Nicolas Vabret

Sign the Petition Support a New York State Biomedical Institute for a Healthier, More Affordable Future

📢 SIGN & SHARE THE PETITION! 📢

New York needs an Empire Biomedical Research Institute to create new statewide funding opportunities for scientists & physician-scientists so that patients and their families get the life-saving and life-changing new therapeutics they're hoping for ✏️ c.org/TDMy2H9JTW

When you have paylines that are that low (e.g. NCI R01: 4%), does it still make sense to discuss half of the applications?
It means < 10% of *discussed* applications will be actually funded.
Not that I am happy with any of this.

Check out our highlight of an exciting new preprint by Dr. Claudia Rivera from Dr. Yasmine Belkaid's group 👇

www.nature.com/articles/s41...

Interesting study from the ppl @solvingforsci.bsky.social. Very much in line with our earlier findings with @preprintclub.bsky.social (www.biorxiv.org/content/10.1...) :
1/ Reviewers can distinguish quality and impact (+novelty in our model)
2/ Trainees want to review
3/ Authors love the experience

Very exciting to finally see clinical data where viral mimicry provides survival benefits

Local activation of mutant RIG-I by short noncoding Y-RNA in the kidney triggers lethal nephritis Y-RNA activates RIG-I gain-of-function mutants in the kidney, causing lethal autoimmune diseases including lupus nephritis.

Short, noncoding YRNA can activate pathological variants of the innate sensor RIG-I, causing autoinflammation and #lupus nephritis in mouse models.

Learn more in #ScienceImmunology: https://scim.ag/43ewTiV

It was a great experience to present our latest work on cancer vaccines in front of an audience of TE experts

Proud of our Yu-Chan Chih for receiving the Trainee Innovation Idea Award for his work on cancer vaccination 👏🥇

Y RNAs getting some of the recognition they deserve

This is a fast moving field and new mechanisms are uncovered (almost) every week.

Check out our latest in @cp-trendscancer.bsky.social where rockstar PhD student @laurarosenberg.bsky.social reviews cancer therapies known to induce innate immune responses through the reactivation of Transposable Elements.

Check out our review on the role of #retroelements and #viralmimicry during cancer treatment! @neoviral.bsky.social

Trump Is Shutting Down the War On Cancer

America’s cancer research system is under threat in one of its most productive moments. www.nytimes.com/2025/09/14/m...

The Empire State can’t afford to fall behind. A group of scientists is launching NY-CURES to fight for state and city level investment in research.✊
📢 Sign up & show Albany we stand UNITED for science.
👉 www.nycures.org @miriammerad.bsky.social @bogunoviclab.bsky.social
#AdvocateForScience #NYCURES

🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀

Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.

Sign up. Stay informed. Join the movement: www.nycures.org/

Generation of Lipid Nanoparticle mRNA Vaccines and Evaluation of Antigen-Specific CD8+ T-Cell Responses mRNA vaccines have revolutionized vaccine development against infectious diseases, as demonstrated by the rapid creation and deployment of vaccines for SARS-CoV-2. In this chapter, we present a protoc...

Latest from us: we detail the protocol we use to generate mRNA-LNPs and to study immune response in preclinical setting.
link.springer.com/protocol/10....

Locus specific human endogenous retroviruses reveal lymphoma subtypes The heterogeneity of cancers is driven by diverse mechanisms underlying oncogenesis such as differential ‘cell-of-origin’ progenitors, mutagenesis, and viral infections. Classification of B-cell lymph...

Read about her work on HERV expression in B-cell lymphomas here 👇
www.cell.com/iscience/ful...

🎉 Congrats to student extraordinaire @bhavyasighs.bsky.social who earned a scholarship from #CIHR AND got a paper accepted in the same week!

Viral piracy of host RNA phosphatase DUSP11 by avipoxviruses Author summary Viruses face a critical challenge of disabling or avoiding host immune defenses. Cells typically recognize the presence of a virus through specific molecular markers, including triphosp...

Another nice example of a host-acquired gene in poxviruses, which modulates the host immune response.
dx.plos.org/10.1371/jour...

Exogenous RNA surveillance by proton-sensing TRIM25 Exogenous messenger RNAs (mRNAs) require cellular machinery for delivery and translation but also encounter inhibitory factors. To investigate their regulation, we performed genome-wide CRISPR screens...

www.science.org/doi/10.1126/...

More great content from @preprintclub.bsky.social @epelmanlab.bsky.social. This @biorxiv-immuno.bsky.social preprint from Liu et al. reports that resident tissue macrophages in the conventional outflow tract regulate intraocular pressure.

Scientists Say NIH Officials Told Them To Scrub mRNA References on Grants - KFF Health News Two senior scientists say National Institutes of Health officials advised them to remove references to mRNA vaccines in grant applications, and they fear the Trump administration will abandon a promis...

Scientists Say NIH Officials Told Them To Scrub mRNA References on Grants kffhealthnews.org/news/article...

NIH to ax grants on vaccine hesitancy, mRNA vaccines Move reflects vaccine skepticism of health secretary Robert F. Kennedy Jr.

NIH to ax grants on vaccine hesitancy, mRNA vaccines www.science.org/content/arti...

Who funds biomedical research? @nature.com
www.nature.com/articles/d41...

Absolutely stellar presentations by Brian Brown, Rafi Ahmed, Michel Sadelain and Craig Crews happening now for day 1 of our immunoschool.

NYC #standupforscience

Join us tomorrow, March 7th, at Washington Square Park!
US Science is under unprecedented attack. Science saves lives, drives innovation and progress. Stand Up for Science, Stand Up for America. #standupforscience2025