A amazing new story by @cate-cholamine.bsky.social led by @forrestdrogers.bsky.social on the environmental modulation of paternal behavior in African striped mice, with a newly discovered molecular player of parental control, Agouti! Terrific study, congrats to all authors!...
20.02.2026 12:48 β π 15 π 3 π¬ 2 π 0
Very sad news. Gail Martin (1944-2026) was a figure in developmental biology. She pioneered the field of ES cells.
A great colleague, a friend and a lovely person.
15.02.2026 08:55 β π 121 π 38 π¬ 6 π 3
Portrait of Dr Carla Shatz, a pioneer who mapped how the brain builds itself. A member of @nationalacademies.org, her work on neural circuits reveals how we become who we are.
More: explorers.com/carla-shatz/
#sciArt #NationalAcademies #Science #Neuroscience @nam.edu @nasonline.org
13.02.2026 14:09 β π 50 π 10 π¬ 0 π 0
Poem for a snowy Boston. Winter Psalm by Richard Hoffman. #poetry
08.02.2026 01:21 β π 10 π 3 π¬ 0 π 0
Can tell how bad it is from 1st sentence: βWhile peer review is an essential part of funding meritorious scientific research, it is also important to consider other factorsβ¦β
30.01.2026 20:38 β π 18 π 5 π¬ 0 π 0
New preprint from our group (collaboration with @sueyeonchung.bsky.social) showing that discriminating odor components within a complex mixture is constrained by neural sensitivity rather than background interference - likely due to sparse representations at the front end.
29.01.2026 14:10 β π 37 π 13 π¬ 1 π 0
Attention-like regulation of theta sweeps in the brain's spatial navigation circuit
Spatial attention supports navigation by prioritizing information from selected locations. A candidate neural mechanism is provided by theta-paced sweeps in grid- and place-cell population activity, which sample nearby space in a left-right-alternating pattern coordinated by parasubicular direction signals. During exploration, this alternation promotes uniform spatial coverage, but whether sweeps can be flexibly tuned to locations of particular interest remains unclear. Using large-scale Neuropixels recordings in freely-behaving rats, we show that sweeps and direction signals are rapidly and dynamically modulated: they track moving targets during pursuit, precede orienting responses during immobility, and reverse during backward locomotion β without prior spatial learning. Similar modulation occurs during REM sleep. Canonical head-direction signals remain head-aligned. These findings identify sweeps as a flexible, attention-like mechanism for selectively sampling allocentric cognitive maps. ### Competing Interest Statement The authors have declared no competing interest. European Research Council, Synergy Grant 951319 (EIM) The Research Council of Norway, Centre of Neural Computation 223262 (EIM, MBM), Centre for Algorithms in the Cortex 332640 (EIM, MBM), National Infrastructure grant (NORBRAIN, 295721 and 350201) The Kavli Foundation, https://ror.org/00kztt736 Ministry of Science and Education, Norway (EIM, MBM) Faculty of Medicine and Health Sciences; NTNU, Norway (AZV)
The hippocampal map has its own attentional control signal!
Our new study reveals that theta #sweeps can be instantly biased towards behaviourally relevant locations. See πΉ in post 4/6 and preprint here π
www.biorxiv.org/content/10.6...
π§΅(1/6)
28.01.2026 10:03 β π 182 π 62 π¬ 4 π 10
Kids, learn Biology this Summer: an amazing opportunity for middle schoolers!...
π§ͺπ§¬π§ π¦ π±ππͺ°πͺ±π§«
21.01.2026 20:55 β π 8 π 3 π¬ 0 π 0
It is an incredible honour to receive this prize. I thank all members of my lab over the years, and my wonderful colleagues and collaborators, who have joined, inspired and supported me on this exciting journey. β€οΈ Biozentrum is a fantastic place to do science!
