Aaron and the Hoskins Lab at UW Madison

Congratulations Andy!

Saccharomyces cerevisiae Ecm2 modulates the catalytic steps of pre-mRNA splicing - PubMed Genetic, biochemical, and structural studies have elucidated the molecular basis for spliceosome catalysis. Splicing is RNA catalyzed and the essential snRNA and protein factors are well-conserved. Ho...

While in the lab Charlie worked on Ecm2

pubmed.ncbi.nlm.nih.gov/33547186/

Great to catch up with my former undergrad Charlie Schneider and @uwbiochem.bsky.social biochemistry major who is in town today and tomorrow representing Merck for the @uwmadisoncals.bsky.social Biotechnology Student-Employer Connector event!

today.wisc.edu/events/view/...

The long-term goal of @cijilim.bsky.social's research group is to understand how mammalian telomeres safeguard the genome. #WARF100 @uwchancellor.bsky.social @uwbiochem.bsky.social https://www.warf.org/commercialize/uw-madison-inventor-profiles/ip_lim/

SpliceDecoder: A High-Throughput Tool for Guiding the Functional Interpretation of Differential Splicing Events Alternative splicing generates different mRNA isoforms from single genes, generating protein diversity essential for normal development and tissue function. Dysregulation of splicing is implicated in ...

new from Olga's lab @olgaanczukow.bsky.social

www.biorxiv.org/content/10.1...

Cell-selective multiplexed bioorthogonal noncanonical amino acid tagging for nascent proteomics Nature Chemical Biology - Engineered aminoacyl-tRNA synthetase (aaRS) mutants have been developed that facilitate ultrafast bioorthogonal noncanonical amino acid tagging (BONCAT) of newly...

Excited to share our work with Eranthie Weerapana and Tim van Opijnen, co-led by Conor Loynd, Soumya Roy, and Sarah Canarelli! We introduce a new generation of BONCAT tools for the versatile characterization of newly synthesized proteins in pathogenic bacteria. rdcu.be/eI4M5

New mechanistic insights into Prespliceosome formation-Roles of DEAD-box proteins Prp5 and Sub2 - PubMed The spliceosome is a highly dynamic structure that undergoes continuous structural alterations through the sequential association and dissociation of small nuclear RNAs and protein factors during prec...

Important new work out from Soo-chen (Happy Retirement!) on the role(s) of Sub2 and Prp5 during spliceosome assembly.

pubmed.ncbi.nlm.nih.gov/41027713/

Assistant Professor of Biochemistry at Vanderbilt University - Nashville, Tennessee job with Vanderbilt University School of Medicine | 12843515 Department of Biochemistry, School of Medicine—Basic Sciences

If you are somehow still compelled to be a PI in the world in which we find ourselves, we'd love to have you as a colleague!

Two positions in Biochemistry at Vanderbilt University.

www.nature.com/naturecareer...

www.nature.com/naturecareer...

Is mitochondrial function at the heart of ribosome-related diseases? Defects in ribosomal machinery cause ribosomopathies such as Diamond Blackfan anemia, classically linked to impaired protein synthesis. However, emerging evidence places mitochondrial dysfunction as a...

From Elif

www.cell.com/trends/cell-...

Congratulations Bart!

A missing enzyme-rescue metabolite as cause of a rare skeletal dysplasia - Nature In mammals, the enzyme TGDS produces UDP-4-keto-6-deoxyglucose, which binds to the catalytic pocket of UDP-xylose synthase, thereby regenerating the essential NAD+ cofactor of UDP-xylose synthase in conditions of low NAD+.

This will be an undergrad assignment soon...

www.nature.com/articles/s41...

🚨🚀 Save the date! Applications for two @RNASociety Junior Representative positions open October 16. Stay tuned for how to apply! #RNASociety #RNA

It's a flyer for Colorado RNA Club's Undergrad Day event on Oct 21st at 1:30PM.

The grad student organizers of Colorado's long-running RNA Club have been putting together this event to demystify the PhD application process for the past few years. Pass along to folks applying to grad school this cycle 🍁

Evolution and characterization of a benzylguanine-binding RNA aptamer - PubMed Repurposing the "protein-labeling toolkit" for RNA research could be a pragmatic approach for developing new RNA-labeling methods. We have evolved an RNA aptamer that tightly binds benzylguanine (bG),...

