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Joe Colgan

@hibernogruppe.bsky.social

Asst. Prof. JGU Mainz πŸ‡©πŸ‡ͺ (he/him)| 🐝🧬 wild bee evolution | πŸŸπŸ’» salmonid genomics | https://github.com/joscolgan

95 Followers  |  175 Following  |  3 Posts  |  Joined: 22.11.2024  |  1.8013

Latest posts by hibernogruppe.bsky.social on Bluesky

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The relationship between sexual dimorphism and intersex correlation: do models support intuition? Abstract. The evolution of sexual dimorphism (the difference in average trait values between females and males, SD), is often thought to be constrained by

Full paper now out in GENETICS:
The relationship between sexual dimorphism and intersex correlation: do models support intuition?
πŸ”— academic.oup.com/genetics/art...
#Evolution #QuantGenetics @GeneticsGSA

23.08.2025 23:16 β€” πŸ‘ 33    πŸ” 12    πŸ’¬ 0    πŸ“Œ 0
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1/ a single job opening receives >1000 applications. (I am not kidding).
How to stand out?

Most bioinformatics CVs look the same: Python, R, RNA-seq, pipelines.
But hiring managers don’t care about skills on paper.
They care about proof. 🧡

22.08.2025 13:15 β€” πŸ‘ 5    πŸ” 1    πŸ’¬ 1    πŸ“Œ 0
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FANTASIA leverages language models to decode the functional dark proteome across the animal tree of life Communications Biology - FANTASIA, a protein language model-based tool, enables large-scale functional annotation across ~1000 animal proteomes, revealing novel gene functions in both model and...

FANTASIA's paper is finally out! Check it out if you're interested in alternative methods to homology for functional annotation in nonmodel organisms πŸ¦πŸ™πŸͺ±πŸ§¬πŸπŸͺ²
@gemmaeling.bsky.social @amrojasm.bsky.social @ibe-barcelona.bsky.social @cabd-upo-csic.bsky.social
@csic.es www.nature.com/articles/s42...

15.08.2025 00:05 β€” πŸ‘ 57    πŸ” 30    πŸ’¬ 2    πŸ“Œ 1
Tree-based differential testing using inferential uncertainty for RNA-seq An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms

🧬πŸ–₯️ Thrilled that our paper "Tree-based differential testing using inferential uncertainty for RNA-seq" genome.cshlp.org/content/earl..., led by @noorpratap.bsky.social, & in collab with @mikelove.bsky.social, @fennecpaaaw.bsky.social and Jason Fan is now accepted at @genomeresearch.bsky.social. 1/4

21.08.2025 19:24 β€” πŸ‘ 39    πŸ” 9    πŸ’¬ 2    πŸ“Œ 1
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Partitioned Multi-MUM finding for scalable pangenomics Pangenome collections are growing to hundreds of high-quality genomes. This necessitates scalable methods for constructing pangenome alignments that can incorporate newly-sequenced assemblies. We prev...

Excited to share a new update to Mumemto, scaling MUM and conserved element finding to any size pangenome! Preprint out now w/ @benlangmead.bsky.social.
Mumemto scales to the new HPRC v2 release and beyond, and can merge in future assemblies without any recomputation! 1/n

27.05.2025 19:35 β€” πŸ‘ 27    πŸ” 15    πŸ’¬ 1    πŸ“Œ 2

Massive thanks to @tegangaetano.bsky.social and @fmanfredini.bsky.social for impecably hosting while I was over - fantastic to hear about all the exciting research going on in Aberdeen🏴󠁧󠁒󠁳󠁣󠁴󠁿, meeting great people🍻, as well as seeing the wildlife🦭🦭🦭

23.05.2025 15:22 β€” πŸ‘ 2    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0
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Annotation of 200 Insect Genomes with BRAKER for Consistent Comparisons across Species The annotation of genomes lags behind their sequencing and assembly. For example, of 5,092 insect species in GenBank, as one of the most widely used databases, only 375 currently have annotated genome...

Annotation of 200 insect genomes. Work driven by @stepbystepsolution.bsky.social and Mario Stanke within @gevol.bsky.social : www.biorxiv.org/content/10.1...

21.04.2025 05:37 β€” πŸ‘ 39    πŸ” 26    πŸ’¬ 1    πŸ“Œ 1
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Simplify and elevate your data visualization with GGally, an R package designed to extend ggplot2.

Visualization: https://ggobi.github.io/ggally/

Details: https://statisticsglobe.com/online-course-data-visualization-ggplot2-r

#tidyverse #datavisualization #datasciencecourse #data #package

13.01.2025 15:23 β€” πŸ‘ 4    πŸ” 1    πŸ’¬ 0    πŸ“Œ 0

🐝Great to have this out @molbioevol.bsky.social and well done Hongfei Xu (not on BlueSky) for all the hard work

16.04.2025 15:53 β€” πŸ‘ 5    πŸ” 3    πŸ’¬ 0    πŸ“Œ 0
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Review: Transcriptomics in the era of long-read sequencing www.nature.com/articles/s41... (read free: rdcu.be/efBjP) 🧬πŸ–₯️πŸ§ͺ

29.03.2025 08:57 β€” πŸ‘ 32    πŸ” 12    πŸ’¬ 1    πŸ“Œ 0
A local synteny visualization with 3 genes across 4 genotypes.

