The synaptic ectokinase VLK triggers the EphB2–NMDAR interaction to drive injury-induced pain Phosphorylation of hundreds of protein extracellular domains is mediated by two kinase families but the functional role of these kinases is underexplored. We find that the presynaptic release of the t...

Excited to see our paper out at Science today! Congratulations to all of the authors! Great job, everyone! Thank you!! @dalvalab @science.org
www.science.org/doi/10.1126/...

20.11.2025 19:37 — 👍 10    🔁 1    💬 0    📌 0

Nano-organization of synapses defines synaptic release properties at cortical neuron dendritic spines Visualization of the submicron organization of excitatory synapses has revealed an unexpectedly ordered architecture consisting of nanocolumns of synaptic proteins that group into nanomodules which sc...

Want to know more about what those nanoscale puncta of synaptic proteins at synapses might do? The latest work from our lab - a project led by Haani Jafri - addresses this question.
www.biorxiv.org/content/10.1...

25.02.2025 21:48 — 👍 0    🔁 0    💬 0    📌 0

Specific neuroblast-derived signals control both cell migration and fate in the rostral migratory stream Functional neuronal circuits require neuroblasts migrate to appropriate locations and then differentiate into neuronal subtypes. However, it remains unknown how neuroblasts in the subventricular zone ...

I am excited to use my first post here to highlight new work from the lab on Biorxiv - A new area for us - EphBs and how they regulate migration and cell fate in the RMS - Please let me know what you think! www.biorxiv.org/content/10.1...

25.02.2025 21:45 — 👍 0    🔁 0    💬 0    📌 0