The American Journal of Pathology @ajpathology

Novel Kinesin Family 1A Variants Linked to Atypical Parkinsonism Elicit Altered Neuronal TDP-43 Interactions and Dendritic Atrophy.

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00204-4/fulltext

21.11.2025 07:08 — 👍 0 🔁 0 💬 0 📌 0

AJP (@ajpathology.bsky.social) is the flagship publication of ASIP, and this year marks 100 years of publishing! We encourage submission of research that address mechanisms of pathogenesis or provide a foundation for future mechanistic studies #OcularPathobiology

13.11.2025 10:50 — 👍 1 🔁 1 💬 0 📌 0

P-Glycoprotein Drives Glioblastoma Survival and Chemotherapy Resistance Drug resistance is a major challenge in cancer therapy, and the expression of efflux pumps such as P-glycoprotein (P-gp, ABCB1) often correlates with poor prognosis in various tumors, including glioblastoma (GB). Considering that different roles for these proteins have been established in the biology of various tumors, this study aimed to investigate the functions of P-gp in GB-derived cells by evaluating its survival, migratory, and apoptosis-regulating capabilities, as well as its potential...

P-Glycoprotein Drives Glioblastoma Survival and Chemotherapy Resistance: Potential as a Promising Liquid Biopsy Biomarker.

Full text: https://ajp.amjpathol.org/article/S0002-9440(24)00476-0/fulltext

19.11.2025 12:12 — 👍 0 🔁 0 💬 0 📌 0

Multiple Roles for Neuregulins and Their ERBB Receptors in Neurodegenerative Disease Pathogenesis and Therapy The role that neurotrophins, such as nerve growth factor, play in the pathogenesis of neurodegenerative diseases has long been appreciated. However, the neuregulin (NRG) family of growth factors and/or their v-erb-B2 avian erythroblastic leukemia viral oncogene homolog (ERBB) receptors have also been implicated in the pathogenesis of conditions, such as Alzheimer disease (AD), frontotemporal lobar degeneration (FTLD), and amyotrophic lateral sclerosis (ALS). In this review, we consider i) the...

#Neurodegenerative Theme Review: Multiple Roles for Neuregulins and their ERBB Receptors in Neurodegenerative Disease Pathogenesis and Therapy.

Free to read: https://ajp.amjpathol.org/article/S0002-9440(25)00119-1/fulltext

17.11.2025 09:07 — 👍 0 🔁 0 💬 0 📌 0

#ArticleinPress: Inactivation of Atp7b Copper Transporter in Intestinal Epithelial Cells Is Associated with Altered Lipid Processing and Cell Growth Machinery Independent from Hepatic Copper Accumulation and Severity of Liver Histology.

#OpenAccess text: https://loom.ly/DQjr5fI

17.11.2025 06:12 — 👍 0 🔁 0 💬 0 📌 0

Novel Perineural Pathways and the Dynamics of SIV-Infected Macrophage Trafficking Out of the Central Nervous System. Authors from @bostoncollege.bsky.social

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00325-6/fulltext

15.11.2025 06:02 — 👍 1 🔁 0 💬 0 📌 0

#ArticleinPress: Specialized Pro-Resolving Mediators MaR1 and LXA4 Resolve Inflammation During Acute Chemical Lung Injury in the Absence of Neutrophils. From @asipath.bsky.social member Bill Muller.

Full text: https://loom.ly/pCpWpvw

14.11.2025 12:57 — 👍 1 🔁 0 💬 0 📌 0

Shared Mechanisms of Blood-Brain Barrier Dysfunction and Neuroinflammation in Coronavirus Disease 2019 and Alzheimer Disease The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has highlighted the virus's impact on the central nervous system and its potential to exacerbate neurodegenerative diseases, like Alzheimer disease (AD). Emerging evidence suggests that SARS-CoV-2 infection contributes to chronic neuroinflammation, a key driver in the etiopathogenesis of AD. Shared mechanisms, including blood-brain barrier (BBB) dysfunction, systemic infla...

