HIPC

Screen shot of paper entitled "MICBG4064A polymorphism reduces risk of mechanical ventilation and death during viral acute lung injury." From JCI Insight publication.

More insights from #IMPACC studies, including polymorphism that might protect in #covid19 in online publication.
Authors include: @skleinstein.bsky.social @bjoernpeters.bsky.social @sesmalab.bsky.social @vivianasimonlab.bsky.social @joanndarce.bsky.social ++ others
insight.jci.org/articles/vie...

Thanks @jschaenmanmd.bsky.social for your comments and sorry if we didn't tag every author. There were too many! #covid19 #treatment #vulnerable

Great to see this work be published, it has been such a wonderful opportunity to be involved with the #IMPACC network - these important findings re immune response to #COVID will be useful for future pandemics especially for vulnerable populations @ast-idcop.bsky.social @niaidnews.bsky.social

Frontiers | Baseline predictors for 28-day COVID-19 severity and mortality among hospitalized patients: results from the IMPACC study IntroductionThe coronavirus disease 2019 (COVID-19) pandemic threatened public health and placed a significant burden on medical resources. The Immunophenoty...

Our collaborators identify chief predictor of #covid19 severity + death. Many authors include members of #IMPACC network: @rrmsky.bsky.social @bjoernpeters.bsky.social @skleinstein.bsky.social @sesmalab.bsky.social
@joanndarce.bsky.social @droferlevy.bsky.social
www.frontiersin.org/journals/med...

Postdoctoral Researcher: Cancer-Immune Interactions in Human Organoid Systems - Tübingen, Baden-Württemberg (DE) job with University of Tübingen | 12841595 We are seeking a highly motivated Postdoctoral Researcher to determine the impact of cancer on immune responses in human organoid systems.

Postdoc Opening – Cancer & Immune Interactions
We’re hiring! Fully funded position to explore next-gen vaccines using organ-on-chip tech.

🔬 Study tumor–immune crosstalk in multi-organ systems
🤝 Work with 6 labs (microfluidics, organoids, bioinfo)

Apply by Aug 25

www.nature.com/naturecareer...

Graphical abstract for #polymorphism associated with severe #COVID19

Our collaborators unpacked a CD16 #polymorphism linked to #severe #covid19
Authors include: @skleinstein.bsky.social @bjoernpeters.bsky.social @sesmalab.bsky.social
@vivianasimonlab.bsky.social
@joanndarce.bsky.social
IMPACC group
insight.jci.org/articles/vie...

Beyond flu, intranasal platforms are also being develop for a range of pathogens.

Understanding immune dynamics at the tissue site, and being able to directly measure them in humans, may dramatically improve development of vaccines that elicit robust protection against respiratory viruses.

Local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans Seasonal influenza vaccines are most frequently delivered as intramuscular inactivated vaccines which elicit systemic responses against the immunodominant hemagglutinin (HA) head domain. An intranasal...

In our new study we show local B-cell immunity and durable memory following live-attenuated influenza intranasal vaccination of humans. We utilized minimally invasive swabbing of human upper airway, following seasonal intramuscular or nasal (FluMist) flu vaccinations
www.biorxiv.org/content/10.1...

Identification of West Nile virus infection by anti-premembrane antibodies in Nicaraguan children prior to 2007–2009 | Microbiology Spectrum Since its arrival to North America in 1999, West Nile virus (WNV) has caused multiple outbreaks in birds and humans, with thousands of human cases in the USA and Canada, whereas in Latin America, WNV ...

Our collaborator Eva Harris
+ others describe way to distinguish #westnile virus infection by anti-premembrane antibodies in Nicaraguan children.
WNV is difficult to distinguish from other flaviviruses in sera.

journals.asm.org/doi/10.1128/...

Good morning from Vancouver! 🌞⛰️ We’re at #ICML2025 presenting at GenBio + MAS. Come chat with us about machine learning in biology!

With @RobertXiangruTang, @ChenLiu, @DanqiLiao. Views like this make the science even sweeter.🧬🧠

#ML #ComputationalBiology #ICML #Vancouver

Our lab door has a "data door" that lets you download for #free 1000+ assays measuring #immune response.
immunespace.org

Image of BRI’s Matthew C. Altman, MD, MPhil; headline reads: “Asthma Exacerbations in Children Caused by Multiple Molecular Pathways”

(1/8): New findings published this week in @jama.com Pediatrics are reshaping how we understand severe childhood asthma — especially in urban, low-income communities. 🧵

Hello to #ASV2025 and be sure to use our #free #data
You can upload from immunespace.org
Including multiplex transcriptional, #cytokine, and #proteomic assays; multiparameter #phenotyping + many computational tools. #virology

Immune ‘dysregulation’ present prior to infection predicts severe responses Stanford Medicine-led research finds that a gene signature capturing immune health or dysfunction can forecast patient outcomes following subsequent viral or bacterial infections.

