Syed A Ahmad, MD

Adjuvant Chemotherapy After Resection of Pancreatic Adenocarcinoma Following Preoperative FOLFIRINOX This cohort study investigates the association of adjuvant chemotherapy following resection of pancreatic adenocarcinoma after preoperative FOLFIRINOX in full or modified dosing with overall survival,...

Adjuvant Chemotherapy After Resection of Localized Pancreatic Adenocarcinoma Following Preoperative FOLFIRINOX ⁦‪@JAMAOnc‬⁩ ⁦‪@MarcBesselink‬⁩

jamanetwork.com/journals/jam...

The role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography–derived parameters as prognostic factors in patients undergoing resection for pancreatic ductal adenocarcinoma The aim of this study is to investigate the role of maximum standardized uptake and tumor-to-liver ratio derived from preoperative 18F-fluorodeoxyglucose positron emission tomography/computed tomograp...

The role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography–derived parameters as prognostic factors in patients undergoing resection for pancreatic ductal adenocarcinoma ⁦‪@SurgJournal‬⁩

www.surgjournal.com/article/S003...

Prognostic significance of the cachexia index for patients with perihilar cholangiocarcinoma The prognostic value of the preoperative cachexia index for patients with perihilar cholangiocarcinoma remains unclear.

Prognostic significance of the cachexia index for patients with perihilar cholangiocarcinoma ⁦‪@SurgJournal‬⁩

www.surgjournal.com/article/S003...

Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) of Extraperitoneal Abdominal Disease, is it Appropriate? - Annals of Surgical Oncology Introduction Cytoreductive surgery-hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) candidates often have extraperitoneal abdominal disease. Current expert peritoneal surface malignancy (PSM) gui...

Cytoreductive Surgery with Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) of Extraperitoneal Abdominal Disease, is it Appropriate? ⁦‪@AnnSurgOncol‬⁩

link.springer.com/article/10.1...

Diagnostic Certainty in Characterizing Liver Lesions in Rectal Cancer: Abbreviated Liver MRI versus CT - Annals of Surgical Oncology Background Early diagnosis of metastases is crucial but routine staging with contrast-enhanced multidetector computed tomography (ceMDCT) is suboptimal. A total of 20% will have indeterminate or too s...

Diagnostic Certainty in Characterizing Liver Lesions in Rectal Cancer: Abbreviated Liver MRI versus CT ⁦‪@AnnSurgOncol‬⁩

link.springer.com/article/10.1...

Significance of Tumor Microvasculature in the Tumor Microenvironment in Adenocarcinoma with EGFR Common Mutations - Annals of Surgical Oncology Background Tumor microvasculature is an important component of the tumor microenvironment (TME), and it has been reported that tumor microvasculature induces TME to become immunosuppressive via vascul...

Significance of Tumor Microvasculature in the Tumor Microenvironment in Adenocarcinoma with EGFR Common Mutations ⁦‪@AnnSurgOncol‬⁩

link.springer.com/article/10.1...

Assessing Endoscopic Response in Locally Advanced Rectal Cancer Treated with Total Neoadjuvant Therapy: Development and Validation of a Highly Accurate Convolutional Neural Network ⁦‪@AnnSurgOncol‬⁩

link.springer.com/article/10.1...

Technical Guidelines for Safe Mesojejunum Dissection During Pancreaticoduodenectomy: Unveiling Critical Techniques in a Complex Procedure - Annals of Surgical Oncology Background Pancreaticoduodenectomy (PD) is a complex procedure involving the dissection of the superior mesenteric artery and vein. However, a safe and standardized technique for dissecting the jejuna...

Technical Guidelines for Safe Mesojejunum Dissection During Pancreaticoduodenectomy: Unveiling Critical Techniques in a Complex Procedure ⁦‪@AnnSurgOncol‬⁩

link.springer.com/article/10.1...

Abuse potential and analgesic efficacy of intravenous hydromorphone bolus administration among hospitalized patients with cancer pain: A double‐blind, double dummy, randomized crossover trial Slow intravenous (iv) hydromorphone infusion resulted in similar abuse liability potential and pain improvement but less sedation than fast injection. These findings, taken together, suggest that the...

Abuse potential and analgesic efficacy of intravenous hydromorphone bolus administration among hospitalized patients with cancer pain: A double‐blind, double dummy, randomized crossover trial ⁦‪@JournalCancer‬⁩

acsjournals.onlinelibrary.wiley.com/doi/10.1002/...

