Ylva Ivarsson

We’re looking for curious, innovative science leaders at EMBL Heidelberg! 🔬🧬🦠

Join a vibrant, interdisciplinary community where collaboration and innovation are nurtured at all levels.

Take a look at these four open positions 👇

PhD student in Biochemistry - Uppsala University PhD student in Biochemistry, Disciplinary Domain of Science and Technology, Faculty of Chemistry, Department of Chemistry - BMC, Uppsala University

We are looking for a PhD student in (mostly )wet-lab biochemistry to work on short linear motifs, intrinsically disordered regions, in the context of the Marie Curie network "IDPro". More info an apply here: www.uu.se/en/about-uu/...

Predicting the protein interaction landscape of a free-living bacterium with pooled-AlphaFold3 https://www.biorxiv.org/content/10.1101/2025.07.01.662654v1

And of course, we could not have done this without NIH funding that has been critical for supporting my students’ training and my career, and for giving us the resources to shed light on some aspects of the molecular basis of human diseases.

Variant characterization in the intrinsically disordered human proteome Variant effect prediction remains a key challenge to resolve in precision medicine. Sophisticated computational models that exploit sequence conservation and structure are increasingly successful in t...

Variant characterization in the intrinsically disordered human proteome - here is how we did it using short linear motif prediction, AlphaFold, and experimentation. Check out our preprint: www.biorxiv.org/cgi/content/...

.. more information about the IDPro network here: idpro.elte.hu

Do you have experience in mechanistic modelling of biological systems and want to do a postdoc with an interdisciplinary team on developing Digital Twins for rare disease? We have the job for you! Check it out below - deadline July 13th, online interviews 24th July.

PhD student in Biochemistry - Uppsala University PhD student in Biochemistry, Disciplinary Domain of Science and Technology, Faculty of Chemistry, Department of Chemistry - BMC, Uppsala University

We are looking for a PhD student in (mostly )wet-lab biochemistry to work on short linear motifs, intrinsically disordered regions, in the context of the Marie Curie network "IDPro". More info an apply here: www.uu.se/en/about-uu/...

A major KI initiative to recruit new assistant professors with outstanding proposals in all areas of medicine, biomedicine and public health. We offer an amazing research environment, great colleagues and generous startup packages. Check it out and get working on your applications! (repost please!)

It's June 20 in New Zealand, which means it's the last day to have your abstract considered for oral presentations at the IUBMB Focussed Meeting on kinases and pseudokinases!

Sequence-based prediction of condensate composition reveals that specificity can emerge from multivalent interactions among disordered regions https://www.biorxiv.org/content/10.1101/2025.06.13.659429v1

Characterizing protein sequence determinants of nuclear condensates by high-throughput pooled imaging with CondenSeq Nature Methods - CondenSeq is an imaging-based, high-throughput platform for characterizing condensate formation within the nuclear environment, uncovering the protein sequence features that...

In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput approach to measure nuclear condensate formation, and applied it to ~14,000 IDPs to find out!

rdcu.be/eq975

“The search is on for 25 researchers from around the world in Lund University’s largest ever international recruitment drive. The main focus will be on AI research and other areas in which the University has a strategic focus.”

www.lunduniversity.lu.se/article/lund...

AlphaFold models of host-pathogen interactions elucidate the prevalence and structural modes of molecular mimicry Pathogens exploit host cellular machinery through protein-protein interactions (PPIs), often using molecular mimicry to hijack host cellular processes. While there have been thousands of host-pathogen...

New lab preprint - Delora Baptista tested AlphaFold 2 and 3 for the prediction of structures of host-pathogen interactions and then applied these to study convergence of binding and molecular mimicry in host-pathogen vs. host-host interactions.
www.biorxiv.org/content/10.1...

"Journal name : POSITIF JOURNAL - we can publish papers of all subjects." Very positive indeed.

TIME CHANGE - Because of a public holiday, we have moved the next seminar to Monday June 16 at 3pm CET. Tune in to hear from Dr. Lucía Chemes (@unsamoficial.bsky.social) and Julian van Gerwen (@julianvangerwen.bsky.social).