A local synteny visualization with 3 genes across 4 genotypes.

Using my Tidyverse local synteny visualization tools first time in 3 months. This a biosynthetic gene cluster with 2 P450s and a O-methyltransferase. Visualized across assemblies for 4 cultivars.

GitHub: github.com/cxli233/Tidy...

19.03.2025 15:25 β€” πŸ‘ 17    πŸ” 3    πŸ’¬ 0    πŸ“Œ 1

Our review on k-mers + pop gen is now published!

doi.org/10.1093/molb...

05.03.2025 17:43 β€” πŸ‘ 40    πŸ” 29    πŸ’¬ 0    πŸ“Œ 0
Combining DNA and protein alignments to improve genome annotation with LiftOn An international, peer-reviewed genome sciences journal featuring outstanding original research that offers novel insights into the biology of all organisms

Friends, LiftOn is now published in @genomeresearch.bsky.social! LiftOn maps genes across genomes using a protein-centric, homology-based approach with both DNA & protein alignments
@stevensalzberg.bsky.social Mihaela Pertea, Jakob Heinz, Alaina Shumate, Celine Hoh, Alan Mao
doi.org/10.1101/gr.2...

03.03.2025 14:24 β€” πŸ‘ 32    πŸ” 15    πŸ’¬ 1    πŸ“Œ 0
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From literature to biodiversity data: mining arthropod organismal and ecological traits with machine learning The fields of taxonomy and biodiversity research have witnessed an exponential growth in published literature. This vast corpus of articles holds information on the diverse biological traits of organi...

Resulting from an @snsf-ch.bsky.social SPARK grant this took some time to mature, but the outcome is very imformative and builds a foundation for where to head next - how to liberate facts/information locked in the published literature www.biorxiv.org/content/10.1... #textmining #biodiversity

25.02.2025 19:31 β€” πŸ‘ 21    πŸ” 12    πŸ’¬ 1    πŸ“Œ 0

Bitte am Sonntag wΓ€hlen gehen! Noch nie war eine Wahl so wichtig fΓΌr Deutschlands Zukunft.
#Btw2025

22.02.2025 10:49 β€” πŸ‘ 15    πŸ” 6    πŸ’¬ 1    πŸ“Œ 0
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The Idiot's Guide to Effective Population Size This is a reference manual for the elegant, yet hideously complex concept of effective population size (Ne), inspired by a classic, self-published manual of automotive repair β€˜for the compleat idiot’...

Wow. This is sooo good. Echoing @urbanevol.bsky.social this user’s manual for Ne should be required reading for popgen and conservation genetics folks. onlinelibrary.wiley.com/doi/10.1111/...

17.02.2025 18:26 β€” πŸ‘ 89    πŸ” 41    πŸ’¬ 1    πŸ“Œ 4
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With @katiejenike.bsky.social and a bunch more of our fellow k-mer enthusiasts, we put together a manuscript on k-mers in biodiversity genomics. A guide if you will, that covers k-mers from basics to some really funky stuff...

genome.cshlp.org/content/35/2...

14.02.2025 22:20 β€” πŸ‘ 68    πŸ” 35    πŸ’¬ 1    πŸ“Œ 1
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A century of theories of balancing selection Traits that affect organismal fitness are often very genetically variable. This genetic variation is vital for populations to adapt to their environments, but it is also surprising given that nature (...

Finally ready to see the world! Theories of balancing selection - past, present and future: www.biorxiv.org/content/10.1... A true collaborative effort that brought together theoreticians and empiricists, models, data, and fresh perspectives on how balancing selection can shape genetic variation.

14.02.2025 16:49 β€” πŸ‘ 29    πŸ” 15    πŸ’¬ 2    πŸ“Œ 1
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OlΓ‘, Brasil! πŸ‡§πŸ‡· Interested in a research stay in Germany? Are you currently a postdoc at a uni or research institution in Brazil? Our CAPES #Fellowship offers you funding for a #research stay for 6-24 mth! Join our info event on 18 Feb! www.humboldt-foundation.de/en/connect/i...

13.02.2025 15:08 β€” πŸ‘ 26    πŸ” 10    πŸ’¬ 0    πŸ“Œ 1
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Principled PCA separates signal from noise in omics count data www.biorxiv.org/content/10....

