@labwaggoner.bsky.social
Focused on innate immune mechanisms governing pathogenesis of disease and on NK-cell based therapies for disease. Opinions expressed are Dr. Waggoner's alone and not on behalf of lab staff or employer.
Review: The dual roles of natural killer cells in liver immunity and tolerance: Implications for health and disease
journals.lww.com/hepcomm/full...
@biorxivpreprint.bsky.social Spike Antibody Fc Drives Protection from SARS-CoV-2 Challenge in Macaques
www.biorxiv.org/content/10.6... @caolannb.bsky.social @carroll-lab.bsky.social @ox.ac.uk
[2/2] ADCC activation of NK cells correlated with bond lifetimes under force, but not with affinity. Thus, lymphocytes are sensitive to the mechanical stability of antibody-antigen interactions
www.biorxiv.org/content/10.6...
@biorxivpreprint.bsky.social
[1/2] After OVA immunizaiton, germinal center antibody affinity changes were heterogeneous (up & down) while mechanical resistance consistently increased, suggesting a selective pressure for mechanical stability @inserm.fr
@biorxivpreprint.bsky.social Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age-Related Declines in Humoral and Cellular Immunity Relative to Shingrix
www.biorxiv.org/content/10.6... @stanforduniversity.bsky.social
@biorxivpreprint.bsky.social Alveolar-basal intermediates actively participate in driving fibrosis after silica-induced lung injury @cincyresearch.bsky.social @drwillzacharias.bsky.social
www.biorxiv.org/content/10.6...
@biorxivpreprint.bsky.social Profiling of DNA-methylation signatures in human ILCs during homeostasis and allergic disease
www.biorxiv.org/content/10.6...
@biorxivpreprint.bsky.social HLA-DRB1*15:01 drives sex- and age-dependent microglial activation and neuroimmune signaling
www.biorxiv.org/content/10.6... @uarizona.bsky.social
HPV-positive tumors harbor a specialized NK cell population that supports patient survival, whereas HPV-negative tumors produce signals that block NK cell function
www.mdpi.com/2072-6694/18...
Review: CD57-Expressing Lymphocytes: From Chronic Viral Response to Age-Related Inflammation
www.mdpi.com/2073-4409/15...
Glutamine is a key nutrient for human NK cells, with IL-2 driving glutaminolysis to support the TCA cycle, generating energy and providing intermediates for de novo pyrimidine synthesis @trinitycollegeuoft.bsky.social @karen--s.bsky.social
sciencedirect.com/science/arti...
Residential greenness π³π²πΏimproves chronic inflammation & enhances immune responses by modulating levels of circulating immune cells & signals that govern their activity
www.sciencedirect.com/science/arti...
(disclosure: SNW is a product of a tree-hugging UG, @stmarysmd.bsky.social)
A series of @cincyresearch.bsky.social reviews on #SickleCellDisease @drpowerhays.bsky.social
doi.org/10.1002/ajh....
doi.org/10.1002/ajh....
doi.org/10.1002/ajh....
doi.org/10.1002/ajh....
Prefusion-stabilized Hantaan virus glycoprotein nucleic acid vaccine elicits potent neutralizing antibody responses via germinal center activation
www.nature.com/articles/s41... @natcomms.nature.com
cDC2A crosstalk with CXCL13+CD8+ T cells and -epithelial cells drives cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus @natcomms.nature.com
www.nature.com/articles/s41...
Cell type-specific enhancers regulate IL-22 expression in innate and adaptive ILC3 #Oltz @ohiostatemed.bsky.social
www.nature.com/articles/s41...
Combining lenalidomide with IL-2 family of cytokines enhances activating receptor and perforin/granzyme expression in NK cells
journals.plos.org/plosone/arti...
Single-Cell Profiling of Splenic Immune Ageing and Chronic Stress Adaptations in Mice With Natural Microbiota
onlinelibrary.wiley.com/doi/10.1002/...
@biorxivpreprint.bsky.social Efficient NK cell transduction with VSV-G-pseudotyped lentiviral vectors
www.biorxiv.org/content/10.6...
@biorxivpreprint.bsky.social Interferon-Ξ± and -Ξ² subtypes have temporally distinct roles in containing viral spread and protecting vital organs
www.biorxiv.org/content/10.6...
@biorxivpreprint.bsky.social Persistent SARS-CoV-2 Spike is Associated with Localized Immune Dysregulation in Long COVID Gut Biopsies
www.biorxiv.org/content/10.6...
@biorxivpreprint.bsky.social T6SS mutants exploit itaconate to support infection of phagocytes
www.biorxiv.org/content/10.6... @columbiauniversity.bsky.social
@biorxivpreprint.bsky.social m6A is a bidirectional regulator during mumps virus infection, simultaneously constraining viral replication and modulating host immune recognition
www.biorxiv.org/content/10.6...
@biorxivpreprint.bsky.social Engineering armoured in vivo CAR T cells through targeted delivery and transient mRNA gating
www.biorxiv.org/content/10.6...
@biorxivpreprint.bsky.social Importance of non-phagocytic CAR signaling as an additional mechanism for CAR-macrophage effector functions
www.biorxiv.org/content/10.6... @inserm.fr
@biorxivpreprint.bsky.social A Genetic Tool for Specific Tracking of Mature Neutrophils
www.biorxiv.org/content/10.6...
@biorxivpreprint.bsky.social @masahirono.bsky.social @monotockylab.bsky.social @imperialcollegeldn.bsky.social
Temporal Mechanisms of T-Cell Fate Decisions under Immune Checkpoint Blockade Resolved by CanonicalTockySeq
www.biorxiv.org/content/10.6...
A logic-gated trispecific engager enhances macrophage killing of cancer cells in solid tumors @natbiotech.nature.com
www.nature.com/articles/s41...
Review @natrevmicro.nature.com @salliepermar.bsky.social @weillcornell.bsky.social
Human herpesvirus evasion of humoral immunity and implications for vaccine development
www.nature.com/articles/s41...
While expansion is comparable, activation and differentiation of T cells diverges between CD3/CD28 beads versus soluble antibody complexes
www.nature.com/articles/s41...