Jon Brudvig

YouTube video by Felix Harder We Finally Know How To Detox Microplastics From Our Cells

It was fun to see Felix Harder break down my #microplastics experiments on YouTube 🧪:

www.youtube.com/watch?v=JZaJ...

I'm working on a follow up post now, with a science update and protocol insights. Stay tuned!

Original post on Substack:
jonbrudvig.substack.com/p/first-evid...

I take that as a major compliment!

In other words, metformin isn't just a glucose-lowering drug—it's a top-down rewiring agent for gut nutrient sensing and hormone modulation, which likely underlies the benefits observed across so many organ systems. 🧪

🧩 Together, these studies reinforce a clear effect on the gut–brain axis: metformin activates AMPK in enteroendocrine cells, restoring their ability to sense nutrient status and secrete hormones that shift metabolism in a positive direction. 🧪

🧬 Study #2 (Diabetes, July 2025):
In high-fat-fed rats, met restored lipid sensing in the upper intestine, triggering release of the gut hormone GIP.

• A chronic high-fat diet blocks GIP secretion in response to feeding. Metformin relieves this blockage, restoring nutrient sensing and satiety. 🧪

🔬 Study #1 (Lancet eBioMedicine, July 2025):
Longitudinal plasma proteomics in ~100 humans before and after met revealed 23 consistently altered proteins.

Top hits are signatures of the enteroendocrine cells that produce GLP-1 and GIP, reinforcing that these are the key cellular targets. 🧪

We’ve known for a while now that metformin doesn’t act primarily in the liver or mitochondria as was once believed. Instead, it concentrates in the gut, where it activates a cellular stress response.

Now, two new studies show exactly how this local response ripples outward to benefit metabolism. 🧪

Metformin doesn’t just lower glucose; it teaches your gut how to sense nutrients again. Two new papers show exactly how this works, and why it matters. 💊🧪💊

Broken down in this thread.
#Longevity #Aging #Healthspan

It means that they didn't let all of the mice age out long enough to die of "natural" causes. That would have been even better, but would have also delayed the publication. Hopefully someone will replicate with a full lifespan study.

Life is Shorter Than You Think. Don’t Miss Your Bonus Chapter.

My new full-length post is a simple inquiry into the true impact of lifestyle interventions, with simple, striking visuals that reframe the entire question.

jonbrudvig.substack.com/p/life-is-sh...

#Longevity #Healthspan #Aging 🧪

Most clinical studies have tested 10, 20, or 25 mg. For depression at least, the effects are dose dependent, with the strongest benefit at 25mg.

Not medical advice, of course

Psilocybin extends lifespan in mice. But this is bigger than just a new geroprotective drug; it suggests an entirely new drug target—and it probably isn't the one you think. 🧪🧠🧪

substack.com/profile/1091...

#longevity #psychedelics #psilocybin

First Evidence of Microplastic Mobilization in a Human Subject – A Self-Experiment I mobilized millions of microplastics in my blood using a simple supplement protocol. Could this be the key to clearing them from our bodies?

In case you missed it, my last Substack post summarizes the #microplastics problem for human health and shares some encouraging initial experiments into a clearance protocol.

This one has generated a LOT of great discussion. Next steps are in the works! 🧪

jonbrudvig.substack.com/p/first-evid...

Plasma proteomics links brain and immune system aging with healthspan and longevity - Nature Medicine In a large-scale proteomic study of biological aging of 11 organs from 44,498 individuals in the UK Biobank, the biological ages of the brain and immune system emerged as strong predictors of healthsp...

The newest paper is open access. You should be able to read it here:

www.nature.com/articles/s41...

Lifestyle as Medicine: The Case for a True Health Initiative - PubMed The power of lifestyle as medicine was perceived thousands of years ago. There is now consistent and compelling science to support the important influence of lifestyle on health. Approximately 80% of ...

That may be true for cancer, but more broadly, an estimated 80% of chronic disease is preventable.

pubmed.ncbi.nlm.nih.gov/28523941/

Plasma proteomics links brain and immune system aging with healthspan and longevity - Nature Medicine In a large-scale proteomic study of biological aging of 11 organs from 44,498 individuals in the UK Biobank, the biological ages of the brain and immune system emerged as strong predictors of healthsp...

