The American Journal of Pathology @ajpathology

Interplay between Leptin and Stearoyl-CoA Desaturase 1 in Estrogen Receptor–Positive Breast Cancer Cells Obesity, a global health challenge, contributes to various cancers, including breast cancer. Complex metabolic dysregulation marks the development of both breast cancer and obesity. Here, the interpla...

Also read the related article: Interplay between Leptin and Stearoyl-CoA Desaturase 1 in Estrogen Receptor–Positive Breast Cancer Cells.

#OpenAccess text: ajp.amjpathol.org/article/S000...

10.11.2025 17:56 — 👍 0 🔁 0 💬 0 📌 0

Read the latest #PressRelease from @ajpathology.bsky.social and @elsevierconnect.bsky.social: New Study Elucidates Obesity’s Role in Fueling Breast Cancer Progression.

Full release: https://shorturl.at/dkGNS

10.11.2025 09:55 — 👍 1 🔁 1 💬 1 📌 0

#Neurodegenerative Theme Review: Brain Connectivity, Neural Networks, and Resilience in Aging and Neurodegeneration. From @asipath.bsky.social member Dr. Christi Kolarcik.

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00027-6/fulltext

10.11.2025 06:47 — 👍 1 🔁 0 💬 0 📌 0

Updates on tau-related drug targets and potential disease-modifying therapies for Alzheimer’s disease Alzheimer’s disease (AD) is a chronic multifactorial neurodegenerative disease affecting a large proportion of the elderly population with detrimental psychological and socioeconomic impacts. This review starts with a brief overview of the molecular aspects of AD. It aims to provide recent updates on several potential protein targets studied as valid therapeutic approaches such as Bassoon protein, triggering receptor expressed on myeloid cells 2 (TREM2), phosphorylated tau (chimeric molecules...

#Neurogedenerative Theme Issue: Updates on tau-related drug targets and potential disease-modifying therapies for Alzheimer’s disease. From @asipath.bsky.social Next- Gen Member Dr. Jessica Fortin and colleagues.

Full text: https://loom.ly/t67JpU8

07.11.2025 12:12 — 👍 0 🔁 1 💬 0 📌 0

Deadline extended!

The Spatial Pathobiology #callforpapers is still open. Submit your work by November 30th for inclusion in this upcoming theme issue.

https://www.editorialmanager.com/ajpa/default2.aspx

07.11.2025 06:33 — 👍 0 🔁 0 💬 0 📌 0

Recent Advances in Chronic Traumatic Encephalopathy Exposure to repeated head impacts (RHI), such as those experienced in contact sports or military service, can lead to the development of chronic traumatic encephalopathy (CTE), a neurodegenerative tauopathy. CTE cannot be diagnosed during life, only by post-mortem neuropathological exam. The pathognomonic lesion of CTE consists of a perivascular accumulation of hyperphosphorylated tau (p-tau) as neurofibrillary tangles and dotlike neurites, preferentially at the depths of cortical sulci. The ...

Recent Advances in Chronic Traumatic Encephalopathy. Authors from @bumedicine.bsky.social

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00295-0/fulltext

#Neurodegenerative Theme Review

06.11.2025 07:22 — 👍 0 🔁 0 💬 0 📌 0

Current Advancements in Digital Neuropathology and Machine Learning for the Study of Neurodegenerative Diseases Computational neurodegenerative neuropathology represents a transformative approach in the analysis and understanding of neurodegenerative diseases through utilization of whole slide images (WSIs) and advanced machine learning/artificial intelligence (ML/AI) techniques. This review explores the emerging field of computational neurodegenerative neuropathology, emphasizing its potential to enhance neuropathologic assessment, diagnosis, and research. Recent advancements in ML/AI technologies hav...

#Neurodegenerative Theme Review: Current Advancements in Digital Neuropathology and Machine Learning for the Study of Neurodegenerative Diseases.

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00046-X/fulltext

05.11.2025 07:06 — 👍 1 🔁 1 💬 0 📌 0

Exploring Vascular Contributions to Cognitive Impairment: Small vessel disease of white matter and micro/nanoplastics Cognitive impairment due to vascular pathology was recognized by Otto Binswanger in 1894, before Alois Alzheimer presented his findings in 1907. Vascular causes of cognitive impairment are likely due to a range of pathologies that are still, a hundred years later, unknown. Recent epidemiological evidence from post-mortem human brains report cases may be afflicted by Alzheimer’s disease, vascular disease or both. Although it is well-known that hypertension and diabetes affect vasculature throu...

Exploring Vascular Contributions to Cognitive Impairment: Small vessel disease of white matter and micro/nanoplastics. From @asipath.bsky.social member Elaine Bearer.

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00294-9/fulltext.