#Neurodegenerative Theme Review: Shared Mechanisms of Blood-Brain Barrier Dysfunction and Neuroinflammation in COVID-19 and Alzheimer’s Disease. Authors from @tulaneu.bsky.social

Free to read: https://ajp.amjpathol.org/article/S0002-9440(25)00118-X/fulltext

14.11.2025 06:21 — 👍 1 🔁 1 💬 0 📌 0

The Biological Intersection Between Chemotherapy-Related Cognitive Impairment and Alzheimer Disease Alzheimer disease (AD) is the most common type of dementia and one of the leading causes of death in elderly patients. The number of patients with AD in the United States is projected to double by 2060. Thus, understanding modifiable risk factors for AD is an urgent public health priority. In parallel with the number of patients with AD, the number of cancer survivors is estimated to increase significantly, and up to 80% of cancer patients treated with chemotherapy will develop cognitive defi...

#Neurodegenerative Theme Review: The Biological Intersection Between Chemotherapy-Related Cognitive Impairment and #AlzheimerDisease. @bcmhouston.bsky.social

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00026-4/fulltext

12.11.2025 06:43 — 👍 0 🔁 0 💬 0 📌 0

Interplay between Leptin and Stearoyl-CoA Desaturase 1 in Estrogen Receptor–Positive Breast Cancer Cells Obesity, a global health challenge, contributes to various cancers, including breast cancer. Complex metabolic dysregulation marks the development of both breast cancer and obesity. Here, the interpla...

Also read the related article: Interplay between Leptin and Stearoyl-CoA Desaturase 1 in Estrogen Receptor–Positive Breast Cancer Cells.

#OpenAccess text: ajp.amjpathol.org/article/S000...

10.11.2025 17:56 — 👍 0 🔁 0 💬 0 📌 0

Read the latest #PressRelease from @ajpathology.bsky.social and @elsevierconnect.bsky.social: New Study Elucidates Obesity’s Role in Fueling Breast Cancer Progression.

Full release: https://shorturl.at/dkGNS

10.11.2025 09:55 — 👍 1 🔁 1 💬 1 📌 0

#Neurodegenerative Theme Review: Brain Connectivity, Neural Networks, and Resilience in Aging and Neurodegeneration. From @asipath.bsky.social member Dr. Christi Kolarcik.

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00027-6/fulltext

10.11.2025 06:47 — 👍 2 🔁 0 💬 0 📌 0

Updates on tau-related drug targets and potential disease-modifying therapies for Alzheimer’s disease Alzheimer’s disease (AD) is a chronic multifactorial neurodegenerative disease affecting a large proportion of the elderly population with detrimental psychological and socioeconomic impacts. This review starts with a brief overview of the molecular aspects of AD. It aims to provide recent updates on several potential protein targets studied as valid therapeutic approaches such as Bassoon protein, triggering receptor expressed on myeloid cells 2 (TREM2), phosphorylated tau (chimeric molecules...

#Neurogedenerative Theme Issue: Updates on tau-related drug targets and potential disease-modifying therapies for Alzheimer’s disease. From @asipath.bsky.social Next- Gen Member Dr. Jessica Fortin and colleagues.

Full text: https://loom.ly/t67JpU8

07.11.2025 12:12 — 👍 1 🔁 1 💬 0 📌 0

Deadline extended!

The Spatial Pathobiology #callforpapers is still open. Submit your work by November 30th for inclusion in this upcoming theme issue.

https://www.editorialmanager.com/ajpa/default2.aspx

07.11.2025 06:33 — 👍 0 🔁 0 💬 0 📌 0

Recent Advances in Chronic Traumatic Encephalopathy Exposure to repeated head impacts (RHI), such as those experienced in contact sports or military service, can lead to the development of chronic traumatic encephalopathy (CTE), a neurodegenerative tauopathy. CTE cannot be diagnosed during life, only by post-mortem neuropathological exam. The pathognomonic lesion of CTE consists of a perivascular accumulation of hyperphosphorylated tau (p-tau) as neurofibrillary tangles and dotlike neurites, preferentially at the depths of cortical sulci. The ...

