Ari Caroline

Successful programming is like evolution by RNA transcription error crossed with Bob Ross. Happy Little Accidents that become features.

Looks like they’ve got it right now.

Think this was a manual intervention due to the social media attention?

Rewiring, Not Retiring: Health and Innovation for the Vanguard Generation - TimmermanReport.com Most of my columns tend to focus on the importance and difficulty of applying emerging technologies to biopharma R&D, aiming to accelerate the delivery of impactful medicines to patients.  Yet, as lon...

Rewiring, Not Retiring: For the "Vanguard Generation" (50+), hitting fifty isn't an inflection point-it's full steam ahead. They grew up w tech-enabled agency & expect products, services tailored for their reality - an underappreciated opportunity. My latest: timmermanreport.com/2025/02/rewi...

“For the biopharma-focused readers of TR, the Open Evidence example serves as a vivid reminder that things don’t change — until they suddenly do.”

AI health-care startup OpenEvidence raises funding from Sequoia at $1 billion valuation The new $75 million cash injection values OpenEvidence at $1 billion, the two companies told CNBC.

Woah - just saw this about latest raise from AI health unicorn (apparently), Open Evidence (h/t Matthew Holt): www.cnbc.com/2025/02/19/a... . My recent Timmerman Report on this topic -> timmermanreport.com/2024/10/and-...

Did BSW and/or FDP surpass the 5% threshold?

What is he playing on? Desktop? Game system with controller?

Is this new?? I was definitely not expecting to hear this from Kennedy. But having a dedicated, sizable budget for replication studies and new standards for printing null/negative studies both, shockingly, sound like really good, fundamental science!

(Thanks for the great coverage, Sarah!)

I’m with you. Doesn’t get more obvious than this. We just need to get folks accustomed.

YouTube video by Andrew Vickers Robin Vickers Batzdorf 2022 Spiders Highlights

Showing off for you, Andrew! m.youtube.com/watch?v=wR3b...

Go Robin!

Really, Sally?? What alternative visualizations do they find more intuitive than these?

+1

Interesting.

It also seems like high nitric oxide levels in the grapes themselves could directly trigger NO-modulated vasodilation which, in turn, would trigger the headaches. Any non-metabolized acetaldehyde would significantly exacerbate the effect. But NO could be a more direct mechanism.

I sometimes forget how flexible proteins are. It becomes really apparent when you use NMR states for an animation. That poor cofactor is getting pushed around a lot 😅

#sciart #blender3d #biocatalysis

Would LC + mass spec be overkill to quantify levels of quercetin molecules in different wines? @seamus.bsky.social , ready for a new project?

I’m quite certain, btw, that we’d find elevated quercetin levels in scotch (particularly Islay) as well. Bourbon, otoh, is completely fine for me.

Inhibition of ALDH2 by quercetin glucuronide suggests a new hypothesis to explain red wine headaches - Scientific Reports Scientific Reports - Inhibition of ALDH2 by quercetin glucuronide suggests a new hypothesis to explain red wine headaches

For those of us who have been suffering with red wine headaches for years and years, this study offers potential validation.

We all knew it wasn’t the sulfites!

Now I just need a study confirming that Merlot grapes are absolutely laced with quercetin glucuronide…

www.nature.com/articles/s41...

And… they lost again.

Dammit @seanmcarroll.bsky.social

I had resolved to limit this new bluesky account to medicine, science, machine learning and complexity.

“Let me see who Sean Carroll is following…”

I’m now following 3 different Sixers reporters. :/