Sources 🧪:

New 2025 Organ Age Study from Wyss-Coray Group:
www.nature.com/articles/s41...

2023 Organ Age Study from Wyss-Coray Group:
www.nature.com/articles/s41...

Time Magazine Piece on Organ Aging Clocks and Brain Aging:
time.com/7301118/brai...

Another Clock:
www.nature.com/articles/s41...

This organ aging test will add a real, data-driven layer of personalization to longevity care and even mainstream medicine. It’s exactly the kind of tool we need to move next-generation preventative care from theory to practice. 🧪

Or maybe you’re three months into your new exercise program and want to assess the impact. If the test shows that you’ve decreased your brain age by three years, along with significant benefits across several other organ systems, that might be the inspiration you need to stay on track. 🧪

If your brain is aging faster than the rest of your body, it may be time to cut alcohol and commit to regular exercise. If your brain is aging slowly but your gut is aging quickly, cleaning up your diet might be the most important place to start (Yes, you should still exercise). 🧪

How will it be used?

As a diagnostic tool to identify disease risk years before symptoms appear and as a feedback tool to track intervention impact in real time.

Want to know where to focus your health efforts? Take the test. 🧪

The rate of aging for each organ can be measured with a simple blood test. 🩸🧪🩸

Vero is bringing this test to the masses—first to select longevity and concierge clinics by the end of the year, and eventually direct-to-consumer. You can sign up for early access at verobioscience.com.

New research from the Wyss-Coray group confirms this idea, showing that organs do indeed age at different rates in a cohort of 40,000+ people. Perhaps more importantly, accelerated organ aging is linked to increased disease risk and earlier mortality. 🧪

First, the scientific premise. Your organs don't all age at the same rate. This might seem intuitive—you’ve seen some people develop Alzheimer’s (brain disease) in old age, while others develop atrial fibrillation (heart disease) or kidney disease. 🧪

What if a quick blood test could tell you how fast each of your organs are aging? 🧪🩸🧪

That’s the promise of Vero Bioscience, a new startup commercializing the organ-specific aging test developed by the Wyss-Coray group at Stanford.

Broken down in this thread.

#Longevity #Aging

Nanoplastic concentrations across the North Atlantic - Nature Observations from 12 hydrocast stations along a transect crossing the North Atlantic from the subtropical gyre to the northern European shelf provide evidence of large amounts of nanoplastics througho...

Given our ever-growing reliance on single-use plastics, this problem is poised to accelerate.

We need the #microplastics equivalent of the Clean Air Act or the Paris Climate Accord. There are realistic, economically feasible solutions to this very real problem.

www.nature.com/articles/s41...

These nanoscale particles aren’t just abundant; they’re bioavailable, entering marine life, contaminating our food supply, and accumulating in human tissues. Early evidence links them to immune dysfunction, cardiovascular disease, dementia, and other health risks we’re only beginning to understand.🧪

A diver surrounded by plastic garbage.

This changes the scale of the #microplastics crisis.
We’ve known about the 3 million tonnes (MT) of floating plastic in our oceans for years. But that’s just the surface. In the North Atlantic alone, 27 MT (9x!) of nanoplastics are suspended in the water column. 🧪

www.nature.com/articles/d41...

Nonuniversality of inflammaging across human populations - Nature Aging Analyzing readouts of inflammaging across four cohorts, Franck and colleagues identify strong variation and observe that inflammaging, in its known form, primarily emerges in industrialized—but not no...

In other words, #inflammaging is environmental, and that makes it modifiable. #Longevity interventions targeting this hallmark of aging could make a large impact in industrialized nations. 🧪

📰 Full (paywalled) study: www.nature.com/articles/s43...

This is a clear demonstration that inflammaging is not a universal biological process; It is the result of environmental mismatch. Our immune systems evolved in one world but are now reacting to another—one with sedentary lifestyles, ultra-processed foods, chronic stress, and low pathogen exposure.🧪

Despite frequent infections, the Tsimane and Orang Asli showed no increase in cytokine-driven inflammation with age. And despite persistently elevated infection-driven inflammation, they exhibit virtually no chronic disease, a pattern also observed in other Indigenous societies around the world. 🧪