Recent Advances in Chronic Traumatic Encephalopathy. Authors from @bumedicine.bsky.social

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00295-0/fulltext

#Neurodegenerative Theme Review

06.11.2025 07:22 — 👍 0 🔁 0 💬 0 📌 0

Current Advancements in Digital Neuropathology and Machine Learning for the Study of Neurodegenerative Diseases Computational neurodegenerative neuropathology represents a transformative approach in the analysis and understanding of neurodegenerative diseases through utilization of whole slide images (WSIs) and advanced machine learning/artificial intelligence (ML/AI) techniques. This review explores the emerging field of computational neurodegenerative neuropathology, emphasizing its potential to enhance neuropathologic assessment, diagnosis, and research. Recent advancements in ML/AI technologies hav...

#Neurodegenerative Theme Review: Current Advancements in Digital Neuropathology and Machine Learning for the Study of Neurodegenerative Diseases.

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00046-X/fulltext

05.11.2025 07:06 — 👍 1 🔁 1 💬 0 📌 0

Exploring Vascular Contributions to Cognitive Impairment: Small vessel disease of white matter and micro/nanoplastics Cognitive impairment due to vascular pathology was recognized by Otto Binswanger in 1894, before Alois Alzheimer presented his findings in 1907. Vascular causes of cognitive impairment are likely due to a range of pathologies that are still, a hundred years later, unknown. Recent epidemiological evidence from post-mortem human brains report cases may be afflicted by Alzheimer’s disease, vascular disease or both. Although it is well-known that hypertension and diabetes affect vasculature throu...

Exploring Vascular Contributions to Cognitive Impairment: Small vessel disease of white matter and micro/nanoplastics. From @asipath.bsky.social member Elaine Bearer.

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00294-9/fulltext.

04.11.2025 06:15 — 👍 3 🔁 2 💬 0 📌 1

Genetically Engineered Mouse Models for Alzheimer Disease and Frontotemporal Dementia Neurodegenerative diseases, including Alzheimer disease, frontotemporal dementia, Parkinson disease, Huntington disease, and amyotrophic lateral sclerosis, are often casually linked to protein aggregation and inclusion. As the origins of those proteinopathies have been biochemically traced and genetically mapped, genetically engineered animal models carrying the specific mutations or variants are widely used for investigating the etiology of these diseases, as well as for testing potential th...

#Neurodegenerative Theme Review

Genetically Engineered Mouse Models for Alzheimer Disease and Frontotemporal Dementia: New Insights from Single-Cell and Spatial Transcriptomics. Authors from @keck.usc.edu

Full text: https://loom.ly/pWmHil0

03.11.2025 06:07 — 👍 0 🔁 0 💬 0 📌 0

#LegacyContent: Glucocorticoid Receptor Signaling Is Critical for Mouse Corneal Development, Inhibition of Inflammatory Response, and Neovascularization of the Cornea.

Free in the #OpenArchive: https://ajp.amjpathol.org/article/S0002-9440(24)00236-0/fulltext

31.10.2025 12:22 — 👍 2 🔁 1 💬 0 📌 0

DEADLINE EXTENDED!

Spatial Pathobiology #Callforpapers new deadline: November 30, 2025.

Submit your work today: https://www.editorialmanager.com/ajpa/default2.aspx

31.10.2025 09:06 — 👍 3 🔁 2 💬 0 📌 0

The November issue of AJP is now live! This is a special issue focused on neuropathology.