04.11.2025 06:15 — 👍 3 🔁 2 💬 0 📌 1

Genetically Engineered Mouse Models for Alzheimer Disease and Frontotemporal Dementia Neurodegenerative diseases, including Alzheimer disease, frontotemporal dementia, Parkinson disease, Huntington disease, and amyotrophic lateral sclerosis, are often casually linked to protein aggregation and inclusion. As the origins of those proteinopathies have been biochemically traced and genetically mapped, genetically engineered animal models carrying the specific mutations or variants are widely used for investigating the etiology of these diseases, as well as for testing potential th...

#Neurodegenerative Theme Review

Genetically Engineered Mouse Models for Alzheimer Disease and Frontotemporal Dementia: New Insights from Single-Cell and Spatial Transcriptomics. Authors from @keck.usc.edu

Full text: https://loom.ly/pWmHil0

03.11.2025 06:07 — 👍 0 🔁 0 💬 0 📌 0

#LegacyContent: Glucocorticoid Receptor Signaling Is Critical for Mouse Corneal Development, Inhibition of Inflammatory Response, and Neovascularization of the Cornea.

Free in the #OpenArchive: https://ajp.amjpathol.org/article/S0002-9440(24)00236-0/fulltext

31.10.2025 12:22 — 👍 2 🔁 1 💬 0 📌 0

DEADLINE EXTENDED!

Spatial Pathobiology #Callforpapers new deadline: November 30, 2025.

Submit your work today: https://www.editorialmanager.com/ajpa/default2.aspx

31.10.2025 09:06 — 👍 3 🔁 2 💬 0 📌 0

The November issue of AJP is now live! This is a special issue focused on neuropathology.

Full issue: https://ajp.amjpathol.org/issue/S0002-9440(24)X0012-7

On the cover: Astrocytes engaging with fibrillar amyloid in rTg-D HOM rats with cortical dyshoric vascular amyloid

30.10.2025 12:28 — 👍 2 🔁 0 💬 0 📌 0

Novel Perineural Pathways and the Dynamics of SIV-Infected Macrophage Trafficking Out of the Central Nervous System A challenge to eradicate HIV is the central nervous system (CNS) reservoir and unknown mechanisms-pathways by which infected macrophages can exit. We used intracisternal injection of superparamagnetic...

Also read the related article: Novel Perineural Pathways and the Dynamics of SIV-Infected Macrophage Trafficking Out of the Central Nervous System.

Full text: ajp.amjpathol.org/article/S000...

29.10.2025 20:34 — 👍 2 🔁 0 💬 0 📌 0

Read the latest #PressRelease from @ajpathology.bsky.social and @elsevierconnect.bsky.social: Researchers Identify Perineural Pathway That Fuels HIV Persistence Despite Treatment.

Full release: https://shorturl.at/x1kYh

29.10.2025 13:34 — 👍 2 🔁 1 💬 1 📌 0

Day two of #PISA2025 begins at 12:30 PM (ET)! Don't miss this special session with Dr. Evan Delgado (MUSC) and Dr. Bryan Wakefield (@uwmadison.bsky.social). Register for FREE here https://loom.ly/polGljk #CareerDevelopment #PathobiologyResearch

29.10.2025 05:04 — 👍 3 🔁 2 💬 0 📌 0

#LegacyContent: Caspase-1 Inhibition Ameliorates Photoreceptor Damage Following Retinal Detachment by Inhibiting Microglial Pyroptosis

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(24)00242-6/fulltext

29.10.2025 06:20 — 👍 1 🔁 0 💬 0 📌 0

#LegacyContent: Artificial Intelligence-Based Histopathological Subtyping of High-Grade Serous #OvarianCancer.

Free in the #OpenArchive: https://ajp.amjpathol.org/article/S0002-9440(24)00243-8/fulltext

28.10.2025 13:19 — 👍 1 🔁 0 💬 0 📌 0

#ArticleinPress: Intra-host genomic variation of Haemophilus influenzae isolates from asymptomatic nasopharyngeal carriers involves genes encoding proteins with diverse inferred functions.

#OpenAccess text: https://loom.ly/1s7mAIM

28.10.2025 06:24 — 👍 1 🔁 2 💬 0 📌 0

#LegacyContent: Sequential Patching Lattice for Image Classification and Enquiry: Streamlining Digital Pathology Image Processing. Authors from @mayoclinic.org.

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(24)00238-4/fulltext

27.10.2025 11:58 — 👍 2 🔁 1 💬 0 📌 0

miR-204-5p Mitigates Disc Degeneration via SKI-Mediated Modulation of Apoptotic Signaling and Matrix Remodeling in Nucleus Pulposus Dysregulation of nucleus pulposus cells (NPCs) is a critical contributor to intervertebral disc degeneration (IDD). One characteristic of degenerated discs is the increased apoptosis of NPCs and the substantial degradation of the extracellular matrix (ECM). This study identified significantly reduced miR-204-5p levels in IDD tissues. Using lipopolysaccharide (LPS)-treated rat NPCs, miR-204-5p overexpression was found to suppress apoptosis, reduce ECM degradation, and enhance ECM synthesis. Me...

miR-204-5p Mitigates Disc Degeneration via SKI-Mediated Modulation of Apoptotic Signaling and Matrix Remodeling in Nucleus Pulposus.

