@labwaggoner.bsky.social
Focused on innate immune mechanisms governing pathogenesis of disease and on NK-cell based therapies for disease. Opinions expressed are Dr. Waggoner's alone and not on behalf of lab staff or employer.
Cell type-specific enhancers regulate IL-22 expression in innate and adaptive ILC3 #Oltz @ohiostatemed.bsky.social
www.nature.com/articles/s41...
Combining lenalidomide with IL-2 family of cytokines enhances activating receptor and perforin/granzyme expression in NK cells
journals.plos.org/plosone/arti...
Single-Cell Profiling of Splenic Immune Ageing and Chronic Stress Adaptations in Mice With Natural Microbiota
onlinelibrary.wiley.com/doi/10.1002/...
@biorxivpreprint.bsky.social Efficient NK cell transduction with VSV-G-pseudotyped lentiviral vectors
www.biorxiv.org/content/10.6...
@biorxivpreprint.bsky.social Interferon-α and -β subtypes have temporally distinct roles in containing viral spread and protecting vital organs
www.biorxiv.org/content/10.6...
@biorxivpreprint.bsky.social Persistent SARS-CoV-2 Spike is Associated with Localized Immune Dysregulation in Long COVID Gut Biopsies
www.biorxiv.org/content/10.6...
@biorxivpreprint.bsky.social T6SS mutants exploit itaconate to support infection of phagocytes
www.biorxiv.org/content/10.6... @columbiauniversity.bsky.social
@biorxivpreprint.bsky.social m6A is a bidirectional regulator during mumps virus infection, simultaneously constraining viral replication and modulating host immune recognition
www.biorxiv.org/content/10.6...
@biorxivpreprint.bsky.social Engineering armoured in vivo CAR T cells through targeted delivery and transient mRNA gating
www.biorxiv.org/content/10.6...
@biorxivpreprint.bsky.social Importance of non-phagocytic CAR signaling as an additional mechanism for CAR-macrophage effector functions
www.biorxiv.org/content/10.6... @inserm.fr
@biorxivpreprint.bsky.social A Genetic Tool for Specific Tracking of Mature Neutrophils
www.biorxiv.org/content/10.6...
@biorxivpreprint.bsky.social @masahirono.bsky.social @monotockylab.bsky.social @imperialcollegeldn.bsky.social
Temporal Mechanisms of T-Cell Fate Decisions under Immune Checkpoint Blockade Resolved by CanonicalTockySeq
www.biorxiv.org/content/10.6...
A logic-gated trispecific engager enhances macrophage killing of cancer cells in solid tumors @natbiotech.nature.com
www.nature.com/articles/s41...
Review @natrevmicro.nature.com @salliepermar.bsky.social @weillcornell.bsky.social
Human herpesvirus evasion of humoral immunity and implications for vaccine development
www.nature.com/articles/s41...
While expansion is comparable, activation and differentiation of T cells diverges between CD3/CD28 beads versus soluble antibody complexes
www.nature.com/articles/s41...
Structural basis and regulation of GSDME pore formation @natcomms.nature.com @uconnresearch.bsky.social
www.nature.com/articles/s41...
ILC2s use multiple S1P receptors to migrate from the gut to distal tissues during helminth infection @sciimmunology.bsky.social @columbiauniversity.bsky.social
www.science.org/doi/10.1126/...
This work is also NIH supported & should have been published open access.
Expanded HSPC inputs reveal early gene expression, chromatin accessibility, and transcription factor roles in T cell program entry @sciimmunology.bsky.social @caltech.edu
www.science.org/doi/10.1126/...
Work was supported by 6 NIH grants, why is it not open access (NOT-OD-25-047)?
Determinants of NK cell-mediated antibody dependent cellular cytotoxicity in SARS-CoV-2 antibodies @fredhutch.org
journals.plos.org/plospathogen...
Review @cp-trendsimmuno.bsky.social
Barrier breakdown: insights into the skin–gut axis in psoriatic arthritis
www.cell.com/trends/immun...
Enucleated cells with Nectin-1 overexpression capture HSV-1 and promote viral elimination for herpes simplex encephalitis therapy @cp-cellreports.bsky.social
www.cell.com/cell-reports...
Polμ is crucial for macrophages to block the unwanted effects of ROS during inflammatory responses
@cp-cellreports.bsky.social
www.cell.com/cell-reports...
Nanoparticles targeting liver sinusoidal endothelial cells improve tolerance to vector and transgene antigens through tolerance spreading @moltherapy.bsky.social
www.cell.com/molecular-th...
Efficient multiplex non-viral engineering and expansion of polyclonal γδ CAR-T cells for immunotherapy @moltherapy.bsky.social @cfi-umn.bsky.social
www.cell.com/molecular-th...
Polymerase trapping as the mechanism of H5 highly pathogenic avian influenza virus genesis @science.org
www.science.org/doi/10.1126/...
Drugs that inhibit KRAS signaling delay the development of pancreatic cancer in mice @science.org @upenn.edu
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Exocytosis exposes Src at the outer surface of cancer cells, poised for therapeutic targeting @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
HIV cure bid has virus trip immune alarm: Strategy produces promising results in cell studies and infected people @science.org
www.science.org/content/arti...
Review @naturemedicine.bsky.social @haanenjohn.bsky.social
Clinical development of cancer vaccines
www.nature.com/articles/s41...
Microglia protein profiles in CSF across Alzheimer’s disease clinical stages @nataging.nature.com
www.nature.com/articles/s43...