We tried this a long time ago and only were able to get as far as a SNAP tag binding aptamer. Happy to see it work!

pubmed.ncbi.nlm.nih.gov/26538152/

Ribozyme‐Catalyzed Site‐Specific Labeling of RNA Using O6‐alkylguanine SNAP‐Tag Substrates SNAPR is a ribozyme that repurposes O6-benzylguanine SNAP-tag substrates for site-specific labeling of RNA with bioorthogonal alkyne and azide functional groups, fluorophores or photocrosslinkers. Th...

I love this idea from @chlab.bsky.social so much...

Ribozyme‐Catalyzed Site‐Specific Labeling of RNA Using O6‐alkylguanine SNAP‐Tag Substrates - Walunj - 2025 - Angewandte Chemie International Edition - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...

I read that as mRNP and was like Karolin is working on RNA now?!?!??

DROL1/DIB1 determines U5 snRNP specificity for intron terminal dinucleotide in Arabidopsis - PubMed Most introns contain GT-AG terminal dinucleotides; although some eukaryotes have introns with AT-AC termini whose splicing is impaired in the Arabidopsis defective repression of OLE3::LUC 1 (drol1) mu...

pubmed.ncbi.nlm.nih.gov/41016390/

From Bench to Breakthrough: How Curiosity Led to an Extraordinarily Effective HIV Drug Federally funded basic research at the University of Utah laid the groundwork for a new HIV-prevention drug now approved for clinical use—demonstrating how curiosity-driven science delivers real-world...

uofuhealth.utah.edu/newsroom/new...

Very happy that Wes Sundquist agreed to deliver the keynote address at ASBMB 2026! For those of you who don't know, his work as key to the development of the new anti-HIV medication Lenacapavir!

Very excited about next week's RNA Maxigroup seminar from Kristen Lynch @upenn.edu ! Thanks to @rnasociety.bsky.social , @uwbiochem.bsky.social, and the CMB program for sponsoring!

Protein Domain Designer tool for the generation of publication-ready protein domain diagrams

New week, new tool: Find our Protein Domain Designer tool to generate publication-ready protein domain diagrams here: domaindesigner.farnunglab.com

CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1 - Nature CDK11 associates with SF3B1 and phosphorylates threonine residues at the N terminus of SF3B1 during spliceosome activation, and the inhibition of CDK11 blocks the activation and leads to widespread intron retention and the accumulation of non-functional spliceosomes on pre-mRNAs and chromatin.

Not as cool though as this substrate of CDK11....
www.nature.com/articles/s41...

Really cool and with interesting implications for translational fidelity.

Our CSO, Dom Reynolds, breaks down the science behind Remix’s pioneering new approach to treating difficult to drug diseases by targeting the cellular complexes that process RNA & working upstream of conventional therapeutic approaches.

➡️ More here: bit.ly/3VGrT2o

We have an open post-doc position in my group to study mRNA cleavage and polyadenylation using biochemical reconstitution and cryoEM.

Please get in touch if you are interested in joining this amazing team! 🔬🧬🤩
#RNA #cryoEM

Heterozygous pathogenic variants in the splicing factor SF1 lead to a large spectrum of neurodevelopmental disorders - PubMed Alternative splicing is highly prevalent in the brain where it orchestrates key processes such as neurogenesis and synaptogenesis, both essential for the nervous system's complexity and plasticity. Dy...

Maybe we should pay more attention to SF1 after all...
pubmed.ncbi.nlm.nih.gov/40987292/

SpliceUp: Predicting SF3B1 mutations in individual cells via aberrant splice site activation from scRNA-seq data Myeloid neoplasms (MN) are clonal heterogeneous disorders initiated by somatic driver mutations in hematopoietic stem and progenitor cells (HSPCs). Among the most common are mutations in RNA splicing ...

www.biorxiv.org/content/10.1...

Congratulations Jie! @jiexiaolab.bsky.social

Congratulations @ceesdekker.bsky.social !