Full issue: https://ajp.amjpathol.org/issue/S0002-9440(24)X0012-7

On the cover: Astrocytes engaging with fibrillar amyloid in rTg-D HOM rats with cortical dyshoric vascular amyloid

30.10.2025 12:28 — 👍 2 🔁 0 💬 0 📌 0

Novel Perineural Pathways and the Dynamics of SIV-Infected Macrophage Trafficking Out of the Central Nervous System A challenge to eradicate HIV is the central nervous system (CNS) reservoir and unknown mechanisms-pathways by which infected macrophages can exit. We used intracisternal injection of superparamagnetic...

Also read the related article: Novel Perineural Pathways and the Dynamics of SIV-Infected Macrophage Trafficking Out of the Central Nervous System.

Full text: ajp.amjpathol.org/article/S000...

29.10.2025 20:34 — 👍 2 🔁 0 💬 0 📌 0

Read the latest #PressRelease from @ajpathology.bsky.social and @elsevierconnect.bsky.social: Researchers Identify Perineural Pathway That Fuels HIV Persistence Despite Treatment.

Full release: https://shorturl.at/x1kYh

29.10.2025 13:34 — 👍 2 🔁 1 💬 1 📌 0

Day two of #PISA2025 begins at 12:30 PM (ET)! Don't miss this special session with Dr. Evan Delgado (MUSC) and Dr. Bryan Wakefield (@uwmadison.bsky.social). Register for FREE here https://loom.ly/polGljk #CareerDevelopment #PathobiologyResearch

29.10.2025 05:04 — 👍 3 🔁 2 💬 0 📌 0

#LegacyContent: Caspase-1 Inhibition Ameliorates Photoreceptor Damage Following Retinal Detachment by Inhibiting Microglial Pyroptosis

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(24)00242-6/fulltext

29.10.2025 06:20 — 👍 1 🔁 0 💬 0 📌 0

#LegacyContent: Artificial Intelligence-Based Histopathological Subtyping of High-Grade Serous #OvarianCancer.

Free in the #OpenArchive: https://ajp.amjpathol.org/article/S0002-9440(24)00243-8/fulltext

28.10.2025 13:19 — 👍 1 🔁 0 💬 0 📌 0

#ArticleinPress: Intra-host genomic variation of Haemophilus influenzae isolates from asymptomatic nasopharyngeal carriers involves genes encoding proteins with diverse inferred functions.

#OpenAccess text: https://loom.ly/1s7mAIM

28.10.2025 06:24 — 👍 1 🔁 2 💬 0 📌 0

#LegacyContent: Sequential Patching Lattice for Image Classification and Enquiry: Streamlining Digital Pathology Image Processing. Authors from @mayoclinic.org.

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(24)00238-4/fulltext

27.10.2025 11:58 — 👍 2 🔁 1 💬 0 📌 0

miR-204-5p Mitigates Disc Degeneration via SKI-Mediated Modulation of Apoptotic Signaling and Matrix Remodeling in Nucleus Pulposus Dysregulation of nucleus pulposus cells (NPCs) is a critical contributor to intervertebral disc degeneration (IDD). One characteristic of degenerated discs is the increased apoptosis of NPCs and the substantial degradation of the extracellular matrix (ECM). This study identified significantly reduced miR-204-5p levels in IDD tissues. Using lipopolysaccharide (LPS)-treated rat NPCs, miR-204-5p overexpression was found to suppress apoptosis, reduce ECM degradation, and enhance ECM synthesis. Me...

miR-204-5p Mitigates Disc Degeneration via SKI-Mediated Modulation of Apoptotic Signaling and Matrix Remodeling in Nucleus Pulposus.

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00250-0/fulltext

27.10.2025 06:20 — 👍 1 🔁 0 💬 0 📌 0

#LegacyContent: The Role of Twist1 in Chronic Pancreatitis–Associated Pancreatic Stellate Cells. Authors from @cedarssinaicancer.bsky.social.

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(24)00234-7/fulltext

26.10.2025 10:02 — 👍 3 🔁 1 💬 0 📌 0

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