Life Metabolism

Original Article: Lysosomes contribute to the synthesis of TCA-related metabolites in the hippocampus url: academic.oup.com/lifemeta/art...

A functionally integrated cross-tissue alternative splicing program during short-term calorie restriction Abstract. Alternative splicing (AS) involves production of several different RNA molecules from a single pre-mRNA. Calorie restriction (CR) is a sustained

functionally integrated cross-tissue alternative splicing program during short-term calorie restriction url: academic.oup.com/lifemeta/art...

Special Issue: Inter-organ crosstalk url:https://academic.oup.com/lifemeta/pages/special-issue-inter-organ-crosstalk

Featured Articles Collection of 2025 url:https://academic.oup.com/lifemeta/pages/featured-articles-collection-of-2025

Volume 4 Issue 6 | Life Metabolism | Oxford Academic Life Metabolism aims to provide an open access platform for the publication of works of high significance and broad interest in all areas of metabolism

Latest issue now online.
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Cytosolic acetyl-CoA: a metabolic regulator of mitophagy Jianhua Xiong; Cytosolic acetyl-CoA: a metabolic regulator of mitophagy, Life Metabolism, , loag002, https://doi.org/10.1093/lifemeta/loag002

Cytosolic acetyl-CoA: a metabolic regulator of mitophagy url: academic.oup.com/lifemeta/art...

Timekeepers of the gut: host circadian rhythms and microbial modulators Abstract. The intestine is more than a digestive organ. It is a system under circadian control, where cellular renewal, barrier integrity, absorption, immu

Timekeepers of the gut: host circadian rhythms and microbial modulators url: academic.oup.com/lifemeta/art...

Gestational progesterone restores menstrual cycle in PCOS patients via enhancing ovary estrogen production Abstract. Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age, typically characterized by irregular mens

Gestational progesterone restores menstrual cycle in PCOS patients via enhancing ovary estrogen production url: academic.oup.com/lifemeta/art...

Predictive value of 1-hour postprandial SPARC levels on metabolic outcomes from mediterranean diet adherence: results from a randomized controlled feeding study url: academic.oup.com/lifemeta/art...

Urate metabolism, in the gut url: academic.oup.com/lifemeta/art...

P5CS-coupled proline metabolism manipulates metabolic dysfunction-associated steatotic liver disease url: academic.oup.com/lifemeta/art...

miR-378 as a metabolic-state-dependent switch controling liver autophagy and fat accumulation Emerging evidence reveals that dysregulated autophagy, particularly the selective degradation of lipid droplets (lipophagy), is crucial to maintaining hepatic lipid balance, yet how its activity is re...

miR-378 as a metabolic-state-dependent switch controling liver autophagy and fat accumulation | EurekAlert! www.eurekalert.org/news-release...

Propionic acid secreted by Akkermansia muciniphila alleviates hepatic fibrosis by antioxidant regulation across the gut−liver axis Abstract. The gut commensal bacterium Akkermansia muciniphila (AKK) has emerged as a candidate for treating liver disorders, yet its therapeutic potential

Propionic acid secreted by Akkermansia muciniphila alleviates hepatic fibrosis by antioxidant regulation across the gut−liver axis url: academic.oup.com/lifemeta/art...

Loss of liver GH signaling causes lean fatty liver A recent study published in Life Metabolism by Wu et al. from Dalian Medical University addresses this knowledge gap. The researchers developed a liver-specific Ghr knockout (...

Loss of liver GH signaling causes lean fatty liver | EurekAlert! www.eurekalert.org/news-release...

Aberrant miR-378 expression promotes hepatic lipid accumulation via hijacking the bile acid-regulated autophagy Abstract. Dysregulated autophagy contributes to liver steatosis, yet its regulation under distinct metabolic contexts remains poorly defined. Here, we iden

Aberrant miR-378 expression promotes hepatic lipid accumulation via hijacking the bile acid-regulated autophagy url: academic.oup.com/lifemeta/art...

Deletion of hepatic growth hormone receptor contributes to the pathogenesis of lean MAFLD by elevating CD36 Abstract. Metabolic dysfunction-associated fatty liver disease (MAFLD) has become the most prevalent chronic liver disease worldwide, affecting both obese

Deletion of hepatic growth hormone receptor contributes to the pathogenesis of lean MAFLD by elevating CD36 url: academic.oup.com/lifemeta/art...

A newly identified reductive uric acid pathway offers hope for gout A new study published in Life Metabolism reports an alternative “reductive pathway” that functions without oxygen. In this route, uric acid is first reduced to a newly identified meta...

A newly identified reductive uric acid pathway offers hope for gout | EurekAlert! www.eurekalert.org/news-release...

Well Met: RIPK1 senses S-adenosyl methionine to ensure cell survival url: academic.oup.com/lifemeta/art...

Review article by Dr. Lauren Palluth, Prof. Joseph S Takahashi and Prof. Carla B Green: Keeping up with the nicotinamides: NADP(H), the forgotten circadian cofactor that keeps metabolic time url: academic.oup.com/lifemeta/art...

The 13th Xiamen Winter Symposium on Lipid Metabolism and Physiology
January 15-18, 2026
Learn more: xws.xmu.edu.cn

A reductive uric acid degradation pathway in anaerobic bacteria Abstract. Uric acid (UA) is a key intermediate in purine degradation across diverse organisms, while its accumulation in humans leads to inflammation and g

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Weight loss benefits of Tirzepatide persist after stopping treatment in Chinese adults | EurekAlert! www.eurekalert.org/news-release...