Our latest preprint compares the dual-arm nanopore workflow with the respiratory metagenomics protocol currently implemented across the NHS, using clinical samples.
👉 www.researchsquare.com/article/rs-8...
@nhsmetagenomicsnet.bsky.social @lukebsnell.bsky.social @ronandoyle.bsky.social
We show no improvement in pathogen detection or genome recovery X10 with longer turnaround time and higher failure rates for the dual-arm approach.
Our latest preprint compares the dual-arm nanopore workflow with the respiratory metagenomics protocol currently implemented across the NHS, using clinical samples.
👉 www.researchsquare.com/article/rs-8...
@nhsmetagenomicsnet.bsky.social @lukebsnell.bsky.social @ronandoyle.bsky.social
Heroic effort by Luke Snell, Suzy Pickering and Rui Galao and many colleagues at KCL, clinical collaborators at GSTT and of course the individuals concerned, several of whom sadly passed away.
This is finally out.
Very short take home. All the variation in spike that produced the immune escape characteristics of Omicron can occur in one single persistently infected individual over the period of a year.
This is why persistent infections matter
www.cell.com/cell-reports...
📣 Foley et al assess #syphilis PCR & serology in >8K Australian patients
#Serology: still essential for first infections & reinfections
#PCR: limited add'l benefit in first infections; w/ serology can improve detection of reinfections
#IDSky #clinmicro #diagnosticstewardship
ow.ly/hh0M50Y5j50
Today marks the end of #WorldAMRAwarenessWeek! Over the last week on LinkedIn, we have been sharing how respiratory metagenomics supports smarter antimicrobial use and personalised care.
👉 Follow our LinkedIn page to find out more: www.linkedin.com/company/1095...
#AMR #WAAW25 #Metagenomics
As #WorldAMRAwarenessWeek wraps up, we share how respiratory metagenomics is transforming care.
Faster and accurate detection of pathogens help clinicians target treatment sooner and reduce unnecessary antibiotics, whilst improving personalised care and antimicrobial stewardship across the NHS.
💬 “Learn at scale, deliver at pace.”
At today’s Genomics Summit, Prof. Ian Abbs highlighted the NHS Respiratory Metagenomics Network as a great example of partnerships driving innovation & improving clinical practice.
📩 Let’s keep the conversation going!
#NHSGenomics2025 #Metagenomics #Genomics
What a year! From expanding to new sites, to celebrating publications and hosting our second annual network event, 2025 has been full of milestones for the network.
🎥 Press play to have a look back at some of what we have achieved this year!
#Metagenomics #LifeSciences
We are proud to be working collaboratively with multiple sites including hospitals and laboratories, across the UK, to help scale and advance respiratory metagenomic testing in the NHS.
👇 Check out our map below to see sites that are currently involved in the network.
#Metagenomics
This is what systematic racism looks like.
H3N2 subclade K dominating early flu season in UK. Emerged at end of the southern hemisphere flu season, varies from the J.2 subclade chosen for this year’s vaccination. Current vaccine still thought to offer protection so…
Get your flu Vax! #IDSky #vaccines
www.gavi.org/vaccineswork...
Our new preprint covering the improvements we made to our respiratory metagenomic assay is out now:
www.medrxiv.org/content/10.1...
✅ Now implemented in 6 NHS hospitals
✅ Increased sensitivity
✅ Increased pathogen genome coverage
(1/3)
Optimisation of whole cell human depletion provides increased sensitivity and microbial genome coverage from respiratory metagenomic assays https://www.medrxiv.org/content/10.1101/2025.10.10.25337716v1
Implementing rapid pan-microbial metagenomics in paediatric intensive care https://www.medrxiv.org/content/10.1101/2025.10.07.25337257v1
What if ICU doctors could diagnose infections in hours, not days?
A new test, developed from a PhD project at King's, now makes this possible.🔬
🔗 www.kcl.ac.uk/metagenomics...
New research article
Rapid pan-microbial metagenomics for pathogen detection and personalised therapy in the intensive care unit: a single-centre prospective observational study
www.thelancet.com/journals/lan...
#IDSky #ClinMicro #OpenAccess #OA
Rapid pan-microbial metagenomics for pathogen detection and personalised therapy in the intensive care unit: a single-centre prospective observational study - The Lancet Microbe www.thelancet.com/journals/lan...
Paracetamol remains an important option to treat pain or fever in pregnant women.
Following rigorous assessment of the available scientific data, we find no evidence that taking paracetamol during pregnancy causes autism in children.
Read more 👉 www.ema.europa.eu/en/news/use-...
El “Acuerdo de la Organización Mundial de la Salud sobre Pandemias” (20 de Mayo de 2025) establece un marco integral de acción ante pandemias, que incluye la prevención de zoonosis, la preparación de los sistemas de salud y la equidad en la respuesta.
jamanetwork.com/journals/jam...
Real-Time Genomic Surveillance for Enhanced Healthcare Outbreak Detection and Control: Clinical and Economic Impact
✅ Just Accepted
⭐ Editor's Choice
✍️ @sundermannaj.bsky.social
#IDSky
Antibody escape drives emergence of diverse spike haplotypes resembling variants of concern in persistent SARS-CoV-2 infections https://www.biorxiv.org/content/10.1101/2025.04.17.648944v1
Hi Phillipa, 👆🏼 the original method, and 👇🏼 the latest version. www.protocols.io/view/pan-mic...
The run starts at 9 and preliminary results are reported before 5pm same day. The pilot service paper from winter 23/24 coming soon!
Next speaker was Luke Blagdon Snell with Same-day pan-microbial metagenomics for personalized therapy and pathogen surveillance on the intensive care unit: a single-centre prospective study (escmid.reg.key4events.com/AbstractList...).
Robbie Hammond presented next with Implementing same-day respiratory metagenomic diagnostics in paediatric intensive care (escmid.reg.key4events.com/AbstractList...). Their method had a turnaround time of 6 hours.
New preprint!
We developed a fast method that allows the use of hybridization capture workflows with @nanoporetech.com without additional ligation-based steps!
We validated our method using targeted viral metagenomics @twistbioscience.com and Viral WGS @Agilent
www.medrxiv.org/content/10.1...
Join us at #ESCMID to discover how experts are utilising real-time Oxford Nanopore sequencing to deliver actionable insights into outbreak detection, pathogen identification, and AMR profiling faster than traditional methods. nanoporetech.com/about/events...
