Sarah Hedtrich

Combining a base editor, transient barrier modulation, and topical mRNA-lipid nanoparticle administration to restore clinically meaningful levels of transglutaminase 1 activity @cp-cellstemcell.bsky.social @hedtrichlab.bsky.social
www.cell.com/cell-stem-ce...
www.cell.com/cell-stem-ce...

Lipid nanoparticle-based non-viral in situ gene editing of congenital ichthyosis-causing mutations in human skin models Hedtrich and colleagues developed a topical, laser-assisted LNP approach to deliver gene editors into human skin. Their method corrects a disease-causing TGM1 mutation in ARCI models, restores TG1 function, and shows excellent safety, highlighting a minimally invasive strategy for treating severe genetic skin disorders.

Online Now! Lipid nanoparticle-based non-viral in situ gene editing of congenital ichthyosis-causing mutations in human skin models #stemcells

Super proud of this work from my lab that has great translational potential and can fundamentally change how we treat skin diseases.

Please 🔁! #MASSIV will be held in Vancouver from January 19-22, 2026. 4-day meeting on #synbio x #tissueengineering.

Some trainee-focused events. >50 talks (10 from abstracts), posters, panel & publishing insights sessions.

www.massivconference.com

Abstract deadline: Nov 14

Engineered Models of Human Disease Join a pioneering conference focused on the development of human-relevant in vitro disease models. The program brings together leading biologists, bioengineers, clinical researchers, computational res...

I’m very excited to speak at Nature Conferences this October. Join me and fellow researchers from across various disciplines to discuss insights on in vitro disease models and tissue engineering. Abstract submissions welcome. 👉 go.nature.com/43xmvlH

Great conference on human-based models coming up! Register now!

From April 14-18, select UBC graduate programs at UBC Vancouver will re-open their applications for US citizens to be considered for September 2025 or January 2026 entry - they are ready to provide quick admissions decisions for these applicants. If you are a prospective graduate student from the United States considering Canada for graduate school – now is the time.

UBC is hosting US Applicant Week from April 14-18, which allows US students to apply during an extended application period for graduate studies. Sixty graduate programs will be reopening applications for US applicants for September 2025 and January 2026 start dates - www.grad.ubc.ca/us-applicant...

Join Us! | King Lab Are you interested in joining the King Lab? More information here!

Come join us at beautiful UBC! The King Lab is recruiting a Post-doc Fellow to develop mathematical theory on infectious disease evolution and emergence, together with Ben Ashby (SFU) #zoonoses #biodiversity www.zoology.ubc.ca/kinglab/join...

Assistant/Associate Professor (Tenure Track), Department of Pharmacology and Therapeutics, Toxicology (L000054) Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

We are recruiting! The McGill University Department of Pharmacology and Therapeutics in the Faculty of Medicine and Health Sciences invites applications for a full-time tenure track Assistant or Associate Professor position in the area of toxicology.
mcgill.wd3.myworkdayjobs.com/en-US/McGill...