The American Journal of Pathology

Targeting Skeletal Muscle in #DuchenneMuscularDystrophy: Integrating in Silico and Experimental Approaches to Sodium-Glucose Cotransporter-2 Inhibition. @ualberta.bsky.social

#OpenAccess text: https://loom.ly/M2rbNQk

The March issue of @ajpathology.bsky.social is now live!

Full issue: https://ajp.amjpathol.org/issue/S0002-9440(25)X0005-5

On the cover: Immunostaining of the small intestine of a Angptl4KO lethal mouse

YAP and TEAD Are Transcriptional Regulators of Neuroendocrine Differentiation and Growth in Carcinoid Cells

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00411-0/fulltext

#LegacyContent: Improving Colorectal Cancer Screening and Risk Assessment through Predictive Modeling on Medical Images and Records.

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00380-3/fulltext

Improving Colorectal Cancer Screening and Risk Assessment through Predictive Modeling on Medical Images and Records.

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00380-3/fulltext

#ArticleinPress: Peroxisome Proliferator-Activated Receptor α Deficiency Induces Vascular Pathologies through Endothelial Senescence in Diabetic Retinopathy

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00466-3/fulltext

#ArticleinPress: Neonatal Thymic Dynamics Influence Autoimmune Pathology by Shaping the Suppressive Potential of Regulatory T Cells

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00467-5/fulltext

Specialized Pro-Resolving Mediators MaR1 and LXA4 Resolve Inflammation During Acute Chemical Lung Injury in the Absence of Neutrophils. From @asipath.bsky.social member Bill Muller.

Full text: https://loom.ly/pCpWpvw

Programmed Death Ligand-1 in Melanoma and Extracellular Vesicles Promotes Local and Regional Immune Suppression through M2-like Macrophage Polarization Tumor-associated macrophages (TAMs) play dual roles (both pro- and antitumor) in tumor progression. TAMs induce programmed death ligand-1 (PD-L1) expression in cancer cells. However, the regulatory ef...

#LegacyContent: Programmed Death Ligand-1 in Melanoma and Extracellular Vesicles Promotes Local and Regional Immune Suppression through M2-like Macrophage Polarization.

#OpenArchive: ajp.amjpathol.org/article/S000...

PathViT: Automated Disease Classification from Skeletal Muscle Histopathology.

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00408-0/fulltext

Read the latest #PressRelease from AJP and @elsevierconnect.bsky.social: Study Finds Lack of Angptl4 Gene Triggers Long-Term Protection Against Inflammatory Bowel Disease by Reprogramming the Immune System

Full release: https://rb.gy/rklsnf

Intra-host genomic variation of Haemophilus influenzae isolates from asymptomatic nasopharyngeal carriers involves genes encoding proteins with diverse inferred functions.

#OpenAccess text: https://loom.ly/1s7mAIM

#LegacyContent: Multi-Class Segmentation Network Based on Tumor Tissue in Endometrial Cancer Pathology Images: ECMTrans-net

Free in the #OpenArchive: https://ajp.amjpathol.org/article/S0002-9440(24)00400-0/fulltext

Hepatocyte-Specific MET Deletion Exacerbates Acetaminophen-Induced Hepatotoxicity in Mice.

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00367-0/fulltext

Segmental Regulation of Intestinal Motility by Colitis and the Adaptive Immune System in the Mouse Ileum and Colon Gastrointestinal motility disturbances are a hallmark of inflammatory bowel disease (IBD); however, their mechanisms remain unclear. This study used a dextran sulfate sodium–induced colitis mouse mode...

#LegacyContent: Segmental Regulation of Intestinal Motility by #Colitis and the Adaptive Immune System in the Mouse Ileum and Colon.

ajp.amjpathol.org/article/S000...

Silencing Ubiquitin-Specific Peptidase 10 Alleviates Persistent Corneal Epithelial Defect in Mice. Authors from @upstate-vision.bsky.social

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00405-5/fulltext

Targeting RORγ to Boost Regulatory T cells and Ameliorate Diabetic Retinopathy in Mice. Authors from @unimelb.bsky.social.

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00363-3/abstract

The D2.B10-Dmdmdx/J mouse model of DMD exhibits a severe mitochondrial deficiency not observed in the C57BL/10ScSn-Dmdmdx/J mouse

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00362-1/fulltext

#ArticleinPress: Emerging Mechanistic Roles of STING Signaling in Kidney Diseases

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00442-0/fulltext

#ArticleinPress: Mechanistic Insights into Glucocorticoid-Induced Ocular Hypertension Using Differences in Mouse Strain Responsiveness.

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00440-7/fulltext

#ArticleinPress: Systemic Disease Progression and Neurodegeneration in the Gbe1ys/ys Mouse Model of Glycogen Storage Disease Type IV. Authors from @dukehealth.bsky.social.

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00437-7/fulltext

#ArticleinPress: DNA Methyltransferase 3A–Dependent Suppression of Hypoxia-Inducible Factor-1α Alleviates Myopia by Reducing Scleral Ferroptosis and Fibroblast Extracellular Matrix Remodeling

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00441-9/fulltext

Periostin deletion reduces corneal opacity and the infiltration of immune cells.

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00364-5/fulltext

Sphingosine Kinase 2 Controls the Aggressive Phenotype of Oral Squamous Cell Carcinoma by Regulating miR-205 and miR-296 through p53 Alterations in miRNAs, p53, and sphingolipid metabolism are associated with head and neck squamous cell carcinoma (HNSCC). However, the role of sphingosine kinase (SK)-2, an enzyme crucial for sphingo...

#LegacyContent: Sphingosine Kinase 2 Controls the Aggressive Phenotype of Oral Squamous Cell Carcinoma by Regulating miR-205 and miR-296 through p53. Authors from University of São Paulo.

Free in the #OpenArchive: ajp.amjpathol.org/article/S000...

The February issue of @ajpathology.bsky.social is up now!

Full issue: https://ajp.amjpathol.org/issue/S0002-9440(25)X0004-3

On the cover: LysM+ leukocytes overcome CD31 (PECAM) blockade after PGE2 treatment.

Prostaglandin E2 Signaling Triggers CD31-Independent Transendothelial Migration in Vitro and in Vivo. From authors at @nufeinbergmed.bsky.social and @uhn.ca

Full text: https://loom.ly/pItFdx0

#ArticleinPress: Iron and Bile Acids Synergize to Exacerbate Congenital Cholestatic Liver Injury via Ferroptosis

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00439-0/fulltext

#ArticleinPress: Delayed Bone Fracture Healing in Hybid (Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization)–Deficient Mice.

#OpenAccess text: https://ajp.amjpathol.org/article/S0002-9440(25)00438-9/fulltext

One more day!

Tomorrow is the deadline for submission of your mechanistic advances in #Ocularpathobiology for our current #callforpapers.

Submit your work for consideration: https://www.editorialmanager.com/ajpa/default2.aspx

The Sugar-Coated Truth of Alcohol-Associated Liver Disease: Galectins as Multifaceted Regulators of Alcohol-Induced Liver Injury. Authors from @emorydeptofmed.bsky.social.

Full text: https://ajp.amjpathol.org/article/S0002-9440(25)00302-5/fulltext