Neuroprotection

Glutamate and excitotoxicity in central nervous system disorders: ionotropic glutamate receptors as a target for neuroprotection Glutamate dysregulation leads to neurological disorders, which has prompted a paradigm shift towards neuroprotection targeting ionotropic glutamate receptors (iGluRs). Neurons may be less susceptible....

Check out 2025 high downloaded paper in #neuroprotection
by Dr. Christian Chapa González
onlinelibrary.wiley.com/doi/10.1002/...

What long COVID-19, ME/CFS, and neuroscience have in common and to gain from one another Long COVID continues to affect millions, with symptoms that mirror those of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This research highlight reveals that both conditions share comm...

Check out #Eurekalert mentions a newly published paper in #neuroprotection
How pandemics reshape our brain?
www.eurekalert.org/news-release...

Learnings from preclinical and clinical work are ready to guide clinical development programs for expanded and improved treatments to prevent and treat AD.

and are agents that appear to slow development and/or progression of AD. Sulfonylureas may actually worsen cognitive deficits and integrity. This evidence influences the treatment of choice for patients with T2D and comorbid cognitive issues or those at risk of the same.

Salient for today's gold standard of care, metformin, dipeptidyl peptidase 4 inhibitors, glucagon-like peptide-1 receptor analogs, and sodium glucose cotransporter 2 inhibitors are glucose-lowering agents with multiple actions, among these is the attenuation of insulin resistance

Insulin resistance in the periphery or the brain disrupts key metabolic processes and systems, including the blood‒brain barrier. Brain insulin resistance sits at the crossroads of neuronal damage that is known to lead to Alzheimer's disease and cognitive impairment in general.

Pernicious dysglycemia occurs not only in the systemic circulation, but also in the brain, where it operates within a semiautonomous bioenergetic “microsystem.”

#Dysglycemia, as observed in type 2 diabetes (T2D), is the primary driver of the development and progression of cognitive dysfunction—and now understood to lead to dementia-related disorders as well.

Don't miss this new review in #neuroprotection:
Beta cells to brain cells: The pivotal role of #insulin and glucose metabolism in #Alzheimer's disease

#diabetes

onlinelibrary.wiley.com/doi/10.1002/...

Instead, it emphasizes how peripheral systems like the immune, vascular, and metabolic axes critically influence CNS repair and resilience. A provocative read reshaping how we approach CNS disorders.

🌟 Just released: The latest editorial in #Neuroprotection—Targeting peripheral processes to protect the CNS—makes a compelling case for shifting the neuroprotection paradigm beyond the brain #Neuroscience #GutBrainAxis #TranslationalResearch
onlinelibrary.wiley.com/doi/10.1002/...

History of pre‐eclampsia negatively impacts stroke severity postpartum in rats Diagrammatic representation of the effect of pre-eclampsia on postpartum stroke severity. e7, gestational day 7; ePE, experimental pre-eclampsia; NormP, normal pregnancy; PP, postpartum; tMCAO, trans...

History of pre-eclampsia negatively impacts stroke severity postpartum in rats

Ari Kropf et al. 🧪

@neuropjournal.bsky.social

onlinelibrary.wiley.com/doi/10.1002/...

How pandemics reshape our brain: Common links and targets between long‐haul COVID‐19, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), oxidative stress, and neurodegeneration Click on the article title to read more.

onlinelibrary.wiley.com/doi/10.1002/...

Neuroprotection publishes work centred around the recent advances and breakthroughs in the fields of neuroprotection and central as well as peripheral nervous system repair.
#neuroprotection #Wileyneuro #neurology #neuroscience
Check out here
onlinelibrary.wiley.com/journal/2770...

Check out our June issue online
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onlinelibrary.wiley.com/toc/2770730x...

#neurosky #Wileyneuro #neurology #neuroscience

Pre-eclampsia leaves a lasting impact by worsening stroke outcomes postpartum in rats Pre-eclampsia (PE), a hypertensive disorder during pregnancy, impairs maternal endothelial function, leading to inflammation and oxidative stress that may increase the risk of severe brain conditions ...

#neuroprotection new article online
#Pre-eclampsia leaves a lasting impact by worsening #stroke outcomes postpartum in rats
Origin link：
onlinelibrary.wiley.com/doi/10.1002/...
EurekAlert Link：
www.eurekalert.org/news-release...

ME/CFS may represent a useful paradigm and research model for the study of the impact of sustained oxidative stress on the central nervous system and the body at large.

Approx. half of the cases of long-haul #COVID19 meet the diagnostic criteria for ME/CFS, burgeoning the number of affected individuals.
Recent strides in neurobiology have yet to transfer the understanding of the neurodegenerative aspects & potential for neuroprotection of ME/CFS

Myalgic encephalomyelitis/chronic fatigue syndrome is a complex multisystem metabolic-immune-inflammatory disorder. It appears to involve the immune system and central nervous system malfunction, with cellular oxidative stress as a predominant feature.

Fatiguing syndromes affect millions of patients in the United States and globally, but are grossly underserved in the clinic and in the contemplative design of basic research.

How pandemics reshape our brain: Common links and targets between long-haul #COVID19, myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), oxidative stress, and #neurodegeneration. [1/5]
#neuroprotection

Targeting astrocyte-mediated inflammatory pathways through pharmacological agents or neuromodulatory interventions (e.g., repetitive transcranial magnetic stimulation) represents a promising strategy for precision medicine approaches in treating treatment-resistant #depression.

Astrocytic dysfunction is regulated not only by immune signaling but also by metabolic and epigenetic pathways, including lactate production and histone lactylation, offering new avenues for mechanistic understanding and therapeutic targeting.

Role of astrocyte in neuroinflammation‐induced loss in neuroplasticity and subsequent onset of depression: A systematic review Mechanistic crosstalk between microglia and astrocytes in major depressive disorder.

New systematic review published in #neuroprotection of
@wileyinresearch
: Role of #astrocyte in #neuroinflammation-induced loss in #neuroplasticity and subsequent onset of #depression by
@ProfBaune
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@WileyNeuro