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00250-0/fulltext

27.10.2025 06:20 — 👍 1 🔁 0 💬 0 📌 0

#LegacyContent: The Role of Twist1 in Chronic Pancreatitis–Associated Pancreatic Stellate Cells. Authors from @cedarssinaicancer.bsky.social.

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(24)00234-7/fulltext

26.10.2025 10:02 — 👍 3 🔁 1 💬 0 📌 0

#LegacyContent: Lactate Contributes to RIPC–Mediated Protection Against Myocardial Ischemia Reperfusion Injury by Facilitating Autophagy via the AMP-Activated Protein Kinase–Mammalian Target of Rapamycin–Transcription Factor EB–Connexin 43 Axis.

https://loom.ly/4ofKbWc

25.10.2025 09:45 — 👍 1 🔁 0 💬 0 📌 0

#ArticleinPress: Hepatocyte-Specific MET Deletion Exacerbates Acetaminophen-Induced Hepatotoxicity in Mice.

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00367-0/fulltext

24.10.2025 12:31 — 👍 1 🔁 0 💬 0 📌 0

Emerging Insights into Protein Post-Translational Modifications in Chlamydia-Host Interactions

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00246-9/fulltext

24.10.2025 09:08 — 👍 1 🔁 0 💬 0 📌 0

#LegacyContent: Single-Nucleus RNA Sequencing Reveals Loss of Distal Convoluted Tubule 1 Renal Tubules in HIV Viral Protein R Transgenic Mice.

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(24)00237-2/fulltext

24.10.2025 06:34 — 👍 2 🔁 1 💬 0 📌 0

#ArticleinPress: Targeting RORγ to Boost Regulatory T cells and Ameliorate Diabetic Retinopathy in Mice. Authors from @unimelb.bsky.social.

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00363-3/abstract

23.10.2025 12:31 — 👍 2 🔁 1 💬 0 📌 0

#LegacyContent: Cardiac Atrophy, Dysfunction, and Metabolic Impairments: A Cancer-Induced Cardiomyopathy Phenotype. @dalhousie.bsky.social

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(24)00241-4/fulltext

23.10.2025 10:55 — 👍 1 🔁 0 💬 0 📌 0

Specialized pro-resolving mediators MaR1 and LXA4 resolve inflammation during acute chemical lung injury in the absence of neutrophils Gastric aspiration pneumonia involves chemical injury to the alveoli of the lungs with inflammation, tissue damage, and recruitment of polymorphonuclear leukocytes (PMNs). PMNs are also known to be in...

In press now in @ajpathology.bsky.social from a friend of the NVI Lab, congrats Maureen! Can’t wait to hear more about your work at Univ. of Colorado!

17.10.2025 14:35 — 👍 4 🔁 3 💬 0 📌 0

NSUN5 Mediates Resistance to Doxorubicin via Upregulation of DNA Damage Repair Proteins BRCA2 and BRIP1 in Colorectal Cancer Despite advancements in diagnosis and therapy, chemotherapy resistance and metastasis remain significant challenges for colorectal cancer (CRC) patients. Addressing resistance to cell death is crucial for improving cancer treatment outcomes. NOP2/Sun RNA methyltransferase 5 (NSUN5) has been implicated in cancers, but its role in chemotherapy resistance in CRC remains unclear. This study revealed that NSUN5 was highly expressed in CRC through bioinformatics analysis and validation with local c...

NSUN5 Mediates Resistance to Doxorubicin via Upregulation of DNA Damage Repair Proteins BRCA2 and BRIP1 in Colorectal Cancer.

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00252-4/fulltext

22.10.2025 12:09 — 👍 1 🔁 0 💬 0 📌 0

Hyperactivation of TAK1 causes skeletal muscle pathology reminiscent of inflammatory myopathies Loss of skeletal muscle mass and strength is a debilitating consequence of various chronic diseases, inflammatory myopathies, and neuromuscular disorders. Inflammation plays a major role in the perpetuation of myopathy in degenerative muscle diseases. TGF-β-activated kinase 1 (TAK1) is a major signaling protein that mediates the activation of multiple signaling pathways in response to inflammatory cytokines and microbial products. Recent studies have demonstrated that TAK1 is essential for th...

Hyperactivation of TAK1 causes skeletal muscle pathology reminiscent of inflammatory myopathies.

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00249-4/fulltext

20.10.2025 06:20 — 👍 2 🔁 1 💬 0 📌 0

The American Journal of Pathology

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