Inter-rater variability for the American Society of Anesthesiologists classification in patients undergoing hepato-pancreato-biliary surgery (MILESTONE-2): international survey among surgeons and anae... This is an international survey and case-vignette study including 1283 participants from 55 countries. Interrater variability regarding the ASA classificat

Inter-rater variability for the American Society of Anesthesiologists classification in patients undergoing hepato-pancreato-biliary surgery (MILESTONE-2): international survey among surgeons and anaesthesiologists ⁦‪@BJSurgery‬⁩

academic.oup.com/bjsopen/arti...

Impact of pre-compression versus non-compression before parenchyma transection in left-sided pancreatic resection on the rate of clinically relevant pancreatic fistula: multicentre randomized clinical... This RCT investigated whether parenchymal pre-compression was effective in reducing pancreatic fistula in distal pancreatectomy. The proportion of patients

Impact of pre-compression versus non-compression before parenchyma transection in left-sided pancreatic resection on the rate of clinically relevant pancreatic fistula: multicentre randomized clinical trial ⁦‪@BJSurgery‬⁩

academic.oup.com/bjs/article-...

Intra- and Interpatient Drug Response Heterogeneity Exist in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Nongynecologic Cancers - Annals of Surgical Onc... Background Select patients with peritoneal metastases are treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). We assayed for intra- and interpatient drug resp...

Intra- and Interpatient Drug Response Heterogeneity Exist in Patients Undergoing Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Nongynecologic Cancers ⁦‪@AnnSurgOncol‬⁩

link.springer.com/article/10.1...

Preoperative Frailty and Malnutrition in Surgical Oncology Patients Predicts Higher Postoperative Adverse Events and Worse Survival: Results of a Blinded, Prospective Trial - Annals of Surgical Oncolo... Background Frailty, a multidimensional state leading to reduced physiologic reserve, is associated with worse postoperative outcomes. Despite the availability of various frailty tools, surgeons often ...

Preoperative Frailty and Malnutrition in Surgical Oncology Patients Predicts Higher Postoperative Adverse Events and Worse Survival: Results of a Blinded, Prospective Trial ⁦‪@AnnSurgOncol‬⁩

link.springer.com/article/10.1...

Time to Surgery Does Not Affect the Survival Outcome in Patients with Perihilar Cholangiocarcinoma - Annals of Surgical Oncology Background The impact of time to surgery (TTS) on survival in patients with perihilar cholangiocarcinoma (PHC) is uncertain. Methods Data from PHC patients scheduled for surgery between 2011 and 2020 ...

Time to Surgery Does Not Affect the Survival Outcome in Patients with Perihilar Cholangiocarcinoma ⁦‪@AnnSurgOncol‬⁩

link.springer.com/article/10.1...

Ancestral Differences in Anticancer Treatment Efficacy and Their Underlying Genomic and Molecular Alterations ⁦‪@CD_AACR‬⁩

aacrjournals.org/cancerdiscov...

Bismuth Corlette Classification of Hilar Cholangiocarcinoma.

Ongoing replication stress tolerance and clonal T cell responses distinguish liver and lung recurrence and outcomes in pancreatic cancer - Nature Cancer Sears and colleagues found that ongoing replication stress pathways and T cell clonal responses differentiate liver and lung recurrence and are associated with different clinical outcomes in the conte...

Ongoing replication stress tolerance and clonal T cell responses distinguish liver and lung recurrence and outcomes in pancreatic cancer ⁦‪@NatureCancer‬⁩

www.nature.com/articles/s43...

The Evolutionary Forest of Pancreatic Cancer ⁦‪@CD_AACR‬⁩

aacrjournals.org/cancerdiscov...

The Evolutionary Forest of Pancreatic Cancer ⁦‪@CD_AACR‬⁩

aacrjournals.org/cancerdiscov...

Nationwide Outcome after Pancreatoduodenectomy in Patients... : Annals of Surgery is perceived so high that a recent randomized trial advocated prophylactic total pancreatectomy (TP) as alternative aiming to lower this risk. However, current outcomes of ISGPS-D PD remain unknown as...

Nationwide Outcome after Pancreatoduodenectomy in Patients at Very High Risk (ISGPS-D) for Postoperative Pancreatic Fistula

journals.lww.com/annalsofsurg...

