Goran Bajic

I did not expect Treg!

My guess is Mojsov et al. 🤗

Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8)

Preprint: www.biorxiv.org/content/10.1...

Congrats!

The Origin and Diversification of Mitochondria Moving beyond the simplistic view of mitochondria as the power house of the cell, Roger et al. present the immense diversity of mitochondria and mitochondrial functions across eukaryotes, and bring th...

Feeling mitochondrially challenged lately?

Here are two classic reviews on #mitochondria that should help.

www.cell.com/current-biol...

www.cell.com/current-biol...

Heads up: @science.org is looking for a new research #editor based in the US or UK to handle papers in #InfectiousDiseases (e.g., #virology, #microbiology, #parasitology) & #microbiome research! This is an amazing opportunity, so don't delay! Applications are due 22 SEP!

Congrats!

New paper from the Coelho lab with a modest contribution from us:

@cryoempapers.bsky.social

Clonotype-enriched somatic hypermutations drive affinity maturation of a public human antibody targeting an occluded sarbecovirus epitope Rao et al. demonstrate that convergent somatic hypermutations in the light chain, enriched within a sarbecovirus-specific public antibody clonotype, drive affinity maturation. This antibody targets a ...

🚨 New Publication!!!

I’m thrilled to share our latest study, “Clonotype-Enriched Somatic Hypermutations Drive Affinity Maturation of a Public Human Antibody Targeting an Occluded Sarbecovirus Epitope”.
www.cell.com/cell-reports... [1/4]

Clonotype-enriched somatic hypermutations drive affinity maturation of a public human antibody targeting an occluded sarbecovirus epitope Rao et al. demonstrate that convergent somatic hypermutations in the light chain, enriched within a sarbecovirus-specific public antibody clonotype, drive affinity maturation. This antibody targets a ...

The latest from us:
www.cell.com/cell-reports...
With Camila Coelho’s lab, we describe how public clonotype #antibody affinity matures against an occluded epitope on #spike we call the central interface epitope! #cryoEM

Mix-it-up: Accessible time-resolved cryo-EM on the millisecond timescale www.biorxiv.org/content/10.1101/2025.07.22.666177v1 #cryoEM

To celebrate @focisimmunology.bsky.social 's annual meeting this week, #Science #Immunology has just released a new free sample collection of recent papers with a focus on human immunology! The collection will be available online to read until the end of July 2025! #FOCIS2025

bit.ly/SciImm_free

So cool!

#cryoEM #antibody

Another fruitful collaboration with the Coelho lab!

www.sciencedirect.com/science/arti...

Conserved sites on the influenza H1 and H3 hemagglutinin recognized by human antibodies Broadly reactive human antibodies recognizing the head and stem of influenza hemagglutinin.

Latest from us: another productive collaboration with the Schmidt lab on #flu #antibody

www.science.org/doi/10.1126/...

Can’t wait to try this new feature out!

All props to our students, Vishal and Iden, who spearheaded this study!

Thanks for sharing. Aaron and I are really proud of this paper.

HHMI kills program aimed at boosting inclusivity in STEM education “Inclusive excellence” program had committed $60 million to 104 institutions

Really disappointed with #HHMI
www.science.org/content/arti...

Thanks for the shoutout 🙏🏻

Human naïve B cells recognize prepandemic influenza virus hemagglutinins Antibodies targeting the influenza hemagglutinin from potentially pandemic H5Nx viruses can be isolated from naïve individuals.

Our long-awaited study in collaboration with the Schmidt lab on H5Nx influenza recognition by naive B cells is out! #antibody #bcell #flu #avianflu #cryoEM

www.science.org/doi/10.1126/...

Thanks for sharing! 😀

Tonight is a fun night of proofreading manuscript journal proofs with Dionne Warwick in the background. #staytuned

Ay ay 🫡

We are hosting a cryo-EM grid nanofabrication workshop on 28 April 2025, as part of the Canadian Cryo-EM Nexus (ccemn.ca).
Learn how to make holey gold or holey carbon grids in your own laboratory!
Space is limited, so please apply at web.cvent.com/event/ee88ac...

Definitely sending someone from my lab 🤗

Defining a highly conserved B cell epitope in the receptor binding motif of SARS-CoV-2 spike glycoprotein SARS-CoV-2 mRNA vaccines induce robust and persistent germinal centre (GC) B cell responses in humans. GCs are microanatomical sites in lymphoid tissues where diversification and affinity maturation o...

Latest from us:
www.biorxiv.org/content/10.1...
Antibody 52 hits every variant we tested. #cryoEM

Looks great!