Happy to see our work on defining a dependency map of short linear motifs out. We use base editing screens to install more than 80000 mutations into SLiMs in more than 4000 proteins to determine their contribution to cell fitness. www.nature.com/articles/s41...
Finally out! Thrilled to share our collaboration with @kulathu.bsky.social, @orafurman.bsky.social, and N Davey. We screened auxiliary domains of USP family #deubiquitinases, revealing short linear motifs (SLiMs), contributing to specificity in complex assembly.
www.biorxiv.org/content/10.1...
IDPSeminas is back again TOMORROW!
Talks from Lucia Strader (@luciastrader.bsky.social) and Heather Meyer! Sign up at idpseminars.com.
Talks start at 1 pm EST / 7 PM CET!! Come learn about transcriptional adaptation and IDRs as environmental sensors and accuators!
US science after a year of Trump
"More than 7,800 research grants terminated or frozen. Some 25,000 scientists and personnel gone from agencies that oversee research." via @nature.com
Dark Age 2.0
Very much looking forward to the next PMC seminar, featring Benjamin Turk and Giorgia Massacci: www.proteinmodules.org/online-semin...
Not sure if Trump getting the Nobel Prize medal from Machado is more embarrassing for Trump, Machado, the Norwegian Nobel Committee, or the USA as a country.
This is such hard news to process. Such an amazing scientist and inspiration for so many of us.
www.embl.org/news/embl-an...
Very much looking forward to the next PMC seminar, featring Benjamin Turk and Giorgia Massacci: www.proteinmodules.org/online-semin...
Engineered base editors with reduced bystander editing through directed evolution - @geochurch.bsky.social @harvardmed.bsky.social @wyssinstitute.bsky.social go.nature.com/4qmupbv
It was fabulous to see everyone in Uppsala!
Last week, we wrapped up our Volkswagen Foundation–funded project with a wonderful final meeting in Uppsala, hosted by Ylva Ivarsson’s group. The photo shows members of our lab together with colleagues from the groups of @ivarssonlab.bsky.social , @hlouchova-lab.bsky.social and Florian Hollfelder.
Don't forget to catch out last seminar of the year on Monday Dec 8!
New paper “Proteome-wide model for human disease genetics” is now live at Nature Genetics: rdcu.be/eRu7K
popEVE (pop.evemodel.org) finds the needles in the haystacks of human genetic variation:
Major new direction in the lab: hacking human cell biology with pathogen effectors (eORFs) - amazing collaboration with @miketilapia.bsky.social lab. Huge congrats to first authors Tomas & He & all co-authors! Check out the pre-print on @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
957 proposals were submitted in the latest round of ERC Synergy applications. They expect to fund 50 which means around 5% success rate. This is really not sustainable and a lot of people are likely avoiding doing this knowing how poor the chances are.
erc.europa.eu/news-events/...
profaff.fr
The new ProfAff database is up and running. Although there are still many things to improve, it is a major upgrade.
I have a PhD opening in my lab for an exiting project using base editor screens to find novel drug targets. Please help spread the word. candidate.hr-manager.net/ApplicationI...
Catch our next seminar on November 10 at 3pm CET! You'll see presentations from Prof. Gideon Schreiber (@weizmanninstitute.bsky.social) and Alessandro Lussana (@alussana.bsky.social).
Register to attend: tinyurl.com/PMCseminar2
Recordings of previous seminars: www.youtube.com/@PMCModularity
🚨🚨🚨
Two super well-funded PhD grants from our MSCA Doctoral Network @evomg-dn.bsky.social at our lab at @melisupf.bsky.social, @crg.eu and the @evomg-bcn.bsky.social Program.
If you're excited about evolution, genomics and biomedical research, this is your DN! 😃
Further info: www.evomg-dn.eu and 👇
new preprint: Ubiquitin is a protein modification linked with degradation but known to regulate other functions. Over 100k ubiquitination sites have been discovered and here we (@julianvangerwen.bsky.social + others) try to prioritize those most critical to the cell www.biorxiv.org/content/10.1...
Don't forget to catch out next seminar on October 13 at 3pm CEST!
Can't wait to see you all there!!
Never thought I would say this, but I need a Dane.. novonordiskfonden.dk/grant/postdo...
Fabulous work by Aimiliani Konstantinou, together with three other #UBIMOTIF members Alicia Córdova-Pérez, Julia K. Varga & Maximilian Vieler. #CYLD, #USP7, #USP11, #USP20, #USP22, #USP33
Finally out! Thrilled to share our collaboration with @kulathu.bsky.social, @orafurman.bsky.social, and N Davey. We screened auxiliary domains of USP family #deubiquitinases, revealing short linear motifs (SLiMs), contributing to specificity in complex assembly.
www.biorxiv.org/content/10.1...
Cool project with the Pless lab on disease-associated variants in a membrane protein, NALCN, that needs to be in complex to function. Most of our computational work was done by PhD student Aleks Panfilova.
Tune in to our next seminar on October 13 at 3pm CEST! We’ll hear from Dr. Cris Viéitez (@crisvieitez.bsky.social) and Dr. Patrick Brunner (@humboldtuni.bsky.social).
Register to attend: tinyurl.com/PMCseminar2
Recordings of previous seminars: www.youtube.com/@PMCModularity
To protein designers (and others)
The Dept of Chemistry, Lund University & the Wallenberg Initiative for Materials Science for Sustainability is looking for an Assoc Senior Lecturer/Assist Professor in Biomolecular materials with a focus on de novo design and synthesis
lu.varbi.com/en/what:job/...
We are back with an exciting seminar on September 8 at 3pm CEST! We’ll hear from Prof. Birthe Kragelund and Maximilian Vieler (@uu.se).
Register to attend:
tinyurl.com/PMCseminar2
Recordings of previous seminars: www.youtube.com/@PMCModularity