Register to attend:
tinyurl.com/PMCseminar2

(1/2)

Sarah Shammas (University of Oxford):Opportunities in DNA binding provided by protein disorder Sonia Longhi (AFMB Marseille): Intrinsic disorder, phase transitions and fibril formation by the Henipavirus V and W proteins: a new hallmark of viral pathogenesis?

IDPSeminars is back with another seminar this week from @sarahshammas.bsky.social and @sonia-longhi.bsky.social!

Come hear about transcriptional regulation and viral pathogenesis!

Thursday June 5th!
PST 10 am EST 1 pm CET 7 pm!

Info: idpseminars.com
Signup form: forms.gle/3yCHeYvuuqLh...

When you ask ChatGTP for advices on what not to do you get honest advices 😂 "Avoid becoming a dean or high-level university administrator, it could reduce the ability to do research and publish. While these roles bring influence, they often pull scientists away from the bench and their networks."

Tiselius Symposium 28 August 2025, Uppsala

Happy to announce the 2025 Tiselius symposium in Uppsala, August 28. Excellent line up of speakers including Lori Passmore @lapassmore.bsky.social, Katja Luck @katjaluck.bsky.social, Markku Varjosalo @varjosal.bsky.social and Arne Elofsson. No fee & short talk slots available tiseliussymposium.org

The genetic architecture of an allosteric hormone receptor Many proteins function as switches, detecting chemicals and transducing their concentrations into cellular responses. Receptor switches are key to the integration of environmental signals, yet it is n...

1 plant hormone receptor ☘️
3,500 mutants, to single-site saturation 🧬
>45,000 binding and abundance measurements 📶

Very happy to present our latest work – where deep mutational scanning meets the world of small molecules.



www.biorxiv.org/content/10.1...



With @benlehner.bsky.social

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FIMM-EMBL Group Leaders in Molecular Medicine FIMM-EMBL Group Leaders in Molecular Medicine

We have 2-3 group leader positions opening @fimm-uh.bsky.social !!

We are looking for outstanding candidates in human genetics and precision medicine.

This time we have a focus on population health data science. E.g. AI for EHR/health data       

Generous starting package 💰

shorturl.at/FAk6n

Defining short linear motif binding determinants by phage display‐based deep mutational scanning Deep mutational scanning (DMS) has emerged as a powerful approach for evaluating the effects of mutations on binding or function. Here, we developed a DMS by phage display protocol to define the spec....

onlinelibrary.wiley.com/doi/10.1002/...

With less than a month to submit abstracts for the
@iubmb.bsky.social Focussed Meeting on (pseudo)Kinases in stunning Queenstown, we are delighted to announce travel scholarships for selected ECRs thanks to @biologists.bsky.social and the Maurice and Phyllis Trust! www.ivvy.com.au/event/IUBMB25/

@ivarssonlab.bsky.social at #VariantEffect25

Join us at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute.bsky.social) and Dr. Jesús Alvardo Valverde (@jesusav.bsky.social).

Register to attend:
tinyurl.com/PMCseminar2
(1/2)

Fabulous day with PhD defense of Dr Konstantinou. Many thanks to the examination committee, the faculty opponent, the #ubimotif #ETN network. Congratulations to the new PhD! Her first first author paper is now online and the second will follow soon. biologydirect.biomedcentral.com/articles/10....

Come and join us! We’re hiring a new Group Leader in Generative Biology at the @sangerinstitute.bsky.social

Building AI models or the data to train them?

Core funding of >$130M a year for a faculty of ~30.

www.nature.com/naturecareer...

acrobat.adobe.com/id/urn:aaid:...

pls RT!

Elucidation of short linear motif-based interactions of the MIT and rhodanese domains of the ubiquitin-specific protease 8 - Biology Direct Ubiquitin-specific protease 8 (USP8) is a deubiquitinating enzyme with essential functions in protein trafficking and stability. It is a multidomain protein, with an N-terminal MIT (microtubule intera...

We uncover that the #USP8 rhodanese domain is a #peptide binding module that binds short linear motifs in potential substrates: biologydirect.biomedcentral.com/articles/10....

We will put forward a 500 million package for 2025-2027 to make Europe a magnet for researchers.

As well as ambitious proposals for R&I in the next EU budget.

We will also offer the best and brightest the right incentives to come to Europe ↓