Waggoner Lab

Gut microbial-derived indole-3-propionate improves cognitive function in Alzheimer’s disease Intermittent fasting enhances cognition in Alzheimer’s disease via gut microbial indole-3-propionic acid activating neuronal PXR.

Gut microbial-derived indole-3-propionate improves cognitive function in Alzheimer’s disease | Science Advances www.science.org/doi/10.1126/...

Theory @cp-immunity.bsky.social
Quantifying the waning of humoral immunity
www.cell.com/immunity/ful...

Molecular subtypes of hepatocellular carcinoma linked to liver cell lineages and clinical outcomes of combination immunotherapy @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...

Innate immune and metabolic signals induce mitochondria-dependent membrane lysis via mitoxyperiosis @cellcellpress.bsky.social @stjuderesearch.bsky.social
www.cell.com/cell/fulltex...

Maternal IgG transfer and neonatal infection synergize via Fc receptor pathways to promote allergic TH2 immunity @sciimmunology.bsky.social
www.science.org/doi/10.1126/...

Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals @science.org
www.science.org/doi/10.1126/...

Review @science.org
Targeted protein degradation in the transmembrane and extracellular space
www.science.org/doi/10.1126/...

Old but gold: ILC-induced T-cell senescence prevents GVHD In this issue of Blood,Tufa et al1 demonstrate that innate lymphoid cells (ILCs) mitigate graft-versus-host disease (GVHD) by inducing T-cell senescence vi

Innate lymphoid cells mitigate graft-versus-host disease (GVHD) by inducing T-cell senescence via IL-9
ashpublications.org/blood/articl...
ashpublications.org/blood/articl...

One mechanism is Ddx3x support of Brwd1 expression at pre B cell stage and support of efficient cell cycle arrest as well as light chain rearrangement (resulting in skewed kappa/lambda usage)

Linked to throttling of B cell development at key checkpoints in bone marrow

Hypergammaglobulinemia and exaggerated IgG2b from MZ compartment associated with B-cell extrinsic lymphopenia limited to Vav1-Cre model

Males still develop B cells in absence of Ddx3x but skewed towards MZ

Happy to share an update to a 2018 preprint from @labwaggoner.bsky.social and our collaborators! Added Mb1-Cre models and mechanistic insights into Ddx3x regulation of B cell development @biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...
Find Ddx3x is required in B cells in females

Broad-spectrum antiviral brincidofovir inhibits Epstein-Barr virus and related gammaherpesvirus in human and nonhuman primate cells @jci.org
www.jci.org/articles/vie...

Mechanical confinement induces ferroptosis through mitochondrial dysfunction @natcomms.nature.com www.nature.com/articles/s41...

Review @natrevneuro.nature.com
Immune dysfunction in Alzheimer disease
www.nature.com/articles/s41...

mRNA engineering of allogeneic mesenchymal stem cells enables coordinated delivery of T cell engagers and immunotherapeutic cues @natbiomedeng.nature.com
www.nature.com/articles/s41...

A distinct, microenvironment-driven route of neoantigen formation that fuels sustained autoreactivity in diabetes
www.nature.com/articles/s41... @natcomms.nature.com @washumedicine.bsky.social

Prolonged T cell dyshomeostasis driven by dysregulated homeostatic cytokine signals (inc IL7 & IL15) following acute SARS-CoV-2 infection @natcomms.nature.com
www.nature.com/articles/s41...

Germline polymorphisms in the immunoglobulin kappa and lambda loci underpinning antibody light chain repertoire variability @natcomms.nature.com
www.nature.com/articles/s41...

Human epidermal Langerhans cells induce tolerance and hamper T cell function upon tick-borne pathogen transmission @natcomms.nature.com
www.nature.com/articles/s41...

Natural killer cells in kidney immune surveillance, injury and fibrosis - Nature Reviews Nephrology This Review discusses the latest advances in natural killer cell biology, including insights into population heterogeneity, and examines the roles of these innate lymphocytes in kidney health and dise...

Review @natrevneph.nature.com
Natural killer cells in kidney immune surveillance, injury and fibrosis
www.nature.com/articles/s41...

Historical and current spatiotemporal patterns of wild and vaccine-derived poliovirus spread @natmicrobiol.nature.com @imperialcollegeldn.bsky.social
www.nature.com/articles/s41...

Tumor-specific bioorthogonal synthesis of proteolysis-targeting chimeras and nanoparticles boosts T cell activity @natbiomedeng.nature.com
www.nature.com/articles/s41...

Organ-specific proteomic aging clocks predict disease and longevity across diverse populations @nataging.nature.com @ox.ac.uk
www.nature.com/articles/s43...

Epigenetic drift is induced by dysregulation of iron metabolism in intestinal stem cells, leading to accumulating gene hypermethylation that propagates through crypt fission with aging
@leibnizfli.bsky.social @nataging.nature.com
www.nature.com/articles/s43...
www.nature.com/articles/s43...

Targeting of HIF2-driven cachexia in kidney cancer @naturemedicine.bsky.social @abu-remaileh.bsky.social
@danafarber.bsky.social @harvardmed.bsky.social
www.nature.com/articles/s41...

Cellular reprogramming and efficacy of neoadjuvant nab-paclitaxel and pembrolizumab in hormone receptor-positive breast cancer
@natcomms.nature.com @stolaney1.bsky.social @danafarber.bsky.social @vanallenlab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...

CTLH ubiquitin ligase substrates ZMYND19 and MKLN1 negatively regulate mTORC1 at the lysosomal membrane @natcomms.nature.com @bgewurz.bsky.social
www.nature.com/articles/s41...

Preprint: SLAMF9 activation by Akkermansia muciniphila-derived lipid LPE(16:0) drives IL-10+ B cell-mediated protection against ulcerative colitis
www.researchsquare.com/article/rs-8...