13.02.2025 15:15 β€” πŸ‘ 12    πŸ” 2    πŸ’¬ 0    πŸ“Œ 0
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ggalign: Bridging the Grammar of Graphics and Biological Multilayered Complexity 🧬πŸ–₯️πŸ§ͺ
Paper: https://www.biorxiv.org/content/10.1101/2025.02.06.636847v1
#Rstats Code: https://github.com/Yunuuuu/ggalign
Docs: https://yunuuuu.github.io/ggalign/
Book (Quarto): https://yunuuuu.github.io/ggalign-book/

08.02.2025 12:14 β€” πŸ‘ 61    πŸ” 30    πŸ’¬ 0    πŸ“Œ 0
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Estimating recombination using only the allele frequency spectrum Standard methods for estimating the population recombination parameter, rho, are dependent on sampling individual genotypes and calculating various types of disequilibria. However, recent machine lear...

New paper with Sarthak Mishra! Maybe it will bring you some joy given all this (waves arms around).

"Estimating recombination using only the allele frequency spectrum"

1/2

www.biorxiv.org/content/10.1...

06.02.2025 16:29 β€” πŸ‘ 71    πŸ” 29    πŸ’¬ 3    πŸ“Œ 0
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What is a differentially expressed gene? The concept of 'Differentially Expressed Genes' (DEGs) is central to RNA-Seq studies, yet their identification suffers from reproducibility issues. This is largely a consequence of the inherent…

What is a differentially expressed gene? https://www.biorxiv.org/content/10.1101/2025.01.31.635902v1 🧬πŸ–₯️πŸ§ͺ https://github.com/Morris-Research-Group/bayexpress

05.02.2025 21:00 β€” πŸ‘ 38    πŸ” 11    πŸ’¬ 1    πŸ“Œ 0
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vcfsim: flexible simulation of all-sites VCFs with missing data VCFs are the most widely used data format for encoding genetic variation. By design, standard VCFs do not include data from sites where all individuals are homozygous for the reference allele ("invari...

A new tool, vcfsim, developed by Paimon Goulart, a stellar undergraduate researcher in my lab! vcfsim allows for the quick and easy simulation (via parameterized msprime simulations) of "all-sites" vcfs, with arbitrary ploidy and amounts of missing data.

www.biorxiv.org/content/10.1...

04.02.2025 02:50 β€” πŸ‘ 50    πŸ” 18    πŸ’¬ 2    πŸ“Œ 0
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CASTER: Direct species tree inference from whole-genome alignments https://www.science.org/doi/10.1126/science.adk9688 🧬πŸ–₯️πŸ§ͺ https://github.com/chaoszhang/ASTER

31.01.2025 21:00 β€” πŸ‘ 15    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0
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locuszoomr: an R package for visualising publication-ready regional gene locus plots https://academic.oup.com/bioinformaticsadvances/advance-article/doi/10.1093/bioadv/vbaf006/7958574 🧬πŸ–₯️πŸ§ͺ #Rstats https://github.com/myles-lewis/locuszoomr

28.01.2025 21:00 β€” πŸ‘ 18    πŸ” 6    πŸ’¬ 0    πŸ“Œ 0
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doubletrouble: an R/Bioconductor package for the identification, classification, and analysis of gene and genome duplications https://pubmed.ncbi.nlm.nih.gov/39862387/ 🧬πŸ–₯️πŸ§ͺ #Rstats https://github.com/almeidasilvaf/doubletrouble

28.01.2025 16:30 β€” πŸ‘ 14    πŸ” 5    πŸ’¬ 1    πŸ“Œ 0
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CASTER: Direct species tree inference from whole-genome alignments Genomes contain mosaics of discordant evolutionary histories, challenging the accurate inference of the tree of life. While genome-wide data are routinely used for discordance-aware phylogenomic analyses, due to modeling and scalability limitations, the...

In a new Science study, researchers present CASTER, a tool that uses arrangements in DNA sequences known as site patterns to infer β€œspecies trees,” which are diagrams that depict the evolutionary relationships among species.

Learn more:

25.01.2025 15:07 β€” πŸ‘ 147    πŸ” 39    πŸ’¬ 4    πŸ“Œ 1
Lestrimelitta robber bees standing on the entrance tube

Lestrimelitta robber bees standing on the entrance tube

Melipona flavolineata stingless bee guards standing on their nest entrance tube

Melipona flavolineata stingless bee guards standing on their nest entrance tube

🐝 3-year Postdoc position 🐝

Join us @bristolbiosci.bsky.social to study the impacts of parasitic bees on tropical bee communities using eDNA, SNPs & field-based surveys.

πŸ“… Deadline: 23 Feb 2025
πŸ’ƒVibrant city
🌎 Collaboration with USP πŸ‡§πŸ‡·
🐝 Details here: tinyurl.com/586u7vau

@leverhulme.bsky.social

20.01.2025 19:19 β€” πŸ‘ 59    πŸ” 52    πŸ’¬ 2    πŸ“Œ 2

Fantastic having @tegangaetano.bsky.social visit @unimainz.bsky.social and a nice experience to develop scientific links between my adopted homeland πŸ‡©πŸ‡ͺ and the country I get most mistaken for 🏴󠁧󠁒󠁳󠁣󠁴󠁿 🐝

24.01.2025 16:36 β€” πŸ‘ 4    πŸ” 0    πŸ’¬ 0    πŸ“Œ 0

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