Shreeya Kedia

How is the persistence of compartmentalized inflammation sustained in MS?
Our new study in
@cp-immunity.bsky.social
offers some hints.

cell.com/immunity/ful...

Thanks and congratulations to all contributors

Microglia activation orchestrates CXCL10-mediated CD8+ T cell recruitment to promote aging-related white matter degeneration - Nature Neuroscience White matter aging leads to degenerative and inflammatory changes. Here the authors show that microglial dysfunction exacerbates glial CXCL10 expression, harmful CD8+ T cell recruitment, myelinated ax...

Pleased to share our latest work on neural-immune interactions in aging white matter.
It was a long journey, made possible by incredible support and persistent efforts of many colleagues across various locations.
Many thanks to everyone involved.
www.nature.com/articles/s41...

I am very honored to receive the DZNE Munich Best Paper Award for our publication "T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis"🎉
Thank you @dzne.science and all the co-authors and collaborators.
www.nature.com/articles/s41...

Oligodendrocytes in Alzheimer’s disease pathophysiology - Nature Neuroscience Emerging evidence highlights the dual role of oligodendrocytes in Alzheimer’s disease, both providing protective mechanisms against the pathology and contributing to its progression.

What is the role of oligodendrocytes and myelin in the pathophysiology of Alzheimer's disease? Really excited to see this review published in @natureneuro.bsky.social
www.nature.com/articles/s41...

Oligodendrocytes in Alzheimer’s disease pathophysiology - Nature Neuroscience Emerging evidence highlights the dual role of oligodendrocytes in Alzheimer’s disease, both providing protective mechanisms against the pathology and contributing to its progression.

A Review on #oligodendrocytes in Alzheimer’s disease pathophysiology from Shreeya Kedia & Mikael Simons 🧪🧠

www.nature.com/articles/s41...

Parental origin of transgene modulates amyloid-β plaque burden in the 5xFAD mouse model of Alzheimer’s disease The 5xFAD transgenic model, popular in Alzheimer’s disease research, exhibits varying cerebral plaque burden depending on the parental source of the transgene. Mice inheriting the transgene paternally...

Are you using 5xFAD mice to study Alzheimer’s disease? Our work out today @cp-neuron.bsky.social may be relevant to you 🐁🧠 Age and sex are known to influence Aβ plaque burden in these mice. Here, we found that the transgene parentage is another strong determinant.

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White matter aging and its impact on brain function Aging leads to a decrease in white matter volume and damage to myelinated axons, contributing to neurodegeneration. Myelin breakdown can trigger inflammation, creating a vicious cycle that causes further damage. Understanding these changes is key to preventing age-related neurodegenerative disease.

How does aging affect the white matter and what are the consequences for brain function and neurodegenerative disease? Thankful to see this review with Mika Simons now published in a fascinating collection on the science of brain aging @cp-neuron.bsky.social
www.cell.com/neuron/fullt...