Metagenomic next-generation sequencing for the detection of bacterial translocation in the blood of patients following liver, biliary tract or pancreatic surgery Dear Editor,

Metagenomic next-generation sequencing for the detection of bacterial translocation in the blood of patients following liver, biliary tract or pancreatic surgery ⁦‪@BJS

academic.oup.com/bjs/article/...

Carbohydrate antigen 19-9 (CA19-9) response after induction FOLFIRINOX for locally advanced pancreatic cancer identifies patients who may benefit from surgical exploration: multicentre, observational ... In this international retrospective cohort study from the Trans-Atlantic Pancreatic Surgery Consortium, the independent prognostic factors for overall surv

Carbohydrate antigen 19-9 (CA19-9) response after induction FOLFIRINOX for locally advanced pancreatic cancer identifies patients who may benefit from surgical exploration: multicentre, observational cohort study @bjs

academic.oup.com/bjs/article/...

Improving Recurrence Prediction in Intrahepatic Cholangiocarcinoma: The Synergistic Impact of the FIB-4 Index and Tumor Burden Score on Post-hepatectomy Outcomes - Annals of Surgical Oncology Background The prognostic role of the fibrosis-4 (FIB-4) index relative to intrahepatic cholangiocarcinoma (ICC) after hepatectomy remains unclear. This study sought to characterize the impact of the ...

Improving Recurrence Prediction in Intrahepatic Cholangiocarcinoma: The Synergistic Impact of the FIB-4 Index and Tumor Burden Score on Post-hepatectomy Outcomes ⁦‪@AnnSurgOncol‬⁩

link.springer.com/article/10.1...

Hierarchically Positioning Laparoscopic Microwave Ablation in the Therapeutic Span of Early Hepatocellular Carcinoma: A Real-Life Comparative Analysis - Annals of Surgical Oncology Background Laparoscopic microwave ablation (LMWA) has yet to gain a specific place in treatment guidelines for early hepatocellular carcinoma (HCC). This study compared the outcomes of LMWA and trans-...

Hierarchically Positioning Laparoscopic Microwave Ablation in the Therapeutic Span of Early Hepatocellular Carcinoma: A Real-Life Comparative Analysis ⁦‪@AnnSurgOncol‬⁩

link.springer.com/article/10.1...

Targeting Patient-Derived Orthotopic Gastric Cancers with a Fluorescent Humanized Anti-CEA Antibody - Annals of Surgical Oncology Background Gastric cancer poses a major diagnostic and therapeutic challenge as surgical resection provides the only opportunity for a cure. Specific labeling of gastric cancer could distinguish resec...

Targeting Patient-Derived Orthotopic Gastric Cancers with a Fluorescent Humanized Anti-CEA Antibody ⁦‪@AnnSurgOncol‬⁩

link.springer.com/article/10.1...

SWOG Study S2104

1%-2% of #pancreatic tumors are #neuroendocrine tumors (#pNETs). Surgery is the only curative treatment, but the disease will recur in many patients. S2104 tests whether adjuvant #chemo extends RFS and OS.
Co-PI: @syedaahmad5.bsky.social
SWOG.org/clinical-trials/S2104

The Duration of Immunotherapy for Mismatch Repair–Deficient Cancers | NEJM An analysis of published studies suggests that a longer duration of immune checkpoint inhibitor therapy is associated with a higher incidence of complete response among patients with mismatch ...

The Duration of Immunotherapy for Mismatch Repair–Deficient Cancers ⁦‪@NEJM‬⁩

www.nejm.org/doi/full/10....

Hepatocellular carcinoma: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up

Hepatocellular carcinoma: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up ⁦‪⁦‪@Annals_Oncology‬⁩

www.sciencedirect.com/science/arti...

Circulating Micro-RNA as a Predictive Biomarker for Radiation Response in Pancreas Cancer - Annals of Surgical Oncology Annals of Surgical Oncology -

Circulating Micro-RNA as a Predictive Biomarker for Radiation Response in Pancreas Cancer ⁦‪@AnnSurgOncol‬⁩

link.springer.com/article/10.1...

Failure to Rescue After Resection of Perhilar Cholangiocarcinoma in an International Multicenter Cohort - Annals of Surgical Oncology Background Failure to rescue (FTR) is defined as the inability to prevent death after the development of a complication. FTR is a parameter in evaluating multidisciplinary postoperative complication m...

Failure to Rescue After Resection of Perhilar Cholangiocarcinoma in an International Multicenter Cohort ⁦‪@AnnSurgOncol‬⁩

link.springer.com/article/10.1...