15.01.2026 19:28 β π 49 π 3 π¬ 11 π 0
Congratulations @doetschlab.bsky.social !!!.... so well deserved ππ₯π
15.01.2026 19:27 β π 1 π 0 π¬ 1 π 0
Ontogeny of the spinal cord dorsal horn
The dorsal horn of the mammalian spinal cord is organized into laminae where each layer is populated by different neuron types, has distinctive circuit connections, and plays specialized roles in beha...
Excited to share @rbrianroome.bsky.social βs beautiful paper on development of the dorsal horn of the mouse spinal cord @science.org
This is how the anatomical organization and cell types that process pain, touch, body position and more are laid down.
www.science.org/doi/10.1126/...
08.01.2026 19:59 β π 132 π 41 π¬ 10 π 2
Thrilled to start my lab at the @whiteheadinstitute.bsky.social @mit.edu and to join such a special community of creative and inspiring colleagues. The Sullivan Lab asks (1) how and (2) why infections make us sick, bridging immunology and neuroscience to understand host defense at the organism scale
06.01.2026 14:08 β π 88 π 17 π¬ 2 π 3
Ascona meetings on neural circuits are amazing conferences in a beautiful setting in Switzerland spanning all scales from genetics and micro-circuit cracking to high level cognition. Check asconacircuits.org for the 2026 program and register soon, as it typically reaches capacity very quickly π§ π§ͺ
05.01.2026 12:22 β π 21 π 5 π¬ 0 π 0
Just finished my first book of the year: a sober, courageous, yet emotional, eye-opening and haunting narrative by an Ukrainian writer, father and staunch pacifist who enlisted the day his country was invaded. A must read for anyone concerned by current world affairs...
03.01.2026 18:03 β π 13 π 1 π¬ 0 π 0
I need one too!...
02.01.2026 01:48 β π 2 π 0 π¬ 0 π 0
Way back in 1999, Kenji Doya sketched a big picture theory of the brain:
1οΈβ£The cerebellum is specialized for supervised learning
2οΈβ£The basal ganglia are for reinforcement learning
3οΈβ£The cerebral cortex is for unsupervised learning
How does this hold up in 2026? www.sciencedirect.com/science/arti...
01.01.2026 15:36 β π 37 π 10 π¬ 3 π 1
I would say, depends: if you are only marginally expert in that field, decline, as other, more available and equally/more expert reviewers can take over. If you are a close expert, let the editor know of your time constraints and do it if they allow extra time. Holiday season is hell for reviews....
18.12.2025 15:56 β π 2 π 0 π¬ 0 π 0
Want to track the dynamics of estrogen in the brain across long periods of time? New paper as part of very fun collab with team UCLA Ed Van Veen and Steph Correa! We use a specialized optical reporter and show that this is possible and actually very easy! www.biorxiv.org/content/10.6...
16.12.2025 20:52 β π 44 π 10 π¬ 1 π 0
Finally, in the MPOA Gal+ Calcr+ hub of parenting, androgens shift the balance: increasing AR activity suppresses retrieval, while removing AR reduces aggression to pups and boosts care. Together: a hormone-to-cell type-to enhancer-to-behavior blueprint for state- and sex-specific parenting π§ 𧬠6/6
13.12.2025 14:13 β π 5 π 1 π¬ 1 π 0
This maternal trigger doesnβt act aloneβit recruits the core parenting hub (MPOA Gal+ Calcr+ neurons). Activating AvPe Brs3+ Vglut2+ neurons drives Fos expression in this hub, showing how a mother-tuned input can power a shared parenting circuit. 5/6
13.12.2025 14:10 β π 3 π 0 π¬ 1 π 0
And we show this is how it works: oxytocin strongly excites these neurons in maternal brains, and deleting Oxtr or prolactin receptor in AvPe Vglut2+ neurons delays pup retrieval. Hormones arenβt just βon/offββthey change what the circuit responds to. 4/6
13.12.2025 14:08 β π 2 π 0 π¬ 1 π 0
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(too?) honest book reviewer. fan of a hot drink, a good book, and a little magical thinking. Originally from NZ, now in Perth, Aus. Lover of sunshine, poetry and solitude. Late identified AuDHD
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