Andres Floto

🎥 Professor @andresfloto.bsky.social
on new funding from: @wellcometrust.bsky.social @gatesfoundation.bsky.social @novonordisk.bsky.social and how VPD-HLRI research is helping reshape antibiotic discovery in the fight against antimicrobial resistance.

Read more:
🔗 bit.ly/4rJy6c2

Defining Permissive Chemical Space in Klebsiella pneumoniae Andres Floto with Vitor Mendes, David Spring, Aaron Weimann, Sebastian Bruchmann, and José Miguel Hernández Lobato of the University of Cambridge in the United Kingdom will experimentally define the f...

Many congratulations to @andresfloto.bsky.social and team for their success in the @gatesfoundation.bsky.social @wellcometrust.bsky.social Novo Nordisk Foundation Grand Challenge for Innovations in Gram negative antibiotic discovery:
gcgh.grandchallenges.org/grant/defini...

A paper in Nature Microbiology presents Antimicrobial Single-Cell Testing, a large-scale live-cell imaging approach that quantifies bacterial killing in real time at single-cell resolution, which can predict treatment outcomes. go.nature.com/3Nwnez8 #microsky 🧪

Bacteria can control what enters their cells, balancing energy and blocking antibiotics.

New study in @natmicrobiol.nature.com uncovers this hidden mechanism of drug resistance: buff.ly/s3YIwyK

@andresfloto.bsky.social @vpd-hlri.bsky.social @unibas.ch

Metabolic control of porin permeability influences antibiotic resistance in Escherichia coli - Nature Microbiology The permeability of bacterial porins is dynamically regulated by periplasmic proton and potassium concentrations, altering antibiotic resistance.

#NewResearch

The permeability of bacterial porins is dynamically regulated by periplasmic proton and potassium concentrations, altering antibiotic resistance.

#MicroSky #AMR 🦠 @andresfloto.bsky.social

www.nature.com/articles/s41...

We're seeking 2️⃣ research associates to join Professor
@andresfloto.bsky.social's lab @vpd-hlri.bsky.social. You'll be part of a multidisciplinary team exploring antibiotic uptake, efflux & metabolism across multiple bacterial pathogens.

Apply before 27 October: buff.ly/SqfTX3A

Thank you. Could I have the sarcasm mug please? VPD Heart and Lung Researxh Institute, Papworth Road. cambridge Biomedical Research Centre Cambridge UK CB2 0BB

Read our #DMMEditorsChoice highlight on the Research Article by Laetitia Pinte, @martavilagonz.bsky.social, @jamesnathanlab.bsky.social, @andresfloto.bsky.social, @pcicuta.bsky.social, @vallierlab.bsky.social and colleagues.

doi.org/10.1242/dmm....

A contextualised protein language model reveals the functional syntax of bacterial evolution Bacteria have evolved a vast diversity of functions and behaviours which are currently incompletely understood and poorly predicted from DNA sequence alone. To understand the syntax of bacterial evolu...

New pre-print up introducing our bacterial protein language model Bacformer, creating a unified representation of entire bacterial genomes led by @macwiatrak.bsky.social www.biorxiv.org/content/10.1...

Check out Maciek's tweetorial for Bacformer with links to code, tutorials and blog post:
bsky.app/profile/macw...

💥 Excited to introduce Bacformer 🦠 - the first foundation model for bacterial genomics. Bacformer represents genomes as sequences of ordered proteins, learning the “grammar” of how genes are arranged, interact and evolve.

Preprint 📝: biorxiv.org/content/10.1...

🧵 1/n

New project led by Professor @andresfloto.bsky.social‬ and Dr Sundeep Chaitanya Vedithi at @cam.ac.uk‬ has received £1.2m funding from @ukri.org‬ to develop point-of-care DNA sequencing for rapid detection of #AMR in leprosy across the Philippines.

Read more: buff.ly/9UYWUBR

@vpd-hlri.bsky.social‬

Postdoctoral Research Associate (Fixed Term) - Job Opportunities - University of Cambridge Postdoctoral Research Associate (Fixed Term) in the Department of Medicine at the University of Cambridge.

One week left to join @andresfloto.bsky.social‬ 's team as a Postdoctoral Research Associate to develop new antibiotics against mycobacteria using permeability-enabled fragment-based #DrugDiscovery.

This 2-year fixed-term position is based in @cambridgebrc.bsky.social‬

🧬Apply by 12 June:

PhD Studentship - University of Cambridge PhD Studentship - Understanding chemical permeability and metabolism in gram-negative organisms in the Department of Medicine at the University of Cambridge.

📢 Few days left to apply for our PhD studentship at @vpd-hlri.bsky.social 📢

Our 3-year programme supervised by @andresfloto.bsky.social explores chemical permeability and metabolism using #ML #GenAI to guide antibiotic drug discovery.

Apply by 15 April➡️ buff.ly/9oCo4ZJ

Opinion: AI can transform health and medicine AI has the potential to transform health and medicine. It won't be straightforward, but if we get it right, the benefits could be enormous. Andres Floto, Mihaela van der Schaar and Eoin McKinney expla...

Hear more from our Professor Eoin McKinney, @andresfloto.bsky.social & Mihaela van der Schaar on how we're unleashing the full potential of AI in health and medicine, and how Cambridge Centre for AI in Medicine puts us in the perfect position to be leaders in the field⬇️

cam.ac.uk/opinion-ai-a...

Exciting PhD studentship opportunity in @andresfloto.bsky.social lab on understanding chemical permeability to advance antibiotic drug discovery www.jobs.cam.ac.uk/job/50800/. Combines experimental approaches with in silico screening and generative AI.

#ICYMI: In a Science study, researchers present “Evo”—a #MachineLearning model capable of decoding and designing DNA, RNA, and protein sequences, from molecular to genome scale, with unparalleled accuracy.

Learn more: scim.ag/41bmK6u