Paul Lapios 🧘‍♂️

Image processing for cryo-electron microscopy Cryo electron microscopy (cryo EM) is a major structural biology method for studying macromolecular complexes and cellular structures in their native states. Stable high resolution cryo microscopes, …

Learn principles of image processing to determine macromolecular structures by #cryoEM: Sign up for EMBO Practical Course on Image processing for cryo-electron microscopy in London, UK, 9–16 September

Deadline: 25 April

meetings.embo.org/event/25-cry...
#EMBOcryoEM #EMBOevents 🧪

Preprint sites bioRxiv and medRxiv launch new era of independence The popular repositories, where scientists post research before peer review, will be managed by a new organization called openRxiv.

A new chapter has begun for two of the world’s most popular preprint platforms, bioRxiv and medRxiv, with the launch of a non-profit organization that will manage them

https://go.nature.com/4iCVnHL

Challenging the Axon’s Classic Shape Forget the traditional tubular shape—researchers are investigating a pearl-on-a-string formation for axons, unlocking new insights into neural signaling in health and disease.

another piece, covering our work! Thanks to Laura Tran at the Scientist!!
www.the-scientist.com/challenging-...

Excited to share our new preprint "Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons" www.biorxiv.org/content/10.1...

We combine optogenetic stimulation of neurons with in situ cryo-ET to characterize membrane dynamics during synaptic vesicle fusion ❄️🔬⏱️

New preprint from the MemTraS team ! www.biorxiv.org/content/10.1...
Great collaboration with @fronzeslab.bsky.social and Vladan Lucic to determine the first cryo electron tomography images of dopamine "synapses" extracted from adult mouse brain.

This study was key to establishing #cryoCLEM and #cryoET in Bordeaux.

It is an important milestone.

@davidp-bdx.bsky.social,
Étienne Herzog and @paulosh.bsky.social took the risk to be the first to use this approach with us.
🙏🙏🙏

Very happy to share our last preprint where we investigated the vesicular organization of dopamine hub synapses with cryo-CLEM. It is a brain structure that emerges as an important regulator of striatal activity. Many thanks to David Perrais, Etienne Herzog and the lab of @fronzeslab.bsky.social !

Cryo-correlative light and electron tomography of dopaminergic axonal varicosities reveals non-synaptic modulation of cortico-striatal synapses https://www.biorxiv.org/content/10.1101/2025.02.07.637058v1