Hiro Eto

Ready to establish your own research group at the Hubrecht Institute for Molecular and Developmental Biology? We’re seeking a tenure-track group leader to develop an innovative research line within our vibrant scientific community. Learn more & apply! https://f.mtr.cool/jncxfqkuds

26.09.2025 13:53 — 👍 15    🔁 14    💬 0    📌 2

E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial monolayers by inducing ADAM-mediated ligand shedding Epithelial stretching promotes the release of EGF receptor ligands that stimulate ERK activation.

A bit delayed, but excited to still share our latest paper, showing that intercellular forces transduced by E-cadherin activate EGFR-ERK signaling in epithelia by inducing EGFR ligand shedding! Mechanical and biochemical signals can act together within a single, linear cascade! tinyurl.com/mr9mj9j2

13.09.2025 18:04 — 👍 69    🔁 25    💬 4    📌 0

Preprint alert!
We combined microfluidics, proteomics, and RNA-seq to map spatiotemporal protein expression during mouse somitogenesis and found a novel regulatory strategy: dynamic antagonistic gradients fine-tune signalling strength.

doi.org/10.1101/2025...

09.09.2025 16:05 — 👍 81    🔁 20    💬 3    📌 4

How do embryos ensure precise tissue patterning? It’s all about timing cell divisions! Our new preprint reveals how cell proliferation syncs with signaling oscillations to regulate precision of somite formation and growth. Check the full story: www.biorxiv.org/content/10.1...

11.03.2025 12:29 — 👍 68    🔁 16    💬 2    📌 1

I am really happy to announce the first Hubrecht Symposium on March 13th 2025! We will organize these yearly events on a specific topic in molecular and developmental biology to emphasize the importance of fundamental research for Dutch science. Free of charge! www.hubrecht.eu/hubrecht-sym...

29.11.2024 12:30 — 👍 44    🔁 18    💬 0    📌 2

Thanks!

25.11.2024 14:32 — 👍 1    🔁 0    💬 0    📌 0

Would be happy to join, thanks!

24.11.2024 09:11 — 👍 1    🔁 0    💬 0    📌 0

I'd be happy to join, thanks!

24.11.2024 09:10 — 👍 1    🔁 0    💬 1    📌 0