Waggoner Lab

Tumor-associated macrophages directly stimulate neurite outgrowth, revealing a dual role in enhancing intratumoral nerve growth and promoting neural repair after severe spinal cord injury @cp-immunity.bsky.social
www.cell.com/immunity/ful...

Exosite-mediated targeting of GSDMB by dimeric granzyme A in lymphocyte pyroptotic killing @cp-immunity.bsky.social
www.cell.com/immunity/ful...

Liver metastases dampen IL18-driven γδ T cell activity and immunotherapy responsiveness in colorectal cancer @cp-cellrepmed.bsky.social
www.cell.com/cell-reports...

Perspective: Polygenic backgrounds influence phenotypic consequences of variants in cells, individuals, and populations
www.cell.com/cell-genomic...

CXCR4 induces memory formation over exhaustion in CAR-T cells to achieve durable leukemia targeting
@natcomms.nature.com
www.nature.com/articles/s41...

Review: Targeting metabolic-epigenetic-immune axis in cancer: molecular mechanisms and therapeutic implications
www.nature.com/articles/s41...

Stenotrophomonas promotes gastrointestinal tumor progression via STING degradation in tumour cells and mitigated immune response @natcomms.nature.com
www.nature.com/articles/s41...

A DNA-based nanodevice senses purinergic signaling and drives an immune switch for resolving inflammation
www.nature.com/articles/s41...
@natcomms.nature.com

Review @natrevrheum.nature.com
Mechanisms of fibrotic tissue remodelling: insights from systemic sclerosis
www.nature.com/articles/s41...

Review @natrevbioeng.nature.com
mRNA technology for the prevention and treatment of HIV-1 infection
www.nature.com/articles/s44...

Review @natrevdrugdiscov.nature.com @grieshaber.bsky.social @biohacker.bsky.social
Roads and detours for CAR T cell therapy in autoimmune diseases
www.nature.com/articles/s41...

A filamentary soft robotic probe for multimodal in utero monitoring of fetal health @natbiomedeng.nature.com
www.nature.com/articles/s41...

YL1004 is a SARS-CoV-2 papain-like protease inhibitor with immunomodulatory and antiviral activity in mice
www.nature.com/articles/s41...
@natcomms.nature.com

A proteogenomic atlas of 1032 brain metastases identifies molecular subtypes, immune landscapes, and therapeutic vulnerabilities @natcomms.nature.com
www.nature.com/articles/s41...

Granzyme B-mimetic nanozyme for nanovesicle targeted anticancer applications @natcomms.nature.com
www.nature.com/articles/s41...

Distinct immune effects of alpha- versus beta-particle emitting radiopharmaceuticals when combined with immune checkpoint inhibition in mice
www.nature.com/articles/s41... @natcomms.nature.com @uwmadison.bsky.social

Protesters in Los Angeles projected an anti-ICE video onto the Twin Towers, an ICE-linked detention facility where the Los Angeles Sheriff’s Department actively collaborates with ICE for deportation screenings.

@biorxivpreprint.bsky.social NK Cells Engineered with a Chimeric Antigen Receptor Delay HIV Rebound and Reshape HIV Reservoir Composition
www.biorxiv.org/content/10.6...

@biorxivpreprint.bsky.social Polymer-lipid hybrid nanoparticle enhances mRNA delivery and T cell-mediated immunity
www.biorxiv.org/content/10.6...

@biorxivpreprint.bsky.social Intestinal Barrier Loss Enables Microbiota-Mediated Purinergic Suppression During Malaria @rafaelpolidoro.bsky.social
www.biorxiv.org/content/10.6...

Fifty Years of NK Cells: Milestones and Future Horizons @ki.se
onlinelibrary.wiley.com/doi/10.1111/...

Increased PD-1+ NK cells and PD-L1 extravillous trophoblasts in recurrent pregnancy loss
www.sciencedirect.com/science/arti...

Review: TGF-β-mediated suppression of NK cell function and targeting strategies in tumor immunotherapy
www.sciencedirect.com/science/arti...

Frequency and dosage of NK cell infusions are crucial factors influencing survival outcomes in patients with recurrent HCC after liver transplantation
link.springer.com/article/10.1...

Dual inhibition of PD-L1 and PVR triggers anti-cancer immune responses in non-small cell lung cancer
aacrjournals.org/mct/article-...

Intratumoral CD4+CD8+ T cells can serve as precursors to single positive T cells in vivo via Rag2 expression, suggesting that tumors act as extrathymic sites of T cell development
www.pnas.org/doi/10.1073/...

You have to read this. Firsthand affidavit from one of the women who was there and recording the video. She talks about how Alex Pretti was directing traffic when she arrived. She watched him be killed in front of her. She's afraid to go home, worried she'll be arrested.

US immigration agents detain two-year-old Minnesota girl: ‘depravity beyond words’ DHS detain a toddler and her father on Thursday and fly them to Texas before returning child on judge’s order

What a sick country:

"Federal immigration agents detained a two-year-old girl and her father in Minneapolis on Thursday and transported them to Texas, according to court records and the family’s lawyers."
www.theguardian.com/us-news/2026...

@biorxivpreprint.bsky.social Reduced late endosome/lysosome function promotes SLE through chronic PI3k activity and SHP-1/SHIP-1 defects
www.biorxiv.org/content/10.6...

@biorxivpreprint.bsky.social Strong sustained type I IFN signaling acts cell intrinsically to impair IFNγ responses and cause tuberculosis susceptibility
www.biorxiv.org/content/10.6... @ucberkeleyofficial.bsky.social