Our collaborator Purvesh Katri, and others, discover a #signature of #immune health.

med.stanford.edu/news/all-new...

@stanfordimmunology.bsky.social

Against a green background, a pattern of consecutive rings has small round faces or icons. Each represents an institution or person who is connected with the center image - Human Immunology Project Consortium. A gov't financed research project aimed at understanding the human immune system.

We are a network of 8 big members:
@lji.org @columbiamed.bsky.social @yalemedicine.bsky.social MIT @seattlechildrens.bsky.social
@stanfordimmunology.bsky.social
Icahn Mt. Sinai @benaroyaresearch.bsky.social
You can upload our #free data at immunespace.org
Image from 2020. 🧪 #ImmuneSky

ADTnorm: robust integration of single-cell protein measurement across CITE-seq datasets - Nature Communications Here the authors present a computational method that expands the potential of multimodal single-cell analyses by delivering an accurate, fast, and user-friendly approach for normalizing and comparing ...

Our collaborators @rgottardo.bsky.social Peter Sims and Ken Stuart (and others) develop tool ADTNorm, a method of helping noisy CITE-seq data to be "normalized"
#antibody
#ImmuneSky

nature.com/articles/s41...

#CITEseq #SingleCell #ADTNorm

ADTnorm: robust integration of single-cell protein measurement across CITE-seq datasets - Nature Communications Here the authors present a computational method that expands the potential of multimodal single-cell analyses by delivering an accurate, fast, and user-friendly approach for normalizing and comparing ...

🧬 New paper out!
🔗 www.nature.com/articles/s41...

Frustrated by noisy CITE-seq data?
ADTNorm helps normalize it and introduces a staining index to assess antibody quality.

Great work by former postdoc Ye Zheng. Supported by @hipcproject.bsky.social

#CITEseq #SingleCell #ADTNorm

Well annotated, curated, multiparameter FREE #immunology data, folks!

Very glad to see our own collaborator @virusesimmunity.bsky.social honored among all of these. #science #immunology #virology #IDSky

Page shows information about Human Immunology Project Consortium and the data from 174 studies, 52 diseases. https://immunespace.org

Our project spans 8+ institutions, with human cohorts studied with multiplex transcriptional, #cytokine, and #proteomic assays; multiparameter #phenotyping of leukocyte subsets + many computational methods.
Get our #data for your own investigations.
#ImmuneSky #IDsky
immunespace.org

Our collaborator Purvesh Khatri writes in preprint on new tool for #single-cell analysis called scMetaIntegrator.
The method provides robust effect size estimates and reproducible p-values.
#ImmuneSky
@stanfordimmunology.bsky.social
@biorxivpreprint.bsky.social
www.biorxiv.org/content/10.1...

New expanded @hipcproject.bsky.social starter pack: go.bsky.app/AozZWPx

Neuroimmune pathophysiology of long COVID Although COVID-19 was originally considered a respiratory illness, it is now well established that SARS-CoV-2 infection can have far-reaching impacts on the nervous system. Neurological symptoms such....

Our collaborator @virusesimmunity.bsky.social
and others review the #neuro #immunology of #LongCovid
#IDSky #ImmuneSky
onlinelibrary.wiley.com/doi/10.1111/...

The Krammer Lab in Vienna is looking for a postdoc in virology/immunology at the Ignaz Semmelweis Institute at the Medical University in Vienna. You can learn more about the opportunity here: t.co/SM61DamVFl

Celebrate of Life for Atul Butte!

Congratulations to our collaborator @camilahcoelho.bsky.social

RIP Atul Butte @atulbutte.bsky.social

My sincere condolences to his family, friends, current and former lab members, and colleagues.

Cell simulation as cell segmentation - Nature Methods Proseg is a segmentation approach for single-cell spatially resolved transcriptomics data that uses unsupervised probabilistic modeling of the spatial distribution of transcripts to accurately segment...

Our collaborator @evnewell.bsky.social + others
outline a new approach to identifying tumor-infiltrating #immune cells from spatial #transcriptomics. They explore cell segmentation methods .
@nature.com
@hutchinnovation.bsky.social
#ImmuneSky

www.nature.com/articles/s41...

Atul has been a constant inspiring force. He is perpetually optimistic and never stops to empower the world with more data and motivate all of us to dig deeper and be more innovative with data. I miss his energy and our conversations. RIP - May memories of Atul continue to inspire us all.