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Melissa Harrison Lab

@harrisonflylab.bsky.social

How transcription is regulated to drive development https://harrisonlab.bmolchem.wisc.edu

65 Followers  |  60 Following  |  3 Posts  |  Joined: 10.02.2025  |  1.5723

Latest posts by harrisonflylab.bsky.social on Bluesky

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We are excited to share our new preprint demonstrating that nucleic acid interactions with SUZ12 constrain PRC2 activity, establishing a kinetic buffer essential for targeted gene silencing and revealing vulnerabilities in diffuse midline gliomas.
www.biorxiv.org/content/10.1...

23.07.2025 23:38 — 👍 38    🔁 17    💬 1    📌 0
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Chip (Ldb1) is a putative cofactor of Zelda forming a functional bridge to CBP during zygotic genome activation Chip/Ldb1 is a crucial cofactor regulating enhancer function and chromatin interactions. Using optogenetics, Galouzis, Kherdjemil et al. show that Chip is only essential during zygotic genome activati...

Check our latest with Yacine Kherdjemil and @eileen-furlong.bsky.social and our colleagues, where we show Chip (Ldb1) is essential only at a narrow window of embryogenesis overlapping ZGA. It functionally and physically bridges CBP to Zelda to regulate gene expression. www.cell.com/molecular-ce...

10.06.2025 07:48 — 👍 13    🔁 4    💬 1    📌 1

Lucky to have the Lewis lab right next door. This collaboration really took advantage of our shred interests and unique strengths. Also a fearless grad student- Sam Krabbenhoft.

30.05.2025 20:32 — 👍 1    🔁 0    💬 0    📌 0

Nice to see this highly collaborative effort pay off and to see our paper out! Love that all the tools in Drosophila allowed us to get at mechanistic details of this conserved process.

30.05.2025 14:43 — 👍 2    🔁 0    💬 0    📌 0
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9 Federally Funded Scientific Breakthroughs That Changed Everything

www.nytimes.com/2025/05/16/s...

16.05.2025 11:41 — 👍 2    🔁 4    💬 0    📌 0

Amazing examples of the fundamental principles that can be learned by studying developing organisms. Great job!

01.04.2025 14:01 — 👍 2    🔁 0    💬 0    📌 0

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