Waggoner Lab

ILC3-derived CSF2 tunes homeostasis of tissue macrophages and neutrophils @mucosalimmunology.bsky.social
www.sciencedirect.com/science/arti... @theonlylabever.bsky.social @uoftpress.bsky.social

Promising candidate for next-generation, non-replicating measles vaccines to complement current vaccination strategies: @biorxivpreprint.bsky.social @columbiauniversity.bsky.social @lji.org
Stabilized Full-Length Measles Fusion Protein
www.biorxiv.org/content/10.1...

Brain-infiltrating CD4 T cells drive inflammatory microglia proliferation during cryptococcal meningitis in mice @natcomms.nature.com
www.nature.com/articles/s41...

Perspective @natcomms.nature.com
@harvardmed.bsky.social @precvaccines.bsky.social @bostonchildrens.bsky.social
Incorporating meningeal immunity into vaccine development
www.nature.com/articles/s41...

Targeting IL-6 signaling in parallel with mTOR inhibition, may reduce lung damage in lymphangioleiomyomatosis (LAM) @natcomms.nature.com @uniofnottingham.bsky.social
www.nature.com/articles/s41...

Cxcl9high macrophages recruit circulating Cxcr3+ plasmablasts into kidneys to promote pathogenesis of lupus nephritis mice
www.nature.com/articles/s42...

Extracellular vesicles derived EBV tegument protein BRRF2 suppresses cGAS phase separation to promote anti-viral innate immune evasion @natcomms.nature.com
www.nature.com/articles/s41...

Human gut bacteria produce structurally related monoglycolipids with contrasting immune functions - Nature Microbiology The authors identify AgcT as the glycosyltransferase required for synthesis of Bacteroides fragilis-derived α-galactosylceramides (BfaGCs), metabolites known to regulate natural killer T cells, and its structural homologue BgsB that synthesizes α-glycosyl diacylglycerols (aGDGs). They establish a functional link between the production of BfaGCs or aGDGs and the activity and development of natural killer T cells.

Human gut bacteria produce structurally related monoglycolipids with contrasting immune functions @natmicrobiol.nature.com @harvardmed.bsky.social
www.nature.com/articles/s41...

A next-generation anti-CTLA-4 probody (folding the Fab fragment of the antibody in a tumor-associated protease-based manner) mitigates toxicity and enhances anti-tumor immunity in mice @natcomms.nature.com
www.nature.com/articles/s41...

Histone lactylation promotes rheumatoid arthritis progression by increasing NFATc2 expression and the production of anti-lactylated histone autoantibodies @natcomms.nature.com
www.nature.com/articles/s41...

Mycobacterium tuberculosis-derived linoleic acid increases regulatory T cell function to promote bacterial survival within macrophages @natmicrobiol.nature.com
www.nature.com/articles/s41...

Review: Viral interferon antagonism shapes host tropism @institutpasteur.bsky.social
journals.plos.org/plospathogen...

“super-adjuvant” nanoparticle system as a modular, customizable platform for next-generation cancer vaccination @cp-cellrepmed.bsky.social @atukoralepu.bsky.social
www.cell.com/cell-reports...

Cohousing or cross-fostering followed by cohousing does not normalize the microbiomes of genetically distinct adult mice @cp-cellreports.bsky.social
www.cell.com/cell-reports...

Developing SEMA4A-directed CAR T cells to overcome low BCMA antigen density in multiple myeloma @cp-cancercell.bsky.social @moffittnews.bsky.social
www.cell.com/cancer-cell/...

Human cytomegalovirus UL78 is a nuclear-localized GPCR necessary for efficient reactivation from latent infection in CD34+ hematopoietic progenitor cells journals.asm.org/doi/10.1128/...

Common cold embecovirus imprinting primes broadly neutralizing antibody responses to SARS-CoV-2 S2 @jem.org @weillcornell.bsky.social
rupress.org/jem/article/...

Role for NF-κB in herpes encephalitis pathology in mice genocopying an inborn error of IRF3-IFN immunity @jem.org @aarhusuniint.bsky.social rupress.org/jem/article/...

Faithful modeling of terminal CD8+T cell dysfunction and epigenetic stabilization in vitro @insight.jci.org
@hazemghoneim.bsky.social @ohiostatemed.bsky.social
insight.jci.org/articles/vie...

Intranodal expansion of follicular T helper cells in patients with multiple sclerosis @insight.jci.org
insight.jci.org/articles/vie...

The role of TCF-1+CD8+ exhausted progenitors and TCF-1 in graft-versus-host responses @insight.jci.org
insight.jci.org/articles/vie...

Homeostatic conditioning and effector cooperativity between CD8+T and NK cells protect against tumor immune escape @frontiersin.bsky.social
www.frontiersin.org/journals/imm...

Sexually dimorphic defects in cytolytic effector molecules, granule trafficking and release, and increased expression of inhibitory receptors on NK cells in patients hospitalized with COVID-19 (greater in male) @ucalgary.bsky.social
www.frontiersin.org/journals/cel...

Tetrameric bispecific KK-LC-1×CD16A-armed cytokine-induced memory-like NK cells enhance antitumor efficacy in gastric cancer
jitc.bmj.com/content/13/1...

Bacteria undergo rapid genetic changes that are selected by alterations in the human gut environment @science.org
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...

Ubiquitin-mediated mitophagy regulates the inheritance of mitochondrial DNA mutations @science.org @universitypress.cambridge.org
www.science.org/doi/10.1126/...

A human pan-disease blood atlas of the circulating proteome
@science.org @buenoalvez.bsky.social
www.science.org/doi/epdf/10....

Selective HLA knockdown and PD-L1 expression prevent allogeneic CAR-NK cell rejection and enhance safety and anti-tumor responses in xenograft mice
www.nature.com/articles/s41...
@natcomms.nature.com @harvardmed.bsky.social @danafarber.bsky.social @broadinstitute.org

Targeting organelle function in T cells for cancer immunotherapy - Nature Reviews Immunology In this Review, the authors discuss the latest advances in our understanding of organelle biology in T cell-mediated antitumour immunity and how this knowledge is being used to power the next generation of cancer immunotherapy applications through pharmacological or genetic manipulation of organelles and intercellular organelle transfer or organelle transplantation.

Review @natrevimmunol.nature.com
Targeting organelle function in T cells for cancer immunotherapy
www.nature.com/articles/s41...

Fibroinflammatory skin diseases are characterized by interferon independent fibroblast EGFR-STAT1 signaling that controls expression of fibrotic genes
@natcomms.nature.com @yalepress.bsky.social
www.nature.com/articles/s41...