Waggoner Lab

Our Brain—Immune Axis Gets A Jolt Facts, data and analytics about biomedical matters

A rundown on the big advances we’re seeing on the brain-immune axis

erictopol.substack.com/p/our-braini...

Molecular characterization of the archaic HLA-B*73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2 #Parham #Adams
www.sciencedirect.com/science/arti...

CD47-mediated selective accumulation of mature Ly49h+ NK cells to the brain associates with the pathogenesis of cerebral malaria in mice
academic.oup.com/jimmunol/adv...
@jimmunol.bsky.social

NKG2A impairs NK cell function during E. multilocularis infection in both humans and mice, suggesting that targeting NKG2A through blockade has the potential to restore NK cell function against this infection
link.springer.com/article/10.1...

NK cells mediate preventive efficacy of intravenous BCG against lung metastasis in mice - Cancer Gene Therapy Cancer Gene Therapy - NK cells mediate preventive efficacy of intravenous BCG against lung metastasis in mice

NK cells mediate preventive efficacy of intravenous BCG against lung metastasis in mice
www.nature.com/articles/s41...

A mucosal vaccine prevents eosinophilic allergic airway inflammation by modulating immune responses to allergens in a murine model of airway disease @natcomms.nature.com
www.nature.com/articles/s41...

A 45 year-old man died after taking a deworming drug for animals. He had read about it having anti-cancer properties from social media sites—according to what his partner told the BBC. He bought the drug enbendazole from online supplier in a different country www.bbc.com/news/article... #medsky

OMG 😱

Broad neuraminidase antibodies confer protection against seasonal and avian influenza viruses
www.nature.com/articles/s41... @natcomms.nature.com

B cell maturation antigen (BCMA) is dispensable for the survival of long-lived plasma cells @natcomms.nature.com
www.nature.com/articles/s41...

TLR4+ ILC2 contribute to persistent type 2 immunity in airway diseases through a non-specific immunological memory @natcomms.nature.com
www.nature.com/articles/s41...

Preprint: Generation of effector CD4+ T cells from Human iPSC
www.biorxiv.org/content/10.1...

Important advance from immigrant scientist funded by #NINDS, critical strengths of US science at risk of permanent destruction

Preprint: PIEZO1 mechanosensing at the plasma membrane as a key regulatory event in nucleic acid-induced immunity, with different functional outcomes based on the cargo structure
www.biorxiv.org/content/10.1...

Exciting new knowledge generated by outstanding immigrant scientists with funding from #NIAID, targets of White House vitriol

Preprint: TCR-enriched nanoscale vesicles shed by activated T cells (ectosomes) are transferred to antigen-primed B cells, where they engage and cluster cognate pMHCII, triggering signaling and specific IgG antibody production
www.biorxiv.org/content/10.1...

Review: Research progress on CAR-based immunotherapy against autoimmune diseases
www.tandfonline.com/doi/epdf/10....

NK Alloreactivity Evaluation According to KIR‐HLA Interaction Models Influences the Outcome of Haploidentical Haematopoietic Stem‐Cell Transplantation Based on Post‐Transplant Cyclophosphamide Haploidentical haematopoietic stem-cell transplantation (haplo-HSCT) is characterised by a high degree of HLA mismatching. Therefore, NK alloreactivity driven by the interactions between KIR and HLA ....

NK cell alloreactivity influences the outcome of haplo-haematopoietic stem-cell transplantation with post-transplant Cyclophosphamide and should be incorporated into the donor selection algorithm for this procedure
onlinelibrary.wiley.com/doi/10.1111/...

Interaction between NK cell and macrophages contributes to controlling tuberculosis disease
journals.plos.org/plospathogen...

Identification of the seven critical residues that control ZIKV-DENV cross-reactivity to engineer a non-cross-reactive ZIKV vaccine @cp-cellreports.bsky.social
www.cell.com/cell-reports...

Core fucosylation of IL-2RB is required for NK cell homeostasis @cp-cellreports.bsky.social
www.cell.com/cell-reports...

Lung structural cells are altered by influenza virus leading to rapid immune protection following re-challenge @natcomms.nature.com www.nature.com/articles/s41...

Intestinal CD4−CD8αβ−TCRαβ+ T cells function as tolerogenic antigen presenting cells in mice
@natcomms.nature.com
www.nature.com/articles/s41...

Transcriptional factor Bach2 plays a vital role in regulating the biological features of ILC2
www.science.org/doi/10.1126/...

TH17 cells regulate epithelial chemokine expression through C/EBPβ and dictate host sensitivity to colitis and cancer immunity
www.science.org/doi/10.1126/...

Treg cells safeguard the intestinal barrier to prevent inflammaging and senescence in a mouse model of premature aging @sciimmunology.bsky.social @mmgomezheras.bsky.social
www.science.org/doi/10.1126/...

Vagal TRPV1+ sensory neurons protect against influenza virus infection by regulating lung myeloid cell dynamics TRPV1+ neurons facilitate host survival from flu infection by controlling viral spread, myeloid cell responses, and immunopathology.

Vagal TRPV1+ sensory neurons facilitate host survival from flu infection by controlling viral spread, myeloid cell responses, and immunopathology @sciimmunology.bsky.social
www.science.org/doi/10.1126/...

Insulin-like growth factor–like family member 2 (IGFL2) expressing peripheral helper CD4 T cells contribute to rheumatoid arthritis via enhanced TGF-β–induced CXCL13 promoting pathogenic macrophages
www.science.org/doi/10.1126/... @sciimmunology.bsky.social

Preprint: Single-cell map of the healthy human immune system across the lifespan reveals unique infant immune signatures
www.biorxiv.org/content/10.1...

Development of soluble Notch agonists that can be used for T cell development in suspension cultures and 3D bioreactors and for enhancing immunity in vivo @cellcellpress.bsky.social
www.cell.com/cell/fulltex...