Sigrid Trägenap

Homeostasis of a representational map in the neocortex - Nature Neuroscience This study investigates how homeostatic mechanisms endow sensory representations in the auditory cortex with resilience against neuron loss. The map of sounds has the ability to recover after microablation by recruiting previously unresponsive neurons.

www.nature.com/articles/s41...

Homeostasis of a representational map in auditory cortex
- so not always stable, depending on the lost neurons, but latent is recoverable

@j-b-eppler.bsky.social

Does your research involve comparing experimental conditions? Then our latest publication is for you: We developed generalized contrastive PCA (gcPCA), a tool for comparing high-dimensional datasets. 🧠📊 doi.org/10.1371/journal.pcbi.1012747
This tool was born out of necessity, here is the story. 🧵
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We are happy to join the Bluesky community! 🦋

Many of our members and friends are already here. We'll continue to bring you #CompNeuro news and opportunities also on this platform.

Help us spread the word and follow us! 💙

I will be presenting in the Worldwide Theoretical Neuroscience Seminar on Wednesday, February 19, at 11 AM ET / 5 PM CET. My talk is titled "Representational drift reflects ongoing balancing of stochastic changes by Hebbian learning."

More information and register for the link at www.wwtns.online.

Subcortically generated movements activate motor cortex during sleep and wake in rats through postnatal day 24 During early postnatal development, cortical motor control emerges from complex interactions between cortical and subcortical circuits. In primary motor cortex (M1), we know that this process depends ...

First paper out of my lab is on bioRxiv! First, a super clickbait-y description.

We stuck an electrode in a rat pup’s primary motor cortex and recorded lots of spikes. You’ll never guess what happened next…

www.biorxiv.org/content/10.1...

Spontaneous activity in brain development!

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Experienced representations are not fully explained by a spontaneous initialization/scaffold, more like a compromise with sensory inputs. However, a critically initialized network with amplifiable, noise-reducing, long-time-scale modes provides a good and flexible starting point for learning!

Experience drives the development of novel, reliable cortical sensory representations from endogenously structured networks Cortical circuits embody remarkably reliable neural representations of sensory stimuli that are critical for perception and action. The fundamental structure of these network representations is though...

When starting this project, we had a similar hypothesis! t1p.de/h5q9r, the final + updated version should be published in ~weeks. Turns out, initial sensory representations (when an animal starts to see) show little overlap with spontaneous dynamics.

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Advent of Comp Neuro ALERT!! 🎄🤖🧠🧪

This advent season I will be posting some papers in Computational and Systems Neuro that I think are *underrated* and deserve some more attention! ✨

Stay tuned not to miss any!

#neuroskyence #neuro #advent