aging
onlinelibrary.wiley.com/doi/10.1002/...

New in #Neuroprotection:
How senescent #astrocytes affect the BBB 🧠🧬

✅ Young astrocytes enhance endothelial barrier function
✅ Senescent astrocytes ↑ angiotensinogen (AGT), losing this effect
✅ AGT knockdown restores barrier-promoting properties

onlinelibrary.wiley.com/doi/10.1002/...

🧠 #Neuroprotection's new case report:
Acute #hemichorea-hemiballism caused by cortical infarcts - a rare #stroke presentation

✅ Early MRI/DWI crucial for atypical dyskinesia
✅ Evidence for corticobasal ganglia circuit disruption

onlinelibrary.wiley.com/doi/10.1002/...

Efficient analysis of toxicity and mechanisms of isoflurane on postoperative delirium by network toxicology and molecular docking Postoperative delirium (POD), a prevalent neurological complication in older surgical patients, adversely affects recovery. Isoflurane, a common inhalational anesthetic, exhibits neurotoxic potential....

🧠 New in #Neuroprotection:
#Isoflurane’s role in postoperative delirium decoded!

✅ 8 core genes (incl. CASP3, COMT, ACE)
✅ Apoptosis & dopaminergic disruption
✅ Estrogen & endocrine-resistance pathways

Full study ➡️ doi.org/10.1002/nep3...

#PostoperativeDelirium

Better understanding complex pathomechanisms in central nervous system disorders as a prerequisite for improved diagnostic and therapeutic approaches Click on the article title to read more.

New editorial in #Neuroprotection:
Understanding CNS pathomechanisms is key to better diagnostics & therapies.
Feat.
🧠 Neuroinflammation& astrocytes
🔄 Adaptive plasticity after injury
⚡ Mitochondrial transfer & stroke
🧬 Stem cells/exosomes
🧑‍⚕️ BBB aging
onlinelibrary.wiley.com/doi/10.1002/...

New in #Neuroprotection:
How senescent #astrocytes affect the BBB 🧠🧬

✅ Young astrocytes enhance endothelial barrier function
✅ Senescent astrocytes ↑ angiotensinogen (AGT), losing this effect
✅ AGT knockdown restores barrier-promoting properties

t.co/rINteh1f9n

We are pleased to announce that
Neuroprotection (ISSN: 2770-730X) has been accepted for coverage by the Emerging Sources Citation Index (ESCI) in Web of Science. And the journal will be accepted by PMC soon!
Check out more:
onlinelibrary.wiley.com/journal/2770...

Glutamate and excitotoxicity in central nervous system disorders: ionotropic glutamate receptors as a target for neuroprotection Glutamate dysregulation leads to neurological disorders, which has prompted a paradigm shift towards neuroprotection targeting ionotropic glutamate receptors (iGluRs). Neurons may be less susceptible....

Check out 2025 high downloaded paper in #neuroprotection
by Dr. Christian Chapa González
onlinelibrary.wiley.com/doi/10.1002/...

What long COVID-19, ME/CFS, and neuroscience have in common and to gain from one another Long COVID continues to affect millions, with symptoms that mirror those of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This research highlight reveals that both conditions share comm...

Check out #Eurekalert mentions a newly published paper in #neuroprotection
How pandemics reshape our brain?
www.eurekalert.org/news-release...

Learnings from preclinical and clinical work are ready to guide clinical development programs for expanded and improved treatments to prevent and treat AD.

and are agents that appear to slow development and/or progression of AD. Sulfonylureas may actually worsen cognitive deficits and integrity. This evidence influences the treatment of choice for patients with T2D and comorbid cognitive issues or those at risk of the same.

Salient for today's gold standard of care, metformin, dipeptidyl peptidase 4 inhibitors, glucagon-like peptide-1 receptor analogs, and sodium glucose cotransporter 2 inhibitors are glucose-lowering agents with multiple actions, among these is the attenuation of insulin resistance

Insulin resistance in the periphery or the brain disrupts key metabolic processes and systems, including the blood‒brain barrier. Brain insulin resistance sits at the crossroads of neuronal damage that is known to lead to Alzheimer's disease and cognitive impairment in general.

Pernicious dysglycemia occurs not only in the systemic circulation, but also in the brain, where it operates within a semiautonomous bioenergetic “microsystem.”

#Dysglycemia, as observed in type 2 diabetes (T2D), is the primary driver of the development and progression of cognitive dysfunction—and now understood to lead to dementia-related disorders as well.

Don't miss this new review in #neuroprotection:
Beta cells to brain cells: The pivotal role of #insulin and glucose metabolism in #Alzheimer's disease

#diabetes

onlinelibrary.wiley.com/doi/10.1002/...

Instead, it emphasizes how peripheral systems like the immune, vascular, and metabolic axes critically influence CNS repair and resilience. A provocative read reshaping how we approach CNS disorders.

🌟 Just released: The latest editorial in #Neuroprotection—Targeting peripheral processes to protect the CNS—makes a compelling case for shifting the neuroprotection paradigm beyond the brain #Neuroscience #GutBrainAxis #TranslationalResearch
onlinelibrary.wiley.com/doi/10.1002/...

History of pre‐eclampsia negatively impacts stroke severity postpartum in rats Diagrammatic representation of the effect of pre-eclampsia on postpartum stroke severity. e7, gestational day 7; ePE, experimental pre-eclampsia; NormP, normal pregnancy; PP, postpartum; tMCAO, trans...

History of pre-eclampsia negatively impacts stroke severity postpartum in rats

Ari Kropf et al. 🧪

@neuropjournal.bsky.social

onlinelibrary.wiley.com/doi/10.1002/...

How pandemics reshape our brain: Common links and targets between long‐haul COVID‐19, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), oxidative stress, and neurodegeneration Click on the article title to read more.

onlinelibrary.wiley.com/doi/10.1002/...

Neuroprotection publishes work centred around the recent advances and breakthroughs in the fields of neuroprotection and central as well as peripheral nervous system repair.
#neuroprotection #Wileyneuro #neurology #neuroscience
Check out here
onlinelibrary.wiley.com/journal/2770...

Check out our June issue online
📚Read
onlinelibrary.wiley.com/toc/2770730x...

#neurosky #Wileyneuro #neurology #neuroscience