Frédéric Rieux-Laucat

Don’t miss ➡️ #InSilicoModeling guides identification of novel #JAK1 variants associated with #ImmuneDysregulation

By M. Jeanpierre, O. Debeaupuis, M. Parlato, @frl-lab.bsky.social & colleagues @inserm.fr @institutimagine.bsky.social

🗞️ doi.org/10.1038/s443...

A great opportunity to do a PhD in a nice and motivating environment in the heart of Paris. Have a look at the 16 project proposals !!

Open call for applications for the International PhD PPU-IMAGINE program!

Don’t miss out on 16 different PhD research projects at Institut Imagine!

Deadline: October 20, 2025

For more information: www.institutimagine.org/en/internati...

Congratulations @damien-glon.bsky.social !
Very happy to be involved in this study with @frl-lab.bsky.social !
🔥

NAP1 switches from an activator to a limiter of interferon induction by trapping TBK1 in condensates TBK1 kinase is a central regulator of type I IFN production. Upon activation of the IFN-β induction pathway, TBK1-adaptor proteins (NAP1, SINTBAD, TANK) form condensates with liquid properties. We sho...

🚨Proud to share the preprint from my postdoc in Yves Gaudin’s lab, in collab with Frédéric Rieux-Laucat’s lab.
🧠Our key finding?
 NAP1 plays a dual role in regulating innate immunity.
📌This work highlights how phase separation modulates antiviral responses and explains some interferonopathies.
🔗⬇️

@quentinriller.bsky.social, @frl-lab.bsky.social et al. present the first case of biallelic CHUK mutations disrupting IKKα kinase function, broadening the understanding of non-canonical NF-κB defects rupress.org/jem/article/...

📘 In Genes & Immunity collection: rupress.org/jem/collecti...
#HKS2025

Thrilled to share our latest in @jem.org! 🚨
A single patient with syndromic immunodeficiency led us to uncover that biallelic point mutations in the IKKα kinase domain disrupt the non-canonical and partially the canonical NF-kB pathway activation. Dive into the details! 🧬 #NFkB #Immunology

Mutations disrupting the kinase domain of IKKα lead to immunodeficiency and immune dysregulation in humans
@jem.org‪
@quentinriller.bsky.social @frl-lab.bsky.social
doi.org/10.1084/jem....

Congratulations Quentin!! it is so deserved for your outstanding PhD work.

Riller et al. @frl-lab.bsky.social @institutimagine.bsky.social show that IKKα kinase deficiency causes syndromic #immunodeficiency & immune dysregulation as a consequence of a major defect in the non-canonical NF-κB pathway and a partial defect in the canonical pathway. https://buff.ly/4gUZZZz

This work was done in @institutimagine.bsky.social in the laboratory of @frl-lab.bsky.social with Bénédicte Neven and collaborators in France and Belgium @casanovalab.bsky.social @anne-puel.bsky.social

Many thanks to all co-authors!

Bienvenu au pays du ciel bleu

Everything you always wanted to know about TCR. An outstanding work. Congratulations

T cell receptor–centric perspective to multimodal single-cell data analysis T cell receptor–centric perspective improves single-cell analysis.

Our massive effort to recontextualize #single #T-cell data is now out in Science Advances! We developed a new system, STEGO, to do a TCR-first analysis, and reanalyzed 12 studies and more than 500 000 individual T-cells.
Supported by @cziscience.bsky.social !
doi.org/10.1126/scia...

Welcome Dusan !! Here the sky is blue and people are nice 😊. So happy to see you here. All the best.

🙋🏻‍♂️

Yes please add me !!

Single-cell atlas of the human immune system reveals sex-specific dynamics of immunosenescence, including a female-specific cytotoxic CD8+ T cell subpopulation @martamele.bsky.social @mariasopenar.bsky.social
papers.ssrn.com/sol3/papers....

I’d be delighted to be added. All the best

How can we better explain that vaccination is the unique way to protect our children? And as said a brillant French pediatrician, Pr Robert Debré, long ago, our children are our eternity….

Surge in worldwide measles cases driven by lack of vaccine coverage, WHO says The WHO and CDC say there were about 10.3 million cases of measles last year, up 20 percent from 2022. Children are especially susceptible to complications.

10.3 million cases of measles occurred worldwide last year, up 20% from 2022, primarily because of inadequate immunization coverage.
The disease resulted in 107,500 deaths last year, mostly killing children under 5!!!!
There are no upsides to shunning vaccines.
www.washingtonpost.com/health/2024/...

Hello, I would be delighted to join

Fantastic !! Count me in !

Immune system adaptation during gender-affirming testosterone treatment - Nature Examination of immunological changes in transgender individuals undergoing gender-affirming testosterone treatment reveals sex hormone-regulated pathways in humans and explains sex-divergent responses...

Recent paper (Nature)-why are males more vulnerable to severe infections (ex acute #COVID), while females suffer more from autoimmunity (SLE, MS etc and also #LongCovid)? X/Y or hormones? We study adaptation of immune systems in gender-affirming testosterone treatment: nature.com/articles/s41...